Bioconductor Affymetrix Probe Listing

Probe Symbol Description Chromosome Chromosome Location GenBank Gene PubMed Gene Ontology Pathway
TC1200000203.mm.2 Rrm2 ribonucleotide reductase M2 12 24708253 NM_009104, BC085136 NM_009104, BC085136 72

blastocyst development

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

protein binding

nuclear envelope

cytoplasm

cytosol

cytosol

cytosol

ribonucleoside-diphosphate reductase complex

ribonucleoside-diphosphate reductase complex

DNA replication

ferric iron binding

deoxyribonucleotide metabolic process

deoxyribonucleotide biosynthetic process

deoxyribonucleotide biosynthetic process

oxidoreductase activity

identical protein binding

protein homodimerization activity

metal ion binding

protein heterotetramerization

00230

00240

00480

01100

04115

TC0800001737.mm.2 Gas6 growth arrest specific 6 8 -13465373 NM_019521, BC005444 NM_019521, BC005444 109

neuron migration

phosphatidylserine binding

positive regulation of protein phosphorylation

positive regulation of cytokine-mediated signaling pathway

positive regulation of glomerular filtration

signaling receptor binding

calcium ion binding

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

protein phosphorylation

phagocytosis

signal transduction

enzyme linked receptor protein signaling pathway

blood coagulation

cellular response to starvation

positive regulation of gene expression

negative regulation of tumor necrosis factor-mediated signaling pathway

macrophage cytokine production

peptidyl-serine phosphorylation

fusion of virus membrane with host plasma membrane

viral genome replication

protein tyrosine kinase activator activity

protein-macromolecule adaptor activity

receptor tyrosine kinase binding

cell-substrate adhesion

positive regulation of TOR signaling

activation of protein kinase B activity

negative regulation of interferon-gamma production

negative regulation of interleukin-1 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

positive regulation of natural killer cell differentiation

positive regulation of peptidyl-serine phosphorylation

cellular response to interferon-alpha

cellular response to drug

B cell chemotaxis

regulation of growth

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

apoptotic cell clearance

apoptotic cell clearance

negative regulation of DNA-binding transcription factor activity

protein kinase B signaling

protein kinase B signaling

protein kinase B signaling

protein kinase B signaling

positive regulation of protein kinase activity

negative regulation of transcription, DNA-templated

viral entry into host cell

receptor-mediated virion attachment to host cell

positive regulation of protein export from nucleus

metal ion binding

receptor ligand activity

receptor ligand activity

receptor ligand activity

positive regulation of fibroblast proliferation

positive regulation of phagocytosis

positive regulation of protein kinase B signaling

positive regulation of protein tyrosine kinase activity

negative regulation of biomineral tissue development

positive regulation of ERK1 and ERK2 cascade

calcium ion transmembrane transport

cellular response to vitamin K

cellular response to glucose stimulus

cellular response to growth factor stimulus

cellular response to growth factor stimulus

protein localization to plasma membrane

hematopoietic stem cell migration to bone marrow

negative regulation of oligodendrocyte apoptotic process

negative regulation of fibroblast apoptotic process

negative regulation of endothelial cell apoptotic process

positive regulation of dendritic cell chemotaxis

negative regulation of dendritic cell apoptotic process

 
TC1500002217.mm.2 Racgap1 Rac GTPase-activating protein 1 15 -99620495 NM_001253808, NM_001253809, NM_012025, BC010715 NM_001253808, NM_001253809, NM_012025, BC010715 NM_001253808, NM_001253809, NM_012025, BC010715 NM_001253808, NM_001253809, NM_012025, BC010715 52

mitotic cytokinesis

actomyosin contractile ring assembly

GTPase activator activity

phosphatidylinositol-3,4,5-trisphosphate binding

nucleus

nucleoplasm

cytoplasm

spindle

cytoskeleton

plasma membrane

ion transport

cell cycle

signal transduction

multicellular organism development

spermatogenesis

neuroblast proliferation

microtubule binding

sulfate transport

lipid binding

membrane

protein kinase binding

cell differentiation

midbody

extrinsic component of cytoplasmic side of plasma membrane

cytoplasmic vesicle

cleavage furrow

positive regulation of cytokinesis

intracellular signal transduction

alpha-tubulin binding

gamma-tubulin binding

regulation of embryonic development

metal ion binding

beta-tubulin binding

spindle midzone

mitotic spindle midzone assembly

cell division

regulation of attachment of spindle microtubules to kinetochore

mitotic spindle

centralspindlin complex

 
TC0100000298.mm.2 Il1rl1 interleukin 1 receptor-like 1 1 40439628, 40439628, 40429569 NM_001025602, NM_010743, BC051445 NM_001025602, NM_010743, BC051445 NM_001025602, NM_010743, BC051445 293

interleukin-33 binding

interleukin-33 binding

interleukin-33 receptor activity

interleukin-33 receptor activity

negative regulation of T-helper 1 type immune response

interleukin-1 receptor activity

protein binding

extracellular region

extracellular space

cytosol

plasma membrane

focal adhesion

signal transduction

negative regulation of cell population proliferation

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

integral component of membrane

hydrolase activity

extracellular matrix

negative regulation of interferon-gamma production

positive regulation of chemokine production

positive regulation of interleukin-5 production

positive regulation of macrophage activation

negative regulation of I-kappaB kinase/NF-kappaB signaling

NAD(P)+ nucleosidase activity

positive regulation of inflammatory response

NAD+ nucleotidase, cyclic ADP-ribose generating

 
TC0400001934.mm.2 Srm spermidine synthase 4 148591512 NM_009272, BC005566 NM_009272, BC005566 24

catalytic activity

spermidine synthase activity

spermidine synthase activity

polyamine metabolic process

polyamine biosynthetic process

spermidine biosynthetic process

spermidine biosynthetic process

transferase activity

identical protein binding

protein homodimerization activity

cellular response to leukemia inhibitory factor

00270

00330

00410

00480

01100

TC1000000372.mm.2 Sesn1 sestrin 1 10 41810573, 41887438 NM_001013370, NM_001162908, BC055753, BC100403 NM_001013370, NM_001162908, BC055753, BC100403 NM_001013370, NM_001162908, BC055753, BC100403 NM_001013370, NM_001162908, BC055753, BC100403 33

fibrillar center

protein binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

positive regulation of macroautophagy

oxidoreductase activity

oxidoreductase activity, acting on peroxide as acceptor

negative regulation of cell growth

TORC2 complex

cellular response to amino acid starvation

cellular response to glucose starvation

regulation of protein kinase B signaling

GATOR2 complex

GATOR2 complex

leucine binding

leucine binding

cellular response to amino acid stimulus

cellular response to leucine

reactive oxygen species metabolic process

cellular oxidant detoxification

regulation of response to reactive oxygen species

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

cellular response to leucine starvation

04115

TC1100000168.mm.2 Cnrip1 cannabinoid receptor interacting protein 1 11 17051858 NM_029861, BC087946 NM_029861, BC087946 27

cytoplasm

plasma membrane

plasma membrane

protein C-terminus binding

regulation of signaling receptor activity

type 1 cannabinoid receptor binding

type 1 cannabinoid receptor binding

myelin sheath

negative regulation of signaling receptor activity

negative regulation of signaling receptor activity

 
TC1400002746.mm.2 Gpr183 G protein-coupled receptor 183 14 -121952330 NM_183031, BC052868 NM_183031, BC052868 50

adaptive immune response

B cell activation involved in immune response

mature B cell differentiation involved in immune response

immune system process

dendritic cell chemotaxis

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

humoral immune response

signal transduction

G protein-coupled receptor signaling pathway

oxysterol binding

oxysterol binding

T cell chemotaxis

membrane

integral component of membrane

osteoclast differentiation

leukocyte chemotaxis

leukocyte chemotaxis

positive regulation of B cell proliferation

positive regulation of B cell proliferation

dendritic cell homeostasis

cell chemotaxis

T follicular helper cell differentiation

positive regulation of ERK1 and ERK2 cascade

regulation of astrocyte chemotaxis

 
TC1500000453.mm.2 Myc myelocytomatosis oncogene 15 61985340 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 NM_001177352, NM_001177353, NM_001177354, NM_010849, BC138931, BC138932 1226

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

MAPK cascade

re-entry into mitotic cell cycle

chromatin

euchromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

core promoter sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

branching involved in ureteric bud morphogenesis

B cell apoptotic process

positive regulation of mesenchymal cell proliferation

regulation of oxidative phosphorylation

positive regulation of B cell apoptotic process

DNA binding

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

spindle

glucose metabolic process

chromatin remodeling

transcription, DNA-templated

DNA-templated transcription, initiation

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

pyruvate transport

amino acid transport

cellular iron ion homeostasis

activation of cysteine-type endopeptidase activity involved in apoptotic process

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

inner mitochondrial membrane organization

cell cycle arrest

regulation of mitotic cell cycle

transcription factor binding

cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

response to radiation

response to radiation

response to gamma radiation

regulation of gene expression

regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of mitochondrial membrane potential

positive regulation of smooth muscle cell migration

Wnt signaling pathway

protein processing

nuclear body

transformation of host cell by virus

axon

ubiquitin protein ligase binding

negative regulation of protein binding

regulation of telomere maintenance

protein-DNA complex disassembly

protein-containing complex

activating transcription factor binding

cellular response to interferon-alpha

cellular response to drug

cellular response to drug

skeletal muscle cell differentiation

middle ear morphogenesis

regulation of apoptotic process

regulation of apoptotic process

positive regulation of catalytic activity

response to alkaloid

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of DNA binding

pigmentation

sequence-specific DNA binding

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

canonical Wnt signaling pathway involved in positive regulation of apoptotic process

protein-containing complex binding

negative regulation of monocyte differentiation

positive regulation of cell cycle

positive regulation of glycolytic process

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of glucose import

lactic acid secretion

protein dimerization activity

positive regulation of fibroblast proliferation

negative regulation of fibroblast proliferation

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

skeletal system morphogenesis

positive regulation of epithelial cell proliferation

detection of mechanical stimulus involved in sensory perception of sound

chromosome organization

negative regulation of cell division

positive regulation of telomerase activity

positive regulation of glial cell proliferation

positive regulation of transcription initiation from RNA polymerase II promoter

negative regulation of cell death

ERK1 and ERK2 cascade

repressing transcription factor binding

E-box binding

cellular response to hypoxia

positive regulation of metanephric cap mesenchymal cell proliferation

positive regulation of cellular respiration

positive regulation of oxidative phosphorylation

regulation of somatic stem cell population maintenance

positive regulation of DNA methylation

positive regulation of DNA biosynthetic process

positive regulation of response to DNA damage stimulus

positive regulation of ATP biosynthetic process

positive regulation of apoptotic signaling pathway

positive regulation of apoptotic signaling pathway

04010

04012

04110

04310

04350

04630

05200

05210

05213

05216

05219

05220

05221

05222

TC0100001550.mm.2 Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 1 167349990 NM_019993, BC003297 NM_019993, BC003297 27

aldehyde dehydrogenase (NAD+) activity

aldehyde dehydrogenase (NAD+) activity

cytoplasm

mitochondrion

cytosol

cytosol

cellular aldehyde metabolic process

carnitine metabolic process

oxidoreductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

aminobutyraldehyde dehydrogenase activity

aminobutyraldehyde dehydrogenase activity

neurotransmitter biosynthetic process

identical protein binding

amine binding

4-trimethylammoniobutyraldehyde dehydrogenase activity

4-trimethylammoniobutyraldehyde dehydrogenase activity

NAD binding

protein homotetramerization

00010

00053

00071

00280

00310

00330

00340

00380

00410

00561

00620

00640

01100

TC0900001182.mm.2 Slc9a9 solute carrier family 9 (sodium/hydrogen exchanger), member 9 9 94669891 NM_177909, BC099942, BC153825 NM_177909, BC099942, BC153825 NM_177909, BC099942, BC153825 22

endosome

plasma membrane

ion transport

cation transport

sodium ion transport

regulation of pH

antiporter activity

solute:proton antiporter activity

sodium:proton antiporter activity

potassium:proton antiporter activity

membrane

integral component of membrane

regulation of intracellular pH

recycling endosome

recycling endosome

transmembrane transport

potassium ion transmembrane transport

sodium ion import across plasma membrane

 
TC0500000298.mm.2 Cenpa centromere protein A 5 30666885 NM_007681, BC011038 NM_007681, BC011038 43

establishment of mitotic spindle orientation

mitotic cytokinesis

chromosome, centromeric region

chromosome, centromeric region

kinetochore

condensed nuclear chromosome kinetochore

condensed chromosome, centromeric region

condensed chromosome, centromeric region

nucleosome

condensed chromosome inner kinetochore

DNA binding

nucleus

nucleus

nucleoplasm

chromosome

pericentric heterochromatin

protein heterodimerization activity

kinetochore assembly

protein localization to chromosome, centromeric region

 
TC1300001814.mm.2 F13a1 coagulation factor XIII, A1 subunit 13 -36867177, -36867177 NM_001166391, NM_028784, BC040274 NM_001166391, NM_028784, BC040274 NM_001166391, NM_028784, BC040274 69

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

extracellular region

cytoplasm

blood coagulation

blood coagulation

hemostasis

transferase activity

transferase activity, transferring acyl groups

peptide cross-linking

peptide cross-linking

peptide cross-linking

metal ion binding

collagen-containing extracellular matrix

blood coagulation, fibrin clot formation

blood coagulation, fibrin clot formation

blood coagulation, fibrin clot formation

04610

TC0400001639.mm.2 Stmn1 stathmin 1 4 134468319 NM_019641, BC010581, BC031831, BC054396 NM_019641, BC010581, BC031831, BC054396 NM_019641, BC010581, BC031831, BC054396 NM_019641, BC010581, BC031831, BC054396 112

mitotic cytokinesis

mitotic cytokinesis

protein binding

cytoplasm

cytoplasm

cytosol

cytoskeleton

microtubule

microtubule depolymerization

microtubule depolymerization

mitotic spindle organization

multicellular organism development

nervous system development

axonogenesis

tubulin binding

tubulin binding

membrane

cell differentiation

regulation of microtubule polymerization or depolymerization

regulation of microtubule polymerization or depolymerization

negative regulation of microtubule polymerization

negative regulation of microtubule polymerization

neuron projection development

negative regulation of Rho protein signal transduction

neuron projection

hepatocyte growth factor receptor signaling pathway

positive regulation of cellular component movement

negative regulation of stress fiber assembly

establishment of skin barrier

negative regulation of thrombin-activated receptor signaling pathway

negative regulation of guanyl-nucleotide exchange factor activity

04010

TC0100002285.mm.2 Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 1 -45908069 NM_016917, BC003438 NM_016917, BC003438 138

lymphocyte homeostasis

endothelium development

iron ion transmembrane transporter activity

iron ion transmembrane transporter activity

iron ion transmembrane transporter activity

protein binding

nucleoplasm

cytosol

plasma membrane

plasma membrane

ion transport

iron ion transport

cellular iron ion homeostasis

synaptic vesicle

ferrous iron transmembrane transporter activity

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

basolateral plasma membrane

peptide hormone binding

peptide hormone binding

peptide hormone binding

regulation of transcription from RNA polymerase II promoter in response to iron

iron ion transmembrane transport

iron ion transmembrane transport

iron ion transmembrane transport

identical protein binding

negative regulation of apoptotic process

positive regulation of transcription by RNA polymerase II

spleen development

iron ion homeostasis

iron ion homeostasis

spleen trabecula formation

multicellular organismal iron ion homeostasis

iron ion export across plasma membrane

 
TC1700001173.mm.2 Rasgrp3 RAS, guanyl releasing protein 3 17 75435904, 75465537 NM_001166493, NM_207246, BC066069, BC066127 NM_001166493, NM_207246, BC066069, BC066127 NM_001166493, NM_207246, BC066069, BC066127 NM_001166493, NM_207246, BC066069, BC066127 21

guanyl-nucleotide exchange factor activity

GTPase activator activity

cytoplasm

Ras protein signal transduction

kinase binding

small GTPase binding

small GTPase binding

guanyl-nucleotide exchange factor complex

regulation of GTPase activity

perinuclear region of cytoplasm

04010

04662

TC0800001247.mm.2 Prmt7 protein arginine N-methyltransferase 7 8 106211053 NM_145404, BC006705, BC057177 NM_145404, BC006705, BC057177 NM_145404, BC006705, BC057177 42

spliceosomal snRNP assembly

fibrillar center

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

chromatin organization

regulation of gene expression by genetic imprinting

protein methylation

methyltransferase activity

histone-arginine N-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

[myelin basic protein]-arginine N-methyltransferase activity

histone methylation

transferase activity

peptidyl-arginine methylation

cell differentiation

methylation

histone arginine methylation

protein-arginine omega-N monomethyltransferase activity

protein-arginine omega-N monomethyltransferase activity

protein-arginine omega-N symmetric methyltransferase activity

protein-arginine omega-N symmetric methyltransferase activity

ribonucleoprotein complex binding

DNA methylation involved in gamete generation

histone methyltransferase activity (H4-R3 specific)

 
TC1300000246.mm.2 H3c8 H3 clustered histone 8 13 23535417 NM_145073, BC125355, BC125357 NM_145073, BC125355, BC125357 NM_145073, BC125355, BC125357 28

nuclear chromosome

nucleosome

nucleus

nucleoplasm

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC1900001203.mm.2 Psat1 phosphoserine aminotransferase 1 19 -15905122, -15905122 NM_001205339, NM_177420, BC004827 NM_001205339, NM_177420, BC004827 NM_001205339, NM_177420, BC004827 34

catalytic activity

O-phospho-L-serine:2-oxoglutarate aminotransferase activity

cytoplasm

cytosol

L-serine biosynthetic process

transaminase activity

cellular amino acid biosynthetic process

transferase activity

pyridoxal phosphate binding

identical protein binding

00260

00750

01100

TC1100004229.mm.2 Cbr2 carbonyl reductase 2 11 -120729484 NM_007621, BC010758 NM_007621, BC010758 25

carbonyl reductase (NADPH) activity

carbonyl reductase (NADPH) activity

carbonyl reductase (NADPH) activity

protein binding

mitochondrion

xylulose metabolic process

glucose metabolic process

NADH oxidation

oxidoreductase activity

identical protein binding

protein self-association

L-xylulose reductase (NADP+) activity

00590

01100

TC0100003478.mm.2 Uck2 uridine-cytidine kinase 2 1 -167226083 NM_030724, BC023789 NM_030724, BC023789 24

nucleotide binding

uridine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

cytosol

CMP salvage

phosphorylation

transferase activity

nucleoside kinase activity

identical protein binding

intracellular membrane-bounded organelle

UMP salvage

00240

00983

01100

TC0200002532.mm.2 Ube2c ubiquitin-conjugating enzyme E2C 2 164769928 NM_026785, BC147032, BC147033 NM_026785, BC147032, BC147033 NM_026785, BC147032, BC147033 25

ubiquitin ligase complex

nucleotide binding

protein polyubiquitination

ubiquitin-protein transferase activity

ATP binding

nucleus

anaphase-promoting complex

cytosol

plasma membrane

ubiquitin-dependent protein catabolic process

cell cycle

exit from mitosis

free ubiquitin chain polymerization

protein ubiquitination

transferase activity

regulation of mitotic metaphase/anaphase transition

anaphase-promoting complex-dependent catabolic process

anaphase-promoting complex-dependent catabolic process

positive regulation of exit from mitosis

ubiquitin-like protein ligase binding

cell division

ubiquitin conjugating enzyme activity

ubiquitin conjugating enzyme activity

protein K48-linked ubiquitination

protein K11-linked ubiquitination

04120

TC0600001606.mm.2 Emp1 epithelial membrane protein 1 6 135362930, 135367492 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 NM_001288627, NM_001288628, NM_010128, BC034257, BC046299, BC050899, BC138491 29

plasma membrane

plasma membrane

cell death

membrane

integral component of membrane

cell growth

bleb assembly

 
TC1300001558.mm.2 H2ac15 H2A clustered histone 15 13 -21753376 NM_178183, BC119335 NM_178183, BC119335 7

nucleosome

DNA binding

nucleus

chromosome

chromatin silencing

protein heterodimerization activity

05322

TC1300001561.mm.2 H3c11 H3 clustered histone 11 13 -21782914 NM_178207, BC116383 NM_178207, BC116383 10

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC0800001094.mm.2 Mt2 metallothionein 2 8 94172617 NM_008630, BC031758 NM_008630, BC031758 217

nucleus

cytoplasm

cytosol

cellular zinc ion homeostasis

cellular zinc ion homeostasis

nitric oxide mediated signal transduction

zinc ion binding

response to bacterium

detoxification of copper ion

detoxification of copper ion

metal ion binding

cellular response to cadmium ion

cellular response to copper ion

cellular response to zinc ion

 
TC0100003193.mm.2 Cfh complement component factor h 1 -140085854 NM_009888, BC066092 NM_009888, BC066092 153

angiogenesis

neutrophil homeostasis

kidney development

kidney development

complement component C3b binding

activation of membrane attack complex

response to dietary excess

organ or tissue specific immune response

immune system process

immune complex clearance

retinal pigment epithelium development

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

nucleus

cytoplasm

plasma membrane

inflammatory response

inflammatory response

immune response

complement activation

complement activation

complement activation

complement activation

complement activation, alternative pathway

complement activation, alternative pathway

mitochondrion organization

visual perception

heparin binding

heparin binding

determination of adult lifespan

external side of plasma membrane

gene expression

immunoglobulin mediated immune response

axon

regulation of complement activation

regulation of complement activation

mitochondrial DNA metabolic process

glomerulus development

glomerulus development

response to cytokine

vascular associated smooth muscle cell differentiation

vascular associated smooth muscle cell differentiation

identical protein binding

neuronal cell body

heparan sulfate proteoglycan binding

innate immune response

ATP metabolic process

photoreceptor cell differentiation

retinal rod cell development

neuromuscular process

cartilage development

organelle localization

retina development in camera-type eye

retina development in camera-type eye

bone development

monocyte aggregation

platelet aggregation

cellular response to lipopolysaccharide

inflammatory response to wounding

creatinine homeostasis

mitochondrial gene expression

regulation of complement-dependent cytotoxicity

04610

05150

TC0600001433.mm.2 Cdca3 cell division cycle associated 3 6 124830175 NM_013538, BC002006 NM_013538, BC002006 23

molecular_function

cytoplasm

adherens junction

cell cycle

cell division

 
TC1000003117.mm.2 Shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 10 -127517122 NM_001252316, NM_028230, BC004825, BC051396 NM_001252316, NM_028230, BC004825, BC051396 NM_001252316, NM_028230, BC004825, BC051396 NM_001252316, NM_028230, BC004825, BC051396 33

translation repressor activity, mRNA regulatory element binding

regulation of oxidative phosphorylation

regulation of oxidative phosphorylation

regulation of oxidative phosphorylation

chromatin binding

catalytic activity

glycine hydroxymethyltransferase activity

glycine hydroxymethyltransferase activity

nucleus

nucleus

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial intermembrane space

mitochondrial matrix

mitochondrial matrix

cytosol

glycine metabolic process

glycine biosynthetic process

L-serine metabolic process

L-serine biosynthetic process

L-serine catabolic process

one-carbon metabolic process

one-carbon metabolic process

zinc ion binding

positive regulation of cell population proliferation

L-allo-threonine aldolase activity

purine nucleobase biosynthetic process

microtubule cytoskeleton

membrane

amino acid binding

transferase activity

glycine biosynthetic process from serine

glycine biosynthetic process from serine

pyridoxal phosphate binding

pyridoxal phosphate binding

response to type I interferon

response to type I interferon

tetrahydrofolate interconversion

mitochondrial nucleoid

identical protein binding

protein homodimerization activity

tetrahydrofolate metabolic process

tetrahydrofolate metabolic process

folic acid metabolic process

mRNA 5'-UTR binding

cobalt ion binding

protein tetramerization

protein homotetramerization

protein homotetramerization

regulation of mitochondrial translation

regulation of mitochondrial translation

protein K63-linked deubiquitination

BRISC complex

BRISC complex

serine binding

regulation of aerobic respiration

regulation of aerobic respiration

00260

00460

00670

01100

TSUnmapped00000029.mm.2 Psd3 pleckstrin and Sec7 domain containing 3 8 -67689081, -67689081, -67689081 NM_177698 22

guanyl-nucleotide exchange factor activity

plasma membrane

membrane

cell junction

ARF protein signal transduction

regulation of ARF protein signal transduction

ruffle membrane

ruffle membrane

cell projection

synapse

04144

TC0800001095.mm.2 Mt1 metallothionein 1 8 94179088 NM_013602, BC027262, BC036990 NM_013602, BC027262, BC036990 NM_013602, BC027262, BC036990 335

copper ion binding

nucleus

cytoplasm

lysosome

cytosol

cytosol

cellular metal ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

nitric oxide mediated signal transduction

zinc ion binding

detoxification of copper ion

detoxification of copper ion

negative regulation of neuron apoptotic process

metal ion binding

metal ion binding

cellular response to chromate

cellular response to cadmium ion

cellular response to copper ion

cellular response to zinc ion

cellular response to zinc ion

 
TC1300000174.mm.2 H3c10 H3 clustered histone 10 13 21717627 NM_178206 3

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC1300001633.mm.2 H3c6 H3 clustered histone 6 13 -23561474 NM_178205, BC156786 NM_178205, BC156786 11

nuclear chromosome

chromatin

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC1500000031.mm.2 Dab2 disabled 2, mitogen-responsive phosphoprotein 15 6386747, 6299788 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 NM_001008702, NM_001037905, NM_001102400, NM_023118, BC006588, BC016887 118

negative regulation of transcription by RNA polymerase II

cell morphogenesis involved in differentiation

fibrillar center

in utero embryonic development

positive regulation of receptor recycling

positive regulation of protein phosphorylation

positive regulation of receptor internalization

integrin binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

nucleus

cytoplasm

cytoplasm

plasma membrane

plasma membrane

plasma membrane

clathrin-coated pit

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

pinocytosis

apoptotic process

activation of JUN kinase activity

multicellular organism development

endoderm development

excretion

protein C-terminus binding

positive regulation of epithelial to mesenchymal transition

positive regulation of epithelial to mesenchymal transition

positive regulation of pathway-restricted SMAD protein phosphorylation

positive regulation of pathway-restricted SMAD protein phosphorylation

negative regulation of neuron projection development

protein transport

membrane

Wnt signaling pathway

apical plasma membrane

myeloid cell differentiation

clathrin coat of coated pit

clathrin-coated vesicle

cell differentiation

clathrin binding

negative regulation of cell growth

positive regulation of cell migration

positive regulation of cell migration

positive regulation of transforming growth factor beta receptor signaling pathway

clathrin-coated vesicle membrane

cytoplasmic vesicle

negative regulation of protein binding

positive regulation of aldosterone biosynthetic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of transcription elongation from RNA polymerase II promoter

leading edge cell differentiation

phosphatidylinositol binding

AP-2 adaptor complex binding

clathrin adaptor activity

clathrin adaptor activity

cargo receptor activity

cargo receptor activity

negative regulation of apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

positive regulation of cell adhesion

positive regulation of cell adhesion

positive regulation of endocytosis

positive regulation of endocytosis

positive regulation of transcription by RNA polymerase II

SMAD binding

clathrin coat assembly

clathrin coat assembly

perinuclear region of cytoplasm

response to steroid hormone

negative regulation of epithelial cell proliferation

low-density lipoprotein particle receptor binding

positive regulation of SMAD protein signal transduction

negative regulation of androgen receptor signaling pathway

negative regulation of ERK1 and ERK2 cascade

cellular response to epidermal growth factor stimulus

hematopoietic stem cell proliferation

cellular response to transforming growth factor beta stimulus

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to plasma membrane

positive regulation of Wnt signaling pathway, planar cell polarity pathway

regulation of Rho-dependent protein serine/threonine kinase activity

positive regulation of clathrin-dependent endocytosis

positive regulation of clathrin-dependent endocytosis

positive regulation of early endosome to late endosome transport

positive regulation of aldosterone secretion

positive regulation of integrin-mediated signaling pathway

negative regulation of extrinsic apoptotic signaling pathway

04144

TC0300001137.mm.2 Sort1 sortilin 1 3 108284063 NM_001271599, NM_019972, BC056343 NM_001271599, NM_019972, BC056343 NM_001271599, NM_019972, BC056343 120

ossification

protein binding

nucleus

lysosome

endosome

early endosome

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cytosol

plasma membrane

plasma membrane

clathrin-coated pit

protein targeting to lysosome

post-Golgi vesicle-mediated transport

Golgi to endosome transport

Golgi to endosome transport

endocytosis

endocytosis

endocytosis

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

multicellular organism development

endosome to lysosome transport

extrinsic apoptotic signaling pathway via death domain receptors

cell surface

endosome membrane

nerve growth factor receptor activity

regulation of gene expression

myotube differentiation

myotube differentiation

membrane

integral component of membrane

integral component of membrane

vesicle organization

vesicle organization

vesicle organization

enzyme binding

clathrin-coated vesicle

trans-Golgi network transport vesicle

cell differentiation

neurotensin receptor activity, non-G protein-coupled

dendrite

cytoplasmic vesicle membrane

cytoplasmic vesicle

endosome transport via multivesicular body sorting pathway

response to insulin

response to insulin

neuronal cell body

intracellular membrane-bounded organelle

negative regulation of fat cell differentiation

glucose import

glucose import

neurotrophin TRK receptor signaling pathway

plasma membrane to endosome transport

nerve growth factor binding

perinuclear region of cytoplasm

negative regulation of lipoprotein lipase activity

Golgi to lysosome transport

positive regulation of epithelial cell apoptotic process

retromer complex binding

04142

04722

TC1300000262.mm.2 H1f1 H1.1 linker histone, cluster member 13 23763667 NM_030609, BC116820, BC116850 NM_030609, BC116820, BC116850 NM_030609, BC116820, BC116850 42

nucleosome

DNA binding

double-stranded DNA binding

protein binding

nucleus

nucleus

chromosome

nucleosome assembly

spermatogenesis

spermatogenesis

heparin binding

cell surface

nucleosome positioning

chromosome condensation

nucleosomal DNA binding

negative regulation of chromatin silencing

vesicle

negative regulation of DNA recombination

positive regulation of receptor-mediated endocytosis

 
TC0300000627.mm.2 Gask1b golgi associated kinase 1B 3 79885929 NM_133187, BC056975 NM_133187, BC056975 14

molecular_function

Golgi apparatus

biological_process

membrane

integral component of membrane

 
TC0700003592.mm.2 Man2a2 mannosidase 2, alpha 2 7 -80349096 NM_172903, BC055006 NM_172903, BC055006 23

Golgi membrane

catalytic activity

alpha-mannosidase activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Golgi apparatus

carbohydrate metabolic process

mannose metabolic process

N-glycan processing

protein deglycosylation

metabolic process

mannosidase activity

membrane

integral component of membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds

carbohydrate binding

metal ion binding

00510

01100

TC1100003118.mm.2 C1qbp complement component 1, q subcomponent binding protein 11 -70977845 NM_007573, BC038075 NM_007573, BC038075 67

negative regulation of transcription by RNA polymerase II

complement component C1q complex binding

complement component C1q complex binding

adaptive immune response

immune system process

transcription corepressor activity

transcription corepressor activity

mRNA binding

mRNA binding

protein kinase C binding

protein binding

hyaluronic acid binding

hyaluronic acid binding

extracellular region

extracellular space

nucleus

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

cytosol

plasma membrane

plasma membrane

mRNA processing

apoptotic process

complement activation, classical pathway

transcription factor binding

transcription factor binding

RNA splicing

translation activator activity

cell surface

cell surface

phosphatidylinositol 3-kinase signaling

membrane

regulation of complement activation

regulation of complement activation

kininogen binding

kininogen binding

adrenergic receptor binding

negative regulation of interferon-gamma production

negative regulation of interleukin-12 production

negative regulation of MDA-5 signaling pathway

negative regulation of RIG-I signaling pathway

ribosome biogenesis

mature ribosome assembly

mature ribosome assembly

mature ribosome assembly

positive regulation of apoptotic process

innate immune response

positive regulation of cell adhesion

negative regulation of mRNA splicing, via spliceosome

negative regulation of mRNA splicing, via spliceosome

presynaptic active zone

negative regulation of defense response to virus

positive regulation of protein kinase B signaling

positive regulation of mitochondrial translation

positive regulation of mitochondrial translation

positive regulation of neutrophil chemotaxis

mitochondrial ribosome binding

mitochondrial ribosome binding

presynapse

glutamatergic synapse

GABA-ergic synapse

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of trophoblast cell migration

positive regulation of dendritic cell chemotaxis

 
TC1500000175.mm.2         NM_020332, NR_106065, BC054379 NM_020332, NR_106065, BC054379 NM_020332, NR_106065, BC054379  

inorganic phosphate transmembrane transporter activity

inorganic phosphate transmembrane transporter activity

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

phosphate ion transport

phosphate ion transmembrane transporter activity

membrane

integral component of membrane

integral component of membrane

regulation of bone mineralization

inorganic diphosphate transmembrane transporter activity

inorganic diphosphate transmembrane transporter activity

inorganic diphosphate transmembrane transporter activity

phosphate ion transmembrane transport

 
TC0500003472.mm.2         NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024 NM_008568, NR_029749, NR_029787, BC065164, BC066024  

nucleotide binding

double-strand break repair via break-induced replication

in utero embryonic development

negative regulation of B cell apoptotic process

DNA binding

DNA helicase activity

DNA helicase activity

DNA replication origin binding

single-stranded DNA binding

single-stranded DNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

cytosol

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

DNA unwinding involved in DNA replication

DNA replication initiation

DNA strand elongation involved in DNA replication

cellular response to DNA damage stimulus

cell cycle

cell aging

sensory perception of sound

cell population proliferation

Wnt signaling pathway

hydrolase activity

regulation of phosphorylation

MCM complex

MCM complex

negative regulation of apoptotic process

regulation of viral genome replication

regulation of viral genome replication

long-term synaptic potentiation

SMAD protein signal transduction

cellular response to inorganic substance

cellular response to xenobiotic stimulus

cellular response to forskolin

single-stranded 3'-5' DNA helicase activity

 
TC0200002990.mm.2 Hacd1 3-hydroxyacyl-CoA dehydratase 1 2 -14026830 NM_001012396, NM_013935, BC138116, BC141017 NM_001012396, NM_013935, BC138116, BC141017 NM_001012396, NM_013935, BC138116, BC141017 NM_001012396, NM_013935, BC138116, BC141017 14

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

multicellular organism development

regulation of G2/M transition of mitotic cell cycle

positive regulation of cell-substrate adhesion

myotube differentiation

membrane

integral component of membrane

lyase activity

3-hydroxyacyl-CoA dehydratase activity

3-hydroxyacyl-CoA dehydratase activity

enzyme binding

sphingolipid biosynthetic process

sphingolipid biosynthetic process

integral component of endoplasmic reticulum membrane

fatty acid elongation

fatty acid elongation

cellular protein-containing complex assembly

very long-chain fatty acid biosynthetic process

very long-chain fatty acid biosynthetic process

hydroxyapatite binding

cementum mineralization

3-hydroxy-arachidoyl-CoA dehydratase activity

3-hydroxy-behenoyl-CoA dehydratase activity

3-hydroxy-lignoceroyl-CoA dehydratase activity

regulation of G1/S transition of mitotic cell cycle

 
TC1800000291.mm.2 Kif20a kinesin family member 20A 18 34624935, 34624623, 34625032 NM_001166406, NM_001166407, NM_009004, BC060608 NM_001166406, NM_001166407, NM_009004, BC060608 NM_001166406, NM_001166407, NM_009004, BC060608 NM_001166406, NM_001166407, NM_009004, BC060608 33

nucleotide binding

mitotic cytokinesis

microtubule bundle formation

microtubule motor activity

ATP binding

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

spindle

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

microtubule binding

protein transport

ATPase activity

protein kinase binding

midbody

cleavage furrow

regulation of cytokinesis

intercellular bridge

midbody abscission

 
TC0700004624.mm.2 Plk1 polo like kinase 1 7 122159434 NM_011121, BC006880 NM_011121, BC006880 147

mitotic sister chromatid segregation

G2/M transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

establishment of mitotic spindle orientation

nucleotide binding

mitotic cell cycle

mitotic cell cycle

mitotic cytokinesis

magnesium ion binding

chromosome, centromeric region

kinetochore

kinetochore

condensed chromosome, centromeric region

chromatin

synaptonemal complex

spindle pole

spindle pole

condensed nuclear chromosome outer kinetochore

microtubule bundle formation

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

chromosome

cytoplasm

cytoplasm

centrosome

centrosome

centriole

spindle

cytoskeleton

spindle microtubule

protein phosphorylation

protein phosphorylation

cell cycle

mitotic spindle assembly checkpoint

centrosome cycle

regulation of mitotic cell cycle

microtubule binding

positive regulation of peptidyl-threonine phosphorylation

anaphase-promoting complex binding

microtubule cytoskeleton

kinase activity

phosphorylation

female meiosis chromosome segregation

protein ubiquitination

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

protein kinase binding

regulation of mitotic metaphase/anaphase transition

midbody

protein destabilization

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cytokinesis

regulation of cytokinesis

protein localization to organelle

centriolar satellite

polar body extrusion after meiotic divisions

identical protein binding

negative regulation of apoptotic process

regulation of protein binding

regulation of protein binding

homologous chromosome segregation

establishment of protein localization

negative regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of proteolysis

nuclear envelope disassembly

spindle midzone

cell division

positive regulation of ubiquitin-protein transferase activity

synaptonemal complex disassembly

protein localization to chromatin

signal transduction involved in G2 DNA damage checkpoint

protein localization to nuclear envelope

mitotic spindle pole

regulation of mitotic spindle assembly

positive regulation of ubiquitin protein ligase activity

regulation of protein localization to cell cortex

04110

04114

04914

TC1700000036.mm.2 Zdhhc14 zinc finger, DHHC domain containing 14 17 5492599 NM_146073, BC059814 NM_146073, BC059814 19

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

protein targeting to membrane

membrane

integral component of membrane

palmitoyltransferase activity

transferase activity

transferase activity, transferring acyl groups

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein-cysteine S-palmitoyltransferase activity

 
TC0400003366.mm.2 Kif2c kinesin family member 2C 4 -117159632, -117159635 NM_134471, BC006841 NM_134471, BC006841 32

nucleotide binding

chromosome, centromeric region

chromosome, centromeric region

kinetochore

microtubule motor activity

ATP binding

nucleus

chromosome

cytoplasm

centrosome

spindle

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

microtubule depolymerization

cell cycle

chromosome segregation

mitotic metaphase plate congression

microtubule binding

microtubule cytoskeleton

ATPase activity

establishment or maintenance of microtubule cytoskeleton polarity

microtubule plus-end

microtubule plus-end binding

cell division

metaphase plate congression

attachment of mitotic spindle microtubules to kinetochore

regulation of chromosome segregation

 
TC1400000176.mm.2 Plau plasminogen activator, urokinase 14 20836661 NM_008873, BC120709, BC120713 NM_008873, BC120709, BC120713 NM_008873, BC120709, BC120713 311

angiogenesis

response to hypoxia

serine-type endopeptidase activity

protein binding

extracellular region

extracellular space

extracellular space

proteolysis

peptidase activity

serine-type peptidase activity

positive regulation of cell population proliferation

cell surface

regulation of signaling receptor activity

smooth muscle cell migration

regulation of smooth muscle cell migration

positive regulation of smooth muscle cell migration

membrane

hydrolase activity

positive regulation of cell migration

plasminogen activation

plasminogen activation

regulation of cell adhesion mediated by integrin

regulation of cell adhesion mediated by integrin

wound healing

regulation of cell population proliferation

fibrinolysis

fibrinolysis

skeletal muscle tissue regeneration

positive regulation of ovulation

neuron death

regulation of smooth muscle cell-matrix adhesion

regulation of hepatocyte proliferation

positive regulation of reactive oxygen species metabolic process

04610

TC1000002650.mm.2 Utp20 UTP20 small subunit processome component 10 -88746606 NM_175158 20

nucleus

nucleolus

nucleolus

plasma membrane

rRNA processing

90S preribosome

small-subunit processome

 
TC0900000659.mm.2 Idh3a isocitrate dehydrogenase 3 (NAD+) alpha 9 54586510 NM_029573, BC034273, BC049956 NM_029573, BC034273, BC049956 NM_029573, BC034273, BC049956 40

magnesium ion binding

isocitrate dehydrogenase (NAD+) activity

isocitrate dehydrogenase (NAD+) activity

mitochondrion

mitochondrion

mitochondrion

tricarboxylic acid cycle

tricarboxylic acid cycle

isocitrate metabolic process

isocitrate metabolic process

2-oxoglutarate metabolic process

NADH metabolic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

myelin sheath

metal ion binding

NAD binding

00020

01100

TC0100000476.mm.2 Cd28 CD28 antigen 1 60746387 NM_007642, BC064058, CD28 NM_007642, BC064058, CD28 NM_007642, BC064058, CD28 502

immunological synapse

protease binding

positive regulation of inflammatory response to antigenic stimulus

plasma membrane

immune response

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

positive regulation of gene expression

negative regulation of gene expression

positive regulation of phosphatidylinositol 3-kinase signaling

membrane

integral component of membrane

protein kinase binding

T cell costimulation

T cell costimulation

T cell costimulation

T cell costimulation

T cell costimulation

positive regulation of interleukin-10 production

positive regulation of interleukin-2 production

positive regulation of interleukin-2 production

positive regulation of interleukin-4 production

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

T cell activation

T cell activation

regulation of T cell proliferation

identical protein binding

negative thymic T cell selection

regulatory T cell differentiation

membrane raft

regulation of regulatory T cell differentiation

positive regulation of mitotic nuclear division

positive regulation of transcription by RNA polymerase II

positive regulation of alpha-beta T cell proliferation

positive regulation of alpha-beta T cell proliferation

positive regulation of isotype switching to IgG isotypes

T cell receptor signaling pathway

T cell receptor signaling pathway

positive regulation of protein kinase B signaling

apoptotic signaling pathway

protein complex involved in cell adhesion

04514

04660

04672

04940

05320

05322

05323

05330

05332

05416

TC0200004511.mm.2 Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 2 -122594472 NM_025961, BC003879 NM_025961, BC003879 37

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial intermembrane space

creatine metabolic process

creatine biosynthetic process

creatine biosynthetic process

multicellular organism development

response to nutrient

learning or memory

response to organic substance

muscle atrophy

amidinotransferase activity

amidinotransferase activity

glycine amidinotransferase activity

membrane

transferase activity

response to peptide hormone

response to mercury ion

positive regulation of cold-induced thermogenesis

00260

00330

01100

TC1600000447.mm.2 Tfrc transferrin receptor 16 32608895, 32609121 NM_011638, BC054522 NM_011638, BC054522 174

positive regulation of protein phosphorylation

double-stranded RNA binding

transferrin receptor activity

transferrin receptor activity

iron ion transmembrane transporter activity

protein binding

extracellular region

extracellular space

nucleus

cytoplasm

mitochondrion

endosome

endosome

early endosome

plasma membrane

plasma membrane

integral component of plasma membrane

clathrin-coated pit

clathrin-coated pit

iron ion transport

iron ion transport

cellular iron ion homeostasis

cellular iron ion homeostasis

endocytosis

receptor-mediated endocytosis

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

endosome membrane

positive regulation of gene expression

negative regulation of mitochondrial fusion

membrane

membrane

integral component of membrane

basolateral plasma membrane

protein kinase binding

osteoclast differentiation

Hsp70 protein binding

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of protein-containing complex assembly

cytoplasmic vesicle

receptor internalization

cellular response to extracellular stimulus

positive regulation of peptidyl-serine phosphorylation

transferrin transport

intracellular signal transduction

cellular response to drug

positive regulation of T cell proliferation

positive regulation of T cell proliferation

identical protein binding

protein homodimerization activity

negative regulation of apoptotic process

positive regulation of I-kappaB kinase/NF-kappaB signaling

intracellular membrane-bounded organelle

protein-containing complex binding

positive regulation of bone resorption

positive regulation of isotype switching

perinuclear region of cytoplasm

perinuclear region of cytoplasm

chaperone binding

positive regulation of NF-kappaB transcription factor activity

recycling endosome

recycling endosome

recycling endosome membrane

extracellular exosome

extracellular exosome

cellular response to iron ion

positive regulation of protein localization to nucleus

HFE-transferrin receptor complex

HFE-transferrin receptor complex

cellular response to leukemia inhibitory factor

04144

04145

04640

TC0200000603.mm.2 Angptl2 angiopoietin-like 2 2 33215960 NM_011923, BC138609, BC138610 NM_011923, BC138609, BC138610 NM_011923, BC138609, BC138610 53

angiogenesis

signaling receptor binding

extracellular region

extracellular space

extracellular space

collagen-containing extracellular matrix

 
TC0900000505.mm.2 H2ax H2A.X variant histone 9 44334714 NM_010436, BC005468, BC010336, H2A, NM_010436, BC005468, BC010336, H2A, NM_010436, BC005468, BC010336, H2A, NM_010436, BC005468, BC010336, H2A, 476

double-strand break repair via homologous recombination

chromosome, telomeric region

chromatin

nucleosome

condensed nuclear chromosome

male germ cell nucleus

XY body

DNA binding

damaged DNA binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

chromosome

centrosome

DNA repair

DNA repair

DNA recombination

chromatin silencing

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

cell cycle

spermatogenesis

nuclear speck

enzyme binding

site of double-strand break

site of double-strand break

histone binding

protein heterodimerization activity

meiotic cell cycle

cellular response to gamma radiation

site of DNA damage

05322

TC1400000322.mm.2 Nt5dc2 5'-nucleotidase domain containing 2 14 31134735, 31131088 NM_027289, BC011230 NM_027289, BC011230 17

cellular_component

5'-nucleotidase activity

 
TC0300000934.mm.2 H3c13 H3 clustered histone 13 3 96268653 NM_178215, BC139251, BC139252, BC156965 NM_178215, BC139251, BC139252, BC156965 NM_178215, BC139251, BC139252, BC156965 NM_178215, BC139251, BC139252, BC156965 5

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC1200002396.mm.2 Cinp cyclin-dependent kinase 2 interacting protein 12 -110872609 NM_026048, NM_027223, BC011066, BC021867 NM_026048, NM_027223, BC011066, BC021867 NM_026048, NM_027223, BC011066, BC021867 NM_026048, NM_027223, BC011066, BC021867 17

molecular_function

cellular_component

nucleus

DNA replication

DNA repair

cellular response to DNA damage stimulus

cell cycle

biological_process

cell division

 
TC1000000422.mm.2 Prep prolyl endopeptidase 10 45067215 NM_011156, BC012869, BC050830 NM_011156, BC012869, BC050830 NM_011156, BC012869, BC050830 58

endopeptidase activity

endopeptidase activity

serine-type endopeptidase activity

nucleus

cytoplasm

cytosol

cytosol

proteolysis

peptidase activity

serine-type peptidase activity

hydrolase activity

protein metabolic process

peptide binding

serine-type exopeptidase activity

oligopeptidase activity

 
TC1900001266.mm.2 Mamdc2 MAM domain containing 2 19 -23302608 NM_174857, BC042773 NM_174857, BC042773 14

glycosaminoglycan binding

extracellular region

interstitial matrix

endoplasmic reticulum

membrane

peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan

extracellular matrix

 
TC0500000888.mm.2 Septin11 septin 11 5 93093415, 93093415 NM_001009818, BC031456, BC062206, BC064466 NM_001009818, BC031456, BC062206, BC064466 NM_001009818, BC031456, BC062206, BC064466 NM_001009818, BC031456, BC062206, BC064466 38

nucleotide binding

stress fiber

GTPase activity

protein binding

GTP binding

cytoplasm

cytoskeleton

septin ring

cell cycle

microtubule cytoskeleton

cell junction

septin complex

septin complex

septin complex

cell division site

cellular protein localization

cell projection

synapse

regulation of synapse organization

cell division

molecular adaptor activity

cytoskeleton-dependent cytokinesis

postsynapse

glutamatergic synapse

GABA-ergic synapse

postsynaptic specialization of symmetric synapse

 
TC0700000236.mm.2 Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 7 16781345 NM_009201, BC029873, BC037462 NM_009201, BC029873, BC037462 NM_009201, BC029873, BC037462 33

plasma membrane

plasma membrane

amino acid transport

glutamine transport

basal plasma membrane

glutamine secretion

neutral amino acid transmembrane transporter activity

L-aspartate transmembrane transporter activity

L-aspartate transmembrane transporter activity

L-glutamine transmembrane transporter activity

L-serine transmembrane transporter activity

symporter activity

L-serine transport

membrane

integral component of membrane

metal ion binding

protein homotrimerization

L-aspartate import across plasma membrane

L-aspartate import across plasma membrane

transport across blood-brain barrier

L-glutamine import across plasma membrane

04974

TC0900002503.mm.2 Hacd3 3-hydroxyacyl-CoA dehydratase 3 9 -64986982 NM_021345, BC031755, BC057023 NM_021345, BC031755, BC057023 NM_021345, BC031755, BC057023 26

protein binding

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

I-kappaB kinase/NF-kappaB signaling

JNK cascade

Rho protein signal transduction

membrane

integral component of membrane

lyase activity

3-hydroxyacyl-CoA dehydratase activity

3-hydroxyacyl-CoA dehydratase activity

enzyme binding

sphingolipid biosynthetic process

integral component of endoplasmic reticulum membrane

fatty acid elongation

fatty acid elongation

nuclear membrane

very long-chain fatty acid biosynthetic process

very long-chain fatty acid biosynthetic process

positive regulation of viral genome replication

positive regulation by virus of viral protein levels in host cell

3-hydroxy-arachidoyl-CoA dehydratase activity

3-hydroxy-behenoyl-CoA dehydratase activity

3-hydroxy-lignoceroyl-CoA dehydratase activity

 
TC1200000664.mm.2 Rhoj ras homolog family member J 12 75308312 NM_023275, BC043719 NM_023275, BC043719 34

nucleotide binding

angiogenesis

GTPase activity

GTPase activity

GTPase activity

protein binding

GTP binding

GTP binding

intracellular anatomical structure

plasma membrane

endocytosis

small GTPase mediated signal transduction

Rho protein signal transduction

regulation of cell shape

regulation of endothelial cell migration

membrane

cell migration

cell projection assembly

actin cytoskeleton organization

actin cytoskeleton organization

Cdc42 protein signal transduction

retina vasculature morphogenesis in camera-type eye

positive regulation of cell migration involved in sprouting angiogenesis

regulation of sprouting angiogenesis

 
TC0100002974.mm.2 Ddx18 DEAD box helicase 18 1 -121553834 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 NM_025860, BC028246, BC103776, BC141230, BC141231 25

nucleotide binding

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nucleic acid binding

RNA binding

helicase activity

ATP binding

nucleus

chromosome

nucleolus

nucleolus

hydrolase activity

 
TC1100003561.mm.2 Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 11 -94343294 NM_029600, BC150788 NM_029600, BC150788 46

nucleotide binding

ATP binding

plasma membrane

integral component of plasma membrane

drug transmembrane transport

ABC-type xenobiotic transporter activity

glucuronoside transmembrane transporter activity

ABC-type glutathione S-conjugate transporter activity

ABC-type bile acid transporter activity

bile acid and bile salt transport

canalicular bile acid transport

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

ATPase activity

transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

xenobiotic transport

xenobiotic transmembrane transporter activity

transmembrane transport

transmembrane transport

icosanoid transmembrane transporter activity

leukotriene transport

anion transmembrane transport

02010

04976

TC1300000245.mm.2 H2ac10 H2A clustered histone 10 13 23533874 NM_175661, BC125011 NM_175661, BC125011 10

nucleosome

DNA binding

nucleus

chromosome

chromatin silencing

protein heterodimerization activity

05322

TC1300002037.mm.2 Cltb clathrin, light polypeptide (Lcb) 13 -54592385 NM_028870, BC070404 NM_028870, BC070404 32

structural molecule activity

trans-Golgi network

cytosol

plasma membrane

plasma membrane

plasma membrane

clathrin-coated pit

intracellular protein transport

membrane

vesicle-mediated transport

clathrin coat

clathrin vesicle coat

clathrin coat of trans-Golgi network vesicle

clathrin coat of coated pit

synaptic vesicle membrane

synaptic vesicle membrane

cytoplasmic vesicle

clathrin heavy chain binding

peptide binding

intracellular membrane-bounded organelle

clathrin coat assembly

ciliary membrane

clathrin-dependent endocytosis

presynaptic endocytic zone membrane

postsynaptic endocytic zone cytoplasmic component

04142

04144

05016

05100

TC1600000335.mm.2 St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 16 23226020, 23290469, 23224739 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 NM_001252505, NM_001252506, NM_145933, BC027833, BC092222, BC096026 78

Golgi trans cisterna

Golgi membrane

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

extracellular region

endoplasmic reticulum

Golgi apparatus

Golgi medial cisterna

N-acetylneuraminate metabolic process

protein glycosylation

sialyltransferase activity

sialyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein N-linked glycosylation via asparagine

protein N-linked glycosylation via asparagine

positive regulation of mononuclear cell proliferation

protein homodimerization activity

negative regulation of chemotaxis

sialylation

regulation of substrate adhesion-dependent cell spreading

protein sialylation

negative regulation of macrophage apoptotic process

00510

00514

01100

TC1300001576.mm.2         NM_178186, BC065803, BC116373 NM_178186, BC065803, BC116373 NM_178186, BC065803, BC116373  

DNA binding

nucleus

chromatin silencing

negative regulation of cell population proliferation

 
TC0300002313.mm.2 Lmna lamin A 3 -88481147, -88483204, -88483204 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 NM_001002011, NM_001111102, NM_019390, BC015302, BC094020 327

protein binding

nucleus

nucleus

nuclear envelope

nuclear envelope

nuclear envelope

lamin filament

nucleoplasm

nucleoplasm

cytosol

intermediate filament

protein import into nucleus

nucleus organization

nucleus organization

nuclear envelope organization

nuclear envelope organization

muscle organ development

protein phosphatase 1 binding

negative regulation of cell population proliferation

positive regulation of gene expression

nuclear matrix

nuclear body

nuclear speck

establishment of cell polarity

regulation of cell migration

establishment or maintenance of microtubule cytoskeleton polarity

regulation of protein stability

nuclear membrane

regulation of telomere maintenance

protein localization to nucleus

cellular protein localization

site of double-strand break

identical protein binding

positive regulation of osteoblast differentiation

perinuclear region of cytoplasm

ventricular cardiac muscle cell development

negative regulation of mesenchymal cell proliferation

negative regulation of release of cytochrome c from mitochondria

positive regulation of cell aging

positive regulation of histone H3-K9 trimethylation

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of adipose tissue development

DNA double-strand break attachment to nuclear envelope

negative regulation of extrinsic apoptotic signaling pathway

05410

05412

05414

TC0600002404.mm.2 Hpgds hematopoietic prostaglandin D synthase 6 -65117292 NM_019455, BC116735, BC116737 NM_019455, BC116735, BC116737 NM_019455, BC116735, BC116737 47

magnesium ion binding

prostaglandin biosynthetic process

glutathione transferase activity

glutathione transferase activity

prostaglandin-D synthase activity

prostaglandin-D synthase activity

calcium ion binding

nucleoplasm

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

prostaglandin metabolic process

prostaglandin metabolic process

glutathione metabolic process

transferase activity

isomerase activity

protein homodimerization activity

intracellular membrane-bounded organelle

negative regulation of male germ cell proliferation

00590

01100

TC1300000181.mm.2         NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162 NM_001177544, NM_178185, BC116373, BC127164, BC134370, BC062251, BC090402, BC110626, BC133661, BC147161, BC147162  

nucleosome

DNA binding

nucleus

nucleus

chromosome

chromatin silencing

negative regulation of cell population proliferation

protein heterodimerization activity

 
TC1300001565.mm.2         NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162 NM_001177544, NM_178185, BC062251, BC090402, BC110626, BC116373, BC127164, BC133661, BC134370, BC147161, BC147162  

nucleosome

DNA binding

nucleus

nucleus

chromosome

chromatin silencing

negative regulation of cell population proliferation

protein heterodimerization activity

 
TC0600003268.mm.2 Ybx3 Y box protein 3 6 -131364857 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 NM_011733, NM_139117, BC027785, BC048242, BC062377 53

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

in utero embryonic development

nucleic acid binding

DNA binding

single-stranded DNA binding

single-stranded DNA binding

RNA binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytosol

gap junction

spermatogenesis

male gonad development

fertilization

regulation of gene expression

ribonucleoprotein complex binding

negative regulation of apoptotic process

positive regulation of organ growth

negative regulation of skeletal muscle tissue development

negative regulation of necroptotic process

cellular response to tumor necrosis factor

cellular hyperosmotic response

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

polysome binding

04530

TC0900000051.mm.2 Mmp27 matrix metallopeptidase 27 9 7571395 NM_001030289 12

metalloendopeptidase activity

extracellular matrix organization

collagen catabolic process

extrinsic component of endoplasmic reticulum membrane

 
TC1300001837.mm.2 Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 13 -38645690 NM_025380, BC048466 NM_025380, BC048466 27

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

translation

negative regulation of cell population proliferation

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

positive regulation of apoptotic process

positive regulation of DNA damage response, signal transduction by p53 class mediator

cellular response to leukemia inhibitory factor

positive regulation of cellular senescence

positive regulation of apoptotic signaling pathway

 
TC1600000650.mm.2 Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 16 44139808, 44139790 NM_028108, BC046283, BC055846, BC057117 NM_028108, BC046283, BC055846, BC057117 NM_028108, BC046283, BC055846, BC057117 NM_028108, BC046283, BC055846, BC057117 26

peptide alpha-N-acetyltransferase activity

protein binding

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

N-terminal protein amino acid acetylation

N-terminal protein amino acid acetylation

mitotic sister chromatid cohesion

N-acetyltransferase activity

H4 histone acetyltransferase activity

histone acetylation

transferase activity

transferase activity, transferring acyl groups

NatA complex

NatA complex

establishment of mitotic sister chromatid cohesion

peptidyl-lysine acetyltransferase activity

mitotic sister chromatid cohesion, centromeric

 
TC0800000564.mm.2 Dctd dCMP deaminase 8 48109957, 48110012, 48099091 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 NM_001161515, NM_001161516, NM_178788, NR_027759, BC031719 16

catalytic activity

dCMP deaminase activity

pyrimidine nucleotide metabolic process

dUMP biosynthetic process

dTMP biosynthetic process

metabolic process

zinc ion binding

nucleotide biosynthetic process

hydrolase activity

identical protein binding

metal ion binding

00240

01100

TC1300001562.mm.2 H2ac22 H2A clustered histone 22 13 -21786773 NM_178184 4

DNA binding

nucleus

chromatin silencing

enzyme binding

05322

TC0100001387.mm.2         NM_008131, NR_106194, BC015086 NM_008131, NR_106194, BC015086 NM_008131, NR_106194, BC015086  

nucleotide binding

magnesium ion binding

angiogenesis

catalytic activity

glutamate-ammonia ligase activity

glutamate-ammonia ligase activity

protein binding

ATP binding

cytoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

endoplasmic reticulum

rough endoplasmic reticulum

cytosol

plasma membrane

glutamate metabolic process

glutamine biosynthetic process

glutamine biosynthetic process

nitrogen compound metabolic process

cell population proliferation

cellular response to starvation

response to glucose

regulation of endothelial cell migration

regulation of endothelial cell migration

membrane

glutamate binding

transferase activity

ligase activity

protein palmitoylation

ammonia assimilation cycle

protein-cysteine S-palmitoyltransferase activity

manganese ion binding

positive regulation of insulin secretion

protein-containing complex

ribosome biogenesis

identical protein binding

cell projection

neuron projection

perikaryon

myelin sheath

myelin sheath

intracellular membrane-bounded organelle

axon terminus

cell body

dynein light chain binding

metal ion binding

positive regulation of epithelial cell proliferation

positive regulation of synaptic transmission, glutamatergic

glial cell projection

regulation of sprouting angiogenesis

regulation of sprouting angiogenesis

regulation of protein localization to nucleolus

 
TC0800000937.mm.2 Asf1b anti-silencing function 1B histone chaperone 8 83955693 NM_024184, BC003428 NM_024184, BC003428 23

chromatin

chromatin

blastocyst hatching

nucleus

nucleoplasm

chromatin organization

chromatin assembly or disassembly

nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

DNA replication-independent nucleosome assembly

protein-containing complex

histone binding

histone binding

 
TC1300000623.mm.2 Sfxn1 sideroflexin 1 13 54071844 NM_027324, BC005743 NM_027324, BC005743 57

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

one-carbon metabolic process

ion transport

iron ion transport

iron ion transport

amino acid transport

ion transmembrane transporter activity

L-serine transmembrane transporter activity

L-serine transport

membrane

integral component of membrane

transmembrane transporter activity

serine transmembrane transporter activity

erythrocyte differentiation

integral component of mitochondrial inner membrane

integral component of mitochondrial inner membrane

D-serine transport

D-serine transmembrane transporter activity

transmembrane transport

serine import into mitochondrion

serine import into mitochondrion

mitochondrial transmembrane transport

 
TC0600001448.mm.2 Nop2 NOP2 nucleolar protein 6 125131882 NM_138747, BC004733, BC007151 NM_138747, BC004733, BC007151 NM_138747, BC004733, BC007151 37

ribosomal large subunit assembly

maturation of LSU-rRNA

RNA methylation

blastocyst formation

RNA binding

nucleus

nucleolus

nucleolus

rRNA processing

methyltransferase activity

positive regulation of cell population proliferation

S-adenosylmethionine-dependent methyltransferase activity

rRNA (cytosine-C5-)-methyltransferase activity

transferase activity

methylation

ribosome biogenesis

rRNA base methylation

regulation of signal transduction by p53 class mediator

 
TC0300001076.mm.2 Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 3 104638663 NM_009196, BC014777 NM_009196, BC014777 88

mitochondrion

centrosome

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

lipid metabolic process

centrosome cycle

monocarboxylic acid transmembrane transporter activity

monocarboxylic acid transmembrane transporter activity

basal plasma membrane

lactate transmembrane transporter activity

symporter activity

monocarboxylic acid transport

monocarboxylic acid transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

lateral plasma membrane

cell junction

response to food

lactate transmembrane transport

plasma membrane lactate transport

plasma membrane lactate transport

glucose homeostasis

identical protein binding

intracellular membrane-bounded organelle

synapse

synapse

carboxylic acid transmembrane transporter activity

regulation of insulin secretion

behavioral response to nutrient

transmembrane transport

cellular response to organic cyclic compound

organic cyclic compound binding

carboxylic acid transmembrane transport

 
TC1500000432.mm.2 Sqle squalene epoxidase 15 59315091 NM_009270, BC042781, BC056361 NM_009270, BC042781, BC056361 NM_009270, BC042781, BC056361 31

squalene monooxygenase activity

squalene monooxygenase activity

endoplasmic reticulum

cellular aromatic compound metabolic process

cholesterol metabolic process

cholesterol metabolic process

response to organic substance

membrane

integral component of membrane

sterol biosynthetic process

sterol biosynthetic process

oxidoreductase activity

regulation of cell population proliferation

intracellular membrane-bounded organelle

flavin adenine dinucleotide binding

FAD binding

lipid droplet formation

00100

01100

TC1700001622.mm.2         NM_007634, NR_039596, BC037662 NM_007634, NR_039596, BC037662 NM_007634, NR_039596, BC037662  

regulation of cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase holoenzyme complex

re-entry into mitotic cell cycle

placenta development

nucleus

nucleus

cytoplasm

centrosome

centrosome

centriole

cytoskeleton

cell cycle

negative regulation of centrosome duplication

negative regulation of centrosome duplication

cyclin-dependent protein serine/threonine kinase regulator activity

protein ubiquitination

SCF ubiquitin ligase complex

cell junction

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

mitotic cell cycle phase transition

cell division

regulation of cell cycle

 
TC0300002955.mm.2 Hadh hydroxyacyl-Coenzyme A dehydrogenase 3 -131233419 NM_008212, BC064712 NM_008212, BC064712 40

3-hydroxyacyl-CoA dehydrogenase activity

3-hydroxyacyl-CoA dehydrogenase activity

protein binding

nucleoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

response to activity

oxidoreductase activity

response to drug

identical protein binding

negative regulation of insulin secretion

regulation of insulin secretion

NAD+ binding

positive regulation of cold-induced thermogenesis

00062

00071

00280

00310

00380

00650

01100

TC0200001748.mm.2 Knstrn kinetochore-localized astrin/SPAG5 binding 2 118814002 NM_026412, BC031709 NM_026412, BC031709 22

mitotic sister chromatid segregation

mitotic sister chromatid segregation

microtubule cytoskeleton organization

chromosome, centromeric region

kinetochore

kinetochore

ruffle

protein binding

nucleus

chromosome

cytoplasm

cytoskeleton

microtubule

plasma membrane

cell cycle

spindle organization

spindle organization

chromosome segregation

cell migration

centriolar satellite

centriolar satellite

microtubule plus-end

microtubule plus-end

protein homodimerization activity

microtubule plus-end binding

cell division

regulation of attachment of spindle microtubules to kinetochore

regulation of attachment of spindle microtubules to kinetochore

cellular response to epidermal growth factor stimulus

mitotic spindle

mitotic spindle

 
TC1100001047.mm.2 Cluh clustered mitochondria (cluA/CLU1) homolog 11 74649503 NM_001081158, BC072573 NM_001081158, BC072573 19

mRNA binding

mRNA binding

cytoplasm

cytoplasm

mitochondrion organization

intracellular distribution of mitochondria

intracellular distribution of mitochondria

 
TC1300001190.mm.2 Dimt1 DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) 13 106947128 NM_025447, BC019799 NM_025447, BC019799 18

rRNA modification

rRNA (adenine-N6,N6-)-dimethyltransferase activity

rRNA (adenine-N6,N6-)-dimethyltransferase activity

RNA binding

nucleus

nucleoplasm

nucleolus

mitochondrial matrix

cytosol

rRNA processing

methyltransferase activity

rRNA methyltransferase activity

transferase activity

rRNA methylation

rRNA methylation

methylation

18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity

positive regulation of rRNA processing

 
TC0500003090.mm.2 Mlec malectin 5 -115142980 NM_175403, BC035300, BC058245 NM_175403, BC035300, BC058245 NM_175403, BC035300, BC058245 27

endoplasmic reticulum

carbohydrate metabolic process

membrane

integral component of membrane

enzyme binding

carbohydrate binding

 
TC1900000152.mm.2 Wdr74 WD repeat domain 74 19 8735838 NM_134139, BC019968, BC024478 NM_134139, BC019968, BC024478 NM_134139, BC019968, BC024478 21

nuclear exosome (RNase complex)

blastocyst formation

molecular_function

nucleus

nucleus

nucleoplasm

nucleolus

nucleolus

rRNA processing

RNA metabolic process

preribosome, large subunit precursor

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

 
TC1200001605.mm.2 Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 12 -32173396, -32173396 NM_001146200, NM_001146201, NM_020272, BC051246 NM_001146200, NM_001146201, NM_020272, BC051246 NM_001146200, NM_001146201, NM_020272, BC051246 NM_001146200, NM_001146201, NM_020272, BC051246 302

nucleotide binding

angiogenesis

regulation of protein phosphorylation

immune system process

positive regulation of acute inflammatory response

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

protein serine/threonine kinase activity

protein binding

ATP binding

cytoplasm

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

phosphatidylinositol 3-kinase complex

phosphatidylinositol 3-kinase complex

phosphatidylinositol 3-kinase complex, class IA

phosphatidylinositol 3-kinase complex, class IB

phosphatidylinositol 3-kinase complex, class IB

protein phosphorylation

endocytosis

chemotaxis

inflammatory response

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of endothelial cell migration

positive regulation of endothelial cell migration

negative regulation of triglyceride catabolic process

phosphatidylinositol 3-kinase signaling

phosphatidylinositol 3-kinase signaling

phosphatidylinositol 3-kinase signaling

membrane

membrane

kinase activity

1-phosphatidylinositol-3-kinase activity

1-phosphatidylinositol-3-kinase activity

1-phosphatidylinositol-3-kinase activity

phosphorylation

cell migration

transferase activity

secretory granule localization

1-phosphatidylinositol-4-phosphate 3-kinase activity

1-phosphatidylinositol-4-phosphate 3-kinase activity

positive regulation of Rac protein signal transduction

positive regulation of Rac protein signal transduction

phosphatidylinositol-3-phosphate biosynthetic process

identical protein binding

positive regulation of catalytic activity

positive regulation of MAP kinase activity

phosphatidylinositol phosphorylation

phosphatidylinositol phosphorylation

ephrin receptor binding

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

phosphatidylinositol-mediated signaling

positive regulation of protein kinase B signaling

phosphatidylinositol kinase activity

cellular response to cAMP

hepatocyte apoptotic process

regulation of calcium ion transmembrane transport

negative regulation of fibroblast apoptotic process

00562

04012

04062

04070

04150

04210

04370

04380

04510

04620

04630

04650

04660

04662

04664

04666

04670

04722

04810

04910

04914

04930

04960

04973

05100

05142

05145

05146

05160

05200

05210

05211

05212

05213

05214

05215

05218

05220

05221

05222

05223

TC1900000184.mm.2 Rab3il1 RAB3A interacting protein (rabin3)-like 1 19 10018193, 10001668, 10018193, 10018193, 10018250, 10001724, 10015046, 10018250 NM_144538, BC020147 NM_144538, BC020147 19

guanyl-nucleotide exchange factor activity

exocytosis

protein transport

kinase binding

identical protein binding

Golgi to plasma membrane transport vesicle

 
TC1000002453.mm.2 Pdxk pyridoxal (pyridoxine, vitamin B6) kinase 10 -78436746 NM_172134, BC027745 NM_172134, BC027745 31

nucleotide binding

magnesium ion binding

ATP binding

nucleoplasm

cytoplasm

cytosol

zinc ion binding

pyridoxal kinase activity

pyridoxal kinase activity

pyridoxal 5'-phosphate salvage

pyridoxal 5'-phosphate salvage

kinase activity

phosphorylation

transferase activity

pyridoxal phosphate binding

potassium ion binding

sodium ion binding

lithium ion binding

small molecule binding

protein homodimerization activity

pyridoxal phosphate biosynthetic process

negative regulation of apoptotic process

metal ion binding

pyridoxal binding

00750

01100

TC0300002500.mm.2 H3c15 H3 clustered histone 15 3 96246699, -96238478 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 NM_054045, BC015270, BC132488, BC132490, BC156965 5

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

05322

TC0300003216.mm.2         NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965 NM_178216, BC094041, BC132488, BC132490, BC156965  

negative regulation of transcription by RNA polymerase II

nuclear chromosome

nucleosome

chromatin binding

nucleus

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

protein-containing complex

regulation of gene silencing

 
TC0500001734.mm.2 Daglb diacylglycerol lipase, beta 5 143464492 NM_144915, BC016105 NM_144915, BC016105 29

prostaglandin biosynthetic process

triglyceride lipase activity

nucleoplasm

plasma membrane

lipid metabolic process

icosanoid metabolic process

G protein-coupled glutamate receptor signaling pathway

neuroblast proliferation

positive regulation of triglyceride catabolic process

membrane

integral component of membrane

lipid catabolic process

lipase activity

lipase activity

hydrolase activity

arachidonic acid metabolic process

arachidonic acid metabolic process

arachidonic acid metabolic process

neurogenesis

neurogenesis

neurotransmitter biosynthetic process

neurotransmitter biosynthetic process

postsynaptic membrane

metal ion binding

regulation of inflammatory response

endocannabinoid signaling pathway

retrograde trans-synaptic signaling by endocannabinoid

 
TC1100000582.mm.2 Cdkn2aipnl CDKN2A interacting protein N-terminal like 11 51967630 NM_029976, BC116362, BC116363 NM_029976, BC116362, BC116363 NM_029976, BC116362, BC116363 20

molecular_function

nucleoplasm

nucleolus

 
TC0200004811.mm.2 Cd93 CD93 antigen 2 -148436650 NM_010740, BC156937, CD93 NM_010740, BC156937, CD93 NM_010740, BC156937, CD93 42

complement component C1q complex binding

calcium ion binding

plasma membrane

plasma membrane

cell adhesion

cell surface

membrane

integral component of membrane

carbohydrate binding

cytoplasmic vesicle

cell-cell adhesion

cell-cell adhesion

 
TC0300001856.mm.2 Ccna2 cyclin A2 3 -36564864 NM_009828, BC052730 NM_009828, BC052730 199

regulation of cyclin-dependent protein serine/threonine kinase activity

G2/M transition of mitotic cell cycle

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase holoenzyme complex

female pronucleus

male pronucleus

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

regulation of DNA replication

cell cycle

cyclin-dependent protein serine/threonine kinase regulator activity

cyclin-dependent protein serine/threonine kinase regulator activity

histone phosphorylation

protein kinase binding

protein kinase binding

protein domain specific binding

mitotic cell cycle phase transition

cell cycle G1/S phase transition

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of fibroblast proliferation

cell division

cyclin A2-CDK2 complex

cyclin A2-CDK2 complex

cyclin A2-CDK2 complex

04110

04914

TC0X00002993.mm.2 Timm8a1 translocase of inner mitochondrial membrane 8A1 X 11609223, -134537255 NM_013898, BC004796, BC094631 NM_013898, BC004796, BC094631 NM_013898, BC004796, BC094631 26

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial intermembrane space

protein targeting to mitochondrion

zinc ion binding

protein transport

membrane

identical protein binding

metal ion binding

chaperone-mediated protein transport

 
TC1000002341.mm.2 Cdk1 cyclin-dependent kinase 1 10 -69335145 NM_007659, BC024396 NM_007659, BC024396 223

G2/M transition of mitotic cell cycle

nucleotide binding

cyclin-dependent protein kinase holoenzyme complex

chromatin binding

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

mitochondrion

mitochondrial matrix

mitochondrial matrix

centrosome

cytosol

cytoskeleton

spindle microtubule

protein phosphorylation

protein phosphorylation

protein phosphorylation

apoptotic process

cell cycle

mitotic G2 DNA damage checkpoint

mitotic G2 DNA damage checkpoint

cell aging

cell population proliferation

RNA polymerase II CTD heptapeptide repeat kinase activity

RNA polymerase II CTD heptapeptide repeat kinase activity

response to organonitrogen compound

positive regulation of gene expression

negative regulation of gene expression

positive regulation of G2/M transition of mitotic cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

chromosome condensation

cyclin binding

midbody

Hsp70 protein binding

animal organ regeneration

protein localization to kinetochore

histone kinase activity

positive regulation of protein import into nucleus

regulation of circadian rhythm

negative regulation of apoptotic process

mitotic cell cycle phase transition

response to ethanol

positive regulation of DNA replication

positive regulation of mitotic cell cycle

rhythmic process

cell division

positive regulation of cardiac muscle cell proliferation

protein-containing complex assembly

mitotic spindle

Golgi disassembly

cyclin B1-CDK1 complex

cyclin-dependent protein kinase activity

positive regulation of protein localization to nucleus

positive regulation of mitochondrial ATP synthesis coupled electron transport

04110

04114

04115

04540

04914

TC1000002264.mm.2 Ddx21 DExD box helicase 21 10 -62580246 NM_019553, BC043655, BC059237 NM_019553, BC043655, BC059237 NM_019553, BC043655, BC059237 47

nucleotide binding

immune system process

positive regulation of myeloid dendritic cell cytokine production

nucleic acid binding

RNA binding

RNA binding

RNA helicase activity

RNA helicase activity

RNA helicase activity

double-stranded RNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

nucleolus

cytoplasm

mitochondrion

cytosol

rRNA processing

transcription by RNA polymerase II

response to virus

hydrolase activity

rRNA binding

snoRNA binding

miRNA binding

identical protein binding

positive regulation of I-kappaB kinase/NF-kappaB signaling

response to exogenous dsRNA

innate immune response

defense response to virus

R-loop disassembly

7SK snRNA binding

 
TC1800000265.mm.2 Wdr36 WD repeat domain 36 18 32837224, 32837224, 32837224 NM_001110015, NM_001110016, NM_144863, BC094453 NM_001110015, NM_001110016, NM_144863, BC094453 NM_001110015, NM_001110016, NM_144863, BC094453 NM_001110015, NM_001110016, NM_144863, BC094453 24

retina homeostasis

nucleolus

rRNA processing

regulation of axon extension

small-subunit processome

Pwp2p-containing subcomplex of 90S preribosome

03008

TC1700001003.mm.2 Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 17 56303336, 56304312 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 NM_001111078, NM_001111079, NM_001111080, NM_010931, BC022167 107

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

chromatin

euchromatin

heterochromatin

heterochromatin

cis-regulatory region sequence-specific DNA binding

DNA binding

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

replication fork

plasma membrane

DNA repair

chromatin organization

ubiquitin-dependent protein catabolic process

cellular response to DNA damage stimulus

cell cycle

zinc ion binding

methyl-CpG binding

maintenance of DNA methylation

maintenance of DNA methylation

maintenance of DNA methylation

histone monoubiquitination

histone monoubiquitination

nuclear matrix

protein ubiquitination

histone ubiquitination

transferase activity

cytoplasmic vesicle

nucleosomal histone binding

positive regulation of cellular protein metabolic process

methylated histone binding

methylated histone binding

histone binding

identical protein binding

hemi-methylated DNA-binding

hemi-methylated DNA-binding

metal ion binding

regulation of epithelial cell proliferation

protein autoubiquitination

protein autoubiquitination

ubiquitin protein ligase activity

ubiquitin protein ligase activity

 
TC1400002836.mm.2 Dok2 docking protein 2 14 70774380 NM_010071, BC004590 NM_010071, BC004590 54

transmembrane receptor protein tyrosine kinase adaptor activity

protein binding

transmembrane receptor protein tyrosine kinase signaling pathway

Ras protein signal transduction

negative regulation of MAPK cascade

 
TC0200001776.mm.2 Nusap1 nucleolar and spindle associated protein 1 2 119618297 NM_001042652, NM_133851, BC004787, BC100392 NM_001042652, NM_133851, BC004787, BC100392 NM_001042652, NM_133851, BC004787, BC100392 NM_001042652, NM_133851, BC004787, BC100392 31

mitotic sister chromatid segregation

microtubule cytoskeleton organization

mitotic cytokinesis

mitotic cytokinesis

DNA binding

nucleus

chromosome

nucleolus

nucleolus

cytoplasm

spindle

cytoskeleton

microtubule

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

microtubule binding

microtubule binding

establishment of mitotic spindle localization

establishment of mitotic spindle localization

positive regulation of mitotic nuclear division

cell division

mitotic spindle

 
TC0100000590.mm.2 Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 1 71557155 NM_026195, BC039925 NM_026195, BC039925 24

catalytic activity

IMP cyclohydrolase activity

IMP cyclohydrolase activity

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

phosphoribosylaminoimidazolecarboxamide formyltransferase activity

mitochondrion

cytosol

cytosol

plasma membrane

purine nucleotide biosynthetic process

'de novo' IMP biosynthetic process

'de novo' IMP biosynthetic process

metabolic process

nucleoside metabolic process

ribonucleotide metabolic process

transferase activity

hydrolase activity

protein homodimerization activity

dihydrofolate metabolic process

tetrahydrofolate biosynthetic process

cellular response to interleukin-7

00230

00670

01100

TC1500001940.mm.2 Cenpm centromere protein M 15 -82233775, -82233775 NM_001080158, NM_025639, NM_178269, BC009160 NM_001080158, NM_025639, NM_178269, BC009160 NM_001080158, NM_025639, NM_178269, BC009160 NM_001080158, NM_025639, NM_178269, BC009160 19

chromosome, centromeric region

kinetochore

molecular_function

nucleus

chromosome

cytoplasm

cytosol

biological_process

 
TC1300001574.mm.2 H2ac12 H2A clustered histone 12 13 -22035121 NM_175659, BC139479, BC146008 NM_175659, BC139479, BC146008 NM_175659, BC139479, BC146008 11

nucleosome

DNA binding

nucleus

chromosome

chromatin silencing

protein heterodimerization activity

05322

TC1300000972.mm.2 Mef2c myocyte enhancer factor 2C 13 83504033, 83573606, 83524742, 83523655 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 NM_001170537, NM_025282, BC026841, BC037731, BC057650 401

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

MAPK cascade

MAPK cascade

MAPK cascade

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

blood vessel development

osteoblast differentiation

osteoblast differentiation

neuron migration

B cell homeostasis

heart looping

endochondral ossification

endochondral ossification

blood vessel remodeling

chondrocyte differentiation

germinal center formation

regulation of germinal center formation

primary heart field specification

secondary heart field specification

outflow tract morphogenesis

sinoatrial valve morphogenesis

cardiac ventricle formation

cardiac ventricle formation

DNA binding

DNA binding

minor groove of adenine-thymine-rich DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

apoptotic process

humoral immune response

multicellular organism development

nervous system development

heart development

heart development

skeletal muscle tissue development

muscle cell fate determination

learning or memory

positive regulation of cardiac muscle hypertrophy

positive regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of alkaline phosphatase activity

neural crest cell differentiation

cardiac muscle hypertrophy in response to stress

nuclear speck

sarcomere

cell differentiation

neuron differentiation

platelet formation

monocyte differentiation

negative regulation of ossification

melanocyte differentiation

positive regulation of bone mineralization

positive regulation of B cell proliferation

protein-containing complex

activating transcription factor binding

cellular response to drug

skeletal muscle cell differentiation

skeletal muscle cell differentiation

cellular response to trichostatin A

B cell proliferation

histone deacetylase binding

histone deacetylase binding

intracellular membrane-bounded organelle

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

cell fate commitment

regulation of megakaryocyte differentiation

positive regulation of myoblast differentiation

positive regulation of neuron differentiation

positive regulation of osteoblast differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of neurotransmitter secretion

protein heterodimerization activity

protein dimerization activity

regulation of synaptic plasticity

positive regulation of skeletal muscle tissue development

neuron development

cell morphogenesis involved in neuron differentiation

embryonic viscerocranium morphogenesis

embryonic skeletal system morphogenesis

negative regulation of epithelial cell proliferation

B cell receptor signaling pathway

smooth muscle cell differentiation

regulation of synapse assembly

regulation of synaptic transmission, glutamatergic

cardiac muscle cell differentiation

cardiac muscle cell differentiation

ventricular cardiac muscle cell differentiation

roof of mouth development

regulation of synaptic activity

positive regulation of cardiac muscle cell proliferation

excitatory postsynaptic potential

transdifferentiation

regulation of sarcomere organization

cartilage morphogenesis

regulation of dendritic spine development

renal tubule morphogenesis

cellular response to lipopolysaccharide

cellular response to calcium ion

cellular response to retinoic acid

cellular response to growth factor stimulus

cellular response to parathyroid hormone stimulus

cellular response to fluid shear stress

cellular response to transforming growth factor beta stimulus

HMG box domain binding

positive regulation of cell proliferation in bone marrow

glomerulus morphogenesis

nephron tubule epithelial cell differentiation

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of vascular associated smooth muscle cell migration

negative regulation of vascular endothelial cell proliferation

sequence-specific double-stranded DNA binding

positive regulation of macrophage apoptotic process

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiac muscle cell differentiation

positive regulation of behavioral fear response

epithelial cell proliferation involved in renal tubule morphogenesis

positive regulation of skeletal muscle cell differentiation

04010

TC0200001045.mm.2 Itga6 integrin alpha 6 2 71786938 NM_001277970, NM_008397, BC058095 NM_001277970, NM_008397, BC058095 NM_001277970, NM_008397, BC058095 274

integrin binding

protein binding

basement membrane

plasma membrane

plasma membrane

adherens junction

cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

integrin complex

external side of plasma membrane

basal plasma membrane

cell surface

cell surface

positive regulation of cell-substrate adhesion

positive regulation of neuron projection development

membrane

integral component of membrane

basolateral plasma membrane

positive regulation of cell-cell adhesion

hemidesmosome

filopodium

positive regulation of cell migration

cell-substrate adhesion

cellular response to extracellular stimulus

insulin-like growth factor I binding

cell adhesion mediated by integrin

integrin alpha6-beta4 complex

nail development

neuregulin binding

positive regulation of phosphorylation

odontogenesis of dentin-containing tooth

positive regulation of apoptotic process

laminin binding

positive regulation of GTPase activity

skin morphogenesis

protein-containing complex binding

basal part of cell

positive regulation of transcription by RNA polymerase II

filopodium assembly

metal ion binding

brown fat cell differentiation

leukocyte migration

leukocyte migration

cell-cell adhesion

negative regulation of extrinsic apoptotic signaling pathway

04510

04512

04514

04640

04810

05145

05200

05222

05410

05412

05414

TC1300000191.mm.2 H2bc12 H2B clustered histone 12 13 22035820 NM_175665, BC147143, BC147144 NM_175665, BC147143, BC147144 NM_175665, BC147143, BC147144 9

nucleosome

innate immune response in mucosa

DNA binding

extracellular space

nucleus

nucleoplasm

nucleoplasm

chromosome

cytosol

nucleosome assembly

antibacterial humoral response

killing of cells of other organism

protein heterodimerization activity

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

05322

TC1300001634.mm.2 H2ac8 H2A clustered histone 8 13 -23570662 NM_178187, BC058544, BC076498 NM_178187, BC058544, BC076498 NM_178187, BC058544, BC076498 12

DNA binding

nucleus

chromatin silencing

enzyme binding

05322

TC0X00003361.mm.2 Prps2 phosphoribosyl pyrophosphate synthetase 2 X -167346319 NM_026662, BC024942 NM_026662, BC024942 23

nucleotide binding

magnesium ion binding

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ATP binding

ATP binding

cytoplasm

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate biosynthetic process

purine nucleotide biosynthetic process

AMP biosynthetic process

nucleoside metabolic process

ribonucleoside monophosphate biosynthetic process

nucleotide biosynthetic process

AMP binding

kinase activity

phosphorylation

transferase activity

GDP binding

ribose phosphate metabolic process

carbohydrate binding

protein-containing complex

identical protein binding

ADP binding

cellular biosynthetic process

metal ion binding

00030

00230

01100

TC1600002082.mm.2 Gart phosphoribosylglycinamide formyltransferase 16 -91621396 NM_010256, BC070465 NM_010256, BC070465 40

nucleotide binding

catalytic activity

phosphoribosylamine-glycine ligase activity

phosphoribosylamine-glycine ligase activity

phosphoribosylformylglycinamidine cyclo-ligase activity

phosphoribosylformylglycinamidine cyclo-ligase activity

phosphoribosylglycinamide formyltransferase activity

ATP binding

cytosol

purine nucleotide biosynthetic process

'de novo' IMP biosynthetic process

glycine metabolic process

metabolic process

biosynthetic process

purine nucleobase biosynthetic process

ribonucleoside monophosphate biosynthetic process

response to organic substance

response to inorganic substance

transferase activity

hydroxymethyl-, formyl- and related transferase activity

ligase activity

adenine biosynthetic process

tetrahydrofolate biosynthetic process

metal ion binding

00230

00670

01100

TC1500001127.mm.2         NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883 NM_001039129, NM_010447, NR_002885, NR_104427, BC080675, BC083136, BC089340, BC092395, NR_002883  

alternative mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

mRNA processing

RNA splicing

mRNA transport

ribonucleoprotein complex

 
TC0800000126.mm.2 Tfdp1 transcription factor Dp 1 8 13338803, 13338750 NM_009361, BC132567, BC132569, BC145344 NM_009361, BC132567, BC132569, BC145344 NM_009361, BC132567, BC132569, BC145344 NM_009361, BC132567, BC132569, BC145344 62

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

cytoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

cell cycle

transcription factor binding

epidermis development

protein domain specific binding

anoikis

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-binding transcription factor activity

regulation of cell cycle

negative regulation of fat cell proliferation

RNA polymerase II transcription regulator complex

positive regulation of G1/S transition of mitotic cell cycle

regulation of DNA biosynthetic process

04110

04350

TC1100000983.mm.2 Pimreg PICALM interacting mitotic regulator 11 72042501 NM_144526, BC020115, BC029115 NM_144526, BC020115, BC029115 NM_144526, BC020115, BC029115 18

molecular_function

nucleus

nucleoplasm

nucleolus

cell cycle

cell division

 
TC1300002543.mm.2 Ccnb1 cyclin B1 13 -100778738 NM_172301, BC011478, BC080202, BC085238 NM_172301, BC011478, BC080202, BC085238 NM_172301, BC011478, BC080202, BC085238 NM_172301, BC011478, BC080202, BC085238 210

regulation of cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase holoenzyme complex

spindle pole

condensed nuclear chromosome outer kinetochore

oocyte maturation

in utero embryonic development

negative regulation of protein phosphorylation

patched binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

mitochondrial matrix

mitochondrial matrix

mitochondrial matrix

centrosome

centrosome

cytosol

cytoskeleton

protein phosphorylation

cell cycle

mitotic spindle organization

mitotic metaphase plate congression

mitotic metaphase plate congression

negative regulation of gene expression

positive regulation of G2/M transition of mitotic cell cycle

membrane

cyclin-dependent protein serine/threonine kinase regulator activity

protein kinase binding

positive regulation of mRNA 3'-end processing

positive regulation of histone phosphorylation

ubiquitin-like protein ligase binding

mitotic cell cycle phase transition

protein-containing complex binding

positive regulation of cell cycle

positive regulation of mitotic cell cycle

positive regulation of fibroblast proliferation

cell division

positive regulation of attachment of spindle microtubules to kinetochore

positive regulation of cardiac muscle cell proliferation

regulation of chromosome condensation

cyclin-dependent protein serine/threonine kinase activator activity

protein-containing complex assembly

regulation of mitotic cell cycle spindle assembly checkpoint

cyclin B1-CDK1 complex

cyclin B1-CDK1 complex

positive regulation of mitochondrial ATP synthesis coupled electron transport

histone H3-S10 phosphorylation involved in chromosome condensation

04110

04114

04115

04914

TC1300000177.mm.2 H2bc15 H2B clustered histone 15 13 21754075 NM_178201 4

nucleus

nucleoplasm

cytosol

05322

TC1800001087.mm.2 Tpgs2 tubulin polyglutamylase complex subunit 2 18 -25136038, -25127222, -25136038 NM_001004361, NM_001142697, NM_001142698, BC080777 NM_001004361, NM_001142697, NM_001142698, BC080777 NM_001004361, NM_001142697, NM_001142698, BC080777 NM_001004361, NM_001142697, NM_001142698, BC080777 19

molecular_function

cellular_component

cytoplasm

cytosol

cytoskeleton

microtubule

biological_process

protein polyglutamylation

protein polyglutamylation

 
TC0200000651.mm.2 Ptgs1 prostaglandin-endoperoxide synthase 1 2 36230425 NM_008969, BC005573, BC023322 NM_008969, BC005573, BC023322 NM_008969, BC005573, BC023322 299

prostaglandin biosynthetic process

prostaglandin biosynthetic process

photoreceptor outer segment

peroxidase activity

prostaglandin-endoperoxide synthase activity

nuclear envelope

cytoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

prostaglandin metabolic process

inflammatory response

response to oxidative stress

learning

memory

regulation of blood pressure

negative regulation of norepinephrine secretion

membrane

oxidoreductase activity

sensory perception of pain

cyclooxygenase pathway

heme binding

keratinocyte differentiation

negative regulation of epinephrine secretion

maintenance of blood-brain barrier

regulation of cell population proliferation

intracellular membrane-bounded organelle

positive regulation of vasoconstriction

positive regulation of smooth muscle contraction

metal ion binding

dioxygenase activity

00590

01100

TC1600001373.mm.2 Tmem41a transmembrane protein 41a 16 -21934326 NM_025693, NR_037773, BC019770 NM_025693, NR_037773, BC019770 NM_025693, NR_037773, BC019770 13

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC1000003152.mm.2 Pa2g4 proliferation-associated 2G4 10 -128557765 NM_011119, BC046532 NM_011119, BC046532 52

nucleic acid binding

transcription corepressor activity

RNA binding

nucleus

nucleolus

cytoplasm

rRNA processing

regulation of translation

ubiquitin protein ligase binding

negative regulation of apoptotic process

positive regulation of cell differentiation

negative regulation of transcription, DNA-templated

ribonucleoprotein complex

 
TC0600002690.mm.2 Mcm2 minichromosome maintenance complex component 2 6 -88883473 NM_008564, BC055318 NM_008564, BC055318 82

nucleotide binding

double-strand break repair via break-induced replication

chromatin

DNA binding

DNA replication origin binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nuclear origin of replication recognition complex

chromosome

cytoplasm

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

DNA unwinding involved in DNA replication

DNA replication initiation

DNA replication initiation

nucleosome assembly

apoptotic process

cell cycle

hydrolase activity

single-stranded DNA helicase activity

enzyme binding

histone binding

MCM complex

MCM complex

3'-5' DNA helicase activity

metal ion binding

cellular response to interleukin-4

cochlea development

mitotic DNA replication initiation

negative regulation of DNA helicase activity

03030

04110

MG-1-pos-10339595_st                
TC1800001437.mm.2 Adrb2 adrenergic receptor, beta 2 18 -62177712 NM_007420, BC032883 NM_007420, BC032883 345

amyloid-beta binding

G-protein alpha-subunit binding

regulation of systemic arterial blood pressure by norepinephrine-epinephrine

diet induced thermogenesis

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

regulation of sodium ion transport

desensitization of G protein-coupled receptor signaling pathway by arrestin

diaphragm contraction

positive regulation of the force of heart contraction by epinephrine

G protein-coupled receptor activity

adrenergic receptor activity

beta2-adrenergic receptor activity

beta2-adrenergic receptor activity

beta2-adrenergic receptor activity

protein binding

nucleus

nucleus

cytoplasm

endosome

Golgi apparatus

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

caveola

receptor-mediated endocytosis

regulation of smooth muscle contraction

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

activation of adenylate cyclase activity

adenylate cyclase binding

positive regulation of cell population proliferation

associative learning

response to cold

positive regulation of protein kinase A signaling

positive regulation of protein kinase A signaling

positive regulation of sodium ion transport

potassium channel regulator activity

membrane

membrane

integral component of membrane

apical plasma membrane

negative regulation of angiogenesis

enzyme binding

negative regulation of ossification

axon

dendrite

positive regulation of bone mineralization

heat generation

B2 bradykinin receptor binding

positive regulation of ATPase activity

neuronal cell body membrane

synaptic transmission, glutamatergic

ionotropic glutamate receptor binding

negative regulation of urine volume

negative regulation of multicellular organism growth

wound healing

sarcolemma

identical protein binding

protein homodimerization activity

positive regulation of apoptotic process

dendritic spine

intracellular membrane-bounded organelle

receptor complex

positive regulation of potassium ion transport

positive regulation of MAPK cascade

protein-containing complex binding

bone resorption

positive regulation of heart contraction

positive regulation of transcription by RNA polymerase II

negative regulation of smooth muscle contraction

negative regulation of smooth muscle contraction

positive regulation of skeletal muscle tissue growth

negative regulation of inflammatory response

brown fat cell differentiation

norepinephrine binding

norepinephrine binding

protein phosphatase 2A binding

regulation of calcium ion transport

regulation of sensory perception of pain

excitatory postsynaptic potential

positive regulation of mini excitatory postsynaptic potential

cellular response to hypoxia

adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway

positive regulation of protein serine/threonine kinase activity

negative regulation of platelet aggregation

receptor-receptor interaction

blood vessel diameter maintenance

glutamatergic synapse

positive regulation of cold-induced thermogenesis

positive regulation of autophagosome maturation

positive regulation of lipophagy

cellular response to amyloid-beta

cellular response to amyloid-beta

positive regulation of calcium ion import across plasma membrane

regulation of synaptic vesicle exocytosis

positive regulation of AMPA receptor activity

04020

04080

04144

04970

TC1500001750.mm.2 Eef1d eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 15 -75894795, -75894795 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 NM_001285429, NM_001285430, NM_001285431, NM_001285432, NM_001285433, NM_001285434, NM_023240, NM_029663, BC079855 35

fibrillar center

DNA binding

translation elongation factor activity

guanyl-nucleotide exchange factor activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

endoplasmic reticulum

cytosol

cytosol

eukaryotic translation elongation factor 1 complex

translation

translational elongation

mRNA transcription

regulation of cell death

heat shock protein binding

activating transcription factor binding

synapse

synapse

cellular response to ionizing radiation

glutamatergic synapse

glutamatergic synapse

 
TC0200000702.mm.2 Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 2 38511696, 38511875 NM_001159631, NM_021606, BC019524 NM_001159631, NM_021606, BC019524 NM_001159631, NM_021606, BC019524 27

nucleotide binding

magnesium ion binding

transcription corepressor binding

protein kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

centrosome

cytosol

cytoskeleton

protein phosphorylation

apoptotic process

cell cycle

chromosome segregation

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

kinesin binding

protein kinase binding

regulation of mitotic metaphase/anaphase transition

ubiquitin protein ligase binding

protein-containing complex

activating transcription factor binding

centriolar satellite

protein autophosphorylation

metal ion binding

cell division

 
TC0900002593.mm.2 Ccnb2 cyclin B2 9 -70407688 NM_007630, BC008247 NM_007630, BC008247 54

regulation of cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase holoenzyme complex

in utero embryonic development

protein binding

nucleus

cytoplasm

cytoplasm

centrosome

centrosome

cytosol

cell cycle

spindle assembly involved in female meiosis I

spindle assembly involved in female meiosis I

G2/MI transition of meiotic cell cycle

G2/MI transition of meiotic cell cycle

microtubule cytoskeleton

membrane

cyclin-dependent protein serine/threonine kinase regulator activity

regulation of growth

T cell homeostasis

mitotic cell cycle phase transition

thymus development

cell division

04110

04114

04115

04914

TC1900000748.mm.2 Add3 adducin 3 (gamma) 19 53140442, 53142755, 53143996 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 NM_001164099, NM_001164100, NM_001164101, NM_001277100, NM_013758, BC037116 31

condensed nuclear chromosome

actin binding

protein kinase C binding

structural constituent of cytoskeleton

calmodulin binding

cytoplasm

cytoskeleton

cytoskeleton

cytoskeleton

plasma membrane

brush border

cell-cell junction

cell cortex

postsynaptic density

postsynaptic density

membrane

response to drug

positive regulation of vasoconstriction

actin filament binding

barbed-end actin filament capping

 
TC0200002263.mm.2 Fkbp1a FK506 binding protein 1a 2 151542482 NM_008019, BC004671, FK506 NM_008019, BC004671, FK506 NM_008019, BC004671, FK506 73

protein peptidyl-prolyl isomerization

protein peptidyl-prolyl isomerization

heart morphogenesis

peptidyl-prolyl cis-trans isomerase activity

peptidyl-prolyl cis-trans isomerase activity

transforming growth factor beta receptor binding

protein binding

FK506 binding

FK506 binding

cytoplasm

cytoplasm

cytosol

muscle contraction

SMAD protein complex assembly

membrane

membrane

sarcoplasmic reticulum

isomerase activity

cytokine-mediated signaling pathway

enzyme binding

Z disc

Hsp70 protein binding

response to caffeine

positive regulation of protein ubiquitination

positive regulation of protein binding

negative regulation of phosphoprotein phosphatase activity

regulation of protein localization

regulation of activin receptor signaling pathway

sarcoplasmic reticulum membrane

type I transforming growth factor beta receptor binding

T cell proliferation

identical protein binding

intracellular membrane-bounded organelle

axon terminus

ion channel binding

synapse

synapse

SMAD binding

activin binding

regulation of immune response

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol

ventricular cardiac muscle tissue morphogenesis

regulation of ryanodine-sensitive calcium-release channel activity

regulation of ryanodine-sensitive calcium-release channel activity

heart trabecula formation

chaperone-mediated protein folding

supramolecular fiber organization

negative regulation of transforming growth factor beta1 activation

regulation of amyloid precursor protein catabolic process

amyloid fibril formation

 
TC1000000937.mm.2 Chst11 carbohydrate sulfotransferase 11 10 82985496 NM_021439, BC137629, BC144793 NM_021439, BC137629, BC144793 NM_021439, BC137629, BC144793 35

N-acetylgalactosamine 4-O-sulfotransferase activity

in utero embryonic development

chondrocyte development

Golgi apparatus

carbohydrate metabolic process

respiratory gaseous exchange by respiratory system

sulfotransferase activity

sulfotransferase activity

post-embryonic development

membrane

integral component of membrane

carbohydrate biosynthetic process

transferase activity

proteoglycan biosynthetic process

chondroitin sulfate metabolic process

chondroitin sulfate biosynthetic process

chondroitin sulfate biosynthetic process

chondroitin sulfate biosynthetic process

embryonic limb morphogenesis

negative regulation of transforming growth factor beta receptor signaling pathway

polysaccharide localization

post-anal tail morphogenesis

regulation of cell population proliferation

embryonic digit morphogenesis

negative regulation of apoptotic process

chondroitin 4-sulfotransferase activity

developmental growth

embryonic viscerocranium morphogenesis

embryonic skeletal system morphogenesis

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

cartilage development

00532

00920

TC0300001378.mm.2 Slc39a8 solute carrier family 39 (metal ion transporter), member 8 3 135825789, 135825656, 135825278 NM_001135149, NM_001135150, NM_026228, BC006731 NM_001135149, NM_001135150, NM_026228, BC006731 NM_001135149, NM_001135150, NM_026228, BC006731 NM_001135149, NM_001135150, NM_026228, BC006731 51

iron ion transmembrane transporter activity

manganese ion transmembrane transporter activity

manganese ion transmembrane transporter activity

manganese ion transmembrane transporter activity

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

lysosome

lysosomal membrane

plasma membrane

plasma membrane

integral component of plasma membrane

transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

protein N-linked glycosylation

arginine metabolic process

ion transport

cobalt ion transport

zinc ion transport

cellular cadmium ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

cellular zinc ion homeostasis

cadmium ion transmembrane transporter activity

cadmium ion transmembrane transporter activity

cadmium ion transmembrane transporter activity

cobalt ion transmembrane transporter activity

bicarbonate transmembrane transporter activity

anion:cation symporter activity

bicarbonate transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

metal ion transport

cellular manganese ion homeostasis

extracellular matrix organization

extracellular matrix organization

organelle membrane

regulation of membrane potential

metal ion transmembrane transporter activity

transmembrane transport

leukocyte adhesion to arterial endothelial cell

cadmium ion transmembrane transport

cadmium ion transmembrane transport

cadmium ion transmembrane transport

manganese ion transmembrane transport

manganese ion transmembrane transport

manganese ion transmembrane transport

zinc ion transmembrane transport

zinc ion transmembrane transport

zinc ion import across plasma membrane

zinc ion import across plasma membrane

zinc ion import across plasma membrane

zinc ion import across plasma membrane

selenite:proton symporter activity

plasma membrane selenite transport

plasma membrane selenite transport

iron ion import across plasma membrane

iron ion import across plasma membrane

zinc:bicarbonate symporter activity

cartilage homeostasis

mitochondrial manganese ion transmembrane transport

 
TC0200000274.mm.2 Plxdc2 plexin domain containing 2 2 16356303 NM_026162, BC057881 NM_026162, BC057881 29

plasma membrane

membrane

integral component of membrane

collagen-containing extracellular matrix

 
TC1500001657.mm.2 Ndrg1 N-myc downstream regulated gene 1 15 -66929317 NM_008681, BC015282, BC071235, BC141246, BC171968 NM_008681, BC015282, BC071235, BC141246, BC171968 NM_008681, BC015282, BC071235, BC141246, BC171968 NM_008681, BC015282, BC071235, BC141246, BC171968 NM_008681, BC015282, BC071235, BC141246, BC171968 82

nucleus

cytoplasm

cytoplasm

cytoplasm

centrosome

cytosol

cytoskeleton

microtubule

plasma membrane

adherens junction

signal transduction

microtubule binding

negative regulation of cell population proliferation

microtubule cytoskeleton

membrane

small GTPase binding

peripheral nervous system myelin maintenance

regulation of cell population proliferation

gamma-tubulin binding

myelin sheath

cadherin binding

mast cell activation

perinuclear region of cytoplasm

recycling endosome membrane

glutamatergic synapse

postsynapse organization

 
TC0200004568.mm.2 Bub1 BUB1, mitotic checkpoint serine/threonine kinase 2 -127800199 NM_001113179, NM_009772, BC029116 NM_001113179, NM_009772, BC029116 NM_001113179, NM_009772, BC029116 63

nucleotide binding

chromosome, centromeric region

kinetochore

kinetochore

condensed chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed chromosome, centromeric region

condensed nuclear chromosome outer kinetochore

protein kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleoplasm

chromosome

cytosol

protein phosphorylation

apoptotic process

cell cycle

chromosome segregation

regulation of sister chromatid cohesion

mitotic spindle assembly checkpoint

kinase activity

phosphorylation

transferase activity

intracellular membrane-bounded organelle

cell division

meiotic sister chromatid cohesion, centromeric

regulation of chromosome segregation

mitotic spindle checkpoint

positive regulation of intrinsic apoptotic signaling pathway

04110

04114

04914

TC1400001665.mm.2         NM_153547, NR_028523, NR_104298, BC037996 NM_153547, NR_028523, NR_104298, BC037996 NM_153547, NR_028523, NR_104298, BC037996 NM_153547, NR_028523, NR_104298, BC037996  

nucleotide binding

molecular_function

protein binding

GTP binding

GTP binding

cellular_component

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

nucleolus

biological_process

cell population proliferation

nuclear body

stem cell division

stem cell population maintenance

midbody

positive regulation of telomere maintenance

positive regulation of protein sumoylation

regulation of cell population proliferation

mRNA 5'-UTR binding

positive regulation of pri-miRNA transcription by RNA polymerase II

positive regulation of protein localization to chromosome, telomeric region

 
TC1100001592.mm.2 Igfbp4 insulin-like growth factor binding protein 4 11 99041243 NM_010517, BC019836 NM_010517, BC019836 101

regulation of cell growth

protein binding

insulin-like growth factor binding

extracellular region

extracellular space

extracellular space

extracellular space

regulation of glucose metabolic process

growth factor binding

insulin-like growth factor I binding

insulin-like growth factor II binding

regulation of growth

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

type B pancreatic cell proliferation

 
TC0400001129.mm.2 Ndc1 NDC1 transmembrane nucleoporin 4 107368046 NM_028355, BC021337 NM_028355, BC021337 28

nucleus

nuclear pore

nuclear pore

cytoplasm

plasma membrane

nuclear pore organization

homologous chromosome pairing at meiosis

spermatogenesis

protein transport

actin cytoskeleton

membrane

integral component of membrane

structural constituent of nuclear pore

protein-macromolecule adaptor activity

nuclear membrane

mRNA transport

nuclear pore complex assembly

nuclear pore localization

nuclear pore transmembrane ring

03013

TC0300000491.mm.2 P2ry1 purinergic receptor P2Y, G-protein coupled 1 3 61002784 NM_001282016, NM_008772, BC138634, BC138635 NM_001282016, NM_008772, BC138634, BC138635 NM_001282016, NM_008772, BC138634, BC138635 NM_001282016, NM_008772, BC138634, BC138635 114

nucleotide binding

G protein-coupled ADP receptor activity

positive regulation of protein phosphorylation

G protein-coupled adenosine receptor signaling pathway

G protein-coupled receptor activity

ATP binding

mitochondrion

plasma membrane

plasma membrane

integral component of plasma membrane

cilium

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

glial cell migration

regulation of cell shape

response to mechanical stimulus

regulation of signaling receptor activity

negative regulation of norepinephrine secretion

postsynaptic density

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

sensory perception of pain

signal transduction involved in regulation of gene expression

platelet activation

dendrite

A1 adenosine receptor binding

positive regulation of inositol trisphosphate biosynthetic process

G protein-coupled purinergic nucleotide receptor signaling pathway

eating behavior

positive regulation of ion transport

positive regulation of ion transport

ADP binding

cell body

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled ATP receptor activity

postsynaptic membrane

positive regulation of transcription by RNA polymerase II

positive regulation of hormone secretion

protein heterodimerization activity

negative regulation of binding

positive regulation of penile erection

positive regulation of ERK1 and ERK2 cascade

cellular response to organic cyclic compound

cellular response to purine-containing compound

protein localization to plasma membrane

relaxation of muscle

scaffold protein binding

blood vessel diameter maintenance

glutamatergic synapse

integral component of presynaptic active zone membrane

regulation of presynaptic cytosolic calcium ion concentration

regulation of synaptic vesicle exocytosis

04080

TC0800002878.mm.2 Nob1 NIN1/RPN12 binding protein 1 homolog 8 -107412488 NM_026277, BC103793, BC117992, BC117993 NM_026277, BC103793, BC117992, BC117993 NM_026277, BC103793, BC117992, BC117993 NM_026277, BC103793, BC117992, BC117993 23

cleavage involved in rRNA processing

nuclease activity

endonuclease activity

endoribonuclease activity

endoribonuclease activity

nucleus

nucleolus

cytoplasm

visual perception

hydrolase activity

maturation of SSU-rRNA

maturation of SSU-rRNA

preribosome, small subunit precursor

ribosomal small subunit biogenesis

metal ion binding

03008

TC0900001414.mm.2 Impdh2 inosine monophosphate dehydrogenase 2 9 108560435 NM_011830, BC010314, BC052671 NM_011830, BC010314, BC052671 NM_011830, BC010314, BC052671 38

nucleotide binding

DNA binding

RNA binding

catalytic activity

IMP dehydrogenase activity

IMP dehydrogenase activity

IMP dehydrogenase activity

nucleus

cytoplasm

cytoplasm

cytosol

purine nucleotide biosynthetic process

purine nucleotide biosynthetic process

GMP biosynthetic process

GTP biosynthetic process

circadian rhythm

oxidoreductase activity

identical protein binding

lymphocyte proliferation

metal ion binding

cellular response to interleukin-4

00230

00983

01100

TC1100003470.mm.2 Prr11 proline rich 11 11 -87089155 NM_175563, BC023918 NM_175563, BC023918 14

molecular_function

nucleus

nucleus

cytoplasm

cytoplasm

cell cycle arrest

regulation of cell cycle

 
TC1600001316.mm.2 Comt catechol-O-methyltransferase 16 -18406881, -18406881 NM_001111062, NM_001111063, NM_007744, BC010402 NM_001111062, NM_001111063, NM_007744, BC010402 NM_001111062, NM_001111063, NM_007744, BC010402 NM_001111062, NM_001111063, NM_007744, BC010402 101

magnesium ion binding

cytoplasm

mitochondrion

cytosol

catecholamine metabolic process

female pregnancy

learning

short-term memory

methyltransferase activity

O-methyltransferase activity

estrogen metabolic process

catechol-containing compound metabolic process

membrane

membrane

integral component of membrane

cellular response to phosphate starvation

catechol O-methyltransferase activity

catechol O-methyltransferase activity

catechol O-methyltransferase activity

catechol O-methyltransferase activity

transferase activity

axon

axon

dendrite

dendrite

methylation

developmental process

negative regulation of renal sodium excretion

neurotransmitter catabolic process

dopamine metabolic process

dopamine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

catecholamine catabolic process

dendritic spine

intracellular membrane-bounded organelle

cell body

postsynaptic membrane

negative regulation of dopamine metabolic process

metal ion binding

response to pain

multicellular organismal reproductive process

negative regulation of smooth muscle cell proliferation

positive regulation of homocysteine metabolic process

regulation of sensory perception of pain

L-dopa O-methyltransferase activity

00140

00350

01100

TC0100003639.mm.2 Adss adenylosuccinate synthetase, non muscle 1 -177763177 NM_007422, BC139404, BC139417 NM_007422, BC139404, BC139417 NM_007422, BC139404, BC139417 23

nucleotide binding

adenylosuccinate synthase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

GTP binding

cytoplasm

mitochondrion

cytosol

purine nucleotide biosynthetic process

AMP biosynthetic process

AMP biosynthetic process

aspartate metabolic process

ligase activity

'de novo' AMP biosynthetic process

IMP metabolic process

IMP metabolic process

metal ion binding

00230

00250

01100

TC1400002057.mm.2 Prmt5 protein arginine N-methyltransferase 5 14 -54507181 NM_013768, BC023905 NM_013768, BC023905 104

negative regulation of transcription by RNA polymerase II

spliceosomal snRNP assembly

p53 binding

chromatin binding

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

Golgi apparatus

cytosol

cytosol

chromatin organization

DNA-templated transcription, termination

regulation of transcription, DNA-templated

protein methylation

methyltransferase activity

methyl-CpG binding

histone-arginine N-methyltransferase activity

protein-arginine N-methyltransferase activity

transferase activity

peptidyl-arginine methylation

methylation

circadian regulation of gene expression

protein-containing complex

methylosome

histone arginine methylation

histone methyltransferase complex

histone methyltransferase complex

protein-arginine omega-N symmetric methyltransferase activity

peptidyl-arginine N-methylation

endothelial cell activation

identical protein binding

ribonucleoprotein complex binding

histone H4-R3 methylation

histone methyltransferase activity (H4-R3 specific)

regulation of DNA methylation

protein-containing complex binding

negative regulation of cell differentiation

protein heterodimerization activity

rhythmic process

positive regulation of oligodendrocyte differentiation

regulation of ERK1 and ERK2 cascade

E-box binding

Golgi ribbon formation

positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway

03013

TC1000000240.mm.2 Arhgap18 Rho GTPase activating protein 18 10 26772511 NM_176837, BC030858 NM_176837, BC030858 22

ruffle

GTPase activator activity

GTPase activator activity

cytoplasm

cytoplasm

cytosol

cytoplasmic microtubule

plasma membrane

signal transduction

small GTPase mediated signal transduction

regulation of cell shape

nuclear speck

regulation of actin filament polymerization

regulation of actin filament polymerization

regulation of actin cytoskeleton organization

regulation of small GTPase mediated signal transduction

regulation of small GTPase mediated signal transduction

regulation of cell motility

 
TC0100001500.mm.2 Slc19a2 solute carrier family 19 (thiamine transporter), member 2 1 164249045 NM_001276455, NM_054087, BC034659 NM_001276455, NM_054087, BC034659 NM_001276455, NM_054087, BC034659 26

plasma membrane

plasma membrane

plasma membrane

plasma membrane

thiamine transmembrane transporter activity

thiamine transmembrane transporter activity

thiamine transmembrane transporter activity

thiamine transmembrane transporter activity

thiamine transport

thiamine transport

membrane

integral component of membrane

vitamin transport

transmembrane transport

thiamine transmembrane transport

vitamin transmembrane transporter activity

04977

TC0100003029.mm.2 Cxcr4 chemokine (C-X-C motif) receptor 4 1 -128588198 NM_009911, BC031665, BC098322 NM_009911, BC031665, BC098322 NM_009911, BC031665, BC098322 580

branching involved in blood vessel morphogenesis

ameboidal-type cell migration

neuron migration

neuron migration

kidney development

positive regulation of protein phosphorylation

epithelial cell development

ventricular septum development

actin binding

G protein-coupled receptor activity

chemokine receptor activity

protein binding

nucleus

cytoplasm

lysosome

endosome

early endosome

late endosome

plasma membrane

plasma membrane

cell-cell junction

chemotaxis

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

germ cell development

nervous system development

brain development

brain development

motor neuron axon guidance

germ cell migration

animal organ morphogenesis

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

integral component of membrane

cell migration

C-C chemokine receptor activity

calcium-mediated signaling

calcium-mediated signaling

cytokine binding

C-C chemokine binding

C-C chemokine binding

neurogenesis

neurogenesis

telencephalon cell migration

cell junction

regulation of cell adhesion

regulation of cell migration

regulation of cell migration

positive regulation of cell migration

growth cone

cell leading edge

cytoplasmic vesicle

ubiquitin protein ligase binding

myosin light chain binding

protein-containing complex

positive regulation of vascular wound healing

hematopoietic stem cell migration

aorta development

C-X-C motif chemokine 12 receptor activity

CXCL12-activated CXCR4 signaling pathway

T cell proliferation

identical protein binding

regulation of programmed cell death

ubiquitin binding

myelin maintenance

endothelial cell differentiation

generation of neurons

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis

regulation of viral process

regulation of chemotaxis

positive regulation of chemotaxis

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception of pain

regulation of calcium ion transport

cardiac muscle contraction

cell chemotaxis

endothelial tube morphogenesis

neural precursor cell proliferation

positive regulation of ERK1 and ERK2 cascade

cellular response to cytokine stimulus

cellular response to cytokine stimulus

positive regulation of calcium ion import

positive regulation of cold-induced thermogenesis

positive regulation of dendrite extension

positive regulation of mesenchymal stem cell migration

positive regulation of macrophage migration inhibitory factor signaling pathway

04060

04062

04144

04360

04670

04672

TC0300002284.mm.2 Fcrls Fc receptor-like S, scavenger receptor 3 -87250964 NM_030707, BC016551 NM_030707, BC016551 22

transmembrane signaling receptor activity

integral component of plasma membrane

cell surface receptor signaling pathway

 
TC1900000508.mm.2 Kif20b kinesin family member 20B 19 34922357 NM_183046, BC151061, BC172148 NM_183046, BC151061, BC172148 NM_183046, BC151061, BC172148 35

nucleotide binding

neural tube closure

microtubule motor activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

centrosome

cytosol

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

cell cycle

regulation of mitotic nuclear division

microtubule binding

microtubule binding

positive regulation of cell population proliferation

positive regulation of cell population proliferation

ATP-dependent microtubule motor activity, plus-end-directed

microtubule cytoskeleton

ATPase activity

ATPase activity

midbody

midbody

positive regulation of cytokinesis

protein localization to microtubule

protein homodimerization activity

cell projection

intercellular bridge

perinuclear region of cytoplasm

neuron projection morphogenesis

WW domain binding

spindle midzone

cell division

regulation of establishment of protein localization

contractile ring

positive regulation of intracellular protein transport

mitotic spindle pole

positive regulation of mitotic cytokinetic process

mitotic spindle midzone

regulation of establishment of cell polarity

regulation of establishment of cell polarity

regulation of neuron migration

positive regulation of neuron migration

 
TC1400000940.mm.2 Pbk PDZ binding kinase 14 65805910 NM_023209, BC020099 NM_023209, BC020099 33

nucleotide binding

mitotic cell cycle

negative regulation of protein phosphorylation

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

protein phosphorylation

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of stress-activated MAPK cascade

cellular response to UV

negative regulation of inflammatory response

 
TC0800002235.mm.2 Neil3 nei like 3 (E. coli) 8 -53586866 NM_146208, BC024921, BC034753 NM_146208, BC024921, BC034753 NM_146208, BC024921, BC034753 34

bubble DNA binding

nucleic acid binding

DNA binding

damaged DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

catalytic activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

nucleus

nucleus

nucleoplasm

chromosome

DNA repair

base-excision repair

base-excision repair

base-excision repair

nucleotide-excision repair

cellular response to DNA damage stimulus

metabolic process

zinc ion binding

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds

lyase activity

DNA N-glycosylase activity

DNA N-glycosylase activity

DNA N-glycosylase activity

metal ion binding

03410

TC1100001155.mm.2 Spag5 sperm associated antigen 5 11 78301590 NM_017407, BC052672 NM_017407, BC052672 31

mitotic sister chromatid segregation

chromosome, centromeric region

kinetochore

chromosome

cytoplasm

spindle

cytosol

cytoskeleton

microtubule

cell cycle

spindle organization

chromosome segregation

microtubule binding

nuclear body

positive regulation of intracellular transport

centriolar satellite

microtubule plus-end

establishment of spindle orientation

cell division

regulation of attachment of spindle microtubules to kinetochore

protein localization to centrosome

mitotic spindle

mitotic spindle

regulation of metaphase plate congression

mitotic spindle pole

positive regulation of spindle assembly

 
TC0800000756.mm.2 Isyna1 myo-inositol 1-phosphate synthase A1 8 70594480 NM_023627, BC003458 NM_023627, BC003458 23

inositol-3-phosphate synthase activity

inositol-3-phosphate synthase activity

cytoplasm

inositol biosynthetic process

lipid metabolic process

phospholipid biosynthetic process

isomerase activity

00562

01100

MG-1-pos-10343293_st                
TC0700003831.mm.2 P2ry2 purinergic receptor P2Y, G-protein coupled 2 7 -100996567, -100996567 NM_008773, BC006613 NM_008773, BC006613 136

G protein-coupled receptor activity

ATP binding

mitochondrion

lysosome

early endosome

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of neuron projection development

positive regulation of smooth muscle cell migration

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

sensory perception of pain

negative regulation of ossification

A1 adenosine receptor binding

positive regulation of prostaglandin secretion

positive regulation of chemokine production

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled UTP receptor activity

positive regulation of penile erection

positive regulation of mucus secretion

blood vessel diameter maintenance

glutamatergic synapse

integral component of presynaptic active zone membrane

regulation of presynaptic cytosolic calcium ion concentration

regulation of synaptic vesicle exocytosis

04080

TC0900001173.mm.2 Plscr4 phospholipid scramblase 4 9 92457377 NM_178711, BC052067 NM_178711, BC052067 14

plasma membrane

plasma membrane

membrane

integral component of membrane

plasma membrane phospholipid scrambling

phospholipid scramblase activity

enzyme binding

CD4 receptor binding

cellular response to lipopolysaccharide

 
TC0X00001322.mm.2 Tceal9 transcription elongation factor A like 9 X 136245079 NM_011712, BC007478 NM_011712, BC007478 19

nucleus

WW domain binding

WW domain binding

 
TC0400001107.mm.2 Dhcr24 24-dehydrocholesterol reductase 4 106561037 NM_053272, BC019797 NM_053272, BC019797 47

delta24(24-1) sterol reductase activity

delta24(24-1) sterol reductase activity

nucleus

cytoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

cytoskeleton

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

Ras protein signal transduction

protein localization

steroid metabolic process

steroid metabolic process

cholesterol metabolic process

negative regulation of cell population proliferation

tissue development

tissue development

membrane

membrane

integral component of membrane

sterol metabolic process

sterol biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

enzyme binding

male genitalia development

plasminogen activation

peptide antigen binding

amyloid precursor protein catabolic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

skin development

delta24-sterol reductase activity

flavin adenine dinucleotide binding

membrane organization

FAD binding

00100

01100

TC1300000148.mm.2 Elmo1 engulfment and cell motility 1 13 20472989, 20090506 NM_080288, NM_198093, BC031782, NR_038122 NM_080288, NM_198093, BC031782, NR_038122 NM_080288, NM_198093, BC031782, NR_038122 NM_080288, NM_198093, BC031782, NR_038122 46

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

cytoplasm

plasma membrane

plasma membrane

plasma membrane

phagocytosis

phagocytosis, engulfment

phagocytosis, engulfment

apoptotic process

actin filament organization

membrane

cell migration

Rac protein signal transduction

Rac protein signal transduction

SH3 domain binding

actin filament-based process

actin cytoskeleton organization

actin cytoskeleton organization

guanyl-nucleotide exchange factor complex

guanyl-nucleotide exchange factor complex

guanyl-nucleotide exchange factor complex

cell motility

cell motility

cell motility

04062

05100

TC0800002529.mm.2 Gab1 growth factor receptor bound protein 2-associated protein 1 8 -80764433, -80764430 NM_021356, BC007483, BC094659 NM_021356, BC007483, BC094659 NM_021356, BC007483, BC094659 95

activation of MAPK activity

angiogenesis

protein binding

cytoplasm

cytosol

cell-cell junction

response to oxidative stress

signal transduction

epidermal growth factor receptor signaling pathway

activation of JUN kinase activity

heart development

epidermis development

regulation of cell migration

actin cytoskeleton reorganization

response to hepatocyte growth factor

cellular response to vascular endothelial growth factor stimulus

vascular endothelial growth factor signaling pathway

positive regulation of cell migration by vascular endothelial growth factor signaling pathway

positive regulation of MAPK cascade

positive regulation of angiogenesis

platelet-derived growth factor receptor signaling pathway

labyrinthine layer development

interleukin-6-mediated signaling pathway

endothelial cell chemotaxis to vascular endothelial growth factor

04012

04722

05100

05211

TC0100001227.mm.2 Cyb5r1 cytochrome b5 reductase 1 1 134405780 NM_028057, BC016266, BC024618 NM_028057, BC016266, BC024618 NM_028057, BC016266, BC024618 21

cytochrome-b5 reductase activity, acting on NAD(P)H

mitochondrion

lipid metabolic process

steroid biosynthetic process

steroid metabolic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

FAD binding

00520

TC0500003516.mm.2 Gna12 guanine nucleotide binding protein, alpha 12 5 -140759943 NM_010302, BC111810 NM_010302, BC111810 87

nucleotide binding

G protein-coupled receptor binding

in utero embryonic development

GTPase activity

GTPase activity

GTPase activity

GTP binding

cytoplasm

heterotrimeric G-protein complex

heterotrimeric G-protein complex

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Rho protein signal transduction

Rho protein signal transduction

regulation of cell shape

regulation of fibroblast migration

membrane

guanyl nucleotide binding

cell differentiation

brush border membrane

brush border membrane

G-protein beta/gamma-subunit complex binding

D5 dopamine receptor binding

D5 dopamine receptor binding

regulation of TOR signaling

regulation of TOR signaling

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal ubiquitin-dependent protein catabolic process

intracellular signal transduction

embryonic digit morphogenesis

metal ion binding

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of vascular associated smooth muscle cell migration

04010

04270

04730

04810

TC0400001312.mm.2         NM_026932, NR_029469, BC054723, BC062876 NM_026932, NR_029469, BC054723, BC062876 NM_026932, NR_029469, BC054723, BC062876 NM_026932, NR_029469, BC054723, BC062876  

nucleus

chromosome

nucleolus

nucleolus

rRNA processing

preribosome, large subunit precursor

nuclear periphery

ribosome biogenesis

ribosomal large subunit biogenesis

 
TC0700001151.mm.2 Prc1 protein regulator of cytokinesis 1 7 80294475, 80294450 NM_001285997, NM_001285998, NM_145150, BC005475 NM_001285997, NM_001285998, NM_145150, BC005475 NM_001285997, NM_001285998, NM_145150, BC005475 NM_001285997, NM_001285998, NM_145150, BC005475 44

microtubule cytoskeleton organization

cytokinesis

microtubule bundle formation

nucleus

nucleoplasm

cytoplasm

spindle

spindle

cytoskeleton

microtubule

plasma membrane

cell cycle

microtubule binding

positive regulation of cell population proliferation

microtubule cytoskeleton

kinesin binding

protein kinase binding

midbody

regulation of cytokinesis

identical protein binding

intercellular bridge

mitotic spindle midzone assembly

cell division

contractile ring

mitotic spindle midzone

 
TC1000001546.mm.2 Cdk4 cyclin-dependent kinase 4 10 127063534 NM_009870, BC046336, BC052694 NM_009870, BC046336, BC052694 NM_009870, BC046336, BC052694 327

G1/S transition of mitotic cell cycle

nucleotide binding

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase holoenzyme complex

chromatin

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

nucleolus

cytoplasm

cytosol

bicellular tight junction

protein phosphorylation

protein phosphorylation

protein phosphorylation

cell cycle

signal transduction

positive regulation of cell population proliferation

RNA polymerase II CTD heptapeptide repeat kinase activity

response to organic substance

response to lead ion

regulation of gene expression

positive regulation of G2/M transition of mitotic cell cycle

membrane

kinase activity

phosphorylation

mediator complex

transferase activity

cyclin binding

cyclin binding

nuclear membrane

cellular response to insulin stimulus

protein-containing complex

response to testosterone

regulation of multicellular organism growth

regulation of cell population proliferation

positive regulation of apoptotic process

protein-containing complex binding

positive regulation of translation

positive regulation of cell size

regulation of insulin receptor signaling pathway

regulation of lipid biosynthetic process

positive regulation of fibroblast proliferation

perinuclear region of cytoplasm

regulation of lipid catabolic process

cell division

regulation of cell cycle

regulation of cell cycle

adipose tissue development

negative regulation of cell cycle arrest

cellular response to lipopolysaccharide

cellular response to interleukin-4

cyclin D2-CDK4 complex

cellular response to phorbol 13-acetate 12-myristate

cellular response to ionomycin

04110

04115

04530

04660

05200

05212

05214

05218

05219

05220

05222

05223

TC0600001839.mm.2 Asns asparagine synthetase 6 -7675164 NM_012055, BC005552 NM_012055, BC005552 29

nucleotide binding

asparagine synthase (glutamine-hydrolyzing) activity

asparagine synthase (glutamine-hydrolyzing) activity

ATP binding

cytosol

cytosol

asparagine biosynthetic process

asparagine biosynthetic process

glutamine metabolic process

cellular amino acid biosynthetic process

ligase activity

cellular response to glucose starvation

identical protein binding

negative regulation of apoptotic process

positive regulation of mitotic cell cycle

00250

00910

01100

TC1100001051.mm.2 Tsr1 TSR1 20S rRNA accumulation 11 74898079 NM_177325, BC031531 NM_177325, BC031531 25

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GTPase activity

GTP binding

nucleus

preribosome, small subunit precursor

U3 snoRNA binding

ribosome biogenesis

 
TC0X00000169.mm.2 Gpr34 G protein-coupled receptor 34 X 13632768 NM_011823, BC165976 NM_011823, BC165976 22

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

G protein-coupled purinergic nucleotide receptor activity

 
TC0600002668.mm.2 Cnbp cellular nucleic acid binding protein 6 -87842614 NM_001109745, NM_001109746, NM_013493, BC058723 NM_001109745, NM_001109746, NM_013493, BC058723 NM_001109745, NM_001109746, NM_013493, BC058723 NM_001109745, NM_001109746, NM_013493, BC058723 53

negative regulation of transcription by RNA polymerase II

nucleic acid binding

DNA binding

single-stranded DNA binding

single-stranded RNA binding

single-stranded RNA binding

mRNA binding

nucleus

cytoplasm

endoplasmic reticulum

cytosol

zinc ion binding

positive regulation of cell population proliferation

translation regulator activity

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

metal ion binding

G-quadruplex DNA binding

G-quadruplex DNA formation

positive regulation of cytoplasmic translation

 
TC0700000487.mm.2 Fbl fibrillarin 7 28169747 NM_007991, BC003813, BC092274 NM_007991, BC003813, BC092274 NM_007991, BC003813, BC092274 62

box C/D RNA 3'-end processing

TFIID-class transcription factor complex binding

fibrillar center

dense fibrillar component

granular component

RNA binding

RNA binding

nucleus

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

nucleolus

rRNA processing

methyltransferase activity

rRNA methyltransferase activity

Cajal body

Cajal body

Cajal body

sno(s)RNA metabolic process

transferase activity

rRNA methylation

rRNA methylation

box C/D RNP complex

small-subunit processome

methylation

snoRNA localization

ATPase binding

histone glutamine methylation

histone glutamine methylation

histone-glutamine methyltransferase activity

histone-glutamine methyltransferase activity

03008

TC0100001058.mm.2 Nifk nucleolar protein interacting with the FHA domain of MKI67 1 118321842 NM_026472, BC058559 NM_026472, BC058559 21

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

condensed nuclear chromosome

nucleic acid binding

RNA binding

RNA binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

cytoplasm

 
TC0500003169.mm.2 Tpcn1 two pore channel 1 5 -120534156 NM_145853, BC058951 NM_145853, BC058951 40

ion channel activity

voltage-gated ion channel activity

voltage-gated calcium channel activity

voltage-gated sodium channel activity

calcium channel activity

lysosome

lysosomal membrane

lysosomal membrane

endosome

ion transport

calcium ion transport

endosome membrane

endosome membrane

positive regulation of autophagy

ligand-gated sodium channel activity

membrane

integral component of membrane

regulation of ion transmembrane transport

sodium ion transmembrane transport

identical protein binding

protein homodimerization activity

transmembrane transport

calcium ion transmembrane transport

NAADP-sensitive calcium-release channel activity

NAADP-sensitive calcium-release channel activity

phosphatidylinositol-3,5-bisphosphate binding

 
TC1900000543.mm.2 Cep55 centrosomal protein 55 19 38054983, 38054983, 38055040 NM_001164362, NM_028293, NM_028760, BC031396 NM_001164362, NM_028293, NM_028760, BC031396 NM_001164362, NM_028293, NM_028760, BC031396 NM_001164362, NM_028293, NM_028760, BC031396 31

mitotic cytokinesis

mitotic cytokinesis

protein binding

cytoplasm

centrosome

cytoskeleton

plasma membrane

cell cycle

regulation of phosphatidylinositol 3-kinase signaling

midbody

midbody

midbody

centriolar satellite

identical protein binding

intercellular bridge

establishment of protein localization

establishment of protein localization

cell division

midbody abscission

Flemming body

cranial skeletal system development

 
TC0200001047.mm.2 Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 2 71873223, 71874903 NM_172665, BC027196 NM_172665, BC027196 52

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

pyruvate dehydrogenase (acetyl-transferring) kinase activity

ATP binding

mitochondrion

mitochondrion

plasma membrane

mitochondrial pyruvate dehydrogenase complex

carbohydrate metabolic process

glucose metabolic process

protein phosphorylation

protein phosphorylation

cell surface receptor signaling pathway

cell population proliferation

intrinsic apoptotic signaling pathway in response to oxidative stress

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of glucose metabolic process

regulation of glucose metabolic process

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

intracellular signal transduction

identical protein binding

protein-containing complex binding

pyruvate dehydrogenase complex

hypoxia-inducible factor-1alpha signaling pathway

04660

04664

04722

05145

05160

TC1300000260.mm.2 H2ac4 H2A clustered histone 4 13 23751087 NM_175660, BC117110, BC153047 NM_175660, BC117110, BC153047 NM_175660, BC117110, BC153047 7

DNA binding

nucleus

chromatin silencing

05322

TC0600001508.mm.2         NM_008021, NM_027697, BC065067, BC075723 NM_008021, NM_027697, BC065067, BC075723 NM_008021, NM_027697, BC065067, BC075723 NM_008021, NM_027697, BC065067, BC075723  

G2/M transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

vasculogenesis

liver development

molecular_function

DNA binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

cellular_component

nucleus

nucleus

DNA repair

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cell cycle

biological_process

positive regulation of cell population proliferation

positive regulation of cell population proliferation

protein kinase binding

negative regulation of stress-activated MAPK cascade

regulation of cell population proliferation

regulation of cell population proliferation

sequence-specific DNA binding

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of Ras protein signal transduction

regulation of cell cycle arrest

regulation of cell cycle arrest

negative regulation of cell aging

regulation of reactive oxygen species metabolic process

positive regulation of double-strand break repair

positive regulation of double-strand break repair

 
TC0600001852.mm.2 Ica1 islet cell autoantigen 1 6 -8630526, -8630526 NM_001252266, NM_010492, BC002030 NM_001252266, NM_010492, BC002030 NM_001252266, NM_010492, BC002030 37

Golgi membrane

protein binding

cytoplasm

Golgi apparatus

Golgi stack

cytosol

cytosol

neurotransmitter transport

membrane

protein domain specific binding

cell junction

dendrite

secretory granule membrane

synaptic vesicle membrane

cytoplasmic vesicle

intracellular membrane-bounded organelle

regulation of protein-containing complex assembly

synapse

regulation of neurotransmitter secretion

perinuclear region of cytoplasm

regulation of insulin secretion

regulation of transport

membrane curvature sensor activity

04940

TC0400003390.mm.2 Cdc20 cell division cycle 20 4 -118432900 NM_023223, BC003215 NM_023223, BC003215 81

mitotic metaphase

protein binding

nucleoplasm

anaphase-promoting complex

anaphase-promoting complex

cytoplasm

centrosome

cytosol

cytoskeleton

cell cycle

mitotic sister chromatid cohesion

nervous system development

protein C-terminus binding

positive regulation of cell population proliferation

anaphase-promoting complex binding

enzyme binding

cell differentiation

anaphase-promoting complex-dependent catabolic process

anaphase-promoting complex-dependent catabolic process

positive regulation of synaptic plasticity

protein-containing complex

regulation of meiotic nuclear division

histone deacetylase binding

perinuclear region of cytoplasm

regulation of dendrite development

cell division

positive regulation of synapse maturation

mitotic spindle assembly

ubiquitin-protein transferase activator activity

positive regulation of ubiquitin protein ligase activity

positive regulation of anaphase-promoting complex-dependent catabolic process

ubiquitin ligase activator activity

04110

04114

04120

TC1100003771.mm.2 Nt5c3b 5'-nucleotidase, cytosolic IIIB 11 -100429351, -100439552, -100422320 NM_001102650, NM_026561, BC015307 NM_001102650, NM_026561, BC015307 NM_001102650, NM_026561, BC015307 15

nucleotide binding

magnesium ion binding

cytoplasm

nucleotide metabolic process

hydrolase activity

metal ion binding

 
TC0400000913.mm.2 Mtap methylthioadenosine phosphorylase 4 89137369 NM_024433, BC003858 NM_024433, BC003858 37

catalytic activity

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

purine ribonucleoside salvage

nucleoside metabolic process

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring pentosyl groups

S-methyl-5-thioadenosine phosphorylase activity

L-methionine salvage from methylthioadenosine

methylation

00270

01100

TC1800001083.mm.2 Slc39a6 solute carrier family 39 (metal ion transporter), member 6 18 -24579880 NM_139143, BC054780, BC055012 NM_139143, BC054780, BC055012 NM_139143, BC054780, BC055012 27

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

endoplasmic reticulum

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

ion transport

zinc ion transport

cellular zinc ion homeostasis

cellular zinc ion homeostasis

membrane

integral component of membrane

metal ion transport

lamellipodium membrane

metal ion transmembrane transporter activity

transmembrane transport

zinc ion transmembrane transport

zinc ion import across plasma membrane

zinc ion import across plasma membrane

 
TC1200001262.mm.2 Adssl1 adenylosuccinate synthetase like 1 12 112620046 NM_007421, BC039943 NM_007421, BC039943 28

nucleotide binding

GTPase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

protein binding

GTP binding

cytoplasm

cytoplasm

cytoplasm

purine nucleotide metabolic process

purine nucleotide biosynthetic process

AMP biosynthetic process

aspartate metabolic process

purine ribonucleoside monophosphate biosynthetic process

membrane

ligase activity

identical protein binding

'de novo' AMP biosynthetic process

IMP metabolic process

IMP metabolic process

metal ion binding

actin filament binding

00230

00250

01100

TC1200001460.mm.2 Lpin1 lipin 1 12 -16535668, -16535668 NM_001130412, NM_015763, NM_172950, BC042462 NM_001130412, NM_015763, NM_172950, BC042462 NM_001130412, NM_015763, NM_172950, BC042462 NM_001130412, NM_015763, NM_172950, BC042462 127

negative regulation of transcription by RNA polymerase II

mitochondrial fission

RNA polymerase II transcription factor binding

transcription coactivator activity

transcription coactivator activity

protein binding

nucleus

nucleus

transcription regulator complex

cytoplasm

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

DNA replication

regulation of transcription by RNA polymerase II

lipid metabolic process

triglyceride mobilization

immune response

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

fatty acid catabolic process

fatty acid catabolic process

membrane

hydrolase activity

triglyceride biosynthetic process

positive regulation of histone deacetylation

ruffle organization

actin cytoskeleton reorganization

negative regulation of myelination

nuclear membrane

cellular response to insulin stimulus

cellular response to insulin stimulus

cellular response to insulin stimulus

histone deacetylase binding

peroxisome proliferator activated receptor binding

cellular lipid metabolic process

cellular lipid metabolic process

fat cell differentiation

regulation of fat cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

phosphatidic acid metabolic process

positive regulation of cold-induced thermogenesis

regulation of phosphatidate phosphatase activity

 
TC0800003162.mm.2 Nup133 nucleoporin 133 8 -123897122 NM_172288, BC023915, BC026845 NM_172288, BC023915, BC026845 NM_172288, BC023915, BC026845 23

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

condensed chromosome outer kinetochore

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

nucleus

nuclear pore

nuclear pore

nuclear pore

chromosome

mRNA export from nucleus

mRNA export from nucleus

protein import into nucleus

nuclear pore organization

protein transport

poly(A)+ mRNA export from nucleus

structural constituent of nuclear pore

structural constituent of nuclear pore

structural constituent of nuclear pore

neural tube development

neurogenesis

nuclear pore outer ring

nuclear pore outer ring

nuclear membrane

paraxial mesoderm development

mRNA transport

somite development

nephron development

03013

TC0X00001276.mm.2 Cenpi centromere protein I X 134308083 NM_145924, BC030328 NM_145924, BC030328 14

chromosome, centromeric region

kinetochore

kinetochore

molecular_function

nucleus

chromosome

cytosol

cytosol

biological_process

nuclear body

nuclear body

centromere complex assembly

 
TC0800003178.mm.2 Egln1 egl-9 family hypoxia-inducible factor 1 8 -124908586 NM_053207, BC006903 NM_053207, BC006903 160

response to hypoxia

iron ion binding

nucleus

cytoplasm

cytoplasm

cytosol

cellular iron ion homeostasis

ferrous iron binding

ferrous iron binding

postsynaptic density

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

2-oxoglutarate-dependent dioxygenase activity

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

enzyme binding

L-ascorbic acid binding

peptidyl-proline dioxygenase activity

peptidyl-proline dioxygenase activity

peptidyl-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity

oxygen homeostasis

positive regulation of apoptotic process

negative regulation of DNA-binding transcription factor activity

regulation of angiogenesis

positive regulation of transcription by RNA polymerase II

metal ion binding

dioxygenase activity

negative regulation of cyclic-nucleotide phosphodiesterase activity

cardiac muscle tissue morphogenesis

heart trabecula formation

ventricular septum morphogenesis

labyrinthine layer development

cellular response to hypoxia

response to nitric oxide

glutamatergic synapse

glutamatergic synapse

regulation of postsynapse organization

regulation of postsynapse organization

regulation of postsynapse organization

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of neuron death

positive regulation of neuron death

negative regulation of CAMKK-AMPK signaling cascade

05200

05211

TC0200005164.mm.2 Sulf2 sulfatase 2 2 -166073898, -166073898 NM_001252578, NM_001252579, NM_028072, BC141086 NM_001252578, NM_001252579, NM_028072, BC141086 NM_001252578, NM_001252579, NM_028072, BC141086 NM_001252578, NM_001252579, NM_028072, BC141086 66

kidney development

chondrocyte development

glomerular filtration

catalytic activity

arylsulfatase activity

calcium ion binding

glycosaminoglycan binding

extracellular space

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

sulfur compound metabolic process

N-acetylglucosamine-6-sulfatase activity

N-acetylglucosamine-6-sulfatase activity

N-acetylglucosamine-6-sulfatase activity

sulfuric ester hydrolase activity

response to wounding

cell surface

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of vascular endothelial growth factor production

esophagus smooth muscle contraction

hydrolase activity

positive regulation of Wnt signaling pathway

positive regulation of Wnt signaling pathway

heparan sulfate proteoglycan metabolic process

heparan sulfate proteoglycan metabolic process

heparan sulfate proteoglycan metabolic process

glomerular basement membrane development

glomerular basement membrane development

glial cell-derived neurotrophic factor receptor signaling pathway

negative regulation of fibroblast growth factor receptor signaling pathway

negative regulation of fibroblast growth factor receptor signaling pathway

metal ion binding

embryonic skeletal system development

cartilage development

bone development

innervation

positive regulation of canonical Wnt signaling pathway

liver regeneration

regulation of hepatocyte proliferation

 
TC1300000033.mm.2 Pitrm1 pitrilysin metallepetidase 1 13 6548156, 6548156 NM_145131, BC006917 NM_145131, BC006917 28

catalytic activity

metalloendopeptidase activity

metalloendopeptidase activity

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial matrix

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

protein processing

hydrolase activity

metal ion binding

 
TC0900000746.mm.2 Adpgk ADP-dependent glucokinase 9 59291571 NM_028121, BC021526 NM_028121, BC021526 28

extracellular region

endoplasmic reticulum

carbohydrate metabolic process

glucose metabolic process

glucose metabolic process

glycolytic process

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, alcohol group as acceptor

ADP-specific glucokinase activity

ADP-specific glucokinase activity

metal ion binding

00010

01100

TC1000000402.mm.2 Cd24a CD24a antigen 10 43579168 NM_009846, BC075622, CD24a NM_009846, BC075622, CD24a NM_009846, BC075622, CD24a 167

response to hypoxia

cell activation

regulation of cytokine-mediated signaling pathway

response to molecule of bacterial origin

pre-B cell differentiation

immune system process

leukocyte migration involved in inflammatory response

positive regulation of T cell mediated immune response to tumor cell

positive regulation of inflammatory response to antigenic stimulus

positive regulation of B cell apoptotic process

protein binding

plasma membrane

plasma membrane

cell adhesion

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

leukocyte cell-cell adhesion

cell surface receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

neuromuscular synaptic transmission

neuromuscular synaptic transmission

negative regulation of neuroblast proliferation

apoptotic mitochondrial changes

external side of plasma membrane

external side of plasma membrane

cell surface

positive regulation of neuron projection development

positive regulation of neuron projection development

membrane

membrane

cell migration

protein kinase binding

regulation of cell-cell adhesion

positive regulation of cell-cell adhesion

carbohydrate binding

apoptotic nuclear changes

protein tyrosine kinase activator activity

Hsp70 protein binding

negative regulation of B cell proliferation

neuron projection development

neuron projection development

anchored component of membrane

T cell costimulation

anchored component of external side of plasma membrane

anchored component of external side of plasma membrane

anchored component of external side of plasma membrane

microvillus membrane

chemokine receptor transport out of membrane raft

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

negative regulation of transforming growth factor beta3 production

positive regulation of integrin activation

positive regulation of integrin activation

positive regulation of cell adhesion mediated by integrin

positive regulation of cell adhesion mediated by integrin

regulation of cell-cell adhesion mediated by integrin

positive regulation of cell-cell adhesion mediated by integrin

negative regulation of erythrocyte clearance

homotypic cell-cell adhesion

negative regulation of erythrocyte aggregation

positive regulation of T cell homeostatic proliferation

positive regulation of activated T cell proliferation

regulation of phosphorylation

cholesterol homeostasis

positive regulation of MAP kinase activity

regulation of MAPK cascade

response to estrogen

innate immune response

membrane raft

membrane raft

regulation of B cell differentiation

negative regulation of neuron differentiation

respiratory burst

negative regulation of T cell homeostatic proliferation

positive regulation of alpha-beta T cell proliferation

positive regulation of alpha-beta T cell proliferation

synaptic vesicle endocytosis

positive regulation of peptidyl-tyrosine phosphorylation

negative regulation of neurogenesis

positive regulation of calcium-mediated signaling

Hsp90 protein binding

ciliary membrane

negative regulation of monocyte chemotactic protein-1 production

apoptotic signaling pathway

negative regulation of inflammatory response to wounding

positive regulation of inflammatory response to wounding

04640

TC1100000995.mm.2 Mybbp1a MYB binding protein (P160) 1a 11 72441326 NM_016776, BC048858, BC052889 NM_016776, BC048858, BC052889 NM_016776, BC048858, BC052889 63

DNA binding

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleolus

nucleolus

nucleolus

cytoplasm

regulation of transcription, DNA-templated

transcription factor binding

zinc ion binding

respiratory electron transport chain

circadian regulation of gene expression

cellular response to glucose starvation

ribosome biogenesis

NLS-dependent protein nuclear import complex

intracellular membrane-bounded organelle

sequence-specific DNA binding

sequence-specific DNA binding

negative regulation of transcription, DNA-templated

rhythmic process

E-box binding

positive regulation of cell cycle arrest

intrinsic apoptotic signaling pathway by p53 class mediator

positive regulation of anoikis

 
TC1900000205.mm.2 Ddb1 damage specific DNA binding protein 1 19 10605596 NM_015735, BC009661 NM_015735, BC009661 77

nucleic acid binding

DNA binding

damaged DNA binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

DNA repair

DNA repair

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

cellular response to DNA damage stimulus

proteasomal protein catabolic process

Wnt signaling pathway

protein ubiquitination

protein ubiquitination

protein-macromolecule adaptor activity

Cul4A-RING E3 ubiquitin ligase complex

Cul4B-RING E3 ubiquitin ligase complex

protein-containing complex

histone H2A monoubiquitination

site of double-strand break

regulation of circadian rhythm

negative regulation of apoptotic process

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein-containing complex binding

positive regulation of viral genome replication

positive regulation of gluconeogenesis

positive regulation of protein catabolic process

positive regulation by virus of viral protein levels in host cell

rhythmic process

biological process involved in interaction with symbiont

UV-damage excision repair

WD40-repeat domain binding

Cul4-RING E3 ubiquitin ligase complex

cullin family protein binding

regulation of mitotic cell cycle phase transition

positive regulation of viral release from host cell

03420

04120

TC0700004451.mm.2 Mki67 antigen identified by monoclonal antibody Ki 67 7 -135689787 NM_001081117 1917

nucleotide binding

chromosome, centromeric region

condensed chromosome

condensed chromosome

DNA binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

cytoplasm

cell cycle

regulation of mitotic nuclear division

protein C-terminus binding

cell population proliferation

nuclear body

meiotic cell cycle

regulation of chromosome segregation

hepatocyte proliferation

regulation of chromatin organization

cholangiocyte proliferation

 
TC1300000572.mm.2 Iars isoleucine-tRNA synthetase 13 49682129 NM_172015, BC067029 NM_172015, BC067029 26

tRNA binding

nucleotide binding

aminoacyl-tRNA editing activity

aminoacyl-tRNA ligase activity

isoleucine-tRNA ligase activity

isoleucine-tRNA ligase activity

isoleucine-tRNA ligase activity

ATP binding

nucleoplasm

cytoplasm

cytosol

translation

tRNA aminoacylation for protein translation

isoleucyl-tRNA aminoacylation

isoleucyl-tRNA aminoacylation

isoleucyl-tRNA aminoacylation

ligase activity

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

GTPase binding

00290

00970

TC1400001676.mm.2 Sh3bp5 SH3-domain binding protein 5 (BTK-associated) 14 -31372613, -31372613 NM_011894, BC018237, BC053741 NM_011894, BC018237, BC053741 NM_011894, BC018237, BC053741 27

protein kinase inhibitor activity

protein kinase inhibitor activity

guanyl-nucleotide exchange factor activity

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

negative regulation of protein kinase activity

membrane

nuclear body

SH3 domain binding

cytoplasmic vesicle membrane

cytoplasmic vesicle

intracellular signal transduction

intracellular signal transduction

negative regulation of protein tyrosine kinase activity

 
TC0800003233.mm.2 Trmt1 tRNA methyltransferase 1 8 84689283, 84689246, 84686323 NM_001164559, NM_001164560, NM_198020, BC027404 NM_001164559, NM_001164560, NM_198020, BC027404 NM_001164559, NM_001164560, NM_198020, BC027404 NM_001164559, NM_001164560, NM_198020, BC027404 21

tRNA binding

tRNA N2-guanine methylation

RNA binding

tRNA (guanine-N2-)-methyltransferase activity

tRNA (guanine-N2-)-methyltransferase activity

nucleus

tRNA processing

methyltransferase activity

transferase activity

methylation

metal ion binding

 
TC0700002617.mm.2 Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 7 -24978168, -24978168 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 BC020177, BC034645, BC037206, BC042894, NM_144921 83

nucleotide binding

amyloid-beta binding

photoreceptor inner segment

P-type sodium:potassium-exchanging ATPase activity

P-type sodium:potassium-exchanging ATPase activity

ATP binding

nucleus

cytoplasm

endoplasmic reticulum

Golgi apparatus

sodium:potassium-exchanging ATPase complex

sodium:potassium-exchanging ATPase complex

ion transport

potassium ion transport

sodium ion transport

cellular sodium ion homeostasis

cellular sodium ion homeostasis

cellular sodium ion homeostasis

memory

adult locomotory behavior

visual learning

potassium transmembrane transporter activity, phosphorylative mechanism

membrane

integral component of membrane

cellular potassium ion homeostasis

cellular potassium ion homeostasis

axon

organelle membrane

D1 dopamine receptor binding

ionotropic glutamate receptor signaling pathway

sodium ion export across plasma membrane

sodium ion export across plasma membrane

sodium ion export across plasma membrane

sarcolemma

response to drug

neuronal cell body

myelin sheath

myelin sheath

heparan sulfate proteoglycan binding

calyx of Held

dendritic spine neck

dendritic spine head

synapse

metal ion binding

chaperone binding

cardiac muscle contraction

regulation of cardiac muscle cell membrane potential

sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential

postsynapse

neuron to neuron synapse

integral component of presynaptic membrane

ion antiporter activity involved in regulation of presynaptic membrane potential

proton transmembrane transport

cellular response to amyloid-beta

neuron projection maintenance

potassium ion import across plasma membrane

potassium ion import across plasma membrane

04260

04960

04964

04970

04971

04972

04973

04974

04976

TC0700002498.mm.2 Tomm40 translocase of outer mitochondrial membrane 40 7 -19701312 NM_001109748, NM_016871, BC100452 NM_001109748, NM_016871, BC100452 NM_001109748, NM_016871, BC100452 30

cation channel activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

mitochondrial outer membrane translocase complex

mitochondrial outer membrane translocase complex

mitochondrial inner membrane

cytosol

protein targeting to mitochondrion

ion transport

protein transmembrane transporter activity

protein transmembrane transporter activity

protein transport

porin activity

membrane

integral component of membrane

protein import into mitochondrial matrix

integral component of mitochondrial outer membrane

integral component of mitochondrial membrane

positive regulation of apoptotic process

mitochondria-associated endoplasmic reticulum membrane

pore complex

protein insertion into mitochondrial membrane

transmembrane transport

preprotein binding

05014

TC0100000222.mm.2 Imp4 IMP4, U3 small nucleolar ribonucleoprotein 1 34439828 NM_178601, BC069930 NM_178601, BC069930 20

fibrillar center

nucleus

nucleolus

nucleolus

rRNA processing

snoRNA binding

preribosome

small-subunit processome

Mpp10 complex

Mpp10 complex

ribosome biogenesis

03008

TC1200001324.mm.2 Cdca7l cell division cycle associated 7 like 12 117843860 NM_146040, BC006933 NM_146040, BC006933 19

fibrillar center

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

regulation of transcription, DNA-templated

positive regulation of cell population proliferation

 
TC0400002457.mm.2 Nol6 nucleolar protein family 6 (RNA-associated) 4 -41114426 NM_139236, BC059820 NM_139236, BC059820 24

condensed nuclear chromosome

RNA binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

mitochondrion

rRNA processing

tRNA export from nucleus

small-subunit processome

CURI complex

UTP-C complex

03008

TC1200001051.mm.2 Glrx5 glutaredoxin 5 12 105032617 NM_028419, BC058371 NM_028419, BC058371 22

nucleus

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial matrix

electron transfer activity

protein disulfide oxidoreductase activity

dendrite

neuronal cell body

[2Fe-2S] cluster assembly

cell redox homeostasis

metal ion binding

iron-sulfur cluster binding

2 iron, 2 sulfur cluster binding

protein maturation by [2Fe-2S] cluster transfer

protein maturation by [4Fe-4S] cluster transfer

 
TC0100000469.mm.2 Cyp20a1 cytochrome P450, family 20, subfamily a, polypeptide 1 1 60343299 NM_030013, BC049147 NM_030013, BC049147 17

monooxygenase activity

iron ion binding

membrane

integral component of membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

heme binding

metal ion binding

 
TC0800001594.mm.2         NM_008737, NR_035436, BC060129 NM_008737, NR_035436, BC060129 NM_008737, NR_035436, BC060129  

angiogenesis

angiogenesis

angiogenesis

branching involved in blood vessel morphogenesis

neuron migration

sprouting angiogenesis

cell migration involved in sprouting angiogenesis

cell migration involved in sprouting angiogenesis

outflow tract septum morphogenesis

vascular endothelial growth factor-activated receptor activity

GTPase activator activity

protein binding

cytoplasm

mitochondrion

early endosome

cytosol

neurofilament

plasma membrane

plasma membrane

plasma membrane

focal adhesion

focal adhesion

substrate-dependent cell migration, cell extension

integrin-mediated signaling pathway

integrin-mediated signaling pathway

multicellular organism development

nervous system development

axon guidance

axon guidance

axonal fasciculation

heart development

motor neuron axon guidance

heparin binding

animal organ morphogenesis

cell surface

positive regulation of endothelial cell migration

positive regulation of endothelial cell migration

membrane

integral component of membrane

dendrite development

cell migration

semaphorin receptor activity

semaphorin receptor activity

semaphorin receptor activity

semaphorin receptor activity

growth factor binding

growth factor binding

protein kinase binding

facial nerve structural organization

trigeminal nerve morphogenesis

trigeminal nerve structural organization

vestibulocochlear nerve structural organization

nerve development

branchiomotor neuron axon guidance

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

cell differentiation

axon

axon

growth cone

negative regulation of axon extension

retinal ganglion cell axon guidance

actin cytoskeleton reorganization

regulation of Cdc42 protein signal transduction

regulation of Cdc42 protein signal transduction

substrate adhesion-dependent cell spreading

cellular response to hepatocyte growth factor stimulus

endothelial cell chemotaxis

cellular response to vascular endothelial growth factor stimulus

ventral trunk neural crest cell migration

vascular endothelial growth factor signaling pathway

vascular endothelial growth factor binding

vascular endothelial growth factor binding

neuropilin signaling pathway

neuropilin signaling pathway

VEGF-activated neuropilin signaling pathway

VEGF-activated neuropilin signaling pathway

positive regulation of phosphorylation

positive regulation of phosphorylation

neuron projection

neuronal cell body

negative regulation of neuron apoptotic process

endothelial cell migration

endothelial cell migration

positive regulation of angiogenesis

viral entry into host cell

metal ion binding

platelet-derived growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

vascular endothelial growth factor receptor signaling pathway

hepatocyte growth factor receptor signaling pathway

sympathetic nervous system development

neuron development

regulation of axon extension involved in axon guidance

positive regulation of axon extension involved in axon guidance

negative regulation of axon extension involved in axon guidance

negative regulation of axon extension involved in axon guidance

artery morphogenesis

axon extension involved in axon guidance

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

positive chemotaxis

positive regulation of filopodium assembly

positive regulation of filopodium assembly

positive regulation of stress fiber assembly

positive regulation of focal adhesion assembly

axonogenesis involved in innervation

dichotomous subdivision of terminal units involved in salivary gland branching

dichotomous subdivision of terminal units involved in salivary gland branching

angiogenesis involved in coronary vascular morphogenesis

cell migration involved in coronary vasculogenesis

coronary artery morphogenesis

retina vasculature morphogenesis in camera-type eye

renal artery morphogenesis

sympathetic ganglion development

trigeminal ganglion development

positive regulation of ERK1 and ERK2 cascade

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway

commissural neuron axon guidance

positive regulation of cell migration involved in sprouting angiogenesis

regulation of retinal ganglion cell axon guidance

sensory neuron axon guidance

sorting endosome

motor neuron migration

sympathetic neuron projection extension

sympathetic neuron projection guidance

glutamatergic synapse

glutamatergic synapse

integral component of postsynaptic membrane

postsynapse organization

postsynapse organization

basal dendrite development

basal dendrite arborization

positive regulation of substrate adhesion-dependent cell spreading

neural crest cell migration involved in autonomic nervous system development

toxin transport

semaphorin-plexin signaling pathway involved in neuron projection guidance

semaphorin-plexin signaling pathway involved in axon guidance

positive regulation of retinal ganglion cell axon guidance

VEGF-activated neuropilin signaling pathway involved in axon guidance

protein localization to early endosome

facioacoustic ganglion development

dorsal root ganglion morphogenesis

otic placode development

positive regulation of actin cytoskeleton reorganization

negative regulation of extrinsic apoptotic signaling pathway

 
TC0800003236.mm.2 Usp10 ubiquitin specific peptidase 10 8 119910359 NM_009462, BC007134 NM_009462, BC007134 38

p53 binding

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

nucleus

nucleus

nucleoplasm

cytoplasm

endosome

early endosome

early endosome

cytosol

cytosol

DNA repair

ubiquitin-dependent protein catabolic process

autophagy

cellular response to DNA damage stimulus

peptidase activity

cysteine-type peptidase activity

regulation of autophagy

regulation of autophagy

protein deubiquitination

protein deubiquitination

hydrolase activity

DNA damage response, signal transduction by p53 class mediator

DNA damage response, signal transduction by p53 class mediator

protein-containing complex

negative regulation of I-kappaB kinase/NF-kappaB signaling

ion channel binding

intermediate filament cytoskeleton

cellular response to interleukin-1

 
TC1000001298.mm.2 Nap1l1 nucleosome assembly protein 1-like 1 10 111473226 NM_001146707, NM_015781, BC076591 NM_001146707, NM_015781, BC076591 NM_001146707, NM_015781, BC076591 44

chromatin

chromatin binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

nucleosome assembly

nervous system development

kinase binding

histone binding

neuron projection

positive regulation of neurogenesis

positive regulation of neural precursor cell proliferation

 
TC1900000718.mm.2 Pdcd11 programmed cell death 11 19 47090765 NM_011053, BC070468 NM_011053, BC070468 30

nucleic acid binding

RNA binding

nucleus

nucleolus

cytosol

rRNA processing

RNA processing

mRNA processing

transcription factor binding

small-subunit processome

 
TC1400001031.mm.2 Rcbtb2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 14 73142509, 73142784 NM_001170694, NM_134083, NR_033185, BC003224 NM_001170694, NM_134083, NR_033185, BC003224 NM_001170694, NM_134083, NR_033185, BC003224 NM_001170694, NM_134083, NR_033185, BC003224 17

acrosomal vesicle

molecular_function

biological_process

cytoplasmic vesicle

 
TC0600001279.mm.2 Pparg peroxisome proliferator activated receptor gamma 6 115422065, 115360950, 115362348, 115361143 NM_001127330, NM_011146, BC021798 NM_001127330, NM_011146, BC021798 NM_001127330, NM_011146, BC021798 1453

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II repressing transcription factor binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

negative regulation of cytokine production

placenta development

response to dietary excess

diet induced thermogenesis

negative regulation of acute inflammatory response

DNA binding

DNA binding

chromatin binding

double-stranded DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

steroid hormone receptor activity

nuclear receptor activity

nuclear receptor activity

nuclear receptor activity

nuclear receptor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

fatty acid metabolic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

inflammatory response

signal transduction

protein C-terminus binding

transcription factor binding

regulation of blood pressure

zinc ion binding

negative regulation of cell population proliferation

negative regulation of cell population proliferation

response to light stimulus

hormone-mediated signaling pathway

regulation of gene expression

macrophage derived foam cell differentiation

negative regulation of macrophage derived foam cell differentiation

negative regulation of cholesterol storage

negative regulation of cholesterol storage

negative regulation of sequestering of triglyceride

long-chain fatty acid transport

negative regulation of angiogenesis

regulation of lipid metabolic process

regulation of lipid metabolic process

fatty acid oxidation

enzyme binding

protein phosphatase binding

cell differentiation

monocyte differentiation

negative regulation of cell growth

estrogen receptor binding

nuclear receptor coactivator activity

negative regulation of BMP signaling pathway

epithelial cell differentiation

response to food

cellular response to insulin stimulus

cellular response to insulin stimulus

negative regulation of collagen biosynthetic process

activating transcription factor binding

response to lipid

response to lipid

peroxisome proliferator activated receptor signaling pathway

peroxisome proliferator activated receptor signaling pathway

peptide binding

glucose homeostasis

regulation of circadian rhythm

identical protein binding

lipoprotein transport

positive regulation of apoptotic process

intracellular membrane-bounded organelle

receptor complex

positive regulation of DNA binding

negative regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

protein self-association

cell fate commitment

cell fate commitment

fat cell differentiation

fat cell differentiation

fat cell differentiation

fat cell differentiation

regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of fatty acid metabolic process

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of fatty acid oxidation

metal ion binding

retinoid X receptor binding

retinoic acid receptor signaling pathway

retinoic acid receptor signaling pathway

cell maturation

perinuclear region of cytoplasm

rhythmic process

negative regulation of smooth muscle cell proliferation

positive regulation of oligodendrocyte differentiation

arachidonic acid binding

DNA binding domain binding

LBD domain binding

WW domain binding

negative regulation of inflammatory response

white fat cell differentiation

white fat cell differentiation

brown fat cell differentiation

positive regulation of DNA-binding transcription factor activity

alpha-actinin binding

negative regulation of telomerase activity

positive regulation of phagocytosis, engulfment

negative regulation of interferon-gamma-mediated signaling pathway

negative regulation of gene silencing by miRNA

E-box binding

cellular response to lithium ion

cellular response to low-density lipoprotein particle stimulus

cellular response to organic cyclic compound

negative regulation of peptide hormone secretion

RNA polymerase II transcription regulator complex

negative regulation of neuroinflammatory response

negative regulation of cellular response to insulin stimulus

positive regulation of pri-miRNA transcription by RNA polymerase II

negative regulation of microglial cell activation

negative regulation of vascular associated smooth muscle cell proliferation

positive regulation of vascular associated smooth muscle cell apoptotic process

negative regulation of vascular endothelial cell proliferation

positive regulation of low-density lipoprotein receptor activity

promoter-specific chromatin binding

negative regulation of pancreatic stellate cell proliferation

negative regulation of signaling receptor activity

03320

04380

05016

05200

05216

TC1900000124.mm.2 Trmt112 tRNA methyltransferase 11-2 19 6909697 NM_001166370, NM_026306, BC016191, BC019418, BC087959 NM_001166370, NM_026306, BC016191, BC019418, BC087959 NM_001166370, NM_026306, BC016191, BC019418, BC087959 NM_001166370, NM_026306, BC016191, BC019418, BC087959 NM_001166370, NM_026306, BC016191, BC019418, BC087959 23

protein binding

nucleus

nucleoplasm

cytoplasm

protein methyltransferase activity

rRNA (guanine) methyltransferase activity

peptidyl-glutamine methylation

peptidyl-glutamine methylation

peptidyl-glutamine methylation

tRNA methylation

rRNA methylation

protein-containing complex

histone lysine methylation

protein heterodimerization activity

perinuclear region of cytoplasm

rRNA (guanine-N7)-methylation

rRNA (guanine-N7)-methylation

positive regulation of rRNA processing

 
TC1000000548.mm.2 Vsir V-set immunoregulatory receptor 10 60346850 NM_001159572, NM_028732, BC003967 NM_001159572, NM_028732, BC003967 NM_001159572, NM_028732, BC003967 43

negative regulation of T cell cytokine production

protein binding

plasma membrane

plasma membrane

external side of plasma membrane

positive regulation of gene expression

positive regulation of endopeptidase activity

membrane

integral component of membrane

enzyme binding

positive regulation of cell migration

BMP signaling pathway

positive regulation of BMP signaling pathway

positive regulation of BMP signaling pathway

zymogen activation

negative regulation of interferon-gamma production

negative regulation of interleukin-10 production

negative regulation of interleukin-17 production

negative regulation of tumor necrosis factor production

identical protein binding

positive regulation of regulatory T cell differentiation

stem cell differentiation

endopeptidase activator activity

positive regulation of collagen catabolic process

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD8-positive, alpha-beta T cell proliferation

positive regulation of stem cell differentiation

 
TC1800000708.mm.2 Psmg2 proteasome (prosome, macropain) assembly chaperone 2 18 67641586 NM_134138, BC016606 NM_134138, BC016606 21

nucleus

nucleus

cytosol

mitotic spindle assembly checkpoint

negative regulation of apoptotic process

proteasome assembly

chaperone-mediated protein complex assembly

regulation of cell cycle

molecular adaptor activity

chaperone complex

 
TC0400001158.mm.2 Kti12 KTI12 homolog, chromatin associated 4 108847856 NM_029571, BC021493 NM_029571, BC021493 12

nucleotide binding

tRNA wobble uridine modification

molecular_function

ATP binding

regulation of transcription by RNA polymerase II

elongator holoenzyme complex

 
TC1100000407.mm.2 Nudcd2 NudC domain containing 2 11 40733660 NM_026023, BC005646 NM_026023, BC005646 19

chromosome, centromeric region

kinetochore

chromosome

cytoplasm

cytosol

cytoskeleton

protein folding

microtubule cytoskeleton

intercellular bridge

unfolded protein binding

mitotic spindle

 
TC1500002221.mm.2 Cers5 ceramide synthase 5 15 -99735591 NM_028015, BC043059, BC046797 NM_028015, BC043059, BC046797 NM_028015, BC043059, BC046797 46

DNA binding

endoplasmic reticulum

endoplasmic reticulum

lipid metabolic process

sphingolipid metabolic process

membrane

integral component of membrane

N-acyltransferase activity

transferase activity

sphingolipid biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

 
TC1900000572.mm.2 Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 19 40659769, 40612365 NM_009848, BC011278 NM_009848, BC011278 128

nucleotide binding

guanosine-diphosphatase activity

ATP binding

basement membrane

extracellular space

plasma membrane

G protein-coupled receptor signaling pathway

synaptic vesicle

nucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

external side of plasma membrane

cell surface

postsynaptic density

membrane

integral component of membrane

basolateral plasma membrane

hydrolase activity

ATPase activity

nucleoside-diphosphatase activity

nucleoside-diphosphatase activity

nucleoside-triphosphatase activity

platelet activation

negative regulation of dopamine secretion

identical protein binding

neuron projection

neuronal cell body

adenosine-diphosphatase activity

adenosine-diphosphatase activity

uridine-diphosphatase activity

ADP catabolic process

synaptic membrane

8-oxo-dGTP phosphohydrolase activity

negative regulation of ATP biosynthetic process

00230

00240

TC1000000830.mm.2 Wdr18 WD repeat domain 18 10 79960151 NM_175450, BC095984 NM_175450, BC095984 29

molecular_function

nucleus

nucleoplasm

nuclear pre-replicative complex

cytoplasm

rRNA processing

multicellular organism development

regulation of DNA-dependent DNA replication initiation

Rix1 complex

 
TC1600001559.mm.2 Fam162a family with sequence similarity 162, member A 16 -36043843 NM_027342, BC010826 NM_027342, BC010826 23

molecular_function

mitochondrion

mitochondrion

mitochondrion

cytosol

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

membrane

integral component of membrane

positive regulation of apoptotic process

positive regulation of apoptotic process

neuron apoptotic process

neuron apoptotic process

cellular response to hypoxia

cellular response to hypoxia

cellular response to hypoxia

positive regulation of release of cytochrome c from mitochondria

positive regulation of release of cytochrome c from mitochondria

positive regulation of release of cytochrome c from mitochondria

 
TC1100003128.mm.2 Nlrp1c-ps NLR family, pyrin domain containing 1C, pseudogene 11 -71242429 NR_027858, BC141384 NR_027858, BC141384 2    
TC0700001400.mm.2 Lipt2 lipoyl(octanoyl) transferase 2 (putative) 7 100159276 NM_026010, BC115472, BC115473 NM_026010, BC115472, BC115473 NM_026010, BC115472, BC115473 15

protein binding

mitochondrion

mitochondrion

mitochondrion

cellular protein modification process

protein lipoylation

protein lipoylation

transferase activity

transferase activity, transferring acyl groups

ligase activity

lipoyl(octanoyl) transferase activity

positive regulation of oxygen metabolic process

00785

01100

TC0200001760.mm.2 Rad51 RAD51 recombinase 2 119112813 NM_011234, BC027384 NM_011234, BC027384 173

recombinase activity

nucleotide binding

nuclear chromosome

telomere maintenance via recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

DNA recombinase assembly

DNA recombinase assembly

chromosome, telomeric region

chromosome, telomeric region

chromatin

condensed chromosome

condensed nuclear chromosome

condensed nuclear chromosome

synaptonemal complex

lateral element

lateral element

regulation of protein phosphorylation

DNA binding

chromatin binding

chromatin binding

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

cytoplasm

mitochondrion

cytoskeleton

DNA metabolic process

DNA unwinding involved in DNA replication

DNA repair

DNA recombination

mitotic recombination

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

reciprocal meiotic recombination

reciprocal meiotic recombination

protein C-terminus binding

DNA-dependent ATPase activity

regulation of double-strand break repair via homologous recombination

telomere maintenance via telomere lengthening

PML body

single-stranded DNA helicase activity

enzyme binding

replication fork processing

replication fork processing

telomere organization

protein-containing complex

site of double-strand break

interstrand cross-link repair

strand invasion

identical protein binding

perinuclear region of cytoplasm

positive regulation of DNA ligation

meiotic cell cycle

DNA polymerase binding

chromosome organization involved in meiotic cell cycle

chromosome organization involved in meiotic cell cycle

cellular response to alkaloid

cellular response to ionizing radiation

cellular response to hydroxyurea

cellular response to camptothecin

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination-dependent replication fork processing

03440

05200

05212

TC0600000788.mm.2 Serbp1 serpine1 mRNA binding protein 1 6 67266978 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 NM_001113564, NM_001113565, NM_001113566, NM_025814, BC013665, BC030502 38

RNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

PML body organization

SUMO binding

 
TC1200000988.mm.2 Tdp1 tyrosyl-DNA phosphodiesterase 1 12 99884517, 99884517 NM_028354, BC019804, BC065162 NM_028354, BC019804, BC065162 NM_028354, BC019804, BC065162 35

single strand break repair

single strand break repair

single strand break repair

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

nuclease activity

exonuclease activity

nucleus

nucleus

nucleoplasm

plasma membrane

DNA repair

DNA repair

double-strand break repair

double-strand break repair

cellular response to DNA damage stimulus

phosphoric diester hydrolase activity

hydrolase activity

3'-tyrosyl-DNA phosphodiesterase activity

3'-tyrosyl-DNA phosphodiesterase activity

intracellular membrane-bounded organelle

 
TC0800000846.mm.2 Mcm5 minichromosome maintenance complex component 5 8 75109508 NM_008566, BC094416 NM_008566, BC094416 41

nucleotide binding

double-strand break repair via break-induced replication

DNA binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA replication initiation

cell cycle

hydrolase activity

single-stranded DNA helicase activity

MCM complex

MCM complex

3'-5' DNA helicase activity

03030

04110

TC0100003449.mm.2 Mpzl1 myelin protein zero-like 1 1 -165592175, -165592180 NM_001001880, NM_001083897, BC072563 NM_001001880, NM_001083897, BC072563 NM_001001880, NM_001083897, BC072563 23

protein binding

integral component of plasma membrane

signal transduction

membrane

integral component of membrane

positive regulation of cell migration

04514

TC0100001985.mm.2 Eya1 EYA transcriptional coactivator and phosphatase 1 1 -14168957 NM_001252192, NM_010164, BC060260, BC066860 NM_001252192, NM_010164, BC060260, BC066860 NM_001252192, NM_010164, BC060260, BC066860 NM_001252192, NM_010164, BC060260, BC066860 151

establishment of mitotic spindle orientation

establishment of mitotic spindle orientation

metanephros development

ureteric bud development

branching involved in ureteric bud morphogenesis

outflow tract morphogenesis

RNA binding

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

DNA repair

double-strand break repair

chromatin organization

protein dephosphorylation

cellular response to DNA damage stimulus

multicellular organism development

pattern specification process

pattern specification process

mesodermal cell fate specification

animal organ morphogenesis

response to ionizing radiation

striated muscle tissue development

histone dephosphorylation

histone dephosphorylation

nuclear body

hydrolase activity

protein sumoylation

cell differentiation

protein-containing complex

protein-DNA complex

cellular protein localization

establishment or maintenance of apical/basal cell polarity

peptidyl-tyrosine dephosphorylation

aorta morphogenesis

ear morphogenesis

inner ear morphogenesis

inner ear morphogenesis

outer ear morphogenesis

middle ear morphogenesis

cell fate commitment

regulation of neuron differentiation

regulation of neuron differentiation

positive regulation of DNA repair

positive regulation of DNA repair

positive regulation of Notch signaling pathway

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

metal ion binding

neuron fate specification

embryonic skeletal system morphogenesis

semicircular canal morphogenesis

anatomical structure development

anatomical structure development

positive regulation of epithelial cell proliferation

pharyngeal system development

lung epithelial cell differentiation

otic vesicle development

otic vesicle morphogenesis

positive regulation of secondary heart field cardioblast proliferation

cochlea morphogenesis

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

 
TC0100002772.mm.2         NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379 NM_172505, NM_198652, NR_040291, BC057309, BC062125, BC131919, BC100379  

chromosome, centromeric region

chromosome, centromeric region

condensed chromosome kinetochore

DNA binding

nucleus

nucleoplasm

chromosome

nucleolus

mitochondrion

cell cycle

chromosome segregation

CENP-A containing nucleosome assembly

histone binding

identical protein binding

regulation of protein-containing complex assembly

regulation of DNA binding

 
TC1700002534.mm.2 Dpy30 dpy-30, histone methyltransferase complex regulatory subunit 17 -74299473, -74299473, -74299473, -74299473 NM_001146222, NM_001146223, NM_001146224, NM_024428, BC002240 NM_001146222, NM_001146223, NM_001146224, NM_024428, BC002240 NM_001146222, NM_001146223, NM_001146224, NM_024428, BC002240 NM_001146222, NM_001146223, NM_001146224, NM_024428, BC002240 NM_001146222, NM_001146223, NM_001146224, NM_024428, BC002240 39

nucleus

nucleoplasm

Golgi apparatus

trans-Golgi network

chromatin organization

chromatin silencing at telomere

endosomal transport

histone methyltransferase complex

identical protein binding

protein homodimerization activity

MLL3/4 complex

Set1C/COMPASS complex

Set1C/COMPASS complex

histone H3-K4 methylation

histone H3-K4 methylation

 
TC1000001894.mm.2 Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 10 -24637913 NM_008813, BC160371 NM_008813, BC160371 131

nucleic acid binding

catalytic activity

exonuclease activity

phosphodiesterase I activity

phosphodiesterase I activity

phosphodiesterase I activity

nucleotide diphosphatase activity

nucleotide diphosphatase activity

nucleotide diphosphatase activity

scavenger receptor activity

insulin receptor binding

calcium ion binding

ATP binding

extracellular region

extracellular space

extracellular space

plasma membrane

integral component of plasma membrane

generation of precursor metabolites and energy

phosphate-containing compound metabolic process

immune response

zinc ion binding

nucleoside triphosphate catabolic process

nucleoside triphosphate catabolic process

cell surface

cell surface

cell surface

membrane

integral component of membrane

hydrolase activity

polysaccharide binding

negative regulation of ossification

negative regulation of cell growth

melanocyte differentiation

regulation of bone mineralization

negative regulation of bone mineralization

inorganic diphosphate transport

inorganic diphosphate transport

cellular phosphate ion homeostasis

sequestering of triglyceride

biomineral tissue development

negative regulation of protein autophosphorylation

cellular response to insulin stimulus

NADH pyrophosphatase activity

identical protein binding

protein homodimerization activity

cell projection

neuron projection

neuronal cell body

cell body

synapse

negative regulation of fat cell differentiation

negative regulation of fat cell differentiation

negative regulation of fat cell differentiation

negative regulation of glycogen biosynthetic process

ATP metabolic process

ATP metabolic process

negative regulation of glucose import

negative regulation of insulin receptor signaling pathway

bone remodeling

metal ion binding

nucleoside-triphosphate diphosphatase activity

nucleoside-triphosphate diphosphatase activity

3'-phosphoadenosine 5'-phosphosulfate metabolic process

nucleic acid phosphodiester bond hydrolysis

apical dendrite

basal dendrite

cyclic-GMP-AMP hydrolase activity

cyclic-GMP-AMP hydrolase activity

cyclic-GMP-AMP hydrolase activity

negative regulation of hh target transcription factor activity

00230

00500

00740

00760

00770

01100

TC1300001635.mm.2 H2bc7 H2B clustered histone 7 13 -23573759 NM_178195, BC160307 NM_178195, BC160307 6

innate immune response in mucosa

DNA binding

extracellular space

nucleoplasm

cytosol

nucleosome assembly

antibacterial humoral response

identical protein binding

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

05322

TC1900000960.mm.2 Banf1 BAF nuclear assembly factor 1 19 -5364632, -5364632 NM_001038231, NM_001286608, NM_011793, NR_104482, BC003709 NM_001038231, NM_001286608, NM_011793, NR_104482, BC003709 NM_001038231, NM_001286608, NM_011793, NR_104482, BC003709 NM_001038231, NM_001286608, NM_011793, NR_104482, BC003709 NM_001038231, NM_001286608, NM_011793, NR_104482, BC003709 37

condensed chromosome

DNA binding

DNA binding

DNA binding

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

cytosol

chromosome segregation

protein C-terminus binding

DNA integration

enzyme binding

chromosome condensation

identical protein binding

protein homodimerization activity

negative regulation of viral genome replication

protein N-terminus binding

establishment of integrated proviral latency

LEM domain binding

 
TC1900000127.mm.2 Ppp1r14b protein phosphatase 1, regulatory inhibitor subunit 14B 19 6975047 NM_008889, BC082545, BC125650, BC125654 NM_008889, BC082545, BC125650, BC125654 NM_008889, BC082545, BC125650, BC125654 NM_008889, BC082545, BC125650, BC125654 23

protein phosphatase inhibitor activity

protein serine/threonine phosphatase inhibitor activity

cytoplasm

phosphatase inhibitor activity

protein phosphatase regulator activity

regulation of phosphorylation

innate immune response

 
TC0900001101.mm.2 Ttk Ttk protein kinase 9 83834688, 83834688 NM_001110265, NM_001284272, NM_009445, BC058851 NM_001110265, NM_001284272, NM_009445, BC058851 NM_001110265, NM_001284272, NM_009445, BC058851 NM_001110265, NM_001284272, NM_009445, BC058851 34

nucleotide binding

kinetochore

kinetochore

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity

protein serine/threonine/tyrosine kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

cytoplasm

spindle

protein phosphorylation

chromosome segregation

mitotic cell cycle checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

membrane

kinase activity

phosphorylation

female meiosis chromosome segregation

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

peptidyl-tyrosine phosphorylation

meiotic spindle assembly checkpoint

meiotic spindle assembly checkpoint

protein localization to kinetochore

protein localization to kinetochore

protein localization to chromosome

identical protein binding

kinetochore binding

protein autophosphorylation

chromosome separation

meiotic prometaphase I

protein localization to meiotic spindle midzone

04110

TC0300001181.mm.2 Dph5 diphthamide biosynthesis 5 3 115888182 NM_027193, BC060372 NM_027193, BC060372 16

diphthine synthase activity

cellular_component

methyltransferase activity

transferase activity

peptidyl-diphthamide biosynthetic process from peptidyl-histidine

methylation

 
TC1400000975.mm.2 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 14 69337150, 69555400 BC043134, NM_026174 BC043134, NM_026174 23

Golgi membrane

autophagosome membrane

guanosine-diphosphatase activity

guanosine-diphosphatase activity

Golgi apparatus

UDP catabolic process

nucleoside diphosphate catabolic process

membrane

nucleoside-diphosphatase activity

nucleoside-diphosphatase activity

nucleoside-triphosphatase activity

integral component of Golgi membrane

cytidine-diphosphatase activity

CTPase activity

uridine-diphosphatase activity

uridine-diphosphatase activity

integral component of autophagosome membrane

00230

00240

04142

TC1100000892.mm.2 Aurkb aurora kinase B 11 69045636 NM_011496, BC003261 NM_011496, BC003261 114

negative regulation of transcription by RNA polymerase II

nucleotide binding

chromosome, centromeric region

kinetochore

condensed chromosome, centromeric region

condensed chromosome, centromeric region

negative regulation of B cell apoptotic process

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

spindle

cytoskeleton

spindle microtubule

protein phosphorylation

cell cycle

spindle organization

mitotic spindle organization

mitotic spindle assembly checkpoint

chromocenter

kinase activity

phosphorylation

transferase activity

kinase binding

midbody

midbody

spindle pole centrosome

negative regulation of protein binding

chromosome passenger complex

chromosome passenger complex

chromosome passenger complex

positive regulation of telomere maintenance via telomerase

regulation of cytokinesis

positive regulation of cytokinesis

protein localization to kinetochore

cellular response to UV

histone serine kinase activity

histone serine kinase activity

cleavage furrow formation

histone H3-S28 phosphorylation

metal ion binding

spindle midzone

mitotic spindle midzone assembly

cell division

positive regulation of telomerase activity

mitotic spindle pole

mitotic spindle pole

positive regulation of telomere capping

positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore

mitotic spindle midzone

 
TC0100003786.mm.2 Smyd2 SET and MYND domain containing 2 1 -189880491 NM_026796, BC023119 NM_026796, BC023119 30

negative regulation of transcription by RNA polymerase II

RNA polymerase II complex binding

p53 binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

chromatin organization

methyltransferase activity

negative regulation of cell population proliferation

protein-lysine N-methyltransferase activity

histone methylation

transferase activity

histone-lysine N-methyltransferase activity

peptidyl-lysine monomethylation

peptidyl-lysine dimethylation

methylation

histone lysine methylation

regulation of DNA damage response, signal transduction by p53 class mediator

metal ion binding

histone methyltransferase activity (H3-K36 specific)

 
TC0600000648.mm.2 Chn2 chimerin 2 6 54039931, 54272821, 54269155, 54264857 NM_001163640, NM_023543, BC051139, BC141060 NM_001163640, NM_023543, BC051139, BC141060 NM_001163640, NM_023543, BC051139, BC141060 NM_001163640, NM_023543, BC051139, BC141060 32

GTPase activator activity

GTPase activator activity

signal transduction

membrane

intracellular signal transduction

regulation of GTPase activity

synapse

metal ion binding

 
MG-1-pos-10342180_st                
TC0100002033.mm.2 Mcm3 minichromosome maintenance complex component 3 1 -20802967 NM_008563, BC031700 NM_008563, BC031700 65

nucleotide binding

double-strand break repair via break-induced replication

DNA binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA replication initiation

DNA strand elongation involved in DNA replication

cell cycle

hydrolase activity

MCM complex

MCM complex

perinuclear region of cytoplasm

mitotic DNA replication initiation

03030

04110

TC0400001465.mm.2 Clspn claspin 4 126556979 NM_175554, BC050848 NM_175554, BC050848 26

DNA replication checkpoint

DNA damage checkpoint

DNA secondary structure binding

DNA binding

nucleus

nucleoplasm

chromosome

Golgi apparatus

DNA repair

cellular response to DNA damage stimulus

cell cycle

mitotic G2 DNA damage checkpoint

mitotic G2 DNA damage checkpoint

anaphase-promoting complex binding

anaphase-promoting complex binding

peptidyl-serine phosphorylation

activation of protein kinase activity

activation of protein kinase activity

mitotic DNA replication checkpoint

mitotic DNA replication checkpoint

 
TC0900002044.mm.2 Slc37a2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 9 -37229148 NM_001145960, NM_020258, BC063326 NM_001145960, NM_020258, BC063326 NM_001145960, NM_020258, BC063326 18

endoplasmic reticulum

glycerol-3-phosphate metabolic process

glycerophosphate shuttle

carbohydrate transport

glycerol-3-phosphate transmembrane transporter activity

antiporter activity

glucose-6-phosphate transport

glucose-6-phosphate transport

glycerol-3-phosphate transmembrane transport

membrane

integral component of membrane

transmembrane transporter activity

integral component of endoplasmic reticulum membrane

integral component of endoplasmic reticulum membrane

phosphate ion transmembrane transport

phosphate ion transmembrane transport

transmembrane transport

glucose 6-phosphate:inorganic phosphate antiporter activity

glucose 6-phosphate:inorganic phosphate antiporter activity

 
TC0100003697.mm.2 Lbr lamin B receptor 1 -181815314 NM_133815, BC021516, BC042522 NM_133815, BC021516, BC042522 NM_133815, BC021516, BC042522 67

DNA binding

protein binding

nucleus

nuclear envelope

nuclear envelope

nuclear inner membrane

nuclear inner membrane

nuclear pore

nuclear lamina

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

nuclear localization sequence binding

steroid metabolic process

cholesterol metabolic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

neutrophil differentiation

nuclear membrane

nuclear membrane

delta14-sterol reductase activity

delta14-sterol reductase activity

chaperone binding

chromo shadow domain binding

NADPH binding

 
TC0600001033.mm.2 Ruvbl1 RuvB-like protein 1 6 88465408 NM_019685, BC004718 NM_019685, BC004718 53

nucleotide binding

box C/D snoRNP assembly

Swr1 complex

Swr1 complex

TFIID-class transcription factor complex binding

DNA helicase activity

DNA helicase activity

transcription coactivator activity

helicase activity

protein binding

ATP binding

nucleus

nucleoplasm

cytosol

DNA repair

DNA recombination

chromatin organization

chromatin remodeling

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

cell cycle

positive regulation of plasminogen activation

nuclear matrix

histone acetylation

hydrolase activity

ATPase activity

TBP-class protein binding

Ino80 complex

Ino80 complex

protein-containing complex

NuA4 histone acetyltransferase complex

NuA4 histone acetyltransferase complex

regulation of growth

3'-5' DNA helicase activity

5'-3' DNA helicase activity

ADP binding

histone H4 acetylation

histone H2A acetylation

ATPase binding

cell division

MLL1 complex

positive regulation of canonical Wnt signaling pathway

R2TP complex

R2TP complex

ribonucleoprotein complex

regulation of fibroblast apoptotic process

04310

TC0700001455.mm.2 Rrm1 ribonucleotide reductase M1 7 102441694 NM_009103, BC016450, BC066217 NM_009103, BC016450, BC066217 NM_009103, BC016450, BC066217 53

nucleotide binding

catalytic activity

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

protein binding

ATP binding

nuclear envelope

cytoplasm

cytosol

ribonucleoside-diphosphate reductase complex

ribonucleoside-diphosphate reductase complex

DNA replication

metabolic process

deoxyribonucleotide biosynthetic process

deoxyribonucleotide biosynthetic process

oxidoreductase activity

purine nucleotide binding

identical protein binding

cell projection

neuronal cell body

protein heterotetramerization

ribonucleoside-diphosphate reductase activity

disordered domain specific binding

00230

00240

00480

01100

TC1700002414.mm.2 Rab31 RAB31, member RAS oncogene family 17 -65651725 NM_133685, BC013063 NM_133685, BC013063 25

nucleotide binding

phagocytic cup

GTPase activity

protein binding

GTP binding

cytoplasm

endosome

early endosome

late endosome

Golgi apparatus

trans-Golgi network

intracellular protein transport

endomembrane system

membrane

GDP binding

cytoplasmic vesicle

receptor internalization

trans-Golgi network membrane

trans-Golgi network membrane

cellular response to insulin stimulus

early phagosome membrane

Golgi to plasma membrane protein transport

Golgi to plasma membrane protein transport

regulated exocytosis

phagocytic vesicle

Golgi vesicle transport

positive regulation of phagocytosis, engulfment

phagosome maturation

04144

MG-1-pos-10340444_st                
TC0700003829.mm.2 P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 7 -100937633 NM_183168, BC027331, BC064095 NM_183168, BC027331, BC064095 NM_183168, BC027331, BC064095 54

G protein-coupled ADP receptor activity

G protein-coupled receptor activity

plasma membrane

phagocytosis

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of smooth muscle cell migration

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

pyrimidine nucleotide binding

transepithelial chloride transport

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

positive regulation of inositol trisphosphate biosynthetic process

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled UDP receptor activity

G protein-coupled UDP receptor activity

G protein-coupled UTP receptor activity

positive regulation of ERK1 and ERK2 cascade

cellular response to prostaglandin E stimulus

cellular response to organic cyclic compound

cellular response to purine-containing compound

positive regulation of vascular associated smooth muscle cell proliferation

cellular response to pyrimidine ribonucleotide

04080

TC1300001555.mm.2 H2bc13 H2B clustered histone 13 13 -21715710 NM_178199 9

innate immune response in mucosa

extracellular space

nucleoplasm

cytosol

antibacterial humoral response

identical protein binding

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

05322

MG-1-pos-10341381_st                
TC0200004598.mm.2 Ckap2l cytoskeleton associated protein 2-like 2 -129268209 NM_181589, BC053443 NM_181589, BC053443 18

molecular_function

cytoplasm

centrosome

centrosome

cytosol

cytosol

cytoskeleton

biological_process

mitotic spindle

mitotic spindle

 
TC0300002797.mm.2 S1pr1 sphingosine-1-phosphate receptor 1 3 -115710432 NM_007901, BC049094, BC051023 NM_007901, BC049094, BC051023 NM_007901, BC049094, BC051023 252

angiogenesis

angiogenesis

G protein-coupled receptor binding

blood vessel maturation

cardiac muscle tissue growth involved in heart morphogenesis

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

G protein-coupled receptor activity

G protein-coupled receptor activity

nucleoplasm

cytoplasm

endosome

plasma membrane

chemotaxis

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

brain development

positive regulation of cell population proliferation

external side of plasma membrane

membrane

integral component of membrane

cell migration

regulation of metabolic process

lamellipodium assembly

regulation of cell adhesion

positive regulation of cell migration

regulation of bone mineralization

leukocyte chemotaxis

intrinsic component of plasma membrane

actin cytoskeleton reorganization

sphingosine-1-phosphate receptor activity

sphingosine-1-phosphate receptor activity

sphingosine-1-phosphate receptor activity

intracellular membrane-bounded organelle

positive regulation of GTPase activity

regulation of bone resorption

positive regulation of transcription by RNA polymerase II

sphingolipid binding

positive regulation of smooth muscle cell proliferation

positive regulation of positive chemotaxis

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

negative regulation of stress fiber assembly

heart trabecula morphogenesis

T cell migration

04080

TC0800001245.mm.2 Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 8 106168853, 106168920 NM_178798, BC038404 NM_178798, BC038404 20

amino acid transmembrane transport

plasma membrane

amino acid transport

basic amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

antiporter activity

ornithine transport

membrane

integral component of membrane

transmembrane transporter activity

intracellular membrane-bounded organelle

transmembrane transport

basic amino acid transmembrane transport

 
TC1800000528.mm.2 Sncaip synuclein, alpha interacting protein (synphilin) 18 52768092, 52767810, 52768143 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 NM_001199151, NM_001199153, NM_001199154, NM_026408, BC098489 40

nucleoplasm

cytoplasm

cell death

ubiquitin protein ligase binding

cytoplasmic ribonucleoprotein granule

dopamine metabolic process

identical protein binding

regulation of neurotransmitter secretion

regulation of inclusion body assembly

05012

TC0700001736.mm.2 Eef2k eukaryotic elongation factor-2 kinase 7 120843599, 120851188, 120842830 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 NM_001267710, NM_001267711, NM_007908, BC003433, BC055361, NM_001251826 47

nucleotide binding

protein serine/threonine kinase activity

elongation factor-2 kinase activity

elongation factor-2 kinase activity

calcium ion binding

calmodulin binding

calmodulin binding

ATP binding

translational elongation

protein phosphorylation

translation factor activity, RNA binding

postsynaptic density

kinase activity

phosphorylation

transferase activity

regulation of protein autophosphorylation

negative regulation of apoptotic process

dendritic spine

positive regulation of endocytosis

protein autophosphorylation

positive regulation of synapse assembly

positive regulation of dendritic spine morphogenesis

 
TC1100001095.mm.2 Tlcd3a TLC domain containing 3A 11 76202091, 76179670, 76179670 NM_027773, BC115519, BC115520 NM_027773, BC115519, BC115520 NM_027773, BC115519, BC115520 15

molecular_function

endoplasmic reticulum

plasma membrane

membrane

integral component of membrane

lipid homeostasis

 
TC0600000772.mm.2 Mad2l1 MAD2 mitotic arrest deficient-like 1 6 66535220 NM_019499, BC089012 NM_019499, BC089012 81

mitotic sister chromatid segregation

establishment of mitotic spindle orientation

chromosome, centromeric region

kinetochore

kinetochore

kinetochore

spindle pole

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

cytoplasm

cytosol

cytoskeleton

cell cycle

mitotic cell cycle checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

mitotic spindle assembly checkpoint

protein C-terminus binding

negative regulation of protein catabolic process

identical protein binding

protein homodimerization activity

negative regulation of apoptotic process

negative regulation of apoptotic process

nuclear pore nuclear basket

negative regulation of mitotic metaphase/anaphase transition

negative regulation of mitotic cell cycle

perinuclear region of cytoplasm

cell division

establishment of centrosome localization

mitotic spindle

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of mitotic cell cycle spindle assembly checkpoint

negative regulation of ubiquitin protein ligase activity

04110

04114

04914

TC1500002141.mm.2 Slc38a1 solute carrier family 38, member 1 15 -96571417, -96571417, -96571417 NM_001166456, NM_001166458, NM_134086, BC030378 NM_001166456, NM_001166458, NM_134086, BC030378 NM_001166456, NM_001166458, NM_134086, BC030378 NM_001166456, NM_001166458, NM_134086, BC030378 45

amino acid transmembrane transport

neutral amino acid:sodium symporter activity

plasma membrane

plasma membrane

integral component of plasma membrane

ion transport

sodium ion transport

amino acid transport

glutamine transport

glutamine transport

amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

L-glutamine transmembrane transporter activity

symporter activity

neutral amino acid transport

membrane

integral component of membrane

basolateral plasma membrane

axon

neuronal cell body

external side of apical plasma membrane

L-alpha-amino acid transmembrane transport

 
TC0500002152.mm.2 Tyms thymidylate synthase 5 -30058199 NM_021288, NR_033402, BC020139 NM_021288, NR_033402, BC020139 NM_021288, NR_033402, BC020139 38

translation repressor activity, mRNA regulatory element binding

mRNA binding

thymidylate synthase activity

thymidylate synthase activity

folic acid binding

nucleus

nucleolus

cytoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

cytosol

dTMP biosynthetic process

dTMP biosynthetic process

regulation of translation

methyltransferase activity

nucleotide biosynthetic process

membrane

transferase activity

negative regulation of translation

methylation

tetrahydrofolate interconversion

protein homodimerization activity

heterocyclic compound binding

sequence-specific mRNA binding

00240

00670

01100

TC0800002153.mm.2 Ankrd37 ankyrin repeat domain 37 8 -45996907 NM_001039562, BC039642, BC092377 NM_001039562, BC039642, BC092377 NM_001039562, BC039642, BC092377 14

protein binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

biological_process

 
TC1300001777.mm.2 Serpinb6a serine (or cysteine) peptidase inhibitor, clade B, member 6a 13 -33917917, -33917917 NM_001164117, NM_001164118, NM_001243192, NM_009254, BC006766, BC057950 NM_001164117, NM_001164118, NM_001243192, NM_009254, BC006766, BC057950 NM_001164117, NM_001164118, NM_001243192, NM_009254, BC006766, BC057950 NM_001164117, NM_001164118, NM_001243192, NM_009254, BC006766, BC057950 NM_001164117, NM_001164118, NM_001243192, NM_009254, BC006766, BC057950 NM_001164117, NM_001164118, NM_001243192, NM_009254, BC006766, BC057950 40

protease binding

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

protein binding

extracellular space

cytoplasm

cytoplasm

cytoplasm

sensory perception of sound

gonad development

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of endopeptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

collagen-containing extracellular matrix

cellular response to osmotic stress

serine protease inhibitor complex

05146

TC1800000509.mm.2 Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 18 50128200 NM_008292, BC022175 NM_008292, BC022175 55

very long-chain fatty acid metabolic process

3-hydroxyacyl-CoA dehydrogenase activity

3-hydroxyacyl-CoA dehydrogenase activity

enoyl-CoA hydratase activity

enoyl-CoA hydratase activity

estradiol 17-beta-dehydrogenase activity

protein binding

mitochondrion

peroxisome

peroxisome

peroxisome

peroxisomal matrix

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation

fatty acid beta-oxidation

androgen metabolic process

estrogen metabolic process

oxidoreductase activity

long-chain-enoyl-CoA hydratase activity

lyase activity

isomerase activity

3-hydroxyacyl-CoA dehydratase activity

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity

very long-chain fatty-acyl-CoA metabolic process

medium-chain fatty-acyl-CoA metabolic process

identical protein binding

protein homodimerization activity

17-beta-hydroxysteroid dehydrogenase (NAD+) activity

17-beta-hydroxysteroid dehydrogenase (NAD+) activity

Sertoli cell development

00120

01100

04146

TC1300001353.mm.2 Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 13 119690350 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 NM_145942, BC023851, BC029693, BC031363, BC034317 44

catalytic activity

hydroxymethylglutaryl-CoA synthase activity

hydroxymethylglutaryl-CoA synthase activity

cytoplasm

cytosol

cytosol

acetyl-CoA metabolic process

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

isoprenoid biosynthetic process

farnesyl diphosphate biosynthetic process, mevalonate pathway

response to purine-containing compound

sterol biosynthetic process

transferase activity

isomerase activity

small molecule binding

protein homodimerization activity

organic acid binding

cellular response to low-density lipoprotein particle stimulus

00072

00280

00650

00900

01100

TC0700003581.mm.2 Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 7 -80094846 NM_173011, BC060030 NM_173011, BC060030 84

magnesium ion binding

isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

peroxisome

cytosol

glyoxylate cycle

tricarboxylic acid cycle

isocitrate metabolic process

NADP metabolic process

NADP biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

metal ion binding

NAD binding

negative regulation of glial cell proliferation

negative regulation of glial cell migration

negative regulation of matrix metallopeptidase secretion

00020

00480

01100

04146

TC0700000652.mm.2 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 7 35119292, 35119292 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 NM_001287514, NM_001287515, NM_001287521, NM_001287523, NM_007678, BC011118, BC028890, BC051102, BC058161 476

urea cycle

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

RNA polymerase I transcription regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

liver development

embryonic placenta development

DNA binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

transcription regulator complex

nucleolus

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase I

mitochondrion organization

Notch signaling pathway

multicellular organism development

transcription factor binding

transcription factor binding

cholesterol metabolic process

negative regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

positive regulation of gene expression

nuclear matrix

cytokine-mediated signaling pathway

kinase binding

kinase binding

protein domain specific binding

myeloid cell differentiation

myeloid cell differentiation

macrophage differentiation

lung development

granulocyte differentiation

granulocyte differentiation

protein-containing complex

Rb-E2F complex

CHOP-C/EBP complex

regulation of cell population proliferation

glucose homeostasis

identical protein binding

protein homodimerization activity

histone deacetylase binding

positive regulation of macrophage activation

intracellular membrane-bounded organelle

sequence-specific DNA binding

sequence-specific DNA binding

protein-containing complex binding

fat cell differentiation

fat cell differentiation

fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

positive regulation of osteoblast differentiation

negative regulation of cell cycle

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase III

protein heterodimerization activity

cell maturation

inner ear development

positive regulation of inflammatory response

white fat cell differentiation

brown fat cell differentiation

lipid homeostasis

interleukin-6-mediated signaling pathway

cellular response to lithium ion

cellular response to tumor necrosis factor

cellular response to organic cyclic compound

HMG box domain binding

RNA polymerase II transcription regulator complex

positive regulation of DNA-templated transcription, initiation

05200

05221

TC1200001834.mm.2 Mis18bp1 MIS18 binding protein 1 12 -65132734 NM_172578, BC052175 NM_172578, BC052175 24

chromosome, centromeric region

condensed nuclear chromosome kinetochore

DNA binding

protein binding

nucleus

chromosome

cell cycle

cell division

 
TC0400002271.mm.2 Wwp1 WW domain containing E3 ubiquitin protein ligase 1 4 -19608299 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 NM_001276292, NM_177327, NR_074089, NR_074090, BC026829, BC150812 40

protein polyubiquitination

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

protein binding

nucleus

cytoplasm

cytosol

plasma membrane

ubiquitin-dependent protein catabolic process

membrane

protein ubiquitination

protein ubiquitination

protein ubiquitination

transferase activity

T cell differentiation

lung development

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

positive regulation of protein catabolic process

negative regulation of transcription, DNA-templated

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

04120

04144

TC0800002399.mm.2 Gdf15 growth differentiation factor 15 8 -70629392, -70629392 NM_011819, BC067248 NM_011819, BC067248 112

activation of MAPK activity

activation of MAPK activity

reduction of food intake in response to dietary excess

reduction of food intake in response to dietary excess

reduction of food intake in response to dietary excess

cytokine activity

extracellular region

extracellular region

extracellular space

extracellular space

nucleus

cytoplasm

Golgi apparatus

growth factor activity

positive regulation of pathway-restricted SMAD protein phosphorylation

BMP signaling pathway

glial cell-derived neurotrophic factor receptor signaling pathway

negative regulation of multicellular organism growth

protein homodimerization activity

protein homodimerization activity

positive regulation of MAPK cascade

positive regulation of protein kinase B signaling

SMAD protein signal transduction

SMAD protein signal transduction

negative regulation of growth hormone receptor signaling pathway

BMP receptor binding

positive regulation of myoblast fusion

 
TC0500002240.mm.2 Nop14 NOP14 nucleolar protein 5 -34638535 NM_029278, BC024998, BC043043 NM_029278, BC024998, BC043043 NM_029278, BC024998, BC043043 21

nucleus

nucleoplasm

nucleolus

nucleolus

rRNA processing

enzyme binding

maturation of SSU-rRNA

Noc4p-Nop14p complex

small-subunit processome

ribosome biogenesis

 
TC0100002354.mm.2 Hspd1 heat shock protein 1 (chaperonin) 1 -55077833, -55077832 NM_010477, BC016400 NM_010477, BC016400 137

nucleotide binding

lipopolysaccharide binding

lipopolysaccharide binding

p53 binding

MyD88-dependent toll-like receptor signaling pathway

positive regulation of T cell mediated immune response to tumor cell

double-stranded RNA binding

ATP binding

extracellular space

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial matrix

mitochondrial matrix

early endosome

peroxisomal matrix

rough endoplasmic reticulum

Golgi apparatus

cytosol

plasma membrane

plasma membrane

clathrin-coated pit

protein folding

activation of cysteine-type endopeptidase activity involved in apoptotic process

response to unfolded protein

high-density lipoprotein particle binding

apoptotic mitochondrial changes

apoptotic mitochondrial changes

cell surface

membrane

isomerase activity

enzyme binding

mitochondrial crista

coated vesicle

secretory granule

secretory granule

ubiquitin protein ligase binding

Golgi cisterna

positive regulation of interferon-alpha production

positive regulation of interferon-alpha production

positive regulation of interferon-alpha production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interferon-gamma production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

protein-containing complex

apolipoprotein binding

apolipoprotein A-I binding

mitochondrial unfolded protein response

protein refolding

B cell proliferation

T cell activation

T cell activation

T cell activation

T cell activation

B cell activation

zymogen granule

positive regulation of macrophage activation

positive regulation of apoptotic process

negative regulation of apoptotic process

myelin sheath

intracellular membrane-bounded organelle

negative regulation of neuron apoptotic process

protein-containing complex binding

protein import into mitochondrial intermembrane space

membrane raft

lipopolysaccharide receptor complex

isotype switching to IgG isotypes

positive regulation of inflammatory response

protein stabilization

positive regulation of T cell activation

positive regulation of T cell activation

positive regulation of T cell activation

chaperone binding

chaperone binding

biological process involved in interaction with symbiont

extracellular exosome

negative regulation of apoptotic process in bone marrow cell

cellular response to interleukin-7

modification-dependent protein binding

negative regulation of reactive oxygen species biosynthetic process

03018

04940

TC1900001095.mm.2 Fads2 fatty acid desaturase 2 19 -10062764 NM_019699, BC057189 NM_019699, BC057189 39

stearoyl-CoA 9-desaturase activity

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

membrane

integral component of membrane

linoleoyl-CoA desaturase activity

oxidoreductase activity

00592

01040

03320

TC0500003369.mm.2 Gtf2i general transcription factor II I 5 -134237831, -134237831 NM_001080746, NM_001080747, NM_001080748, NM_001080749, NM_010365, BC053044 NM_001080746, NM_001080747, NM_001080748, NM_001080749, NM_010365, BC053044 NM_001080746, NM_001080747, NM_001080748, NM_001080749, NM_010365, BC053044 NM_001080746, NM_001080747, NM_001080748, NM_001080749, NM_010365, BC053044 NM_001080746, NM_001080747, NM_001080748, NM_001080749, NM_010365, BC053044 NM_001080746, NM_001080747, NM_001080748, NM_001080749, NM_010365, BC053044 81

RNA polymerase II activating transcription factor binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

transcription by RNA polymerase II

embryo development

transition between slow and fast fiber

negative regulation of angiogenesis

cell projection

neuronal cell body

mitogen-activated protein kinase binding

negative regulation of cytosolic calcium ion concentration

positive regulation of DNA repair by transcription from RNA polymerase II promoter

03022

TC0200005334.mm.2         NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480  

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

cellular_component

regulation of transcription by RNA polymerase II

 
TC0400001274.mm.2 Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 4 117019401, 117019401 NM_001111277, NM_175135, BC115657, BC115658 NM_001111277, NM_175135, BC115657, BC115658 NM_001111277, NM_175135, BC115657, BC115658 NM_001111277, NM_175135, BC115657, BC115658 22

cytoplasmic translational initiation

translation initiation factor activity

translation initiation factor activity

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

cytoplasm

eukaryotic translation initiation factor 2B complex

eukaryotic translation initiation factor 2B complex

translational initiation

translation factor activity, RNA binding

response to heat

response to glucose

oligodendrocyte development

guanyl-nucleotide exchange factor complex

response to peptide hormone

T cell receptor signaling pathway

03013

TC0100002583.mm.2 Tmbim1 transmembrane BAX inhibitor motif containing 1 1 -74288246 NM_027154, BC004752 NM_027154, BC004752 23

death receptor binding

lysosome

lysosomal membrane

endosome

Golgi apparatus

endosome membrane

membrane

integral component of membrane

negative regulation of catalytic activity

intracellular membrane-bounded organelle

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of Fas signaling pathway

negative regulation of protein localization to plasma membrane

positive regulation of blood vessel remodeling

 
TC1300000240.mm.2         NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303 NM_178188, NM_178203, NM_178204, BC119295, BC119297, BC127164, BC160302, BC160303  

nuclear chromosome

nucleosome

DNA binding

nucleus

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

chromatin silencing

negative regulation of cell population proliferation

enzyme binding

protein-containing complex

regulation of gene silencing

 
TC0200002876.mm.2 Camk1d calcium/calmodulin-dependent protein kinase ID 2 -5293456, -5293456 NM_177343, BC141413, BC141414 NM_177343, BC141413, BC141414 NM_177343, BC141413, BC141414 27

nucleotide binding

catalytic activity

protein kinase activity

protein serine/threonine kinase activity

calmodulin-dependent protein kinase activity

calmodulin-dependent protein kinase activity

calmodulin binding

ATP binding

intracellular anatomical structure

nucleus

cytoplasm

cytoplasm

protein phosphorylation

inflammatory response

nervous system development

metabolic process

positive regulation of neuron projection development

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

positive regulation of CREB transcription factor activity

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of phagocytosis

regulation of dendrite development

positive regulation of respiratory burst

regulation of granulocyte chemotaxis

positive regulation of neutrophil chemotaxis

 
MG-1-pos-10339928_st                
TC0800001231.mm.2         NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773 NM_026532, NR_033574, BC003955, BC083165, BC086773  

nuclear outer membrane

nucleoplasm

cytosol

protein import into nucleus

protein import into nucleus

protein import into nucleus

protein export from nucleus

nucleocytoplasmic transport

structural constituent of nuclear pore

small GTPase binding

nuclear membrane

positive regulation of protein import into nucleus

identical protein binding

nuclear pore central transport channel

nuclear pore central transport channel

nuclear import signal receptor activity

protein localization to nuclear pore

nucleocytoplasmic carrier activity

negative regulation of vascular endothelial growth factor production

 
TC0900002451.mm.2 Kif23 kinesin family member 23 9 -61917277 NM_024245, BC047273 NM_024245, BC047273 34

nucleotide binding

mitotic cytokinesis

actomyosin contractile ring assembly

microtubule motor activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

centrosome

spindle

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

cell cycle

microtubule binding

microtubule binding

ATPase activity

midbody

positive regulation of cytokinesis

intercellular bridge

mitotic spindle midzone assembly

mitotic spindle midzone assembly

cell division

plus-end-directed vesicle transport along microtubule

mitotic spindle

Flemming body

centralspindlin complex

 
TC0600003302.mm.2 Lrp6 low density lipoprotein receptor-related protein 6 6 -134446477 NM_008514, BC060704 NM_008514, BC060704 224

gastrulation with mouth forming second

somitogenesis

neural tube closure

neural tube closure

neural tube closure

negative regulation of protein phosphorylation

heart looping

morphogenesis of an epithelium

positive regulation of mesenchymal cell proliferation

pericardium morphogenesis

pericardium morphogenesis

axis elongation

low-density lipoprotein particle receptor activity

low-density lipoprotein particle receptor activity

signaling receptor binding

frizzled binding

protein binding

early endosome

early endosome

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

plasma membrane

caveola

regulation of transcription, DNA-templated

negative regulation of protein kinase activity

endocytosis

positive regulation of cytosolic calcium ion concentration

chemical synaptic transmission

chemical synaptic transmission

multicellular organism development

embryonic pattern specification

embryonic pattern specification

dorsal/ventral axis specification

anterior/posterior pattern specification

anterior/posterior pattern specification

cell surface

cell surface

positive regulation of neuron projection development

neural crest formation

neural crest formation

neural crest cell differentiation

neural crest cell differentiation

coreceptor activity

membrane

integral component of membrane

Wnt signaling pathway

Wnt-protein binding

Wnt-protein binding

kinase inhibitor activity

toxin transmembrane transporter activity

cerebellum morphogenesis

cerebellum morphogenesis

thalamus development

thalamus development

cerebral cortex cell migration

forebrain radial glial cell differentiation

forebrain generation of neurons

Wnt signaling pathway involved in forebrain neuroblast division

Wnt signaling pathway involved in forebrain neuroblast division

neural tube development

formation of radial glial scaffolds

cerebral cortex development

cerebral cortex development

regulation of ossification

embryonic limb morphogenesis

embryonic limb morphogenesis

forebrain development

midbrain development

midbrain development

midbrain-hindbrain boundary development

midbrain-hindbrain boundary development

cytoplasmic vesicle

apolipoprotein binding

apolipoprotein binding

negative regulation of smooth muscle cell apoptotic process

limb morphogenesis

limb morphogenesis

embryonic forelimb morphogenesis

embryonic forelimb morphogenesis

embryonic hindlimb morphogenesis

embryonic hindlimb morphogenesis

external genitalia morphogenesis

external genitalia morphogenesis

post-anal tail morphogenesis

post-anal tail morphogenesis

cell migration involved in gastrulation

regulation of cell population proliferation

odontogenesis of dentin-containing tooth

odontogenesis of dentin-containing tooth

embryonic digit morphogenesis

embryonic digit morphogenesis

identical protein binding

protein homodimerization activity

Wnt-activated receptor activity

neuronal cell body

neuronal cell body

positive regulation of apoptotic process

synapse

synapse

negative regulation of fat cell differentiation

positive regulation of ossification

positive regulation of bone resorption

positive regulation of cell cycle

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

bone remodeling

bone remodeling

embryonic camera-type eye morphogenesis

embryonic camera-type eye morphogenesis

generation of neurons

skeletal system morphogenesis

negative regulation of epithelial cell proliferation

positive regulation of DNA-binding transcription factor activity

positive regulation of DNA-binding transcription factor activity

positive regulation of DNA-binding transcription factor activity

response to folic acid

roof of mouth development

roof of mouth development

convergent extension

convergent extension

retina morphogenesis in camera-type eye

embryonic retina morphogenesis in camera-type eye

embryonic retina morphogenesis in camera-type eye

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

regulation of cell development

face morphogenesis

face morphogenesis

bone morphogenesis

bone morphogenesis

branching involved in mammary gland duct morphogenesis

branching involved in mammary gland duct morphogenesis

trachea cartilage morphogenesis

trachea cartilage morphogenesis

mammary placode formation

mammary gland duct morphogenesis

canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development

canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation

cellular response to cholesterol

dopaminergic neuron differentiation

negative regulation of protein serine/threonine kinase activity

coreceptor activity involved in Wnt signaling pathway

protein localization to plasma membrane

primitive streak formation

primitive streak formation

receptor-mediated endocytosis involved in cholesterol transport

receptor-mediated endocytosis involved in cholesterol transport

Wnt signaling pathway involved in somitogenesis

Wnt signaling pathway involved in somitogenesis

axis elongation involved in somitogenesis

axis elongation involved in somitogenesis

cell-cell adhesion

Norrin signaling pathway

Wnt-Frizzled-LRP5/6 complex

Wnt signalosome

negative regulation of non-canonical Wnt signaling pathway

negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis

negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis

negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis

negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis

negative regulation of planar cell polarity pathway involved in pericardium morphogenesis

negative regulation of planar cell polarity pathway involved in neural tube closure

04310

TC0X00000166.mm.2 Ddx3x DEAD box helicase 3, X-linked X 13281021 NM_010028, BC150862, BC172016 NM_010028, BC150862, BC172016 NM_010028, BC150862, BC172016 56

nucleotide binding

immune system process

nucleic acid binding

DNA binding

DNA helicase activity

RNA binding

RNA binding

RNA helicase activity

RNA helicase activity

mRNA binding

GTPase activity

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

centrosome

cytosol

eukaryotic translation initiation factor 3 complex

plasma membrane

translational initiation

regulation of translation

apoptotic process

inflammatory response

chromosome segregation

gamete generation

transcription factor binding

poly(A) binding

eukaryotic initiation factor 4E binding

extrinsic apoptotic signaling pathway via death domain receptors

response to virus

cytoplasmic stress granule

cytoplasmic stress granule

RNA secondary structure unwinding

positive regulation of gene expression

membrane

Wnt signaling pathway

hydrolase activity

ATPase activity

nucleoside-triphosphatase activity

negative regulation of translation

cytosolic small ribosomal subunit

cell differentiation

positive regulation of cell growth

negative regulation of cell growth

primary miRNA processing

primary miRNA processing

cell leading edge

negative regulation of protein-containing complex assembly

translation initiation factor binding

positive regulation of protein autophosphorylation

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

RNA strand annealing activity

stress granule assembly

stress granule assembly

positive regulation of toll-like receptor 7 signaling pathway

positive regulation of toll-like receptor 8 signaling pathway

intracellular signal transduction

RNA stem-loop binding

positive regulation of translation in response to endoplasmic reticulum stress

ribosome biogenesis

mature ribosome assembly

cell projection

gamma-tubulin binding

ribosomal small subunit binding

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

P granule

CTPase activity

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

protein serine/threonine kinase activator activity

positive regulation of viral genome replication

innate immune response

positive regulation of translation

positive regulation of transcription by RNA polymerase II

positive regulation of translational initiation

mRNA 5'-UTR binding

lipid homeostasis

inflammasome complex

primary miRNA binding

cellular response to arsenic-containing substance

cellular response to osmotic stress

positive regulation of protein serine/threonine kinase activity

NLRP3 inflammasome complex

positive regulation of canonical Wnt signaling pathway

intrinsic apoptotic signaling pathway

cellular response to virus

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of NLRP3 inflammasome complex assembly

negative regulation of NIK/NF-kappaB signaling

positive regulation of NIK/NF-kappaB signaling

positive regulation of protein acetylation

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of protein K63-linked ubiquitination

protein localization to cytoplasmic stress granule

negative regulation of intrinsic apoptotic signaling pathway

04622

TC0X00002052.mm.2 Nkrf NF-kappaB repressing factor X -36885990 NM_029891, BC138828, BC138829 NM_029891, BC138828, BC138829 NM_029891, BC138828, BC138829 27

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

 
TC0900001042.mm.2 Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 9 77917364 NM_134255, BC022911 NM_134255, BC022911 33

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

fatty acid elongase activity

fatty acid elongase activity

membrane

integral component of membrane

transferase activity

fatty acid elongation, saturated fatty acid

sphingolipid biosynthetic process

integral component of endoplasmic reticulum membrane

fatty acid elongation, monounsaturated fatty acid

fatty acid elongation, monounsaturated fatty acid

fatty acid elongation, polyunsaturated fatty acid

fatty acid elongation, polyunsaturated fatty acid

very long-chain fatty acid biosynthetic process

very long-chain fatty acid biosynthetic process

cell projection

neuronal cell body

positive regulation of fatty acid biosynthetic process

dendritic tree

3-oxo-arachidoyl-CoA synthase activity

3-oxo-cerotoyl-CoA synthase activity

3-oxo-lignoceronyl-CoA synthase activity

01040

TC0X00001382.mm.2 Prps1 phosphoribosyl pyrophosphate synthetase 1 X 140456602 NM_021463, BC054772 NM_021463, BC054772 35

nucleotide binding

magnesium ion binding

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ATP binding

ATP binding

cytoplasm

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate biosynthetic process

purine nucleobase metabolic process

purine nucleotide biosynthetic process

purine nucleotide biosynthetic process

AMP biosynthetic process

nervous system development

nucleoside metabolic process

ribonucleoside monophosphate biosynthetic process

nucleotide biosynthetic process

AMP binding

kinase activity

phosphorylation

transferase activity

GDP binding

ribose phosphate metabolic process

carbohydrate binding

protein-containing complex

urate biosynthetic process

identical protein binding

protein homodimerization activity

ADP binding

cellular biosynthetic process

hypoxanthine biosynthetic process

metal ion binding

00030

00230

01100

TC1900000529.mm.2 Kif11 kinesin family member 11 19 37376381 NM_010615, BC060670 NM_010615, BC060670 58

nucleotide binding

spindle pole

microtubule motor activity

ATP binding

nucleus

cytoplasm

spindle

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

microtubule-based movement

cell cycle

spindle organization

mitotic centrosome separation

microtubule binding

ATP-dependent microtubule motor activity, plus-end-directed

protein kinase binding

protein-containing complex

regulation of mitotic centrosome separation

spindle assembly

cell division

mitotic spindle

mitotic spindle assembly

mitotic spindle assembly

 
TC0100001351.mm.2 Ivns1abp influenza virus NS1A binding protein 1 151344485, 151344497, 151344497 NM_001039511, NM_001039512, NM_054102, BC004092 NM_001039511, NM_001039512, NM_054102, BC004092 NM_001039511, NM_001039512, NM_054102, BC004092 NM_001039511, NM_001039512, NM_054102, BC004092 29

protein binding

nucleus

cytoplasm

cytosol

cytoskeleton

RNA splicing

response to virus

negative regulation of protein ubiquitination

negative regulation of intrinsic apoptotic signaling pathway

 
TC0800000968.mm.2 Syce2 synaptonemal complex central element protein 2 8 84872110, 84872257 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 NM_001168244, NM_001168246, NM_027954, NR_031759, BC094628, BC132534 31

synaptonemal complex

central element

central element

protein binding

nucleus

nucleoplasm

nucleoplasm

chromosome

cell cycle

synaptonemal complex assembly

cell division

meiotic cell cycle

 
TC0500000732.mm.2 Paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase 5 76951301 NM_025939, BC018153, BC052691 NM_025939, BC018153, BC052691 NM_025939, BC018153, BC052691 38

nucleotide binding

catalytic activity

phosphoribosylaminoimidazole carboxylase activity

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

ATP binding

cytoplasm

cytosol

purine nucleotide biosynthetic process

'de novo' IMP biosynthetic process

metabolic process

lyase activity

carboxy-lyase activity

ligase activity

identical protein binding

00230

01100

MG-1-pos-10341832_st                
TC0900002369.mm.2 Scamp5 secretory carrier membrane protein 5 9 -57441326 NM_020270, BC018613 NM_020270, BC018613 22

Golgi membrane

positive regulation of cytokine production

endosome

Golgi apparatus

plasma membrane

exocytosis

synaptic vesicle

synaptic vesicle

protein transport

membrane

integral component of membrane

cell junction

integral component of synaptic vesicle membrane

cytoplasmic vesicle

trans-Golgi network membrane

trans-Golgi network membrane

response to endoplasmic reticulum stress

protein-containing complex binding

synapse

negative regulation of endocytosis

positive regulation of calcium ion-dependent exocytosis

recycling endosome membrane

recycling endosome membrane

regulation of synaptic vesicle endocytosis

 
TC0700004201.mm.2 Cdr2 cerebellar degeneration-related 2 7 -120957039, -120957036 NM_007672, BC117530, BC118511 NM_007672, BC117530, BC118511 NM_007672, BC117530, BC118511 20

molecular_function

cytoplasm

biological_process

 
TC0400000506.mm.2 Anp32b acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 4 46450925 NM_130889, BC003489, BC005628, BC093506 NM_130889, BC003489, BC005628, BC093506 NM_130889, BC003489, BC005628, BC093506 NM_130889, BC003489, BC005628, BC093506 35

G1/S transition of mitotic cell cycle

vasculature development

nucleus

nucleus

nucleus

positive regulation of cell population proliferation

ventricular system development

histone binding

regulation of apoptotic process

negative regulation of apoptotic process

inner ear development

roof of mouth development

positive regulation of G1/S transition of mitotic cell cycle

 
TC0300001757.mm.2 Ect2 ect2 oncogene 3 -27097221, -27097221 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 NM_001177625, NM_001177626, NM_007900, BC023881, BC025565, BC032155, BC045614 48

mitotic cytokinesis

mitotic cytokinesis

cell morphogenesis

guanyl-nucleotide exchange factor activity

GTPase activator activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytoskeleton

cell-cell junction

bicellular tight junction

cell cortex

cell cycle

nervous system development

protein transport

nuclear body

cell junction

cell differentiation

midbody

small GTPase binding

activation of protein kinase activity

cleavage furrow

positive regulation of cytokinesis

regulation of Rho protein signal transduction

intracellular signal transduction

positive regulation of protein import into nucleus

protein homodimerization activity

positive regulation of apoptotic process

positive regulation of GTPase activity

positive regulation of neuron differentiation

regulation of protein kinase activity

protein homooligomerization

cell division

regulation of attachment of spindle microtubules to kinetochore

cellular response to hydrogen peroxide

bicellular tight junction assembly

cellular response to calcium ion

cellular response to ionizing radiation

mitotic spindle

activation of GTPase activity

activation of GTPase activity

centralspindlin complex

regulation of cytokinesis, actomyosin contractile ring assembly

 
TC1600001011.mm.2 Itsn1 intersectin 1 (SH3 domain protein 1A) 16 91729370, 91729370, 91729370 NM_001110275, NM_001110276, NM_010587, BC172688 NM_001110275, NM_001110276, NM_010587, BC172688 NM_001110275, NM_001110276, NM_010587, BC172688 NM_001110275, NM_001110276, NM_010587, BC172688 71

guanyl-nucleotide exchange factor activity

calcium ion binding

protein binding

nucleus

nuclear envelope

cytoplasm

cytoplasm

endosome

cytosol

plasma membrane

plasma membrane

clathrin-coated pit

clathrin-coated pit

clathrin-coated pit

exocytosis

endocytosis

small GTPase mediated signal transduction

protein transport

membrane

endosomal transport

kinase activator activity

lamellipodium

cell junction

endocytic vesicle

cytoplasmic vesicle

cellular protein localization

regulation of Rho protein signal transduction

intracellular signal transduction

presynaptic membrane

cell projection

neuron projection

neuronal cell body

dendritic spine

negative regulation of neuron apoptotic process

calyx of Held

synapse

metal ion binding

synaptic vesicle endocytosis

synaptic vesicle endocytosis

positive regulation of protein kinase B signaling

molecular adaptor activity

molecular adaptor activity

positive regulation of growth hormone secretion

positive regulation of dendritic spine development

proline-rich region binding

apical dendrite

intracellular vesicle

intracellular vesicle

presynaptic endocytic zone

postsynaptic actin cytoskeleton

glutamatergic synapse

clathrin-dependent synaptic vesicle endocytosis

regulation of modification of postsynaptic actin cytoskeleton

positive regulation of caveolin-mediated endocytosis

 
TC0300000656.mm.2 Tmem154 transmembrane protein 154 3 84666191 NM_177260, BC096432, BC113174, BC113175 NM_177260, BC096432, BC113174, BC113175 NM_177260, BC096432, BC113174, BC113175 NM_177260, BC096432, BC113174, BC113175 11

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC0200003697.mm.2 Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 2 -69193894 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 NM_001199123, NM_001199124, NM_025565, BC027121, BC033605 23

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

condensed chromosome kinetochore

molecular_function

nucleus

chromosome

cytosol

cell cycle

mitotic spindle organization

chromosome segregation

chromosome segregation

Ndc80 complex

Ndc80 complex

cell division

 
TC0600002491.mm.2 Mat2a methionine adenosyltransferase II, alpha 6 -72432795 NM_145569, BC003451, BC058360 NM_145569, BC003451, BC058360 NM_145569, BC003451, BC058360 42

nucleotide binding

methionine adenosyltransferase activity

methionine adenosyltransferase activity

methionine adenosyltransferase activity

ATP binding

cytosol

cytosol

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

one-carbon metabolic process

circadian rhythm

response to hormone

amino acid binding

transferase activity

protein hexamerization

response to drug

identical protein binding

metal ion binding

methionine adenosyltransferase complex

methionine adenosyltransferase complex

protein heterooligomerization

response to cAMP

cellular response to leukemia inhibitory factor

00270

01100

TC1400001931.mm.2 Wdhd1 WD repeat and HMG-box DNA binding protein 1 14 -47240943 NM_172598, BC063740 NM_172598, BC063740 22

mitotic cell cycle

chromosome, centromeric region

DNA binding

chromatin binding

chromatin binding

RNA binding

protein binding

nucleus

nucleoplasm

DNA-dependent DNA replication

DNA repair

RNA processing

regulation of chromosome organization

nuclear replication fork

RNA polymerase binding

heterochromatin maintenance

 
TC0M00000011.mm.2                
TC1400001314.mm.2 Ipo5 importin 5 14 120915846, 120911193 NM_023579, BC052392, BC054814 NM_023579, BC052392, BC054814 NM_023579, BC052392, BC054814 40

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

protein import into nucleus

NLS-bearing protein import into nucleus

ribosomal protein import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transport

small GTPase binding

positive regulation of protein import into nucleus

nuclear import signal receptor activity

nuclear import signal receptor activity

cellular response to amino acid stimulus

 
TC1100003941.mm.2 Kpna2 karyopherin (importin) alpha 2 11 -106988628 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 NM_010655, BC003274, BC006720, BC082280, BC094011 97

protein binding

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

cytosol

cytosol

protein import into nucleus

NLS-bearing protein import into nucleus

NLS-bearing protein import into nucleus

nuclear localization sequence binding

nuclear localization sequence binding

cytoplasmic stress granule

histone deacetylase binding

nuclear import signal receptor activity

nuclear import signal receptor activity

repressing transcription factor binding

entry of viral genome into host nucleus through nuclear pore complex via importin

entry of viral genome into host nucleus through nuclear pore complex via importin

extrinsic component of postsynaptic specialization membrane

glutamatergic synapse

postsynapse to nucleus signaling pathway

positive regulation of viral life cycle

positive regulation of viral life cycle

 
TC0X00001272.mm.2         NM_133196, NR_037299, BC036719 NM_133196, NR_037299, BC036719 NM_133196, NR_037299, BC036719  

nucleic acid binding

RNA binding

mRNA binding

nucleus

nucleoplasm

mRNA cleavage and polyadenylation specificity factor complex

mRNA cleavage and polyadenylation specificity factor complex

mRNA polyadenylation

mRNA processing

nuclear body

mRNA 3'-end processing

cleavage body

pre-mRNA cleavage required for polyadenylation

 
TC0200000245.mm.2 Mrc1 mannose receptor, C type 1 2 14229413 NM_008625, BC141338 NM_008625, BC141338 108

transmembrane signaling receptor activity

protein binding

mannose binding

endosome

plasma membrane

plasma membrane

plasma membrane

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

cell surface

endosome membrane

membrane

integral component of membrane

carbohydrate binding

signaling receptor activity

cargo receptor activity

cellular response to lipopolysaccharide

cellular response to interferon-gamma

cellular response to interleukin-4

04145

TC0600002044.mm.2 Slc35b4 solute carrier family 35, member B4 6 -34155878 NM_021435, BC033512 NM_021435, BC033512 19

UDP-N-acetylglucosamine transmembrane transporter activity

UDP-N-acetylglucosamine transmembrane transporter activity

UDP-xylose transmembrane transporter activity

UDP-xylose transmembrane transporter activity

endoplasmic reticulum

Golgi apparatus

regulation of gluconeogenesis

carbohydrate transport

UDP-xylose transmembrane transport

membrane

integral component of membrane

transmembrane transporter activity

integral component of Golgi membrane

integral component of endoplasmic reticulum membrane

transmembrane transport

UDP-N-acetylglucosamine transmembrane transport

 
TC1900000560.mm.2 Hells helicase, lymphoid specific 19 38930989 NM_008234, BC100394 NM_008234, BC100394 65

nucleotide binding

chromosome, centromeric region

urogenital system development

chromatin binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

pericentric heterochromatin

pericentric heterochromatin

DNA methylation

DNA methylation

chromatin silencing

DNA methylation-dependent heterochromatin assembly

DNA methylation-dependent heterochromatin assembly

cell cycle

multicellular organism development

maintenance of DNA methylation

maintenance of DNA methylation

hydrolase activity

lymphocyte differentiation

pericentric heterochromatin assembly

pericentric heterochromatin assembly

negative regulation of apoptotic process

lymphocyte proliferation

lymphocyte proliferation

cell division

cellular response to leukemia inhibitory factor

negative regulation of intrinsic apoptotic signaling pathway

 
TC1500000614.mm.2 Rpl8 ribosomal protein L8 15 76904070 NM_012053, BC043017 NM_012053, BC043017 28

cytoplasmic translation

cytoplasmic translation

RNA binding

structural constituent of ribosome

protein binding

cytoplasm

ribosome

translation

postsynaptic density

large ribosomal subunit

rRNA binding

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

polysomal ribosome

synapse

synapse

postsynapse

03010

MG-1-pos-10342684_st                
TC1200001939.mm.2 Sgpp1 sphingosine-1-phosphate phosphatase 1 12 -75714247 NM_030750, BC037592 NM_030750, BC037592 31

endoplasmic reticulum

endoplasmic reticulum membrane

plasma membrane

sphingolipid metabolic process

sphinganine-1-phosphate metabolic process

sphingosine metabolic process

sphingosine metabolic process

membrane

membrane

integral component of membrane

hydrolase activity

ER to Golgi ceramide transport

sphingosine-1-phosphate phosphatase activity

sphingosine-1-phosphate phosphatase activity

sphingosine-1-phosphate phosphatase activity

regulation of keratinocyte differentiation

regulation of epidermis development

phospholipid dephosphorylation

extrinsic apoptotic signaling pathway

intrinsic apoptotic signaling pathway

00600

TC0100002411.mm.2 Wdr12 WD repeat domain 12 1 -60076867, -60076867, -60076867 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 NM_001199060, NM_001199061, NM_021312, BC004748, BC052386, BC096651 23

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

protein binding

nucleus

nucleoplasm

nucleolus

rRNA processing

Notch signaling pathway

preribosome, large subunit precursor

preribosome, large subunit precursor

ribosome biogenesis

regulation of cell cycle

PeBoW complex

PeBoW complex

 
TC0600001813.mm.2 Slc25a13 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 6 -6041217 NM_001177572, NM_015829, BC016571 NM_001177572, NM_015829, BC016571 NM_001177572, NM_015829, BC016571 49

L-glutamate transmembrane transporter activity

L-glutamate transmembrane transporter activity

L-glutamate transmembrane transporter activity

calcium ion binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

ATP biosynthetic process

transport

L-aspartate transmembrane transporter activity

L-aspartate transmembrane transporter activity

aspartate transmembrane transport

aspartate transmembrane transport

aspartate transmembrane transport

L-glutamate transmembrane transport

L-glutamate transmembrane transport

membrane

integral component of membrane

transmembrane transporter activity

identical protein binding

malate-aspartate shuttle

malate-aspartate shuttle

malate-aspartate shuttle

cellular respiration

metal ion binding

response to calcium ion

transmembrane transport

 
TC0800002927.mm.2 Sf3b3 splicing factor 3b, subunit 3 8 -110810491 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 NM_133953, BC011412, BC042580, BC139015, BC139016 28

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

U2 snRNP

U12-type spliceosomal complex

nucleolus

mRNA processing

RNA splicing

U2 snRNA binding

negative regulation of protein catabolic process

protein-containing complex binding

U2-type precatalytic spliceosome

catalytic step 2 spliceosome

03040

TC1100003401.mm.2 Ccl3 chemokine (C-C motif) ligand 3 11 -83647842 NM_011337, BC111443 NM_011337, BC111443 260

monocyte chemotaxis

cytokine activity

protein binding

extracellular region

extracellular space

extracellular space

chemotaxis

inflammatory response

immune response

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

chemokine activity

chemokine activity

chemokine activity

regulation of cell shape

neutrophil chemotaxis

neutrophil chemotaxis

leukocyte chemotaxis

positive regulation of interleukin-1 beta production

positive regulation of tumor necrosis factor production

positive regulation of neuron apoptotic process

positive regulation of GTPase activity

astrocyte cell migration

positive regulation of osteoclast differentiation

positive regulation of transcription by RNA polymerase II

CCR chemokine receptor binding

macrophage chemotaxis

lymphocyte chemotaxis

positive regulation of inflammatory response

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

cellular response to interferon-gamma

cellular response to interleukin-1

cellular response to tumor necrosis factor

04060

04062

04620

05142

05323

TC0700000896.mm.2 Nav2 neuron navigator 2 7 49246188, 48959072 NM_001111016, NM_175272, XR_105111, XR_105112 NM_001111016, NM_175272, XR_105111, XR_105112 NM_001111016, NM_175272, XR_105111, XR_105112 NM_001111016, NM_175272, XR_105111, XR_105112 34

regulation of systemic arterial blood pressure by baroreceptor feedback

interstitial matrix

nucleoplasm

nervous system development

nervous system development

sensory perception of sound

sensory perception of smell

locomotory behavior

heparin binding

optic nerve development

glossopharyngeal nerve development

vagus nerve development

cerebellar cortex development

extracellular matrix

3'-5' DNA helicase activity

 
TC1100004183.mm.2 Sgsh N-sulfoglucosamine sulfohydrolase (sulfamidase) 11 -119343488 NM_018822, BC130268 NM_018822, BC130268 46

protein binding

glycosaminoglycan binding

lysosome

lysosome

glycosaminoglycan catabolic process

glycosaminoglycan catabolic process

N-acetylglucosamine-6-sulfatase activity

sulfuric ester hydrolase activity

sulfuric ester hydrolase activity

N-sulfoglucosamine sulfohydrolase activity

N-sulfoglucosamine sulfohydrolase activity

heparan sulfate proteoglycan catabolic process

heparan sulfate proteoglycan catabolic process

heparan sulfate proteoglycan metabolic process

00531

01100

04142

TC0200001053.mm.2 Map3k20 mitogen-activated protein kinase kinase kinase 20 2 72285700, 72285700, 72285636 NM_001164791, NM_023057, NM_178084, BC023718 NM_001164791, NM_023057, NM_178084, BC023718 NM_001164791, NM_023057, NM_178084, BC023718 NM_001164791, NM_023057, NM_178084, BC023718 25

DNA damage checkpoint

nucleotide binding

magnesium ion binding

magnesium ion binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

MAP kinase kinase kinase activity

MAP kinase kinase kinase activity

ATP binding

ATP binding

nucleus

cytoplasm

cytoplasm

cytosol

protein phosphorylation

protein phosphorylation

cytoskeleton organization

cell cycle

cell cycle arrest

activation of JUN kinase activity

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

embryonic digit morphogenesis

embryonic digit morphogenesis

positive regulation of apoptotic process

metal ion binding

stress-activated MAPK cascade

limb development

limb development

cellular response to gamma radiation

positive regulation of mitotic DNA damage checkpoint

04010

04530

MG-1-pos-10343802_st                
TC0400001395.mm.2 Pabpc4 poly(A) binding protein, cytoplasmic 4 4 123282910 NM_130881, NM_148917, BC003283, BC010345, BC056432 NM_130881, NM_148917, BC003283, BC010345, BC056432 NM_130881, NM_148917, BC003283, BC010345, BC056432 NM_130881, NM_148917, BC003283, BC010345, BC056432 NM_130881, NM_148917, BC003283, BC010345, BC056432 21

RNA binding

mRNA binding

mRNA 3'-UTR binding

nucleus

nucleus

cytoplasm

cytosol

cytosol

poly(A) binding

poly(A) binding

poly(U) RNA binding

poly(U) RNA binding

cytoplasmic stress granule

cytoplasmic stress granule

regulation of mRNA stability

myeloid cell development

ribonucleoprotein complex

ribonucleoprotein complex

03013

03015

03018

TC1100001049.mm.2 Mettl16 methyltransferase like 16 11 74770862 NM_026197, BC049897, BC054724 NM_026197, BC049897, BC054724 NM_026197, BC049897, BC054724 23

RNA methylation

mRNA (N6-adenosine)-methyltransferase activity

mRNA (N6-adenosine)-methyltransferase activity

RNA binding

nucleus

nucleus

cytoplasm

mRNA catabolic process

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

methyltransferase activity

posttranscriptional regulation of gene expression

posttranscriptional regulation of gene expression

transferase activity

U6 snRNA 3'-end binding

methylation

RNA stem-loop binding

23S rRNA (adenine(1618)-N(6))-methyltransferase activity

mRNA destabilization

rRNA base methylation

mRNA methylation

mRNA methylation

U6 snRNA (adenine-(43)-N(6))-methyltransferase activity

snRNA (adenine-N6)-methylation

negative regulation of 3'-UTR-mediated mRNA stabilization

 
TC0800001116.mm.2 Arl2bp ADP-ribosylation factor-like 2 binding protein 8 94667090, 94666599 NM_024191, NM_024269, BC002131, BC024708 NM_024191, NM_024269, BC002131, BC024708 NM_024191, NM_024269, BC002131, BC024708 NM_024191, NM_024269, BC002131, BC024708 23

transcription coactivator activity

protein binding

nucleus

cytoplasm

mitochondrion

mitochondrial intermembrane space

mitochondrial intermembrane space

centrosome

cytoskeleton

cilium

midbody

GTPase regulator activity

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

cell projection

maintenance of protein location in nucleus

maintenance of protein location in nucleus

 
TC0100002576.mm.2 Tns1 tensin 1 1 -73910231 NM_001289895, NM_027884 NM_001289895, NM_027884 27

actin binding

focal adhesion

focal adhesion

cell-substrate junction assembly

fibroblast migration

cell-substrate junction

 
TC0100000682.mm.2         NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102 NM_001001981, NM_001033606, NM_001136222, NM_001136226, NM_028817, BC031529, BC141102  

nucleotide binding

long-chain fatty acid metabolic process

long-chain fatty acid metabolic process

catalytic activity

long-chain fatty acid-CoA ligase activity

long-chain fatty acid-CoA ligase activity

ATP binding

nucleus

nucleolus

nucleolus

mitochondrion

mitochondrial outer membrane

peroxisome

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

lipid droplet

lipid droplet

cytosol

plasma membrane

rRNA processing

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

multicellular organism development

spermatogenesis

membrane

integral component of membrane

ligase activity

protein kinase binding

protein domain specific binding

cell differentiation

neuron differentiation

small-subunit processome

very-low-density lipoprotein particle assembly

long-chain fatty-acyl-CoA metabolic process

ribosome biogenesis

positive regulation of Golgi to plasma membrane protein transport

intracellular membrane-bounded organelle

long-chain fatty acid import into cell

arachidonate-CoA ligase activity

perinuclear region of cytoplasm

positive regulation of secretion

meiotic cell cycle

decanoate-CoA ligase activity

positive regulation of phosphatidylcholine biosynthetic process

 
TC0900001652.mm.2 Kif15 kinesin family member 15 9 122951080 NM_010620, BC060710 NM_010620, BC060710 26

nucleotide binding

microtubule motor activity

ATP binding

cytoplasm

cytoskeleton

kinesin complex

microtubule

microtubule-based movement

microtubule binding

ATPase activity

 
TC0800000096.mm.2 Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 8 11758364, 11728057, 11779283, 11728057, 11758364 NM_001113517, NM_001113518, NM_017402, BC044838 NM_001113517, NM_001113518, NM_017402, BC044838 NM_001113517, NM_001113518, NM_017402, BC044838 NM_001113517, NM_001113518, NM_017402, BC044838 81

storage vacuole

hematopoietic progenitor cell differentiation

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

cytosol

plasma membrane

focal adhesion

Golgi organization

small GTPase mediated signal transduction

nervous system development

protein kinase binding

protein kinase binding

lamellipodium

lamellipodium assembly

cell junction

growth cone

small GTPase binding

positive regulation of protein binding

protein-containing complex

regulation of Rho protein signal transduction

intracellular signal transduction

cell projection

neuron projection

neuronal cell body

positive regulation of apoptotic process

positive regulation of GTPase activity

positive regulation of GTPase activity

positive regulation of GTPase activity

astrocyte cell migration

positive regulation of growth hormone secretion

postsynaptic actin cytoskeleton organization

GABA-ergic synapse

presynaptic actin cytoskeleton organization

regulation of GTP binding

04810

MG-1-pos-10339670_st                
TC1500001937.mm.2 Snu13 SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) 15 -82041344 NM_011482, BC026755, BC054450, BC083315 NM_011482, BC026755, BC054450, BC083315 NM_011482, BC026755, BC054450, BC083315 NM_011482, BC026755, BC054450, BC083315 26

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

maturation of LSU-rRNA

box C/D snoRNP assembly

dense fibrillar component

RNA binding

nucleus

spliceosomal complex

U4atac snRNP

nucleolus

plasma membrane

mRNA processing

single fertilization

RNA splicing

maturation of SSU-rRNA

snoRNA binding

U4 snRNA binding

U4atac snRNA binding

box C/D RNP complex

box C/D RNP complex

box C/D RNP complex

small-subunit processome

protein-containing complex

U3 snoRNA binding

box C/D RNA binding

box C/D RNA binding

ribosome biogenesis

U4/U6 x U5 tri-snRNP complex

U4/U6 x U5 tri-snRNP complex

ATPase binding

U2-type precatalytic spliceosome

precatalytic spliceosome

ribonucleoprotein complex

03008

03040

TC1400000179.mm.2 Adk adenosine kinase 14 21076151, 21052573 NM_001243041, NM_134079, BC009659 NM_001243041, NM_134079, BC009659 NM_001243041, NM_134079, BC009659 58

nucleotide binding

adenosine kinase activity

adenosine kinase activity

adenosine kinase activity

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

cytosol

plasma membrane

purine ribonucleoside salvage

dATP biosynthetic process

positive regulation of cardiac muscle hypertrophy

kinase activity

transferase activity

phosphotransferase activity, alcohol group as acceptor

positive regulation of T cell proliferation

type B pancreatic cell proliferation

adenosine metabolic process

metal ion binding

00230

01100

TC0500001576.mm.2 Tbl2 transducin (beta)-like 2 5 135149685 NM_013763, BC039273, BC048185 NM_013763, BC039273, BC048185 NM_013763, BC039273, BC048185 25

endoplasmic reticulum

protein kinase binding

endoplasmic reticulum unfolded protein response

translation initiation factor binding

cellular response to glucose starvation

phosphoprotein binding

cellular response to hypoxia

 
TC1100000573.mm.2 Nhp2 NHP2 ribonucleoprotein 11 51619772 NM_026631, BC024944 NM_026631, BC024944 29

cleavage involved in rRNA processing

maturation of LSU-rRNA

RNA binding

RNA binding

protein binding

nucleus

telomerase holoenzyme complex

nucleolus

rRNA processing

telomere maintenance via telomerase

rRNA pseudouridine synthesis

snRNA pseudouridine synthesis

box H/ACA snoRNP complex

box H/ACA snoRNP complex

box H/ACA snoRNA binding

box H/ACA snoRNA binding

ribosome biogenesis

telomerase RNA binding

box H/ACA telomerase RNP complex

03008

TC0500002059.mm.2 Pus7 pseudouridylate synthase 7 5 -23740164, -23740164 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 NM_001289780, NM_001289781, NM_178403, BC008544, BC138533, BC145316 18

pseudouridine synthesis

RNA binding

nucleus

nucleus

tRNA processing

RNA modification

pseudouridine synthase activity

pseudouridine synthase activity

isomerase activity

negative regulation of translation

enzyme binding

tRNA pseudouridine synthesis

regulation of hematopoietic stem cell differentiation

mRNA pseudouridine synthesis

regulation of mesoderm development

 
TC0700000383.mm.2 Plaur plasminogen activator, urokinase receptor 7 24462482 NM_011113, BC160226 NM_011113, BC160226 190

positive regulation of protein phosphorylation

signaling receptor binding

protein binding

extracellular region

plasma membrane

plasma membrane

integral component of plasma membrane

cell surface

membrane

enzyme binding

protein domain specific binding

regulation of proteolysis

urokinase plasminogen activator receptor activity

anchored component of membrane

positive regulation of homotypic cell-cell adhesion

urokinase plasminogen activator signaling pathway

negative regulation of apoptotic process

positive regulation of DNA binding

positive regulation of epidermal growth factor receptor signaling pathway

mesenchymal cell differentiation

epithelial cell differentiation involved in prostate gland development

positive regulation of release of cytochrome c from mitochondria

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

04610

TC1600001379.mm.2 Etv5 ets variant 5 16 -22381312, -22381312 NM_023794, BC034680 NM_023794, BC034680 283

negative regulation of transcription by RNA polymerase II

transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

neuromuscular synaptic transmission

locomotory behavior

cell differentiation

cellular response to oxidative stress

sequence-specific DNA binding

positive regulation of neuron differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

male germ-line stem cell asymmetric division

regulation of synapse organization

positive regulation of glial cell proliferation

regulation of branching involved in mammary gland duct morphogenesis

skeletal muscle acetylcholine-gated channel clustering

sequence-specific double-stranded DNA binding

 
TC1500001896.mm.2 Rpl3 ribosomal protein L3 15 -80077780 NM_013762, BC009655, BC083134, BC094059, BC158039 NM_013762, BC009655, BC083134, BC094059, BC158039 NM_013762, BC009655, BC083134, BC094059, BC158039 NM_013762, BC009655, BC083134, BC094059, BC158039 NM_013762, BC009655, BC083134, BC094059, BC158039 42

ribosomal large subunit assembly

RNA binding

structural constituent of ribosome

intracellular anatomical structure

nucleus

nucleolus

cytoplasm

cytosol

ribosome

translation

5S rRNA binding

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

protein-containing complex

synapse

cellular response to interleukin-4

03010

TC1600001143.mm.2 Ubald1 UBA-like domain containing 1 16 -4874778 NM_145359, BC013706, BC064081 NM_145359, BC013706, BC064081 NM_145359, BC013706, BC064081 15

molecular_function

cellular_component

biological_process

 
TC0400000464.mm.2 Melk maternal embryonic leucine zipper kinase 4 44300916 NM_010790, BC085276 NM_010790, BC085276 40

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

calcium ion binding

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

plasma membrane

cell cortex

protein phosphorylation

apoptotic process

cell cycle

cell population proliferation

lipid binding

intrinsic apoptotic signaling pathway in response to oxidative stress

membrane

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

positive regulation of apoptotic process

protein autophosphorylation

neural precursor cell proliferation

 
TC1400001920.mm.2 Cnih1 cornichon family AMPA receptor auxiliary protein 1 14 -46775567 NM_009919, BC034868 NM_009919, BC034868 18

molecular_function

cellular_component

endoplasmic reticulum

Golgi apparatus

biological_process

membrane

integral component of membrane

vesicle-mediated transport

 
TC0400001667.mm.2 Cnr2 cannabinoid receptor 2 (macrophage) 4 135911679, 135895188 NM_009924, BC024052 NM_009924, BC024052 286

G protein-coupled receptor activity

G protein-coupled receptor activity

cannabinoid receptor activity

cannabinoid receptor activity

protein binding

cytoplasm

endoplasmic reticulum

plasma membrane

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

membrane

integral component of membrane

regulation of metabolic process

sensory perception of pain

dendrite

leukocyte chemotaxis

extrinsic component of cytoplasmic side of plasma membrane

negative regulation of synaptic transmission, GABAergic

response to lipopolysaccharide

negative regulation of mast cell activation

cannabinoid signaling pathway

cell projection

neuron projection

neuronal cell body

negative regulation of action potential

negative regulation of inflammatory response

negative regulation of nitric-oxide synthase activity

04080

TC1400002215.mm.2 Fdft1 farnesyl diphosphate farnesyl transferase 1 14 -63145150, -63145150 NM_010191, BC054722, BC138301, BC138302 NM_010191, BC054722, BC138301, BC138302 NM_010191, BC054722, BC138301, BC138302 NM_010191, BC054722, BC138301, BC138302 44

catalytic activity

farnesyl-diphosphate farnesyltransferase activity

farnesyl-diphosphate farnesyltransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

ergosterol biosynthetic process

metabolic process

steroid metabolic process

cholesterol metabolic process

isoprenoid biosynthetic process

lipid biosynthetic process

biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

transferase activity

transferase activity, transferring alkyl or aryl (other than methyl) groups

intracellular membrane-bounded organelle

farnesyl diphosphate metabolic process

farnesyl diphosphate metabolic process

metal ion binding

squalene synthase activity

00100

01100

TC0400001856.mm.2 Dhrs3 dehydrogenase/reductase (SDR family) member 3 4 144893136, 144892826, 144893076 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 NM_001172424, NM_011303, BC008980, BC010972, BC013540 30

retinoid metabolic process

retinoid metabolic process

outflow tract morphogenesis

retinol dehydrogenase activity

retinol dehydrogenase activity

lipid droplet

membrane

integral component of membrane

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

regulation of ossification

retinol metabolic process

regulation of retinoic acid receptor signaling pathway

negative regulation of retinoic acid receptor signaling pathway

NADP-retinol dehydrogenase activity

roof of mouth development

bone morphogenesis

cardiac septum morphogenesis

00830

01100

TC0100003500.mm.2 Nuf2 NUF2, NDC80 kinetochore complex component 1 -169497933 NM_023284, BC020026 NM_023284, BC020026 22

chromosome, centromeric region

kinetochore

condensed nuclear chromosome kinetochore

nucleus

nucleoplasm

chromosome

cytosol

cell cycle

mitotic spindle organization

attachment of spindle microtubules to kinetochore

Ndc80 complex

Ndc80 complex

protein-containing complex binding

meiotic chromosome segregation

cell division

attachment of mitotic spindle microtubules to kinetochore

kinetochore organization

 
TC1500000053.mm.2 Nup155 nucleoporin 155 15 8109312 NM_133227, BC050919 NM_133227, BC050919 28

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

nucleus

nuclear envelope

nuclear pore

cytoplasm

RNA export from nucleus

mRNA export from nucleus

protein import into nucleus

protein import into nucleus

nucleocytoplasmic transport

nuclear envelope organization

protein transport

membrane

structural constituent of nuclear pore

nuclear membrane

protein localization to nuclear inner membrane

nuclear pore inner ring

mRNA transport

atrial cardiac muscle cell action potential

03013

TC1100002224.mm.2 Fignl1 fidgetin-like 1 11 -11800287 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 NM_001163359, NM_001163360, NM_021891, BC051942, BC052415 23

nucleotide binding

nuclear chromosome

osteoblast differentiation

ATP binding

nucleus

nucleus

cytoplasm

male meiotic nuclear division

microtubule-severing ATPase activity

regulation of double-strand break repair via homologous recombination

hydrolase activity

ATPase activity

cytoplasmic microtubule organization

osteoblast proliferation

negative regulation of apoptotic process

metal ion binding

perinuclear region of cytoplasm

regulation of cell cycle

cellular response to ionizing radiation

negative regulation of intrinsic apoptotic signaling pathway

 
TC0900000255.mm.2 Ncapd3 non-SMC condensin II complex, subunit D3 9 27030164, 27060415 NM_178113, BC048190 NM_178113, BC048190 20

condensed chromosome kinetochore

condensed chromosome, centromeric region

condensed chromosome

condensin complex

condensin complex

condensin complex

chromatin binding

nucleus

nucleoplasm

pericentric heterochromatin

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

methylated histone binding

histone binding

germinal vesicle

cell division

meiotic chromosome separation

 
TC1400001174.mm.2 Uchl3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 14 101653966 NM_016723, BC048481 NM_016723, BC048481 43

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

intracellular anatomical structure

nucleoplasm

cytoplasm

cytosol

proteolysis

ubiquitin-dependent protein catabolic process

adult walking behavior

peptidase activity

peptidase activity

cysteine-type peptidase activity

protein deubiquitination

protein deubiquitination

protein deubiquitination

protein deubiquitination

hydrolase activity

protein catabolic process

protein catabolic process

cellular response to insulin stimulus

eating behavior

ubiquitin binding

positive regulation of fat cell differentiation

retina development in camera-type eye

ubiquitinyl hydrolase activity

 
TC0600001427.mm.2 Phb2 prohibitin 2 6 124712288 NM_007531, BC145875 NM_007531, BC145875 81

mitophagy

mitophagy

immunoglobulin production

protein binding

nucleus

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

mitochondrial inner membrane

plasma membrane

protein import into nucleus

mitochondrion organization

mitochondrion organization

sister chromatid cohesion

activation of phospholipase C activity

protein C-terminus binding

cell surface

cell surface

postsynaptic density

membrane

nuclear matrix

cell migration

CD40 signaling pathway

axon

positive regulation of exit from mitosis

protein-containing complex

negative regulation of intracellular estrogen receptor signaling pathway

negative regulation of intracellular estrogen receptor signaling pathway

amide binding

negative regulation of mammary gland epithelial cell proliferation

mitochondrial prohibitin complex

induction by virus of host autophagy

RIG-I signaling pathway

B cell activation

identical protein binding

protein homodimerization activity

negative regulation of apoptotic process

negative regulation of DNA-binding transcription factor activity

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

sphingolipid binding

sphingolipid binding

protein heterodimerization activity

protein N-terminus binding

presynaptic active zone

protein stabilization

positive regulation of DNA-binding transcription factor activity

mammary gland branching involved in thelarche

mammary gland alveolus development

regulation of branching involved in mammary gland duct morphogenesis

positive regulation of ERK1 and ERK2 cascade

cell periphery

inner mitochondrial membrane protein complex

glutamatergic synapse

GABA-ergic synapse

antiviral innate immune response

regulation of cardiolipin metabolic process

positive regulation of NIK/NF-kappaB signaling

positive regulation of cell cycle G1/S phase transition

regulation of cytochrome-c oxidase activity

regulation of cytochrome-c oxidase activity

activation of protein kinase C activity

 
TC0100003877.mm.2 Poglut2 protein O-glucosyltransferase 2 1 -44106545 NM_023645, BC023141 NM_023645, BC023141 23

nucleoplasm

endoplasmic reticulum

endoplasmic reticulum lumen

cytosol

endomembrane system

transferase activity

transferase activity, transferring glycosyl groups

protein O-linked glycosylation via serine

UDP-glucosyltransferase activity

UDP-xylosyltransferase activity

glucosyltransferase activity

 
TC1400000910.mm.2 Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 14 63860311 NM_028228, BC115636 NM_028228, BC115636 17

nuclear chromosome

chromosome, centromeric region

kinetochore

chromosome, telomeric region

nucleic acid binding

nucleus

nucleoplasm

chromosome

nucleolus

mitochondrion

spindle

telomere maintenance via telomerase

mitotic metaphase plate congression

telomerase inhibitor activity

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of protein ubiquitination

regulation of protein stability

negative regulation of telomere maintenance via telomerase

protein-containing complex binding

negative regulation of telomerase activity

telomerase RNA binding

protein localization to chromosome, telomeric region

protein localization to nucleolus

positive regulation of telomeric DNA binding

positive regulation of protein localization to nucleolus

 
TC1300000173.mm.2 H2ac13 H2A clustered histone 13 13 21716411 NM_178182, BC099406 NM_178182, BC099406 16

DNA binding

nucleus

chromatin silencing

negative regulation of cell population proliferation

05322

TC1500001973.mm.2 Pacsin2 protein kinase C and casein kinase substrate in neurons 2 15 -83375606, -83375606, -83375606 NM_001159509, NM_001159510, NM_011862, BC023502 NM_001159509, NM_001159510, NM_011862, BC023502 NM_001159509, NM_001159510, NM_011862, BC023502 NM_001159509, NM_001159510, NM_011862, BC023502 42

protein binding

phospholipid binding

cytoplasm

cytoplasm

endosome

cytosol

cytosol

cytoskeleton

plasma membrane

plasma membrane

caveola

caveola

cell-cell junction

endocytosis

cytoskeleton organization

signal transduction

cytoskeletal protein binding

lipid binding

membrane

nuclear speck

extrinsic component of membrane

actin cytoskeleton organization

regulation of endocytosis

cytoplasmic vesicle

protein localization to endosome

identical protein binding

cell projection

intracellular membrane-bounded organelle

negative regulation of endocytosis

cell projection morphogenesis

modulation of chemical synaptic transmission

modulation of chemical synaptic transmission

recycling endosome membrane

phosphatidic acid binding

caveola assembly

caveolin-mediated endocytosis

plasma membrane tubulation

plasma membrane tubulation

plasma membrane tubulation

glutamatergic synapse

glutamatergic synapse

 
TC1100003817.mm.2 Dusp3 dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) 11 -101971143 NM_028207, BC016269 NM_028207, BC016269 39

inactivation of MAPK activity

in utero embryonic development

immunological synapse

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleoplasm

cytosol

cytosol

protein dephosphorylation

cytoskeletal protein binding

protein tyrosine/serine/threonine phosphatase activity

protein tyrosine/serine/threonine phosphatase activity

dephosphorylation

hydrolase activity

phosphatase activity

protein kinase binding

negative regulation of cell migration

receptor tyrosine kinase binding

MAP kinase phosphatase activity

MAP kinase phosphatase activity

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of MAPK cascade

positive regulation of mitotic cell cycle

positive regulation of mitotic cell cycle

negative regulation of JNK cascade

negative regulation of JNK cascade

negative regulation of T cell receptor signaling pathway

negative regulation of T cell receptor signaling pathway

negative regulation of T cell activation

negative regulation of T cell activation

negative regulation of chemotaxis

regulation of focal adhesion assembly

regulation of focal adhesion assembly

negative regulation of ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

cellular response to epidermal growth factor stimulus

cellular response to epidermal growth factor stimulus

positive regulation of focal adhesion disassembly

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

protein tyrosine kinase binding

04010

TC0800001258.mm.2 Utp4 UTP4 small subunit processome component 8 106893639 NM_011574, BC027399, BC068113 NM_011574, BC027399, BC068113 NM_011574, BC027399, BC068113 28

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

fibrillar center

nucleus

chromosome

nucleolus

regulation of transcription, DNA-templated

rRNA processing

maturation of SSU-rRNA

90S preribosome

small-subunit processome

t-UTP complex

t-UTP complex

ribosome biogenesis

03008

TC0700002950.mm.2 Cd33 CD33 antigen 7 -43527455 NM_001111058, NM_021293, BC132379, CD33 NM_001111058, NM_021293, BC132379, CD33 NM_001111058, NM_021293, BC132379, CD33 NM_001111058, NM_021293, BC132379, CD33 24

plasma membrane

cell adhesion

external side of plasma membrane

membrane

integral component of membrane

carbohydrate binding

sialic acid binding

04640

TC0200005349.mm.2         NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

molecular_function

cellular_component

nucleus

regulation of transcription by RNA polymerase II

biological_process

 
TC1100003221.mm.2 Rpa1 replication protein A1 11 -75300258 NM_001164223, NM_026653, BC019119 NM_001164223, NM_026653, BC019119 NM_001164223, NM_026653, BC019119 73

telomere maintenance

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

condensed chromosome

condensed nuclear chromosome

lateral element

male germ cell nucleus

in utero embryonic development

nucleic acid binding

DNA binding

chromatin binding

damaged DNA binding

damaged DNA binding

single-stranded DNA binding

nucleus

nucleus

nucleoplasm

nucleoplasm

DNA replication factor A complex

DNA replication factor A complex

DNA replication

DNA unwinding involved in DNA replication

DNA repair

base-excision repair

nucleotide-excision repair

nucleotide-excision repair

mismatch repair

DNA recombination

cellular response to DNA damage stimulus

telomere maintenance via telomerase

positive regulation of cell population proliferation

PML body

hemopoiesis

protein localization to chromosome

single-stranded telomeric DNA binding

metal ion binding

homeostasis of number of cells within a tissue

chromosome organization

meiotic cell cycle

meiotic cell cycle

site of DNA damage

G-rich strand telomeric DNA binding

03030

03420

03430

03440

TC0200003267.mm.2 Dolk dolichol kinase 2 -30284228 NM_177648, BC026973 NM_177648, BC026973 16

dolichol kinase activity

dolichol kinase activity

endoplasmic reticulum

membrane

integral component of membrane

kinase activity

phosphorylation

transferase activity

integral component of endoplasmic reticulum membrane

integral component of endoplasmic reticulum membrane

dolichyl monophosphate biosynthetic process

dolichyl monophosphate biosynthetic process

00510

01100

TC0100001844.mm.2 Pacc1 proton activated chloride channel 1 1 191325901 NM_025864, BC027151 NM_025864, BC027151 15

chloride channel activity

plasma membrane

integral component of plasma membrane

ion transport

chloride transport

chloride transport

membrane

integral component of membrane

chloride channel complex

pH-gated chloride channel activity

pH-gated chloride channel activity

 
TC1100001741.mm.2 Mettl2 methyltransferase like 2 11 105126424 NM_172567, BC089591 NM_172567, BC089591 23

cellular_component

tRNA processing

methyltransferase activity

transferase activity

tRNA methylation

tRNA methylation

methylation

tRNA (cytosine-3-)-methyltransferase activity

tRNA (cytosine-3-)-methyltransferase activity

tRNA (cytosine-3-)-methyltransferase activity

00340

00350

TC0600001443.mm.2 Lpar5 lysophosphatidic acid receptor 5 6 125067919, 125071334 NM_001163268, NM_001163269, BC116702, BC117528 NM_001163268, NM_001163269, BC116702, BC117528 NM_001163268, NM_001163269, BC116702, BC117528 NM_001163268, NM_001163269, BC116702, BC117528 39

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

integral component of membrane

positive regulation of CREB transcription factor activity

positive regulation of CREB transcription factor activity

behavioral response to pain

behavioral response to pain

 
TC0500000494.mm.2 Ncapg non-SMC condensin I complex, subunit G 5 45669924 NM_019438, BC137834, BC144960 NM_019438, BC137834, BC144960 NM_019438, BC137834, BC144960 26

condensed chromosome, centromeric region

condensed chromosome

condensed chromosome

condensin complex

condensin complex

condensin complex

molecular_function

cytoplasm

cytoplasm

mitotic chromosome condensation

mitotic chromosome condensation

 
TC0700000421.mm.2 Exosc5 exosome component 5 7 25659152 NM_138586, NR_104358, BC034358 NM_138586, NR_104358, BC034358 NM_138586, NR_104358, BC034358 25

nuclear exosome (RNase complex)

cytoplasmic exosome (RNase complex)

exosome (RNase complex)

molecular_function

RNA binding

nucleoplasm

nucleolus

nucleolus

cytoplasm

rRNA processing

RNA catabolic process

rRNA catabolic process

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

U4 snRNA 3'-end processing

transcriptionally active chromatin

exonucleolytic catabolism of deadenylated mRNA

DNA deamination

defense response to virus

nuclear mRNA surveillance

polyadenylation-dependent snoRNA 3'-end processing

03018

TC1600000480.mm.2 Itgb5 integrin beta 5 16 33829664 NM_001145884, NM_010580, BC046280, BC058246 NM_001145884, NM_010580, BC046280, BC058246 NM_001145884, NM_010580, BC046280, BC058246 NM_001145884, NM_010580, BC046280, BC058246 91

signaling receptor binding

integrin binding

integrin binding

protein binding

plasma membrane

focal adhesion

focal adhesion

cell adhesion

cell-matrix adhesion

cell-matrix adhesion

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin complex

cell surface

cell surface

membrane

integral component of membrane

cell migration

cell leading edge

cell adhesion mediated by integrin

integrin alphav-beta5 complex

integrin alphav-beta5 complex

signaling receptor activity

stress fiber assembly

stress fiber assembly

receptor complex

epithelial cell-cell adhesion

glutamatergic synapse

integral component of synaptic membrane

04145

04510

04512

04810

05410

05412

05414

MG-1-pos-10338463_st                
TC0900001453.mm.2 Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 9 110132023 NM_009211, BC052423 NM_009211, BC052423 101

XY body

DNA binding

chromatin binding

protein binding

intracellular anatomical structure

nucleus

nucleus

nucleoplasm

cytoplasm

DNA packaging

chromatin organization

nucleosome disassembly

chromatin remodeling

nervous system development

insulin receptor signaling pathway

animal organ morphogenesis

SWI/SNF complex

SWI/SNF complex

SWI/SNF complex

SWI/SNF complex

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

histone binding

ATP-dependent chromatin remodeling

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

protein N-terminus binding

SWI/SNF superfamily-type complex

npBAF complex

npBAF complex

nBAF complex

nBAF complex

 
TC0100002894.mm.2 Bcl2 B cell leukemia/lymphoma 2 1 -106538175, -106712164 NM_009741, NM_177410, BC068988, BC095964 NM_009741, NM_177410, BC068988, BC095964 NM_009741, NM_177410, BC068988, BC095964 NM_009741, NM_177410, BC068988, BC095964 742

protein polyubiquitination

cell morphogenesis

response to acid chemical

ossification

ovarian follicle development

metanephros development

ureteric bud development

branching involved in ureteric bud morphogenesis

branching involved in ureteric bud morphogenesis

behavioral fear response

leukocyte homeostasis

B cell homeostasis

kidney development

kidney development

release of cytochrome c from mitochondria

regulation of cell-matrix adhesion

protease binding

lymphocyte homeostasis

lymphocyte homeostasis

lymphoid progenitor cell differentiation

B cell lineage commitment

T cell lineage commitment

immune system development

response to ischemia

renal system process

protein binding

intracellular anatomical structure

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

cytosol

cytosol

protein dephosphorylation

melanin metabolic process

regulation of nitrogen utilization

cellular calcium ion homeostasis

apoptotic process

apoptotic process

cellular response to DNA damage stimulus

response to oxidative stress

actin filament organization

axonogenesis

cell aging

transcription factor binding

cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

male gonad development

extrinsic apoptotic signaling pathway via death domain receptors

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic mitochondrial changes

response to toxic substance

response to toxic substance

post-embryonic development

post-embryonic development

animal organ morphogenesis

response to iron ion

response to UV-B

response to gamma radiation

regulation of gene expression

regulation of autophagy

negative regulation of autophagy

negative regulation of calcium ion transport into cytosol

regulation of glycoprotein biosynthetic process

negative regulation of cardiac muscle cell apoptotic process

mesenchymal cell development

positive regulation of neuron maturation

positive regulation of smooth muscle cell migration

channel activity

membrane

membrane

integral component of membrane

channel inhibitor activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

protein phosphatase binding

cochlear nucleus development

gland morphogenesis

regulation of transmembrane transporter activity

mitochondrial crista

hemopoiesis

B cell differentiation

T cell differentiation

T cell differentiation

negative regulation of ossification

positive regulation of cell growth

negative regulation of cell growth

melanocyte differentiation

melanocyte differentiation

negative regulation of cell migration

positive regulation of B cell proliferation

hair follicle morphogenesis

axon regeneration

ubiquitin protein ligase binding

regulation of protein stability

nuclear membrane

nuclear membrane

mitochondrial membrane

endoplasmic reticulum calcium ion homeostasis

glomerulus development

negative regulation of cellular pH reduction

regulation of protein localization

protein-containing complex

negative regulation of myeloid cell apoptotic process

T cell differentiation in thymus

positive regulation of peptidyl-serine phosphorylation

negative regulation of osteoblast proliferation

response to cytokine

response to cytokine

response to nicotine

organ growth

regulation of growth

positive regulation of multicellular organism growth

B cell proliferation

cellular response to glucose starvation

response to drug

response to drug

response to hydrogen peroxide

identical protein binding

protein homodimerization activity

regulation of apoptotic process

T cell homeostasis

T cell homeostasis

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

regulation of programmed cell death

positive regulation of catalytic activity

myelin sheath

CD8-positive, alpha-beta T cell lineage commitment

pigmentation

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

ear development

ear development

protein-containing complex binding

regulation of viral genome replication

response to ethanol

positive regulation of melanocyte differentiation

negative regulation of mitotic cell cycle

negative regulation of retinal cell programmed cell death

regulation of mitochondrial membrane permeability

pore complex

protein heterodimerization activity

protein heterodimerization activity

focal adhesion assembly

developmental pigmentation

developmental pigmentation

regulation of developmental pigmentation

positive regulation of developmental pigmentation

positive regulation of developmental pigmentation

perinuclear region of cytoplasm

spleen development

spleen development

thymus development

thymus development

response to steroid hormone

digestive tract morphogenesis

developmental growth

oocyte development

positive regulation of skeletal muscle fiber development

pigment granule organization

homeostasis of number of cells within a tissue

regulation of catalytic activity

B cell receptor signaling pathway

response to glucocorticoid

response to glucocorticoid

BH domain binding

neuron apoptotic process

neuron apoptotic process

BH3 domain binding

defense response to virus

protein phosphatase 2A binding

regulation of cell cycle

regulation of mitochondrial membrane potential

regulation of calcium ion transport

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

repressing transcription factor binding

cellular response to organic substance

cellular response to hypoxia

reactive oxygen species metabolic process

extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway in absence of ligand

cell-cell adhesion

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of reactive oxygen species metabolic process

negative regulation of anoikis

negative regulation of apoptotic signaling pathway

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway

04141

04210

04510

04722

05014

05145

05200

05210

05215

05222

TC1000003119.mm.2 Lrp1 low density lipoprotein receptor-related protein 1 10 -127538157 NM_008512 324

protease binding

astrocyte activation involved in immune response

cardiac septum development

calcium ion binding

protein binding

nucleus

cytoplasm

endosome

early endosome

Golgi apparatus

cytoskeleton

plasma membrane

integral component of plasma membrane

clathrin-coated pit

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

phagocytosis

lysosomal transport

positive regulation of cytosolic calcium ion concentration

protein kinase C-activating G protein-coupled receptor signaling pathway

multicellular organism development

cholesterol metabolic process

cell population proliferation

external side of plasma membrane

negative regulation of cell-substrate adhesion

positive regulation of cholesterol efflux

positive regulation of cell death

positive regulation of neuron projection development

negative regulation of neuron projection development

negative regulation of smooth muscle cell migration

coreceptor activity

membrane

integral component of membrane

basolateral plasma membrane

alpha-2 macroglobulin receptor activity

cell junction

clathrin-coated vesicle

negative regulation of Wnt signaling pathway

dendrite

clathrin heavy chain binding

positive regulation of protein binding

positive regulation of lipid transport

regulation of cholesterol transport

regulation of phospholipase A2 activity

insulin-responsive compartment

regulation of actin cytoskeleton organization

apolipoprotein binding

positive regulation of insulin secretion involved in cellular response to glucose stimulus

aorta morphogenesis

cargo receptor activity

cargo receptor activity

neuronal cell body

negative regulation of apoptotic process

receptor complex

apoptotic cell clearance

negative regulation of neuron apoptotic process

cellular lipid catabolic process

axonal growth cone

protein-containing complex binding

apical part of cell

synapse

positive regulation of axon extension

positive regulation of endocytosis

metal ion binding

perinuclear region of cytoplasm

positive regulation of axon extension involved in regeneration

positive regulation of collateral sprouting of injured axon

positive regulation of phagocytosis

positive regulation of protein transport

negative regulation of cytosolic calcium ion concentration

negative regulation of focal adhesion assembly

negative regulation of cell death

coronary vasculature development

chemoattraction of axon

positive regulation of ERK1 and ERK2 cascade

amyloid-beta clearance

amyloid-beta clearance by transcytosis

amyloid-beta clearance by transcytosis

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

transport across blood-brain barrier

positive regulation of Schwann cell migration

positive regulation of amyloid-beta clearance

positive regulation of protein localization to plasma membrane

positive regulation of cholesterol import

positive regulation of transcytosis

cellular response to amyloid-beta

positive regulation of vascular associated smooth muscle cell migration

positive regulation of lysosomal protein catabolic process

positive regulation of chemokine (C-X-C motif) ligand 2 production

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

05010

05144

TC0500001692.mm.2 Eif3b eukaryotic translation initiation factor 3, subunit B 5 140419304 NM_133916, BC023767, BC031704, BC051065 NM_133916, BC023767, BC031704, BC051065 NM_133916, BC023767, BC031704, BC051065 NM_133916, BC023767, BC031704, BC051065 38

nucleic acid binding

RNA binding

translation initiation factor activity

translation initiation factor activity

translation initiation factor activity

protein binding

cytoplasm

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex

translation

translational initiation

translational initiation

translational initiation

regulation of translational initiation

translation initiation factor binding

synapse

synapse

eukaryotic translation initiation factor 3 complex, eIF3m

IRES-dependent viral translational initiation

viral translational termination-reinitiation

03013

TC0100001858.mm.2 Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 1 191821472 NM_010892, BC010302, BC011316, BC057576 NM_010892, BC010302, BC011316, BC057576 NM_010892, BC010302, BC011316, BC057576 NM_010892, BC010302, BC011316, BC057576 48

mitotic sister chromatid segregation

nucleotide binding

chromosome, centromeric region

kinetochore

condensed nuclear chromosome

spindle pole

blastocyst development

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

centrosome

cytoskeleton

microtubule

protein phosphorylation

protein phosphorylation

cell cycle

chromosome segregation

chromosome segregation

chromosome segregation

kinase activity

phosphorylation

transferase activity

protein phosphatase binding

midbody

positive regulation of telomere maintenance via telomerase

protein-containing complex

negative regulation of DNA binding

regulation of mitotic centrosome separation

protein autophosphorylation

metal ion binding

centrosome separation

cell division

meiotic cell cycle

positive regulation of telomerase activity

regulation of attachment of spindle microtubules to kinetochore

mitotic spindle assembly

negative regulation of centriole-centriole cohesion

positive regulation of telomere capping

 
TC1300000259.mm.2 H2bc3 H2B clustered histone 3 13 23746733 NM_175664, BC116853, BC116857 NM_175664, BC116853, BC116857 NM_175664, BC116853, BC116857 18

nucleosome

DNA binding

nucleus

nucleoplasm

nucleoplasm

chromosome

cytosol

nucleosome assembly

protein heterodimerization activity

05322

TC0600001474.mm.2 D6Wsu163e DNA segment, Chr 6, Wayne State University 163, expressed 6 126939965 NM_138594, BC016429 NM_138594, BC016429 17

molecular_function

cytoplasm

cytoplasm

regulation of mast cell degranulation

regulation of mast cell degranulation

 
TC1500002223.mm.2 Lima1 LIM domain and actin binding 1 15 -99778467, -99778467 NM_001113545, NM_023063, BC031490 NM_001113545, NM_023063, BC031490 NM_001113545, NM_023063, BC031490 51

stress fiber

ruffle

actin binding

actin monomer binding

protein binding

cytoplasm

cytosol

cytoskeleton

plasma membrane

plasma membrane

brush border

focal adhesion

lipid metabolic process

steroid metabolic process

cholesterol metabolic process

actin cytoskeleton

actin cytoskeleton

actin cytoskeleton

membrane

cell migration

intestinal cholesterol absorption

negative regulation of actin filament depolymerization

brush border membrane

ruffle organization

ruffle organization

cleavage furrow

cholesterol homeostasis

cell projection

metal ion binding

actin filament binding

actin filament binding

actin filament binding

actin filament bundle assembly

actin filament bundle assembly

 
TC1300000175.mm.2 H2bc14 H2B clustered histone 14 13 21722043 NM_178200, BC139381, BC139382 NM_178200, BC139381, BC139382 NM_178200, BC139381, BC139382 13

nucleosome

DNA binding

nucleus

nucleoplasm

nucleoplasm

chromosome

cytosol

nucleosome assembly

protein heterodimerization activity

05322

TC0400003349.mm.2 Mmachc methylmalonic aciduria cblC type, with homocystinuria 4 -116702433 NM_025962, BC054756 NM_025962, BC054756 21

cytoplasm

cytoplasm

mitochondrion

glutathione metabolic process

cobalamin metabolic process

cobalamin metabolic process

oxidoreductase activity

transferase activity

cobalamin binding

demethylase activity

demethylase activity

cyanocobalamin reductase (cyanide-eliminating) activity

cyanocobalamin reductase (cyanide-eliminating) activity

protein homodimerization activity

glutathione binding

demethylation

FAD binding

FAD binding

04977

TC1700000477.mm.2 Rpl10a ribosomal protein L10A 17 28328564, 28328470 NM_011287, BC006039, BC083346 NM_011287, BC006039, BC083346 NM_011287, BC006039, BC083346 33

maturation of LSU-rRNA

cytoplasmic translation

RNA binding

structural constituent of ribosome

mitochondrion

ribosome

translation

postsynaptic density

large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

polysomal ribosome

synapse

synapse

03010

TC0700004409.mm.2 Oat ornithine aminotransferase 7 -132557474 NM_016978, BC008119 NM_016978, BC008119 49

catalytic activity

ornithine-oxo-acid transaminase activity

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrial matrix

transaminase activity

arginine catabolic process to proline via ornithine

transferase activity

arginine catabolic process to glutamate

pyridoxal phosphate binding

identical protein binding

identical protein binding

00330

01100

TC1300000167.mm.2                
TC0300002334.mm.2 Fdps farnesyl diphosphate synthetase 3 -89093587 NM_001253751, NM_134469, BC048497, BC087886 NM_001253751, NM_134469, BC048497, BC087886 NM_001253751, NM_134469, BC048497, BC087886 NM_001253751, NM_134469, BC048497, BC087886 37

dimethylallyltranstransferase activity

geranyltranstransferase activity

geranyltranstransferase activity

nucleoplasm

cytoplasm

mitochondrion

mitochondrial matrix

peroxisome

cytosol

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

isoprenoid biosynthetic process

sterol biosynthetic process

transferase activity

farnesyl diphosphate biosynthetic process

farnesyl diphosphate biosynthetic process

positive regulation of cholesterol biosynthetic process

metal ion binding

positive regulation of cell growth involved in cardiac muscle cell development

00900

01100

TC1900000170.mm.2 Eef1g eukaryotic translation elongation factor 1 gamma 19 8967040 NM_026007, BC023495, BC083071, BC099413, BC117547, BC118522 NM_026007, BC023495, BC083071, BC099413, BC117547, BC118522 NM_026007, BC023495, BC083071, BC099413, BC117547, BC118522 NM_026007, BC023495, BC083071, BC099413, BC117547, BC118522 NM_026007, BC023495, BC083071, BC099413, BC117547, BC118522 NM_026007, BC023495, BC083071, BC099413, BC117547, BC118522 32

translation elongation factor activity

nucleus

cytoplasm

cytoplasm

endoplasmic reticulum

translation

translational elongation

 
TC0100003649.mm.2 Smyd3 SET and MYND domain containing 3 1 -178951959 NM_027188, BC052431, BC061485 NM_027188, BC052431, BC061485 NM_027188, BC052431, BC061485 29

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II complex binding

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

chromatin organization

nucleosome assembly

negative regulation of protein kinase activity

methyltransferase activity

myotube cell development

transferase activity

histone-lysine N-methyltransferase activity

histone-lysine N-methyltransferase activity

histone-lysine N-methyltransferase activity

methylation

positive regulation of peptidyl-serine phosphorylation

histone lysine methylation

establishment of protein localization

positive regulation of transcription by RNA polymerase II

metal ion binding

cellular response to dexamethasone stimulus

 
TC1600001320.mm.2 Cdc45 cell division cycle 45 16 -18780446 NM_001161623, NM_009862, BC028635 NM_001161623, NM_009862, BC028635 NM_001161623, NM_009862, BC028635 41

double-strand break repair via break-induced replication

chromatin binding

DNA replication origin binding

single-stranded DNA binding

nucleus

nucleoplasm

centrosome

DNA replication

DNA replication initiation

cell cycle

DNA replication preinitiation complex

regulation of chromatin silencing at telomere

ciliary basal body

mitotic DNA replication preinitiation complex assembly

04110

TC0100003612.mm.2 Chml choroideremia-like 1 -175682237 NM_021350, BC118932 NM_021350, BC118932 17

GDP-dissociation inhibitor activity

GTPase activator activity

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

Rab-protein geranylgeranyltransferase complex

Rab-protein geranylgeranyltransferase complex

intracellular protein transport

small GTPase mediated signal transduction

vesicle-mediated transport

protein geranylgeranylation

protein geranylgeranylation

small GTPase binding

 
TC0400002110.mm.2 Noc2l NOC2 like nucleolar associated transcriptional repressor 4 156236014, 156236009 NM_021303, BC020013 NM_021303, BC020013 25

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

p53 binding

negative regulation of B cell apoptotic process

chromatin binding

transcription corepressor activity

transcription corepressor activity

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

nucleolus

nucleolus

cytosol

apoptotic process

Noc1p-Noc2p complex

Noc2p-Noc3p complex

nucleosome binding

nucleosomal histone binding

chromatin assembly

cellular response to UV

negative regulation of histone acetylation

negative regulation of histone acetylation

negative regulation of histone acetylation

ribosomal large subunit biogenesis

histone binding

histone binding

histone binding

repressing transcription factor binding

repressing transcription factor binding

negative regulation of intrinsic apoptotic signaling pathway

 
TC0200001972.mm.2         NM_024193, NR_028528, BC021355 NM_024193, NR_028528, BC021355 NM_024193, NR_028528, BC021355  

fibrillar center

molecular_function

RNA binding

cellular_component

nucleus

sno(s)RNA-containing ribonucleoprotein complex

cytoplasm

biological_process

snoRNA binding

snoRNA binding

box C/D RNP complex

small-subunit processome

ribosome biogenesis

pre-snoRNP complex

histone methyltransferase binding

 
TC0100003027.mm.2 Dars aspartyl-tRNA synthetase 1 -128412117, -128363706 NM_145507, NM_177445, BC008638 NM_145507, NM_177445, BC008638 NM_145507, NM_177445, BC008638 31

nucleotide binding

nucleic acid binding

RNA binding

aminoacyl-tRNA ligase activity

aspartate-tRNA ligase activity

aspartate-tRNA ligase activity

ATP binding

cytoplasm

cytosol

cytosol

translation

tRNA aminoacylation for protein translation

aspartyl-tRNA aminoacylation

aspartyl-tRNA aminoacylation

ligase activity

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

synapse

00970

TC0700004293.mm.2 Coro1a coronin, actin binding protein 1A 7 -126699773, -126699773 NM_009898, BC002136, BC053398 NM_009898, BC002136, BC053398 NM_009898, BC002136, BC053398 88

immunological synapse

immunological synapse

phagolysosome assembly

phagocytic cup

actin binding

actin monomer binding

protein binding

cytoplasm

early endosome

cytoskeleton

actin filament

plasma membrane

plasma membrane

cell-cell junction

calcium ion transport

phagocytosis

actin filament organization

actin filament organization

protein C-terminus binding

regulation of actin polymerization or depolymerization

cytoskeletal protein binding

regulation of cell shape

actin cytoskeleton

membrane

cell migration

cell migration

lamellipodium

actin cytoskeleton organization

positive regulation of cell migration

axon

leukocyte chemotaxis

regulation of actin filament polymerization

cortical actin cytoskeleton

cell leading edge

negative regulation of vesicle fusion

cytoplasmic vesicle

cell-substrate adhesion

myosin heavy chain binding

stereocilium tip

uropod organization

regulation of actin cytoskeleton organization

protein-containing complex

response to cytokine

nerve growth factor signaling pathway

positive regulation of T cell proliferation

identical protein binding

protein homodimerization activity

T cell homeostasis

natural killer cell degranulation

negative regulation of neuron apoptotic process

phosphatidylinositol 3-kinase binding

synapse

phagocytic vesicle

homeostasis of number of cells within a tissue

positive regulation of T cell activation

positive chemotaxis

actin filament binding

actin filament binding

actin filament binding

negative regulation of actin nucleation

regulation of release of sequestered calcium ion into cytosol

early endosome to recycling endosome transport

cellular response to interleukin-4

glutamatergic synapse

04145

TC0900001005.mm.2 Fam214a family with sequence similarity 214, member A 9 74952879, 74976110, 74953052 NM_001113283, NM_153584, BC031353 NM_001113283, NM_153584, BC031353 NM_001113283, NM_153584, BC031353 15

molecular_function

cellular_component

biological_process

 
TC0100002739.mm.2 Ncl nucleolin 1 -86344718 NM_010880, BC005460 NM_010880, BC005460 127

angiogenesis

fibrillar center

dense fibrillar component

nucleic acid binding

DNA binding

single-stranded DNA binding

RNA binding

RNA binding

signaling receptor binding

calcium ion binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

spliceosomal complex

chromosome

nucleolus

nucleolus

cytoplasm

cell cortex

endocytosis

protein C-terminus binding

cell surface

negative regulation of translation

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

selenocysteine insertion sequence binding

cytoplasmic ribonucleoprotein granule

rRNA primary transcript binding

telomeric DNA binding

histone binding

identical protein binding

negative regulation of apoptotic process

laminin binding

sequence-specific DNA binding

DNA topoisomerase binding

positive regulation of transcription by RNA polymerase II

positive regulation of mRNA splicing, via spliceosome

mRNA 5'-UTR binding

cellular response to lipopolysaccharide

cellular response to epidermal growth factor stimulus

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

ErbB-4 class receptor binding

cellular response to leukemia inhibitory factor

ribonucleoprotein complex

regulation of rRNA processing

 
TC1600000788.mm.2 Pros1 protein S (alpha) 16 62854306 NM_011173, BC128316 NM_011173, BC128316 48

calcium ion binding

extracellular region

extracellular space

extracellular space

extracellular space

blood coagulation

hemostasis

negative regulation of blood coagulation

protein-containing complex

fibrinolysis

protein-containing complex binding

positive regulation of phagocytosis

negative regulation of coagulation

04610

TC1300000192.mm.2 H2bc11 H2B clustered histone 11 13 22043197 NM_178198 5

nucleus

nucleoplasm

cytosol

05322

TC0700002828.mm.2 Gpi1 glucose-6-phosphate isomerase 1 7 -34201326 NM_008155, BC086640, BC088995, BC157972, BC172124 NM_008155, BC086640, BC088995, BC157972, BC172124 NM_008155, BC086640, BC088995, BC157972, BC172124 NM_008155, BC086640, BC088995, BC157972, BC172124 NM_008155, BC086640, BC088995, BC157972, BC172124 230

in utero embryonic development

mesoderm formation

positive regulation of immunoglobulin production

glucose-6-phosphate isomerase activity

glucose-6-phosphate isomerase activity

glucose-6-phosphate isomerase activity

glucose-6-phosphate isomerase activity

cytokine activity

protein binding

extracellular region

extracellular space

nucleoplasm

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

carbohydrate metabolic process

gluconeogenesis

glycolytic process

glycolytic process

glycolytic process

growth factor activity

positive regulation of endothelial cell migration

isomerase activity

ubiquitin protein ligase binding

erythrocyte homeostasis

glucose homeostasis

neuron projection

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

myelin sheath

response to morphine

negative regulation of neuron apoptotic process

monosaccharide binding

monosaccharide binding

glucose 6-phosphate metabolic process

glucose 6-phosphate metabolic process

ciliary membrane

glycolytic process through glucose-6-phosphate

canonical glycolysis

00010

00030

00500

00520

01100

TC1300001374.mm.2 Net1 neuroepithelial cell transforming gene 1 13 -3882017, -3882017 NM_001047159, NM_019671, BC004699 NM_001047159, NM_019671, BC004699 NM_001047159, NM_019671, BC004699 33

guanyl-nucleotide exchange factor activity

protein binding

nucleus

cytoplasm

plasma membrane

small GTPase binding

regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

intracellular signal transduction

positive regulation of apoptotic process

positive regulation of GTPase activity

myoblast migration

cellular response to hydrogen peroxide

cellular response to ionizing radiation

positive regulation of substrate adhesion-dependent cell spreading

 
TC1000002488.mm.2 Polr2e polymerase (RNA) II (DNA directed) polypeptide E 10 -80035952 NM_025554, BC026842, BC045521 NM_025554, BC026842, BC045521 NM_025554, BC026842, BC045521 24

DNA binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

nucleoplasm

RNA polymerase II, core complex

RNA polymerase II, core complex

RNA polymerase III complex

RNA polymerase I complex

transcription, DNA-templated

transcription by RNA polymerase II

transcription by RNA polymerase II

00230

00240

01100

03020

05016

TC0800003076.mm.2 Aprt adenine phosphoribosyl transferase 8 -122574636 NM_009698, BC005667 NM_009698, BC005667 95

adenine binding

adenine binding

adenine phosphoribosyltransferase activity

adenine phosphoribosyltransferase activity

adenine phosphoribosyltransferase activity

adenine phosphoribosyltransferase activity

nucleoplasm

cytoplasm

cytosol

purine ribonucleoside salvage

purine ribonucleoside salvage

adenine salvage

adenine salvage

lactation

grooming behavior

nucleoside metabolic process

AMP binding

AMP binding

transferase activity

transferase activity, transferring glycosyl groups

AMP salvage

adenine metabolic process

adenine metabolic process

adenine metabolic process

00230

01100

TC0300001255.mm.2 Sec24d Sec24 related gene family, member D (S. cerevisiae) 3 123267495 NM_027135, BC049257, BC067020 NM_027135, BC049257, BC067020 NM_027135, BC049257, BC067020 23

SNARE binding

SNARE binding

in utero embryonic development

endoplasmic reticulum to Golgi vesicle-mediated transport

zinc ion binding

zinc ion binding

COPII vesicle coat

COPII vesicle coat

intracellular membrane-bounded organelle

endoplasmic reticulum exit site

COPII-coated vesicle cargo loading

COPII-coated vesicle cargo loading

04141

TC0700000870.mm.2 Nomo1 nodal modulator 1 7 46033695 NM_153057, BC033923, BC072630 NM_153057, BC033923, BC072630 NM_153057, BC033923, BC072630 28

molecular_function

endoplasmic reticulum membrane

endoplasmic reticulum membrane

biological_process

membrane

integral component of membrane

carbohydrate binding

protein-containing complex

 
MG-1-pos-10340458_st                
TC0800002523.mm.2 Abce1 ATP-binding cassette, sub-family E (OABP), member 1 8 -79683441 NM_015751, BC005422 NM_015751, BC005422 31

ribosomal subunit export from nucleus

nucleotide binding

iron ion binding

ATP binding

cytoplasm

mitochondrion

cytosol

eukaryotic translation initiation factor 3 complex

translational initiation

translational termination

ATPase activity

ribosomal small subunit binding

endoribonuclease inhibitor activity

negative regulation of endoribonuclease activity

 
TC0300002203.mm.2 Tmem144 transmembrane protein 144 3 -79812563, -79812563, -79812563, -79812563 NM_027495, BC018493 NM_027495, BC018493 11

molecular_function

cellular_component

biological_process

carbohydrate transmembrane transporter activity

membrane

integral component of membrane

carbohydrate transmembrane transport

 
TC0400002010.mm.2 Nol9 nucleolar protein 9 4 152039320, 152039320, 152039337 NM_001159599, NM_028727, BC125432, BC132099 NM_001159599, NM_028727, BC125432, BC132099 NM_001159599, NM_028727, BC125432, BC132099 NM_001159599, NM_028727, BC125432, BC132099 19

nucleotide binding

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA

RNA binding

ATP binding

nucleus

nucleolus

rRNA processing

RNA processing

kinase activity

transferase activity

intermediate filament cytoskeleton

polynucleotide 5'-hydroxyl-kinase activity

polynucleotide 5'-hydroxyl-kinase activity

 
TC0600000388.mm.2 Tbxas1 thromboxane A synthase 1, platelet 6 38918985 NM_011539, BC029014 NM_011539, BC029014 29

prostaglandin biosynthetic process

monooxygenase activity

thromboxane-A synthase activity

thromboxane-A synthase activity

thromboxane-A synthase activity

iron ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

icosanoid metabolic process

prostaglandin metabolic process

membrane

integral component of membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

lyase activity

isomerase activity

heme binding

cellular chloride ion homeostasis

positive regulation of vasoconstriction

metal ion binding

hydroperoxy icosatetraenoate dehydratase activity

00590

01100

TC0400002460.mm.2 Ubap2 ubiquitin-associated protein 2 4 -41194314 NM_026872, BC007179 NM_026872, BC007179 25

nucleus

cytoplasm

 
TC1300001751.mm.2 Gmds GDP-mannose 4, 6-dehydratase 13 -31819585 NM_146041, BC031788, BC093502 NM_146041, BC031788, BC093502 NM_146041, BC031788, BC093502 21

cytoplasm

GDP-mannose 4,6-dehydratase activity

lyase activity

GDP-mannose metabolic process

'de novo' GDP-L-fucose biosynthetic process

00051

00520

01100

TC1100001634.mm.2 Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 11 101010397, 101009440, 101009440, 101009440 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 NM_001243049, NM_001243050, NM_001243051, NM_016920, BC066839, BC071182 48

vacuolar proton-transporting V-type ATPase, V0 domain

protein binding

cytoplasm

Golgi apparatus

cytosol

plasma membrane

plasma membrane

ion transport

vacuolar acidification

synaptic vesicle

proton transmembrane transporter activity

membrane

integral component of membrane

regulation of macroautophagy

vacuolar proton-transporting V-type ATPase complex

nuclear speck

integral component of synaptic vesicle membrane

cytoplasmic vesicle

proton-transporting V-type ATPase, V0 domain

intracellular organelle

intracellular membrane-bounded organelle

proton-transporting ATPase activity, rotational mechanism

perinuclear region of cytoplasm

ATPase binding

ATPase binding

toxin transport

proton transmembrane transport

00190

01100

04142

04145

04966

05323

TC0200001843.mm.2 Sord sorbitol dehydrogenase 2 122234838 NM_146126, BC024124, BC030875, BC092291 NM_146126, BC024124, BC030875, BC092291 NM_146126, BC024124, BC030875, BC092291 NM_146126, BC024124, BC030875, BC092291 41

L-iditol 2-dehydrogenase activity

L-iditol 2-dehydrogenase activity

L-iditol 2-dehydrogenase activity

mitochondrion

cilium

sorbitol metabolic process

sorbitol catabolic process

sorbitol catabolic process

zinc ion binding

response to hormone

membrane

oxidoreductase activity

flagellated sperm motility

motile cilium

identical protein binding

cell projection

fructose biosynthetic process

D-xylulose reductase activity

response to cadmium ion

response to copper ion

metal ion binding

L-xylitol catabolic process

L-xylitol metabolic process

NAD binding

extracellular exosome

00051

01100

TC0900000504.mm.2 Dpagt1 dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 9 44326814 NM_007875, BC003943, BC010474 NM_007875, BC003943, BC010474 NM_007875, BC003943, BC010474 29

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity

UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity

UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity

UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

UDP-N-acetylglucosamine metabolic process

protein N-linked glycosylation

dolichol-linked oligosaccharide biosynthetic process

dolichol-linked oligosaccharide biosynthetic process

dolichyl diphosphate biosynthetic process

phospho-N-acetylmuramoyl-pentapeptide-transferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

dolichol metabolic process

intracellular membrane-bounded organelle

metal ion binding

00510

01100

TC1900000664.mm.2 Sfxn3 sideroflexin 3 19 45047575 NM_001178012, NM_001178013, NM_053197, BC012208 NM_001178012, NM_001178013, NM_053197, BC012208 NM_001178012, NM_001178013, NM_053197, BC012208 NM_001178012, NM_001178013, NM_053197, BC012208 34

mitochondrion

mitochondrion

mitochondrion

one-carbon metabolic process

ion transport

amino acid transport

ion transmembrane transporter activity

membrane

integral component of membrane

transmembrane transporter activity

serine transmembrane transporter activity

serine transmembrane transporter activity

integral component of mitochondrial inner membrane

mitochondrial membrane

transmembrane transport

serine import into mitochondrion

serine import into mitochondrion

mitochondrial transmembrane transport

mitochondrial transmembrane transport

 
TC1200001598.mm.2 Dus4l dihydrouridine synthase 4-like (S. cerevisiae) 12 -31640054 NM_028002, BC109351 NM_028002, BC109351 15

catalytic activity

tRNA processing

oxidoreductase activity

tRNA dihydrouridine synthase activity

flavin adenine dinucleotide binding

 
TC1500001155.mm.2 Ptger4 prostaglandin E receptor 4 (subtype EP4) 15 -5233398 NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 NM_001136079, NM_008965, BC009023, BC011193 209

negative regulation of cytokine production

positive regulation of cytokine production

positive regulation of protein phosphorylation

negative regulation of peptide secretion

G protein-coupled receptor activity

prostaglandin receptor activity

prostaglandin E receptor activity

prostaglandin E receptor activity

prostaglandin E receptor activity

plasma membrane

plasma membrane

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

JNK cascade

positive regulation of cell population proliferation

positive regulation of gene expression

negative regulation of hydrogen peroxide metabolic process

regulation of circadian sleep/wake cycle, wakefulness

positive regulation of smooth muscle cell migration

membrane

integral component of membrane

regulation of ossification

nuclear membrane

response to lipopolysaccharide

negative regulation of interleukin-1 alpha production

negative regulation of tumor necrosis factor production

positive regulation of interleukin-10 production

positive regulation of interleukin-8 production

negative regulation of integrin activation

positive regulation of urine volume

positive regulation of renal sodium excretion

T-helper cell differentiation

negative regulation of circadian sleep/wake cycle, REM sleep

chemokinesis

positive regulation of tyrosine phosphorylation of STAT protein

neuronal cell body

positive regulation of cAMP-mediated signaling

neuron projection terminus

positive regulation of osteoblast differentiation

positive regulation of ossification

positive regulation of bone resorption

positive regulation of cell adhesion

positive regulation of circadian sleep/wake cycle, non-REM sleep

positive regulation of protein secretion

negative regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of inflammatory response

positive regulation of inflammatory response

regulation of stress fiber assembly

negative regulation of nitric-oxide synthase biosynthetic process

bone development

positive regulation of mucus secretion

ERK1 and ERK2 cascade

cellular response to mechanical stimulus

cellular response to prostaglandin E stimulus

positive regulation of wound healing

ductus arteriosus closure

positive regulation of hyaluronan biosynthetic process

negative regulation of ductus arteriosus closure

negative regulation of small intestine smooth muscle contraction

positive regulation of calcitonin secretion

positive regulation of chemokinesis

positive regulation of substance P secretion

positive regulation of matrix metallopeptidase secretion

negative regulation of endothelin production

positive regulation of substance P secretion, neurotransmission

positive regulation of ovarian follicle development

positive regulation of antral ovarian follicle growth

positive regulation of neutrophil extravasation

negative regulation of eosinophil extravasation

04080

TC1300002036.mm.2 Nop16 NOP16 nucleolar protein 13 -54584190 NM_178605, BC012213 NM_178605, BC012213 21

nucleus

nucleoplasm

nucleolus

nucleolus

ribosomal large subunit biogenesis

intracellular membrane-bounded organelle

 
TC1700000657.mm.2 Lsm2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated 17 34982129, 34981853, 34982129, 34981853 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 NM_001110101, NM_001204273, NM_001204274, NM_030597, BC014288, BC049543 32

spliceosomal tri-snRNP complex assembly

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

P-body

RNA binding

protein binding

nucleus

nucleoplasm

spliceosomal complex

U6 snRNP

cytoplasm

mRNA processing

mRNA catabolic process

RNA splicing

protein kinase binding

small GTPase binding

U4/U6 x U5 tri-snRNP complex

U4/U6 x U5 tri-snRNP complex

U2-type precatalytic spliceosome

precatalytic spliceosome

catalytic step 2 spliceosome

catalytic step 2 spliceosome

Lsm2-8 complex

Lsm1-7-Pat1 complex

03018

03040

TC1500000002.mm.2 Selenop selenoprotein P 15 3270766, 3270976, 3270810 NM_001042613, NM_001042614, NM_009155, BC001991 NM_001042613, NM_001042614, NM_009155, BC001991 NM_001042613, NM_001042614, NM_009155, BC001991 NM_001042613, NM_001042614, NM_009155, BC001991 74

selenium compound metabolic process

selenium compound metabolic process

selenium compound metabolic process

protein binding

extracellular region

extracellular region

extracellular space

brain development

locomotory behavior

selenium binding

selenium binding

post-embryonic development

sexual reproduction

regulation of growth

 
TC0800002503.mm.2 Tmem184c transmembrane protein 184C 8 -77595979, -77595977 NM_145599, BC004056 NM_145599, BC004056 16

transporter activity

transport

membrane

integral component of membrane

 
TC0200004725.mm.2 Tasp1 taspase, threonine aspartase 1 2 -139833478, -139976218 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 NM_001159640, NM_001159641, NM_001289611, NM_175225, NR_110350, NR_110351, NR_110352, BC024597 25

threonine-type endopeptidase activity

threonine-type endopeptidase activity

cytoplasm

proteolysis

peptidase activity

hydrolase activity

identical protein binding

positive regulation of transcription, DNA-templated

protein maturation

 
TC1000000752.mm.2 Slc19a1 solute carrier family 19 (folate transporter), member 1 10 77033211, 77032738 NM_001199271, NM_031196, BC015263 NM_001199271, NM_031196, BC015263 NM_001199271, NM_031196, BC015263 60

folic acid binding

folic acid binding

plasma membrane

plasma membrane

integral component of plasma membrane

organic anion transmembrane transporter activity

folic acid transmembrane transporter activity

folic acid transmembrane transporter activity

folate:anion antiporter activity

folate:anion antiporter activity

antiporter activity

methotrexate transmembrane transporter activity

methotrexate transmembrane transporter activity

organic anion transport

folic acid transport

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

apical plasma membrane

brush border membrane

vitamin transport

methotrexate transport

methotrexate transport

transmembrane transport

cyclic-GMP-AMP binding

vitamin transmembrane transporter activity

folate transmembrane transport

folate transmembrane transport

folate transmembrane transport

folate import across plasma membrane

folate import across plasma membrane

04977

TC1100004296.mm.2 Nme1 NME/NM23 nucleoside diphosphate kinase 1 11 -93958924, -93958924 NM_008704, BC005629, NME/NM23 NM_008704, BC005629, NME/NM23 NM_008704, BC005629, NME/NM23 75

nucleotide binding

magnesium ion binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

negative regulation of myeloid leukocyte differentiation

single-stranded DNA binding

deoxyribonuclease activity

nucleoside diphosphate kinase activity

nucleoside diphosphate kinase activity

ATP binding

GTP binding

nucleus

cytoplasm

mitochondrion

mitochondrial outer membrane

centrosome

cytosol

intermediate filament

nucleoside diphosphate phosphorylation

GTP biosynthetic process

UTP biosynthetic process

CTP biosynthetic process

endocytosis

nervous system development

lactation

nucleotide metabolic process

negative regulation of gene expression

positive regulation of neuron projection development

membrane

kinase activity

phosphorylation

transferase activity

intermediate filament binding

enzyme binding

protein kinase binding

cell differentiation

mammary gland development

ruffle membrane

identical protein binding

gamma-tubulin binding

ribosomal small subunit binding

myelin sheath

positive regulation of DNA binding

metal ion binding

perinuclear region of cytoplasm

positive regulation of epithelial cell proliferation

00230

00240

01100

TC0X00001784.mm.2 Pqbp1 polyglutamine binding protein 1 X -7894518, -7894518 NM_001252528, NM_001252529, NM_019478, BC009657, BC051673, BC157976 NM_001252528, NM_001252529, NM_019478, BC009657, BC051673, BC157976 NM_001252528, NM_001252529, NM_019478, BC009657, BC051673, BC157976 NM_001252528, NM_001252529, NM_019478, BC009657, BC051673, BC157976 NM_001252528, NM_001252529, NM_019478, BC009657, BC051673, BC157976 NM_001252528, NM_001252529, NM_019478, BC009657, BC051673, BC157976 33

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

activation of innate immune response

positive regulation of defense response to virus by host

immune system process

double-stranded DNA binding

nucleus

nucleus

cytoplasm

cytoplasm

centrosome

cilium

mRNA processing

protein C-terminus binding

RNA splicing

cytoplasmic stress granule

nuclear body

nuclear speck

nuclear speck

neuron projection development

positive regulation of type I interferon production

stress granule assembly

ribonucleoprotein complex binding

ribonucleoprotein complex binding

regulation of RNA splicing

regulation of RNA splicing

innate immune response

regulation of dendrite morphogenesis

defense response to virus

cellular response to exogenous dsRNA

neuronal ribonucleoprotein granule

ciliary base

positive regulation of non-motile cilium assembly

03040

TC0700002989.mm.2 Fcgrt Fc fragment of IgG receptor and transporter 7 -45092992 NM_010189, BC003786 NM_010189, BC003786 108

extracellular space

endosome

plasma membrane

immune response

external side of plasma membrane

membrane

integral component of membrane

IgG binding

beta-2-microglobulin binding

beta-2-microglobulin binding

 
TC0200000636.mm.2 Gsn gelsolin 2 35256358, 35266743, 35282379 NM_001206367, NM_001206368, NM_001206369, NM_146120, BC023143, BC060377 NM_001206367, NM_001206368, NM_001206369, NM_146120, BC023143, BC060377 NM_001206367, NM_001206368, NM_001206369, NM_146120, BC023143, BC060377 NM_001206367, NM_001206368, NM_001206369, NM_146120, BC023143, BC060377 NM_001206367, NM_001206368, NM_001206369, NM_146120, BC023143, BC060377 NM_001206367, NM_001206368, NM_001206369, NM_146120, BC023143, BC060377 128

ruffle

podosome

actin binding

calcium ion binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

extracellular region

extracellular space

extracellular space

extracellular space

nucleus

cytoplasm

cytoplasm

cytosol

cytoskeleton

plasma membrane

focal adhesion

phagocytosis, engulfment

apoptotic process

central nervous system development

actin polymerization or depolymerization

actin polymerization or depolymerization

positive regulation of gene expression

striated muscle atrophy

actin cytoskeleton

actin cytoskeleton

vesicle-mediated transport

sarcoplasm

lamellipodium

cell projection organization

cell projection assembly

actin cytoskeleton organization

actin filament polymerization

actin filament polymerization

actin filament depolymerization

actin filament depolymerization

regulation of cell adhesion

actin cap

cortical actin cytoskeleton

protein destabilization

protein-containing complex

response to muscle stretch

phosphatidylinositol 3-kinase catalytic subunit binding

phosphatidylinositol 3-kinase catalytic subunit binding

sequestering of actin monomers

myelin sheath

actin nucleation

myosin II binding

phagocytic vesicle

negative regulation of viral entry into host cell

metal ion binding

phosphatidylinositol-mediated signaling

perinuclear region of cytoplasm

actin filament severing

actin filament severing

actin filament severing

actin filament binding

barbed-end actin filament capping

positive regulation of actin nucleation

actin filament capping

actin filament capping

relaxation of cardiac muscle

cilium assembly

cellular response to cadmium ion

cellular response to interferon-gamma

regulation of podosome assembly

cardiac muscle cell contraction

actin filament reorganization

renal protein absorption

hepatocyte apoptotic process

positive regulation of keratinocyte apoptotic process

regulation of establishment of T cell polarity

regulation of plasma membrane raft polarization

regulation of receptor clustering

positive regulation of protein processing in phagocytic vesicle

amyloid fibril formation

positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

04666

04810

MG-1-pos-10339064_st                
TC1800001138.mm.2 Stard4 StAR-related lipid transfer (START) domain containing 4 18 -33199137 NM_133774, BC005642 NM_133774, BC005642 24

cytoplasm

mitochondrion

endoplasmic reticulum

endoplasmic reticulum

cytosol

cytosol

lipid transport

lipid binding

positive regulation of cholesterol esterification

cholesterol transport involved in cholesterol storage

cholesterol transport involved in cholesterol storage

cholesterol binding

cholesterol binding

cholesterol binding

cytoplasmic vesicle

intracellular cholesterol transport

intracellular cholesterol transport

cholesterol esterification

cholesterol import

cholesterol import

positive regulation of bile acid biosynthetic process

cholesterol transfer activity

cholesterol transfer activity

 
TC1000002043.mm.2         NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697 NM_007444, NM_009665, BC011110, BC071220, BC080791, BC092072, BC138696, BC138697  

in utero embryonic development

adenosylmethionine decarboxylase activity

adenosylmethionine decarboxylase activity

adenosylmethionine decarboxylase activity

protein binding

cytosol

cytosol

polyamine biosynthetic process

spermine biosynthetic process

spermine biosynthetic process

spermidine biosynthetic process

spermidine biosynthetic process

lyase activity

carboxy-lyase activity

putrescine binding

putrescine binding

identical protein binding

 
TC1900001510.mm.2 Arhgap19 Rho GTPase activating protein 19 19 -41766587 NM_001163495, NM_027667, BC086680, BC139195 NM_001163495, NM_027667, BC086680, BC139195 NM_001163495, NM_027667, BC086680, BC139195 NM_001163495, NM_027667, BC086680, BC139195 22

GTPase activator activity

cytoplasm

plasma membrane

signal transduction

intracellular membrane-bounded organelle

regulation of small GTPase mediated signal transduction

 
TC1900001691.mm.2 Gpam glycerol-3-phosphate acyltransferase, mitochondrial 19 -55067635, -55067635 NM_008149, BC019201 NM_008149, BC019201 58

regulation of cytokine production

glycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

plasma membrane

glycerol-3-phosphate metabolic process

lipid metabolic process

fatty acid metabolic process

fatty acid metabolic process

acyl-CoA metabolic process

triglyceride metabolic process

glycerophospholipid metabolic process

diacylglycerol biosynthetic process

phosphatidic acid biosynthetic process

phosphatidylglycerol biosynthetic process

O-acyltransferase activity

phospholipid biosynthetic process

response to glucose

positive regulation of triglyceride biosynthetic process

response to activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

triglyceride biosynthetic process

triglyceride biosynthetic process

mitochondrial membrane

mitochondrial membrane

interleukin-2 production

cellular response to insulin stimulus

positive regulation of multicellular organism growth

positive regulation of activated T cell proliferation

cellular lipid metabolic process

defense response to virus

fatty acid homeostasis

phospholipid homeostasis

negative regulation of activation-induced cell death of T cells

00561

00564

01100

TC1400000742.mm.2 Abhd4 abhydrolase domain containing 4 14 54259282, 54254128 NM_001205181, NM_134076, BC017532 NM_001205181, NM_134076, BC017532 NM_001205181, NM_134076, BC017532 26

lysophospholipase activity

lysophospholipase activity

mitochondrion

lipid droplet

lipid metabolic process

phosphatidic acid biosynthetic process

lipid catabolic process

hydrolase activity

lysophosphatidic acid acyltransferase activity

carboxylic ester hydrolase activity

lipid homeostasis

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

 
TC0800000621.mm.2 Hpgd hydroxyprostaglandin dehydrogenase 15 (NAD) 8 56294551 NM_008278, BC021157 NM_008278, BC021157 43

prostaglandin E receptor activity

extracellular space

nucleoplasm

cytoplasm

cytoplasm

cytosol

lipid metabolic process

fatty acid metabolic process

prostaglandin metabolic process

prostaglandin metabolic process

transforming growth factor beta receptor signaling pathway

female pregnancy

female pregnancy

parturition

basolateral plasma membrane

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

identical protein binding

positive regulation of apoptotic process

response to ethanol

negative regulation of cell cycle

NAD binding

NAD+ binding

ductus arteriosus closure

positive regulation of vascular associated smooth muscle cell proliferation

regulation of prostaglandin catabolic process

 
TC1200000132.mm.2 E2f6 E2F transcription factor 6 12 16810964 NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F NM_033270, NR_027677, BC019166, BC037656, BC057929, E2F 48

regulation of transcription involved in G1/S transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleoplasm

DNA replication factor A complex

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cell cycle

protein dimerization activity

MLL1 complex

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

 
TC0700000904.mm.2 Prmt3 protein arginine N-methyltransferase 3 7 49778357 NM_133740, BC050775 NM_133740, BC050775 35

protein binding

cytoplasm

cytosol

protein methylation

methyltransferase activity

protein-arginine N-methyltransferase activity

protein-arginine N-methyltransferase activity

transferase activity

peptidyl-arginine methylation

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

negative regulation of protein ubiquitination

methylation

protein-arginine omega-N asymmetric methyltransferase activity

ribosome binding

metal ion binding

dendritic spine morphogenesis

modified amino acid binding

 
TC0800001906.mm.2         NM_177089, NM_199323, NR_106187, BC153048 NM_177089, NM_199323, NR_106187, BC153048 NM_177089, NM_199323, NR_106187, BC153048 NM_177089, NM_199323, NR_106187, BC153048  

microtubule cytoskeleton organization

microtubule cytoskeleton organization

nucleus

cytoplasm

cytosol

cytoskeleton

cell cycle

mitotic spindle organization

cell population proliferation

cell population proliferation

nuclear receptor binding

protein domain specific binding

cerebral cortex development

cerebral cortex development

neurogenesis

interkinetic nuclear migration

estrogen receptor binding

nuclear receptor coactivator activity

regulation of microtubule-based process

glucocorticoid receptor binding

retinoic acid receptor binding

retinoic acid receptor binding

peroxisome proliferator activated receptor binding

peroxisome proliferator activated receptor binding

retinoid X receptor binding

retinoid X receptor binding

thyroid hormone receptor binding

thyroid hormone receptor binding

cell division

 
TC0200004410.mm.2 Gpr176 G protein-coupled receptor 176 2 -118277097 NM_201367, BC052037 NM_201367, BC052037 18

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

membrane

integral component of membrane

rhythmic process

circadian behavior

 
TC1600000166.mm.2 Rrn3 RRN3 RNA polymerase I transcription factor homolog (yeast) 16 13780698 NM_001039521, BC138774, BC138776 NM_001039521, BC138774, BC138776 NM_001039521, BC138774, BC138776 36

RNA polymerase I core binding

RNA polymerase I core promoter sequence-specific DNA binding

RNA polymerase I general transcription initiation factor activity

in utero embryonic development

nucleus

nucleolus

DNA-templated transcription, initiation

transcription initiation from RNA polymerase I promoter

transcription initiation from RNA polymerase I promoter

nucleolus organization

cytoplasm organization

cell population proliferation

positive regulation of neuron projection development

ribosome biogenesis

positive regulation of transcription, DNA-templated

homeostasis of number of cells

RNA polymerase binding

negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

regulation of DNA-templated transcription, initiation

 
TC0X00003021.mm.2 Tceal8 transcription elongation factor A (SII)-like 8 X -136168983 NM_001168578, NM_025703, BC027269 NM_001168578, NM_025703, BC027269 NM_001168578, NM_025703, BC027269 18

nucleus

WW domain binding

 
TC1900000099.mm.2 Cdca5 cell division cycle associated 5 19 6085096 NM_026410, BC052904 NM_026410, BC052904 34

mitotic cell cycle

mitotic cell cycle

chromatin

protein binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

double-strand break repair

double-strand break repair

cell cycle

mitotic sister chromatid cohesion

mitotic sister chromatid cohesion

mitotic sister chromatid cohesion

mitotic chromosome condensation

mitotic metaphase plate congression

mitotic metaphase plate congression

positive regulation of exit from mitosis

positive regulation of exit from mitosis

protein-containing complex binding

cell division

regulation of cohesin loading

regulation of cohesin loading

 
TC0200003109.mm.2 Hnmt histamine N-methyltransferase 2 -24002912 NM_080462, BC033928 NM_080462, BC033928 21

regulation of neurotransmitter levels

histamine metabolic process

histamine catabolic process

nucleoplasm

cytoplasm

centrosome

cytosol

methyltransferase activity

N-methyltransferase activity

transferase activity

methylation

neuron projection

histamine N-methyltransferase activity

00340

TC0100003610.mm.2 Fh1 fumarate hydratase 1 1 -175601377 NM_010209, BC006048 NM_010209, BC006048 55

urea cycle

negative regulation of histone H3-K36 methylation

regulation of arginine metabolic process

catalytic activity

fumarate hydratase activity

fumarate hydratase activity

fumarate hydratase activity

nucleus

chromosome

cytoplasm

mitochondrion

mitochondrion

mitochondrion

cytosol

tricarboxylic acid cycle

tricarboxylic acid cycle

fumarate metabolic process

fumarate metabolic process

fumarate metabolic process

malate metabolic process

malate metabolic process

DNA repair

cellular response to DNA damage stimulus

lyase activity

site of double-strand break

histone binding

tricarboxylic acid cycle enzyme complex

homeostasis of number of cells within a tissue

positive regulation of cold-induced thermogenesis

positive regulation of double-strand break repair via nonhomologous end joining

00020

01100

05200

05211

TC0900000254.mm.2 Thyn1 thymocyte nuclear protein 1 9 26999676 NM_144543, BC016594 NM_144543, BC016594 22

molecular_function

nucleus

nucleus

biological_process

 
TC0700000647.mm.2 Pepd peptidase D 7 34912406 NM_008820, BC086644, BC131945, BC131973 NM_008820, BC086644, BC131945, BC131973 NM_008820, BC086644, BC131945, BC131973 NM_008820, BC086644, BC131945, BC131973 40

aminopeptidase activity

peptidase activity

peptidase activity

metallopeptidase activity

hydrolase activity

dipeptidase activity

manganese ion binding

collagen catabolic process

metal ion binding

proline dipeptidase activity

 
TC1400002641.mm.2 Ednrb endothelin receptor type B 14 -103814614, -103814614 NM_001136061, NM_001276296, NM_007904, BC026553 NM_001136061, NM_001276296, NM_007904, BC026553 NM_001136061, NM_001276296, NM_007904, BC026553 NM_001136061, NM_001276296, NM_007904, BC026553 243

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

neural crest cell migration

positive regulation of protein phosphorylation

G protein-coupled receptor activity

endothelin receptor activity

endothelin receptor activity

endothelin receptor activity

protein binding

plasma membrane

regulation of pH

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

peripheral nervous system development

posterior midgut development

regulation of blood pressure

regulation of blood pressure

positive regulation of cell population proliferation

negative regulation of neuron maturation

vein smooth muscle contraction

membrane

integral component of membrane

peptide hormone binding

sensory perception of pain

calcium-mediated signaling

cGMP-mediated signaling

melanocyte differentiation

melanocyte differentiation

melanocyte differentiation

regulation of fever generation

type 1 angiotensin receptor binding

nuclear membrane

negative regulation of cellular protein metabolic process

response to lipopolysaccharide

enteric smooth muscle cell differentiation

positive regulation of urine volume

positive regulation of renal sodium excretion

epithelial fluid transport

vasoconstriction

vasodilation

negative regulation of apoptotic process

pigmentation

pigmentation

membrane raft

developmental pigmentation

macrophage chemotaxis

response to pain

enteric nervous system development

enteric nervous system development

regulation of epithelial cell proliferation

regulation of sensory perception of pain

positive regulation of penile erection

endothelin receptor signaling pathway

response to endothelin

04020

04080

04916

TC0X00002269.mm.2 Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 X -57231484, -57231484 NM_152801, BC156697 NM_152801, BC156697 35

guanyl-nucleotide exchange factor activity

protein binding

cell-cell junction

lamellipodium

lamellipodium assembly

regulation of Rho protein signal transduction

intracellular signal transduction

cell projection

04810

05212

TC0200002474.mm.2 Srsf6 serine and arginine-rich splicing factor 6 2 162931507 NM_026499, BC012039 NM_026499, BC012039 30

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

RNA binding

mRNA binding

protein binding

nucleus

mRNA splice site selection

mRNA splice site selection

mRNA processing

RNA splicing

negative regulation of gene expression

regulation of keratinocyte proliferation

nuclear speck

nuclear speck

pre-mRNA binding

negative regulation of keratinocyte differentiation

negative regulation of mRNA splicing, via spliceosome

positive regulation of epithelial cell proliferation involved in lung morphogenesis

negative regulation of cell death

regulation of wound healing

negative regulation of type B pancreatic cell apoptotic process

03040

TC1300001131.mm.2 Mrps27 mitochondrial ribosomal protein S27 13 99344785 NM_173757, BC049149 NM_173757, BC049149 26

tRNA binding

RNA binding

protein binding

nucleolus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial small ribosomal subunit

ribosome

regulation of translation

cell population proliferation

rRNA binding

positive regulation of mitochondrial translation

mitochondrial ribosome binding

 
TC0500001894.mm.2 Cyp51 cytochrome P450, family 51 5 -4080673 NM_020010, BC031813 NM_020010, BC031813 55

monooxygenase activity

iron ion binding

endoplasmic reticulum

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

sterol 14-demethylase activity

sterol 14-demethylase activity

membrane

integral component of membrane

sterol metabolic process

sterol biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

heme binding

cholesterol biosynthetic process via 24,25-dihydrolanosterol

negative regulation of protein catabolic process

intracellular membrane-bounded organelle

metal ion binding

negative regulation of protein secretion

negative regulation of amyloid-beta clearance

00100

01100

TC0900002115.mm.2 Sc5d sterol-C5-desaturase 9 -42254176 NM_172769, BC024132 NM_172769, BC024132 30

C-5 sterol desaturase activity

C-5 sterol desaturase activity

iron ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

steroid metabolic process

lipid biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

oxidoreductase activity

cholesterol biosynthetic process via lathosterol

cholesterol biosynthetic process via lathosterol

intracellular membrane-bounded organelle

00100

01100

TC1000002443.mm.2 Pwp2 PWP2 periodic tryptophan protein homolog (yeast) 10 -78170909 NM_029546, BC112325, BC128480 NM_029546, BC112325, BC128480 NM_029546, BC112325, BC128480 23

ribosomal small subunit assembly

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nucleus

small-subunit processome

Pwp2p-containing subcomplex of 90S preribosome

03008

TC0600001440.mm.2 Pianp PILR alpha associated neural protein 6 124998609, 124996719, 124998436 NM_001145926, NM_001145927, NM_175696, BC065170 NM_001145926, NM_001145927, NM_175696, BC065170 NM_001145926, NM_001145927, NM_175696, BC065170 NM_001145926, NM_001145927, NM_175696, BC065170 18

molecular_function

biological_process

membrane

integral component of membrane

basolateral plasma membrane

regulation of immune response

 
TC1100001730.mm.2 Itgb3 integrin beta 3 11 104607999 NM_016780, BC125518, BC125520 NM_016780, BC125518, BC125520 NM_016780, BC125518, BC125520 424

positive regulation of endothelial cell proliferation

positive regulation of cell-matrix adhesion

fibronectin binding

fibronectin binding

protease binding

positive regulation of leukocyte migration

protein disulfide isomerase activity

protein kinase C binding

integrin binding

integrin binding

integrin binding

protein binding

nucleus

nucleoplasm

plasma membrane

cell-cell junction

focal adhesion

focal adhesion

focal adhesion

cell-substrate junction assembly

cell adhesion

cell-matrix adhesion

cell-matrix adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

regulation of G protein-coupled receptor signaling pathway

integrin complex

integrin complex

external side of plasma membrane

cell surface

cell surface

cell surface

positive regulation of endothelial cell migration

positive regulation of gene expression

negative regulation of macrophage derived foam cell differentiation

positive regulation of fibroblast migration

positive regulation of fibroblast migration

negative regulation of lipid storage

smooth muscle cell migration

positive regulation of smooth muscle cell migration

membrane

integral component of membrane

apical plasma membrane

apical plasma membrane

cell migration

fibroblast growth factor binding

enzyme binding

enzyme binding

C-X3-C chemokine binding

cell junction

platelet activation

regulation of cell migration

positive regulation of cell migration

lamellipodium membrane

filopodium membrane

microvillus membrane

cell-substrate adhesion

insulin-like growth factor I binding

activation of protein kinase activity

negative regulation of lipid transport

ruffle membrane

regulation of protein localization

regulation of actin cytoskeleton organization

protein-containing complex

cell adhesion mediated by integrin

cell adhesion mediated by integrin

positive regulation of cell adhesion mediated by integrin

positive regulation of osteoblast proliferation

heterotypic cell-cell adhesion

substrate adhesion-dependent cell spreading

integrin alpha9-beta1 complex

integrin alphav-beta3 complex

alphav-beta3 integrin-PKCalpha complex

alphav-beta3 integrin-PKCalpha complex

alphav-beta3 integrin-IGF-1-IGF1R complex

alphav-beta3 integrin-HMGB1 complex

cellular response to platelet-derived growth factor stimulus

apolipoprotein A-I-mediated signaling pathway

neuregulin binding

melanosome

identical protein binding

cell projection

vascular endothelial growth factor receptor 2 binding

receptor complex

apoptotic cell clearance

apoptotic cell clearance

synapse

postsynaptic membrane

positive regulation of osteoclast differentiation

positive regulation of angiogenesis

positive regulation of bone resorption

positive regulation of bone resorption

viral entry into host cell

platelet-derived growth factor receptor signaling pathway

positive regulation of fibroblast proliferation

positive regulation of smooth muscle cell proliferation

cell projection morphogenesis

positive regulation of peptidyl-tyrosine phosphorylation

negative regulation of lipoprotein metabolic process

cell adhesion molecule binding

extracellular matrix binding

negative chemotaxis

regulation of release of sequestered calcium ion into cytosol

regulation of serotonin uptake

negative regulation of cell death

regulation of protein tyrosine kinase activity

fibrinogen binding

fibrinogen binding

positive regulation of ERK1 and ERK2 cascade

platelet aggregation

alpha9-beta1 integrin-ADAM8 complex

positive regulation of glomerular mesangial cell proliferation

glutamatergic synapse

glutamatergic synapse

regulation of postsynaptic neurotransmitter receptor internalization

integral component of synaptic membrane

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway

regulation of extracellular matrix organization

negative regulation of low-density lipoprotein receptor activity

positive regulation of T cell migration

04145

04380

04510

04512

04640

04810

05410

05412

05414

TC0X00002643.mm.2 Eif2s3x eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked X -94188708 NM_012010, BC063755, BC139234, BC139235 NM_012010, BC063755, BC139234, BC139235 NM_012010, BC063755, BC139234, BC139235 NM_012010, BC063755, BC139234, BC139235 29

tRNA binding

nucleotide binding

formation of translation preinitiation complex

translation initiation factor activity

translation initiation factor activity

GTPase activity

GTP binding

cytoplasm

cytosol

eukaryotic translation initiation factor 2 complex

eukaryotic translation initiation factor 2 complex

translation

translational initiation

translation factor activity, RNA binding

hydrolase activity

positive regulation of translational fidelity

03013

TC0500000260.mm.2 Insig1 insulin induced gene 1 5 28071411 NM_153526, BC132167, BC132499 NM_153526, BC132167, BC132499 NM_153526, BC132167, BC132499 37

protein binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

lipid metabolic process

triglyceride metabolic process

cholesterol biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

response to sterol depletion

oxysterol binding

steroid metabolic process

cholesterol metabolic process

lipid binding

negative regulation of steroid biosynthetic process

membrane

integral component of membrane

sterol biosynthetic process

sterol biosynthetic process

cellular response to insulin stimulus

SREBP signaling pathway

SREBP signaling pathway

SREBP-SCAP-Insig complex

SREBP-SCAP-Insig complex

cellular response to sterol

SREBP-SCAP complex retention in endoplasmic reticulum

SREBP-SCAP complex retention in endoplasmic reticulum

inner ear morphogenesis

middle ear morphogenesis

cholesterol homeostasis

negative regulation of fat cell differentiation

negative regulation of fatty acid biosynthetic process

roof of mouth development

cranial suture morphogenesis

negative regulation of protein exit from endoplasmic reticulum

negative regulation of cargo loading into COPII-coated vesicle

 
TC0700003024.mm.2 Grwd1 glutamate-rich WD repeat containing 1 7 -45825225, -45825222 NM_153419, BC028896 NM_153419, BC028896 19

chromatin binding

DNA replication origin binding

nucleus

nucleoplasm

chromosome

nucleolus

cytosol

DNA replication

nucleosome assembly

nucleosome disassembly

protein-containing complex

histone binding

 
TC0700002980.mm.2 Prmt1 protein arginine N-methyltransferase 1 7 -44976754 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 NM_001252476, NM_001252477, NM_019830, NR_045521, BC002249, BC051953, BC062964 104

in utero embryonic development

protein binding

nucleus

nucleus

cytoplasm

cytosol

protein methylation

methyltransferase activity

N-methyltransferase activity

protein methyltransferase activity

protein methyltransferase activity

positive regulation of cell population proliferation

methyl-CpG binding

histone-arginine N-methyltransferase activity

membrane

protein-arginine N-methyltransferase activity

protein-arginine N-methyltransferase activity

[cytochrome c]-arginine N-methyltransferase activity

histone methylation

transferase activity

peptidyl-arginine methylation

enzyme binding

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine

snoRNP binding

neuron projection development

methylation

protein-containing complex

methylosome

protein-arginine omega-N monomethyltransferase activity

protein-arginine omega-N asymmetric methyltransferase activity

protein-arginine omega-N asymmetric methyltransferase activity

peptidyl-arginine omega-N-methylation

histone methyltransferase activity

histone methyltransferase activity

identical protein binding

histone H4-R3 methylation

histone H4-R3 methylation

histone methyltransferase activity (H4-R3 specific)

positive regulation of erythrocyte differentiation

regulation of megakaryocyte differentiation

negative regulation of megakaryocyte differentiation

positive regulation of hemoglobin biosynthetic process

mitogen-activated protein kinase p38 binding

protein homooligomerization

positive regulation of p38MAPK cascade

S-adenosyl-L-methionine binding

 
TC1100004051.mm.2 Cd300lb CD300 molecule like family member B 11 -114922778 NM_199221, CD300, BC160263 NM_199221, CD300, BC160263 NM_199221, CD300, BC160263 21

immune system process

neutrophil mediated immunity

transmembrane signaling receptor activity

protein binding

plasma membrane

membrane

integral component of membrane

positive regulation of mast cell activation

cellular response to lipopolysaccharide

 
TC1200002077.mm.2 Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 12 -84373875, -84373875 NM_001026214, NM_001286049, NM_001286058, NM_007647, BC015247 NM_001026214, NM_001286049, NM_001286058, NM_007647, BC015247 NM_001026214, NM_001286049, NM_001286058, NM_007647, BC015247 NM_001026214, NM_001286049, NM_001286058, NM_007647, BC015247 NM_001026214, NM_001286049, NM_001286058, NM_007647, BC015247 29

guanosine-diphosphatase activity

guanosine-diphosphatase activity

guanosine-diphosphatase activity

extracellular region

endoplasmic reticulum

endoplasmic reticulum lumen

protein N-linked glycosylation

nucleoside diphosphate catabolic process

regulation of phosphatidylinositol 3-kinase signaling

membrane

hydrolase activity

nucleoside-diphosphatase activity

nucleoside-diphosphatase activity

uridine-diphosphatase activity

uridine-diphosphatase activity

uridine-diphosphatase activity

positive regulation of glycolytic process

ATP metabolic process

'de novo' posttranslational protein folding

00230

00240

TC1800000583.mm.2 Slc12a2 solute carrier family 12, member 2 18 57878677 NM_009194 193

transporter activity

protein binding

cytosol

plasma membrane

ion transport

potassium ion transport

sodium ion transport

chloride transport

cellular sodium ion homeostasis

cell volume homeostasis

cell volume homeostasis

hyperosmotic response

gamma-aminobutyric acid signaling pathway

sodium:potassium:chloride symporter activity

sodium:potassium:chloride symporter activity

sodium:potassium:chloride symporter activity

ammonium transmembrane transporter activity

ammonium transmembrane transporter activity

basal plasma membrane

T cell chemotaxis

T cell chemotaxis

potassium ion transmembrane transporter activity

symporter activity

cation:chloride symporter activity

potassium:chloride symporter activity

ammonium transport

ammonium transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

apical plasma membrane

lateral plasma membrane

protein kinase binding

cellular potassium ion homeostasis

transepithelial chloride transport

cellular chloride ion homeostasis

cytoplasmic vesicle membrane

multicellular organism growth

maintenance of blood-brain barrier

sodium ion transmembrane transport

cellular response to potassium ion

cell projection

neuron projection

neuronal cell body

neuronal cell body

cell body

positive regulation of cell volume

metal ion transmembrane transporter activity

detection of mechanical stimulus involved in sensory perception of sound

chaperone binding

Hsp90 protein binding

chloride ion homeostasis

potassium ion homeostasis

sodium ion homeostasis

transmembrane transport

branching involved in mammary gland duct morphogenesis

mammary duct terminal end bud growth

negative regulation of vascular wound healing

transepithelial ammonium transport

cell periphery

cell periphery

inorganic anion import across plasma membrane

inorganic cation import across plasma membrane

sodium ion import across plasma membrane

regulation of spontaneous synaptic transmission

regulation of spontaneous synaptic transmission

regulation of spontaneous synaptic transmission

chloride transmembrane transport

chloride transmembrane transport

positive regulation of aspartate secretion

regulation of matrix metallopeptidase secretion

potassium ion import across plasma membrane

potassium ion import across plasma membrane

cellular response to chemokine

cellular response to chemokine

04970

04972

TC0200001144.mm.2 Gm14461 predicted gene 14461 2 78237546 NM_177843 10    
TC0700004363.mm.2 Rgs10 regulator of G-protein signalling 10 7 -128373624 NM_026418, BC109178 NM_026418, BC109178 37

G-protein alpha-subunit binding

GTPase activator activity

protein binding

nucleus

cytoplasm

cytosol

G protein-coupled acetylcholine receptor signaling pathway

regulation of G protein-coupled receptor signaling pathway

negative regulation of signal transduction

neuronal cell body

dendritic spine

positive regulation of GTPase activity

axon terminus

 
TC1600000763.mm.2 Cpox coproporphyrinogen oxidase 16 58670207 NM_007757, BC017680 NM_007757, BC017680 42

coproporphyrinogen oxidase activity

coproporphyrinogen oxidase activity

coproporphyrinogen oxidase activity

structural constituent of eye lens

P-type sodium:potassium-exchanging ATPase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial intermembrane space

mitochondrial intermembrane space

cytosol

porphyrin-containing compound biosynthetic process

protoporphyrinogen IX biosynthetic process

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme biosynthetic process

potassium ion transport

sodium ion transport

membrane

oxidoreductase activity

identical protein binding

protein homodimerization activity

00860

01100

TC0800003008.mm.2 Gcsh glycine cleavage system protein H (aminomethyl carrier) 8 -116981966 NM_026572, BC014745 NM_026572, BC014745 19

aminomethyltransferase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

glycine cleavage complex

protein lipoylation

protein lipoylation

glycine decarboxylation via glycine cleavage system

glycine decarboxylation via glycine cleavage system

enzyme binding

 
TC0600000839.mm.2 Polr1a polymerase (RNA) I polypeptide A 6 71909052 NM_009088, BC053744 NM_009088, BC053744 28

RNA polymerase I activity

DNA binding

chromatin binding

DNA-directed 5'-3' RNA polymerase activity

DNA-directed 5'-3' RNA polymerase activity

protein binding

nucleus

nucleoplasm

chromosome

RNA polymerase I complex

RNA polymerase I complex

RNA polymerase I complex

transcription, DNA-templated

zinc ion binding

rRNA transcription

transferase activity

nucleotidyltransferase activity

metal ion binding

negative regulation of protein localization to nucleolus

00230

00240

01100

03020

TC0800001106.mm.2 Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 8 94386428 NM_022331, BC013523 NM_022331, BC013523 48

protein binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

cellular calcium ion homeostasis

response to unfolded protein

membrane

integral component of membrane

ubiquitin-dependent ERAD pathway

endoplasmic reticulum unfolded protein response

endoplasmic reticulum unfolded protein response

endoplasmic reticulum unfolded protein response

retrograde protein transport, ER to cytosol

regulation of protein ubiquitination

endoplasmic reticulum calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

response to endoplasmic reticulum stress

response to endoplasmic reticulum stress

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

endoplasmic reticulum quality control compartment

ion channel binding

ion channel binding

protein targeting to ER

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of ER-associated ubiquitin-dependent protein catabolic process

regulation of ER-associated ubiquitin-dependent protein catabolic process

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

Lewy body core

ubiquitin ligase-substrate adaptor activity

negative regulation of intrinsic apoptotic signaling pathway

04141

TC0300000968.mm.2 Prkab2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 3 97658211 NM_182997, BC060228 NM_182997, BC060228 46

AMP-activated protein kinase activity

AMP-activated protein kinase activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cAMP-dependent protein kinase complex

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

signal transduction

apical plasma membrane

enzyme binding

protein kinase binding

protein kinase binding

nucleotide-activated protein kinase complex

nucleotide-activated protein kinase complex

identical protein binding

regulation of catalytic activity

regulation of primary metabolic process

positive regulation of cold-induced thermogenesis

04910

04920

05410

TC0400000507.mm.2 Nans N-acetylneuraminic acid synthase (sialic acid synthase) 4 46489328 NM_053179, BC003307, BC057977 NM_053179, BC003307, BC057977 NM_053179, BC003307, BC057977 19

catalytic activity

cytoplasm

cytosol

carbohydrate biosynthetic process

transferase activity

N-acylneuraminate-9-phosphate synthase activity

N-acylneuraminate-9-phosphate synthase activity

glycosylation

00520

01100

TC0200002729.mm.2         NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480 NM_001099308, NM_001164689, NM_001177480  

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

cellular_component

regulation of transcription by RNA polymerase II

 
TC0300003106.mm.2 Prkacb protein kinase, cAMP dependent, catalytic, beta 3 -146729578, -146729578, -146729578, -146729578 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 NM_001164198, NM_001164199, NM_001164200, NM_011100, BC054533 67

nucleotide binding

magnesium ion binding

magnesium ion binding

neural tube closure

protein kinase activity

protein serine/threonine kinase activity

cAMP-dependent protein kinase activity

cAMP-dependent protein kinase activity

ATP binding

ATP binding

nucleus

nucleus

cytoplasm

centrosome

cytosol

cytosol

plasma membrane

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase complex

protein phosphorylation

protein phosphorylation

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

protein kinase A signaling

membrane

kinase activity

phosphorylation

transferase activity

ubiquitin protein ligase binding

protein kinase A regulatory subunit binding

perinuclear region of cytoplasm

negative regulation of meiotic cell cycle

regulation of protein processing

ciliary base

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

04010

04020

04062

04114

04210

04270

04310

04340

04540

04720

04740

04742

04910

04912

04914

04916

04962

04970

04971

04976

05020

05146

05414

TC0500001517.mm.2 Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 5 129942108 NM_001001327, NM_001286382, NM_027121, BC085133, BC125315, BC138132 NM_001001327, NM_001286382, NM_027121, BC085133, BC125315, BC138132 NM_001001327, NM_001286382, NM_027121, BC085133, BC125315, BC138132 NM_001001327, NM_001286382, NM_027121, BC085133, BC125315, BC138132 NM_001001327, NM_001286382, NM_027121, BC085133, BC125315, BC138132 NM_001001327, NM_001286382, NM_027121, BC085133, BC125315, BC138132 25

endoplasmic reticulum

endoplasmic reticulum membrane

membrane

integral component of membrane

oxidoreductase activity

peptidyl-glutamic acid carboxylation

peptidyl-glutamic acid carboxylation

cellular response to oxidative stress

vitamin K metabolic process

vitamin K metabolic process

vitamin K metabolic process

vitamin-K-epoxide reductase (warfarin-sensitive) activity

vitamin-K-epoxide reductase (warfarin-sensitive) activity

vitamin-K-epoxide reductase (warfarin-sensitive) activity

quinone binding

 
TC1700002167.mm.2 Polh polymerase (DNA directed), eta (RAD 30 related) 17 -46171354 NM_030715, BC128366 NM_030715, BC128366 46

DNA synthesis involved in DNA repair

DNA binding

damaged DNA binding

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

nucleus

nucleoplasm

replication fork

cytosol

DNA replication

DNA repair

pyrimidine dimer repair

postreplication repair

cellular response to DNA damage stimulus

response to radiation

response to UV-C

transferase activity

nucleotidyltransferase activity

site of double-strand break

error-prone translesion synthesis

metal ion binding

cellular response to UV-C

cellular response to UV-C

DNA biosynthetic process

 
TC1000002212.mm.2 Mcu mitochondrial calcium uniporter 10 -59446983 NM_001033259, BC139254, BC139257 NM_001033259, BC139254, BC139257 NM_001033259, BC139254, BC139257 80

calcium channel activity

calcium channel activity

protein binding

mitochondrion

mitochondrion

mitochondrial inner membrane

ion transport

calcium ion transport

mitochondrial calcium ion transmembrane transport

mitochondrial calcium ion transmembrane transport

uniporter activity

uniporter activity

membrane

integral component of membrane

calcium-mediated signaling

integral component of mitochondrial inner membrane

integral component of mitochondrial inner membrane

positive regulation of insulin secretion

calcium channel complex

calcium channel complex

calcium import into the mitochondrion

calcium import into the mitochondrion

glucose homeostasis

identical protein binding

identical protein binding

protein complex oligomerization

mitochondrial calcium ion homeostasis

mitochondrial calcium ion homeostasis

positive regulation of mitochondrial calcium ion concentration

positive regulation of mitochondrial calcium ion concentration

calcium ion transmembrane transport

positive regulation of neutrophil chemotaxis

positive regulation of mitochondrial fission

actin filament reorganization

uniplex complex

uniplex complex

 
TC1100002001.mm.2 Slc26a11 solute carrier family 26, member 11 11 119355556 NM_178743, BC132493, BC137897 NM_178743, BC132493, BC137897 NM_178743, BC132493, BC137897 17

nucleoplasm

lysosome

lysosomal membrane

endoplasmic reticulum

Golgi apparatus

plasma membrane

integral component of plasma membrane

ion transport

secondary active sulfate transmembrane transporter activity

sulfate transport

anion transmembrane transporter activity

sulfate transmembrane transporter activity

anion:anion antiporter activity

membrane

integral component of membrane

intracellular membrane-bounded organelle

transmembrane transport

 
TC1700002497.mm.2 Ndc80 NDC80 kinetochore complex component 17 -71496099 NM_023294, BC020131 NM_023294, BC020131 29

mitotic sister chromatid segregation

establishment of mitotic spindle orientation

chromosome, centromeric region

kinetochore

kinetochore

condensed chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed nuclear chromosome outer kinetochore

protein binding

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

centrosome

cell cycle

mitotic spindle organization

spindle assembly involved in female meiosis I

spindle assembly involved in female meiosis I

chromosome segregation

G2/MI transition of meiotic cell cycle

attachment of spindle microtubules to kinetochore

cyclin binding

Ndc80 complex

Ndc80 complex

regulation of protein stability

identical protein binding

centrosome duplication

cell division

metaphase plate congression

attachment of mitotic spindle microtubules to kinetochore

attachment of mitotic spindle microtubules to kinetochore

kinetochore organization

kinetochore organization

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of protein localization to kinetochore

 
TC1700001969.mm.2 Tcf19 transcription factor 19 17 -35512734 NM_001163763, NM_001163764, NM_025674, BC004617 NM_001163763, NM_001163764, NM_025674, BC004617 NM_001163763, NM_001163764, NM_025674, BC004617 NM_001163763, NM_001163764, NM_025674, BC004617 29

G1/S transition of mitotic cell cycle

nucleus

nucleus

regulation of gene expression

regulation of gene expression

type B pancreatic cell proliferation

 
TC1000002586.mm.2 Appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 10 -83600033 NM_145220, BC048906 NM_145220, BC048906 34

ruffle

phosphatidylserine binding

diet induced thermogenesis

protein binding

nucleus

cytoplasm

cytoplasm

endosome

plasma membrane

plasma membrane

protein import into nucleus

cell cycle

transforming growth factor beta receptor signaling pathway

cell population proliferation

cold acclimation

endosome membrane

endosome membrane

regulation of fibroblast migration

membrane

signaling

small GTPase binding

cytoplasmic vesicle

vesicle

early phagosome

ruffle membrane

adiponectin-activated signaling pathway

regulation of toll-like receptor 4 signaling pathway

phosphatidylinositol binding

cellular response to hepatocyte growth factor stimulus

early phagosome membrane

glucose homeostasis

identical protein binding

protein homodimerization activity

cell projection

macropinosome

protein-containing complex binding

regulation of innate immune response

negative regulation of fatty acid oxidation

negative regulation of glucose import

negative regulation of glucose import

negative regulation of neurogenesis

protein homotetramerization

positive regulation of phagocytosis, engulfment

positive regulation of cold-induced thermogenesis

negative regulation of cytokine production involved in inflammatory response

negative regulation of cellular response to insulin stimulus

positive regulation of macropinocytosis

positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis

regulation of G1/S transition of mitotic cell cycle

negative regulation of neural precursor cell proliferation

 
TC1600001025.mm.2 Smim11 small integral membrane protein 11 16 92301302 NM_138743, BC005668 NM_138743, BC005668 18

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC1500000710.mm.2 Adsl adenylosuccinate lyase 15 80948489 NM_009634, BC020187 NM_009634, BC020187 34

catalytic activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

mitochondrion

cytosol

cytosol

purine nucleotide metabolic process

purine nucleotide biosynthetic process

AMP biosynthetic process

AMP biosynthetic process

response to nutrient

aerobic respiration

purine ribonucleotide biosynthetic process

ribonucleoside monophosphate biosynthetic process

lyase activity

protein-containing complex

identical protein binding

'de novo' AMP biosynthetic process

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

00230

00250

01100

TC0200001663.mm.2 Nop10 NOP10 ribonucleoprotein 2 112261925 NM_025403, BC028497 NM_025403, BC028497 16

snoRNA guided rRNA pseudouridine synthesis

pseudouridine synthesis

RNA binding

protein binding

nucleus

telomerase holoenzyme complex

rRNA processing

telomere maintenance via telomerase

nuclear body

snoRNA binding

rRNA pseudouridine synthesis

snRNA pseudouridine synthesis

box H/ACA snoRNP complex

box H/ACA snoRNP complex

box H/ACA snoRNA binding

box H/ACA snoRNA binding

ribosome biogenesis

telomerase RNA binding

telomerase RNA binding

box H/ACA telomerase RNP complex

box H/ACA telomerase RNP complex

03008

TC1800000535.mm.2 Snx24 sorting nexing 24 18 53245624 NM_029394, BC051168 NM_029394, BC051168 15

cellular_component

biological_process

lipid binding

phosphatidylinositol-5-phosphate binding

protein transport

membrane

cytoplasmic vesicle

phosphatidylinositol-3-phosphate binding

phosphatidylinositol binding

phosphatidylinositol-4-phosphate binding

phosphatidylinositol phosphate binding

 
TC1200001908.mm.2 Dhrs7 dehydrogenase/reductase (SDR family) member 7 12 -72650352 NM_025522, BC016189 NM_025522, BC016189 18

biological_process

oxidoreductase activity

 
TC0X00002266.mm.2         NM_146234, NR_039576, BC032271 NM_146234, NR_039576, BC032271 NM_146234, NR_039576, BC032271  

Golgi membrane

cytoplasm

endosome

early endosome

early endosome

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

plasma membrane

plasma membrane

cation transport

cobalt ion transport

copper ion transport

iron ion transport

cobalt ion transmembrane transporter activity

ferrous iron transmembrane transporter activity

magnesium ion transmembrane transporter activity

magnesium ion transport

membrane

integral component of membrane

inorganic cation transmembrane transporter activity

inorganic cation transmembrane transporter activity

integral component of endoplasmic reticulum membrane

membrane insertase activity

protein insertion into ER membrane by stop-transfer membrane-anchor sequence

tail-anchored membrane protein insertion into ER membrane

EMC complex

EMC complex

 
TC0500000434.mm.2 Lyar Ly1 antibody reactive clone 5 38220481 NM_025281, BC116923, BC116927 NM_025281, BC116923, BC116927 NM_025281, BC116923, BC116927 30

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

photoreceptor outer segment

immune system process

DNA binding

DNA binding

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

rRNA processing

rRNA processing

activating transcription factor binding

identical protein binding

cell projection

innate immune response

negative regulation of innate immune response

positive regulation of transcription by RNA polymerase I

metal ion binding

erythrocyte development

positive regulation of phagocytosis

transcription regulator inhibitor activity

 
TC1000000566.mm.2 Lrrc20 leucine rich repeat containing 20 10 61475832 NM_153542, BC036304 NM_153542, BC036304 15

molecular_function

cellular_component

biological_process

 
TC0900001987.mm.2 Fli1 Friend leukemia integration 1 9 -32422203 NM_008026, BC138791, BC138792 NM_008026, BC138791, BC138792 NM_008026, BC138791, BC138792 133

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

chromatin binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleus

nucleoplasm

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

blood circulation

animal organ morphogenesis

cellular process

nuclear body

cell differentiation

megakaryocyte development

sequence-specific DNA binding

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
TC0500000289.mm.2 Selenoi selenoprotein I 5 30232580 NM_027652, BC106097, BC115783, BC117551 NM_027652, BC106097, BC115783, BC117551 NM_027652, BC106097, BC115783, BC117551 NM_027652, BC106097, BC115783, BC117551 20

ethanolaminephosphotransferase activity

ethanolaminephosphotransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

lipid metabolic process

phosphatidylethanolamine biosynthetic process

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

membrane

integral component of membrane

transferase activity

phosphotransferase activity, for other substituted phosphate groups

metal ion binding

00564

00565

01100

TC0200002478.mm.2 Mybl2 myeloblastosis oncogene-like 2 2 163054634 NM_008652, BC050842 NM_008652, BC050842 77

mitotic cell cycle

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

nucleoplasm

nucleoplasm

regulation of transcription, DNA-templated

Myb complex

positive regulation of neuron apoptotic process

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

mitotic spindle assembly

cellular response to leukemia inhibitory factor

sequence-specific double-stranded DNA binding

 
TC1400002150.mm.2 Ska3 spindle and kinetochore associated complex subunit 3 14 -57806560 NM_198605, BC117500, BC117501 NM_198605, BC117500, BC117501 NM_198605, BC117500, BC117501 19

mitotic cell cycle

mitotic cell cycle

chromosome, centromeric region

kinetochore

condensed chromosome outer kinetochore

condensed chromosome outer kinetochore

molecular_function

chromosome

cytoplasm

centrosome

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cell cycle

chromosome segregation

chromosome segregation

regulation of microtubule polymerization or depolymerization

cell division

mitotic spindle

 
TC0X00002671.mm.2 Las1l LAS1-like (S. cerevisiae) X -95935312, -95935320 NM_152822, BC141155 NM_152822, BC141155 25

maturation of 5.8S rRNA

maturation of LSU-rRNA

nucleus

cytoplasm

rRNA processing

preribosome, large subunit precursor

MLL1 complex

 
TC1600001390.mm.2 Rfc4 replication factor C (activator 1) 4 16 -23113947 NM_145480, BC003335 NM_145480, BC003335 29

nucleotide binding

DNA binding

DNA clamp loader activity

DNA clamp loader activity

ATP binding

nucleus

nucleoplasm

DNA replication factor C complex

DNA replication factor C complex

DNA replication

DNA-dependent DNA replication

DNA repair

single-stranded DNA helicase activity

enzyme binding

Ctf18 RFC-like complex

Elg1 RFC-like complex

positive regulation of DNA-directed DNA polymerase activity

03030

03420

03430

TC0X00003431.mm.2 Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit X -73916869 NM_001177965, NM_019870, BC027219 NM_001177965, NM_019870, BC027219 NM_001177965, NM_019870, BC027219 31

peptide alpha-N-acetyltransferase activity

protein binding

nucleus

nucleolus

cytoplasm

cytoplasm

cytosol

protein acetylation

N-terminal protein amino acid acetylation

N-acetyltransferase activity

acetyltransferase activity

transferase activity

transferase activity, transferring acyl groups

N-terminal peptidyl-serine acetylation

N-terminal peptidyl-glutamic acid acetylation

NatA complex

NatA complex

ribosome binding

peptide-serine-N-acetyltransferase activity

peptide-glutamate-N-acetyltransferase activity

negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric

 
TC1100001156.mm.2 Aldoc aldolase C, fructose-bisphosphate 11 78324197, 78323072 NM_009657, BC004802, BC008184 NM_009657, BC004802, BC008184 NM_009657, BC004802, BC008184 84

catalytic activity

fructose-bisphosphate aldolase activity

fructose-bisphosphate aldolase activity

fructose-bisphosphate aldolase activity

cytoplasm

mitochondrion

cytosol

glycolytic process

apoptotic process

aging

cytoskeletal protein binding

lyase activity

fructose 1,6-bisphosphate metabolic process

fructose 1,6-bisphosphate metabolic process

axon

identical protein binding

protein-containing complex binding

postsynaptic cytosol

00010

00030

00051

01100

TC1100003125.mm.2 Nlrp1b NLR family, pyrin domain containing 1B 11 -71153101, -71153101 NM_001040696, NM_001162414, BC141354 NM_001040696, NM_001162414, BC141354 NM_001040696, NM_001162414, BC141354 30

nucleotide binding

immune system process

ATP binding

nucleus

nucleoplasm

cytoplasm

cytosol

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

inflammatory response

membrane

enzyme binding

protein domain specific binding

protein catabolic process

interleukin-1 alpha production

interleukin-1 beta production

interleukin-1 beta production

regulation of apoptotic process

innate immune response

neuron apoptotic process

defense response to virus

inflammasome complex

pyroptosis

pyroptosis

NLRP1 inflammasome complex

self proteolysis

antiviral innate immune response

NLRP1 inflammasome complex assembly

04621

TC1100001973.mm.2 Birc5 baculoviral IAP repeat-containing 5 11 117849236 NM_001012273, NM_009689, BC004702 NM_001012273, NM_009689, BC004702 NM_001012273, NM_009689, BC004702 215

G2/M transition of mitotic cell cycle

microtubule cytoskeleton organization

nuclear chromosome

mitotic cytokinesis

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

cysteine-type endopeptidase inhibitor activity

protein binding

nucleus

nucleus

chromosome

cytoplasm

cytoplasm

cytoplasm

centriole

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cytoplasmic microtubule

protein phosphorylation

apoptotic process

cell cycle

chromosome segregation

mitotic spindle assembly checkpoint

regulation of mitotic cell cycle

microtubule binding

zinc ion binding

embryo development

negative regulation of peptidase activity

tubulin binding

apical plasma membrane

enzyme binding

peptidase inhibitor activity

midbody

interphase microtubule organizing center

small GTPase binding

protein-containing complex localization

positive regulation of exit from mitosis

chromosome passenger complex

protein-containing complex

identical protein binding

protein homodimerization activity

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cell cycle

negative regulation of transcription, DNA-templated

positive regulation of mitotic cell cycle

metal ion binding

protein heterodimerization activity

chaperone binding

cell division

establishment of chromosome localization

regulation of cell cycle

regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of type B pancreatic cell proliferation

05200

05210

TC0400002222.mm.2 Cibar1 CBY1 interacting BAR domain containing 1 4 -12153141 NM_026558, BC020162 NM_026558, BC020162 19

protein binding

phospholipid binding

nucleus

cytoplasm

mitochondrial inner membrane

centriole

cytoskeleton

cilium

inner mitochondrial membrane organization

cell projection organization

limb morphogenesis

limb morphogenesis

ciliary transition zone

ciliary basal body

cell projection

positive regulation of smoothened signaling pathway

cilium assembly

cilium assembly

membrane organization

ciliary base

 
TC1900000188.mm.2 Fads1 fatty acid desaturase 1 19 10182887 NM_146094, BC022139, BC026831, BC026848, BC063053 NM_146094, BC022139, BC026831, BC026848, BC063053 NM_146094, BC022139, BC026831, BC026848, BC063053 NM_146094, BC022139, BC026831, BC026848, BC063053 NM_146094, BC022139, BC026831, BC026848, BC063053 35

nucleus

mitochondrion

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid biosynthetic process

cellular response to starvation

membrane

integral component of membrane

linoleoyl-CoA desaturase activity

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

arachidonic acid metabolic process

long-chain fatty acid biosynthetic process

intracellular membrane-bounded organelle

acyl-CoA delta5-desaturase activity

acyl-CoA delta5-desaturase activity

01040

TC1300000182.mm.2         NM_001195421, NM_175657, BC115448, BC152397 NM_001195421, NM_175657, BC115448, BC152397 NM_001195421, NM_175657, BC115448, BC152397 NM_001195421, NM_175657, BC115448, BC152397  

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

protein domain specific binding

protein-containing complex

negative regulation of megakaryocyte differentiation

 
TC1300001564.mm.2 H4c18 H4 clustered histone 18 13 -21831791 NM_175657, BC115448, BC152397 NM_175657, BC115448, BC152397 NM_175657, BC115448, BC152397 5

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

protein domain specific binding

protein-containing complex

negative regulation of megakaryocyte differentiation

05322

TC0X00002238.mm.2 Mospd1 motile sperm domain containing 1 X -53344593 NM_027409, BC018329, BC085100, BC100442 NM_027409, BC018329, BC085100, BC100442 NM_027409, BC018329, BC085100, BC100442 NM_027409, BC018329, BC085100, BC100442 18

negative regulation of transcription by RNA polymerase II

molecular_function

nucleus

cytoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

membrane

integral component of membrane

cell differentiation

positive regulation of transcription by RNA polymerase II

perinuclear region of cytoplasm

 
TC1100004219.mm.2 Alyref Aly/REF export factor 11 -120594515 NM_011568, BC120588, BC137658 NM_011568, BC120588, BC137658 NM_011568, BC120588, BC137658 39

nucleic acid binding

single-stranded DNA binding

RNA binding

nucleus

spliceosomal complex

cytoplasm

mRNA processing

RNA splicing

mRNA transport

03013

03015

03040

TC0700001980.mm.2         NM_023140, NR_033611, BC033506, BC087885 NM_023140, NR_033611, BC033506, BC087885 NM_023140, NR_033611, BC033506, BC087885 NM_023140, NR_033611, BC033506, BC087885  

regulation of the force of heart contraction

protein kinase C binding

protein binding

nucleus

nucleus

cytoplasm

cytosol

cellular iron ion homeostasis

electron transfer activity

negative regulation of cardiac muscle hypertrophy

protein disulfide oxidoreductase activity

Z disc

dendrite

identical protein binding

[2Fe-2S] cluster assembly

cell redox homeostasis

metal ion binding

iron-sulfur cluster binding

protein maturation by iron-sulfur cluster transfer

 
MG-1-pos-10339502_st                
TC0300001306.mm.2 Elovl6 ELOVL family member 6, elongation of long chain fatty acids (yeast) 3 129532385 NM_130450, BC051041, BC098492, BC100576 NM_130450, BC051041, BC098492, BC100576 NM_130450, BC051041, BC098492, BC100576 NM_130450, BC051041, BC098492, BC100576 55

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

fatty acid elongase activity

fatty acid elongase activity

fatty acid elongase complex

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups other than amino-acyl groups

fatty acid elongation, saturated fatty acid

fatty acid elongation, saturated fatty acid

sphingolipid biosynthetic process

integral component of endoplasmic reticulum membrane

integral component of endoplasmic reticulum membrane

fatty acid elongation

fatty acid elongation, monounsaturated fatty acid

fatty acid elongation, polyunsaturated fatty acid

long-chain fatty acid biosynthetic process

very long-chain fatty acid biosynthetic process

3-oxo-arachidoyl-CoA synthase activity

3-oxo-cerotoyl-CoA synthase activity

3-oxo-lignoceronyl-CoA synthase activity

positive regulation of cold-induced thermogenesis

01040

TC1200001436.mm.2 Ddx1 DEAD box helicase 1 12 -13219306 NM_134040, BC008570, BC010624 NM_134040, BC008570, BC010624 NM_134040, BC008570, BC010624 51

nucleotide binding

immune system process

positive regulation of myeloid dendritic cell cytokine production

nucleic acid binding

DNA binding

chromatin binding

transcription coregulator activity

RNA binding

RNA helicase activity

double-stranded RNA binding

helicase activity

nuclease activity

exonuclease activity

protein binding

ATP binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

cytosol

double-strand break repair

tRNA splicing, via endonucleolytic cleavage and ligation

mRNA processing

tRNA processing

poly(A) binding

response to virus

cytoplasmic stress granule

cytoplasmic stress granule

hydrolase activity

DNA duplex unwinding

DNA/RNA helicase activity

positive regulation of I-kappaB kinase/NF-kappaB signaling

response to exogenous dsRNA

innate immune response

defense response to virus

cleavage body

tRNA-splicing ligase complex

nucleic acid phosphodiester bond hydrolysis

protein localization to cytoplasmic stress granule

ribonucleoprotein complex

 
TC1200000797.mm.2 Acot2 acyl-CoA thioesterase 2 12 83987860 NM_134188, BC064469 NM_134188, BC064469 24

very long-chain fatty acid metabolic process

response to hypoxia

long-chain fatty acid metabolic process

mitochondrion

mitochondrion

mitochondrion

lipid metabolic process

fatty acid metabolic process

acyl-CoA metabolic process

acyl-CoA metabolic process

acyl-CoA metabolic process

palmitoyl-CoA hydrolase activity

hydrolase activity

thiolester hydrolase activity

very long-chain fatty acid catabolic process

acyl-CoA hydrolase activity

acyl-CoA hydrolase activity

acyl-CoA hydrolase activity

carboxylic ester hydrolase activity

myristoyl-CoA hydrolase activity

01040

TC1000003224.mm.2 Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 10 -61432496 NM_010124, BC015082, BC119539 NM_010124, BC015082, BC119539 NM_010124, BC015082, BC119539 78

protein binding

cytoplasm

regulation of translation

regulation of translational initiation

memory

eukaryotic initiation factor 4E binding

eukaryotic initiation factor 4E binding

insulin receptor signaling pathway

negative regulation of translation

cAMP-mediated signaling

translation repressor activity

TOR signaling

social behavior

negative regulation of translational initiation

negative regulation of translational initiation

regulation of synaptic plasticity

modulation of chemical synaptic transmission

modulation of chemical synaptic transmission

postsynapse

 
TC1100002813.mm.2 Gemin5 gem nuclear organelle associated protein 5 11 -58120000, -58120000 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 NM_001166669, NM_001166670, NM_001166671, NM_172558, BC137802, BC144922 23

RNA 7-methylguanosine cap binding

spliceosomal snRNP assembly

RNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

nucleus

nucleoplasm

cytoplasm

cytosol

mRNA processing

translation

regulation of translation

RNA splicing

nuclear body

snRNA binding

U1 snRNA binding

U4 snRNA binding

U4atac snRNA binding

SMN complex

SMN-Gemin2 complex

SMN-Sm protein complex

ribosome binding

03013

TC0100001836.mm.2 Nsl1 NSL1, MIS12 kinetochore complex component 1 191063020 NM_198654, BC029086 NM_198654, BC029086 14

mitotic sister chromatid segregation

MIS12/MIND type complex

MIS12/MIND type complex

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

molecular_function

nucleus

chromosome

cell cycle

chromosome segregation

nuclear speck

cell division

 
TC1300001631.mm.2 H4c6 H4 clustered histone 6 13 -23551285 NM_175655, BC156748 NM_175655, BC156748 5

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

protein domain specific binding

protein-containing complex

negative regulation of megakaryocyte differentiation

05322

TC0200002442.mm.2 Fam83d family with sequence similarity 83, member D 2 158768098 NM_027975, BC068129 NM_027975, BC068129 16

epithelial to mesenchymal transition

cytoplasm

spindle

cytosol

cytosol

cytoskeleton

cell cycle

signal transduction

microtubule binding

cell population proliferation

microtubule cytoskeleton

cell migration

kinesin binding

protein kinase binding

protein kinase binding

regulation of TOR signaling

regulation of TOR signaling

regulation of protein catabolic process

intercellular bridge

cell division

metaphase plate congression

regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade

mitotic spindle

mitotic spindle pole

mitotic spindle pole

protein localization to mitotic spindle

protein localization to mitotic spindle

positive regulation of cell cycle G1/S phase transition

positive regulation of cell cycle G1/S phase transition

 
TC1600001191.mm.2 Emp2 epithelial membrane protein 2 16 -10281748 NM_007929, BC041670 NM_007929, BC041670 31

membrane raft assembly

T cell mediated cytotoxicity

regulation of cell-matrix adhesion

regulation of cell-matrix adhesion

positive regulation of cell-matrix adhesion

regulation of glomerular filtration

integrin binding

integrin binding

nucleus

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

plasma membrane

plasma membrane

actin filament organization

cell adhesion

cell adhesion

cell-matrix adhesion

embryo implantation

embryo implantation

cell death

positive regulation of cell population proliferation

cell surface

regulation of endothelial cell migration

membrane

integral component of membrane

apical plasma membrane

cell migration

kinase binding

protein kinase binding

protein kinase binding

cytoplasmic vesicle

bleb assembly

activation of protein kinase activity

protein localization to cell surface

blood vessel endothelial cell migration

regulation of kinase activity

early endosome to late endosome transport

membrane raft

membrane raft

apical part of cell

regulation of angiogenesis

actin-mediated cell contraction

protein localization to plasma membrane

positive regulation of integrin-mediated signaling pathway

positive regulation of integrin-mediated signaling pathway

positive regulation of integrin-mediated signaling pathway

regulation of vasculogenesis

 
TC0900001656.mm.2 Exosc7 exosome component 7 9 123113230 NM_001081188, BC052656, BC094932, BC132363, BC145675 NM_001081188, BC052656, BC094932, BC132363, BC145675 NM_001081188, BC052656, BC094932, BC132363, BC145675 NM_001081188, BC052656, BC094932, BC132363, BC145675 NM_001081188, BC052656, BC094932, BC132363, BC145675 21

nuclear exosome (RNase complex)

cytoplasmic exosome (RNase complex)

exosome (RNase complex)

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

RNA binding

nucleus

cytoplasm

rRNA processing

rRNA catabolic process

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

U1 snRNA 3'-end processing

U4 snRNA 3'-end processing

U5 snRNA 3'-end processing

exonucleolytic catabolism of deadenylated mRNA

nuclear mRNA surveillance

nuclear polyadenylation-dependent rRNA catabolic process

nuclear polyadenylation-dependent tRNA catabolic process

nuclear polyadenylation-dependent mRNA catabolic process

03018

TC1100002549.mm.2 Hmmr hyaluronan mediated motility receptor (RHAMM) 11 -40701387 NM_013552, BC021427 NM_013552, BC021427 47

hyaluronic acid binding

cytoplasm

centrosome

cytosol

microtubule cytoskeleton

04512

TC1900001514.mm.2 Exosc1 exosome component 1 19 -41922979 NM_001164561, NM_025644, BC024423 NM_001164561, NM_025644, BC024423 NM_001164561, NM_025644, BC024423 25

nuclear exosome (RNase complex)

exosome (RNase complex)

RNA binding

protein binding

nucleus

nucleolus

cytoplasm

rRNA processing

RNA processing

03018

TC0800001263.mm.2 Nip7 NIP7, nucleolar pre-rRNA processing protein 8 107056876 NM_001164472, NM_025391, NR_028367, BC003972 NM_001164472, NM_025391, NR_028367, BC003972 NM_001164472, NM_025391, NR_028367, BC003972 NM_001164472, NM_025391, NR_028367, BC003972 19

RNA binding

nucleus

nucleoplasm

nucleolus

nucleolus

cytosol

preribosome, large subunit precursor

ribosome biogenesis

ribosome assembly

ribosomal large subunit biogenesis

 
TC0900001210.mm.2 Tfdp2 transcription factor Dp 2 9 96259247, 96196274, 96258704 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 NM_001184706, NM_001184708, NM_001184709, NM_001184710, NM_001184711, NM_178667, BC141080 37

mitotic cell cycle

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

transcription coregulator activity

protein binding

nucleus

nuclear envelope

nucleoplasm

nucleoplasm

transcription regulator complex

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cell cycle

transcription factor binding

protein domain specific binding

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of cell cycle

mitotic spindle

RNA polymerase II transcription regulator complex

04110

TC0100001178.mm.2 Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 1 131910457 NM_001145804, NM_175294, BC039951 NM_001145804, NM_175294, BC039951 NM_001145804, NM_175294, BC039951 32

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

chromatin

chromatin

cellular glucose homeostasis

chromatin binding

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

transcription coactivator activity

nucleus

nucleus

nucleoplasm

chromosome

nucleolus

cytoplasm

cytoplasm

cytoplasm

regulation of DNA replication

DNA repair

chromatin organization

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

transcription factor binding

release from viral latency

replication fork processing

interstrand cross-link repair

interstrand cross-link repair

glucose homeostasis

positive regulation by host of viral transcription

positive regulation by host of viral genome replication

positive regulation of transcription by RNA polymerase II

regulation of insulin receptor signaling pathway

positive regulation of insulin receptor signaling pathway

regulation of DNA strand elongation

cellular response to X-ray

modulation by host of RNA binding by virus

modulation by host of viral RNA-binding transcription factor activity

 
TC1500001005.mm.2 Troap trophinin associated protein 15 99074972 NM_001162506, NM_030159, BC145227 NM_001162506, NM_030159, BC145227 NM_001162506, NM_030159, BC145227 12

molecular_function

cellular_component

cytoplasm

cell adhesion

biological_process

 
TC1900000212.mm.2 Prpf19 pre-mRNA processing factor 19 19 10898644, 10895230 NM_001253843, NM_001253844, NM_134129, BC004070 NM_001253843, NM_001253844, NM_134129, BC004070 NM_001253843, NM_001253844, NM_134129, BC004070 NM_001253843, NM_001253844, NM_134129, BC004070 38

protein polyubiquitination

spliceosomal tri-snRNP complex assembly

spliceosomal complex assembly

generation of catalytic spliceosome for first transesterification step

mRNA splicing, via spliceosome

Prp19 complex

Prp19 complex

inner cell mass cell proliferation

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

DNA replication factor A complex

spliceosomal complex

cytoplasm

cytoplasm

lipid droplet

cytoskeleton

DNA repair

double-strand break repair via nonhomologous end joining

mRNA processing

cellular response to DNA damage stimulus

RNA splicing

lipid biosynthetic process

proteasomal protein catabolic process

proteasomal protein catabolic process

nuclear speck

transferase activity

ubiquitin-ubiquitin ligase activity

cellular protein localization

site of double-strand break

identical protein binding

negative regulation of neuron differentiation

positive regulation of neuron differentiation

positive regulation of mRNA splicing, via spliceosome

positive regulation of astrocyte differentiation

positive regulation of astrocyte differentiation

ubiquitin protein ligase activity

protein K63-linked ubiquitination

U2-type catalytic step 1 spliceosome

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

catalytic step 2 spliceosome

signal transduction involved in DNA damage checkpoint

03040

04120

TC0500000054.mm.2 Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 5 8893720 NM_008830, BC150687 NM_008830, BC150687 156

Golgi membrane

nucleotide binding

ATP binding

nucleoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

plasma membrane

plasma membrane

focal adhesion

lipid transport

actin cytoskeleton

membrane

integral component of membrane

apical plasma membrane

ATPase activity

cytoplasmic vesicle

positive regulation of cholesterol transport

bile acid secretion

ATPase-coupled transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

xenobiotic transmembrane transporter activity

phospholipid translocation

phospholipid translocation

intercellular canaliculus

transmembrane transport

lipid homeostasis

positive regulation of phospholipid translocation

phosphatidylcholine floppase activity

phosphatidylcholine floppase activity

phosphatidylethanolamine flippase activity

ceramide floppase activity

response to fenofibrate

cellular response to bile acid

positive regulation of phospholipid transport

02010

04976

TC0400003849.mm.2 Mrto4 mRNA turnover 4, ribosome maturation factor 4 -139347439 NM_023536, BC005734, BC138221, BC145205 NM_023536, BC005734, BC138221, BC145205 NM_023536, BC005734, BC138221, BC145205 NM_023536, BC005734, BC138221, BC145205 26

ribosomal large subunit assembly

nuclear-transcribed mRNA catabolic process

intracellular anatomical structure

nucleus

nucleolus

cytoplasm

rRNA processing

preribosome, large subunit precursor

ribosome biogenesis

ribosomal large subunit biogenesis

 
TC0700000798.mm.2         NM_025880, NR_028533, BC016099, BC059896 NM_025880, NR_028533, BC016099, BC059896 NM_025880, NR_028533, BC016099, BC059896 NM_025880, NR_028533, BC016099, BC059896  

molecular_function

cellular_component

biological_process

 
MG-1-pos-10341561_st                
TC1700001888.mm.2 Rps18 ribosomal protein S18 17 -33951997 NM_011296, BC081458, BC081459, BC093500, BC100604 NM_011296, BC081458, BC081459, BC093500, BC100604 NM_011296, BC081458, BC081459, BC093500, BC100604 NM_011296, BC081458, BC081459, BC093500, BC100604 NM_011296, BC081458, BC081459, BC093500, BC100604 42

nucleic acid binding

RNA binding

structural constituent of ribosome

protein binding

intracellular anatomical structure

nucleus

cytoplasm

cytosol

cytosol

ribosome

translation

postsynaptic density

small ribosomal subunit

rRNA binding

protein kinase binding

cytosolic small ribosomal subunit

synapse

synapse

03010

TC0X00001323.mm.2 Bex3 brain expressed X-linked 3 X 136270252 NM_001110233, NM_001110234, NM_009750, BC027815 NM_001110233, NM_001110234, NM_009750, BC027815 NM_001110233, NM_001110234, NM_009750, BC027815 NM_001110233, NM_001110234, NM_009750, BC027815 35

signaling receptor binding

death receptor binding

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

cytosol

apoptotic process

signal transduction

extrinsic apoptotic signaling pathway via death domain receptors

identical protein binding

metal ion binding

04722

TC0800000987.mm.2 Orc6 origin recognition complex, subunit 6 8 85299631 NM_001163791, NM_019716, NR_028268, BC080739 NM_001163791, NM_019716, NR_028268, BC080739 NM_001163791, NM_019716, NR_028268, BC080739 NM_001163791, NM_019716, NR_028268, BC080739 21

origin recognition complex

fibrillar center

DNA binding

nucleus

nucleoplasm

nuclear origin of replication recognition complex

DNA replication

DNA-dependent DNA replication

DNA replication initiation

negative regulation of cell division

04110

TC1400002600.mm.2 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 14 -99076633 NM_028315, BC027357 NM_028315, BC027357 27

3'-5'-exoribonuclease activity

3'-5'-exoribonuclease activity

nuclear exosome (RNase complex)

nuclear exosome (RNase complex)

cytoplasmic exosome (RNase complex)

exosome (RNase complex)

RNA binding

nuclease activity

endonuclease activity

endonuclease activity

exonuclease activity

ribonuclease activity

guanyl-nucleotide exchange factor activity

nucleus

nucleoplasm

cytoplasm

cytosol

rRNA processing

rRNA catabolic process

rRNA catabolic process

hydrolase activity

CUT catabolic process

03018

TC0700003988.mm.2 Rrp8 ribosomal RNA processing 8 7 -105731729, -105731729 NM_025897, NM_133951, BC022923, BC046799 NM_025897, NM_133951, BC022923, BC046799 NM_025897, NM_133951, BC022923, BC046799 NM_025897, NM_133951, BC022923, BC046799 23

rDNA heterochromatin assembly

rDNA heterochromatin assembly

nucleus

nucleoplasm

chromatin silencing complex

chromatin silencing complex

nucleolus

nucleolus

cytosol

plasma membrane

chromatin organization

rRNA processing

methyltransferase activity

transferase activity

methylation

rDNA heterochromatin

rDNA heterochromatin

methylated histone binding

methylated histone binding

cellular response to glucose starvation

cellular response to glucose starvation

regulation of transcription by glucose

regulation of transcription by glucose

positive regulation of cell cycle arrest

intrinsic apoptotic signaling pathway by p53 class mediator

 
TC0200004953.mm.2         NM_016661, BC015304, BC086781, BC108367 NM_016661, BC015304, BC086781, BC108367 NM_016661, BC015304, BC086781, BC108367 NM_016661, BC015304, BC086781, BC108367  

chronic inflammatory response to antigenic stimulus

adenosylhomocysteinase activity

adenosylhomocysteinase activity

adenosylhomocysteinase activity

copper ion binding

protein binding

nucleus

cytosol

cytosol

cytosol

response to nutrient

S-adenosylhomocysteine catabolic process

S-adenosylhomocysteine catabolic process

adenyl nucleotide binding

S-adenosylmethionine cycle

circadian sleep/wake cycle

identical protein binding

neuron projection

protein self-association

NAD binding

 
TC1000001579.mm.2 Prim1 DNA primase, p49 subunit 10 128015214 NM_008921, BC089544 NM_008921, BC089544 29

DNA primase activity

DNA primase activity

DNA-directed 5'-3' RNA polymerase activity

protein binding

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

DNA replication

DNA replication, synthesis of RNA primer

DNA replication, synthesis of RNA primer

DNA replication, synthesis of RNA primer

transferase activity

nucleotidyltransferase activity

metal ion binding

primosome complex

00230

00240

01100

03030

TC0X00002556.mm.2 Gk glycerol kinase X -85701936 NM_008194, NM_212444, BC003767 NM_008194, NM_212444, BC003767 NM_008194, NM_212444, BC003767 47

nucleotide binding

glycerol kinase activity

glycerol kinase activity

glycerol kinase activity

ATP binding

nucleus

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

cytosol

carbohydrate metabolic process

glycerol metabolic process

glycerol metabolic process

glycerol-3-phosphate metabolic process

triglyceride metabolic process

membrane

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, alcohol group as acceptor

regulation of fatty acid metabolic process

histone binding

glucose homeostasis

response to ethanol

glycerol-3-phosphate biosynthetic process

00561

01100

03320

TC1100001010.mm.2 Atp2a3 ATPase, Ca++ transporting, ubiquitous 11 72961168 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 NM_001163336, NM_001163337, NM_016745, BC017639, BC026147 37

nucleotide binding

calcium transmembrane transporter activity, phosphorylative mechanism

calcium transmembrane transporter activity, phosphorylative mechanism

calcium ion binding

protein binding

ATP binding

endoplasmic reticulum

endoplasmic reticulum

ion transport

calcium ion transport

cellular calcium ion homeostasis

cellular calcium ion homeostasis

activation of cysteine-type endopeptidase activity involved in apoptotic process

proton-exporting ATPase activity, phosphorylative mechanism

cysteine-type endopeptidase activator activity involved in apoptotic process

calcium ion transmembrane transporter activity

membrane

integral component of membrane

sarcoplasmic reticulum

ATPase activity

calcium-dependent ATPase activity

organelle membrane

endoplasmic reticulum calcium ion homeostasis

sarcoplasmic reticulum membrane

ion channel binding

metal ion binding

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

calcium ion transmembrane transport

calcium ion transmembrane transport

negative regulation of receptor binding

calcium ion transport from cytosol to endoplasmic reticulum

04020

04972

05010

TC1600000088.mm.2 Mettl22 methyltransferase like 22 16 8470812 NM_146247, BC024814 NM_146247, BC024814 16

nucleus

nucleus

nucleoplasm

nucleolus

protein methylation

methyltransferase activity

protein methyltransferase activity

protein methyltransferase activity

transferase activity

heat shock protein binding

methylation

protein-containing complex

 
TC1100000028.mm.2 Pes1 pescadillo ribosomal biogenesis factor 1 11 3963974 NM_022889, BC004844, BC011142 NM_022889, BC004844, BC011142 NM_022889, BC004844, BC011142 35

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

condensed chromosome

RNA binding

protein binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

cytosol

rRNA processing

rRNA processing

rRNA processing

nucleolus organization

cell population proliferation

preribosome, large subunit precursor

protein localization to organelle

ribosome biogenesis

regulation of cell cycle

PeBoW complex

PeBoW complex

PeBoW complex

 
TC1400001935.mm.2 Dlgap5 DLG associated protein 5 14 -47387778 NM_144553, BC058087, NM_001145949 NM_144553, BC058087, NM_001145949 NM_144553, BC058087, NM_001145949 24

nucleus

nucleus

cytoplasm

mitochondrion

cytosol

cytoskeleton

cell cycle

mitotic spindle organization

chromosome segregation

regulation of mitotic cell cycle

microtubule binding

signaling

spindle pole centrosome

spindle pole centrosome

centriolar satellite

kinetochore assembly

centrosome localization

 
TC0400002275.mm.2 Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 4 -19876837 NM_175406, BC087899 NM_175406, BC087899 45

lysosomal membrane

endosome

early endosome

early endosome

ion transport

vacuolar transport

vacuolar acidification

proton transmembrane transporter activity

membrane

apical plasma membrane

vacuolar proton-transporting V-type ATPase complex

vacuolar proton-transporting V-type ATPase complex

proton-transporting V-type ATPase, V0 domain

plasma membrane proton-transporting V-type ATPase complex

proton-transporting ATPase activity, rotational mechanism

proton transmembrane transport

00190

01100

04142

04145

04966

05323

MG-1-pos-10340389_st                
TC0500001732.mm.2 Kdelr2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 5 143403819 NM_025841, BC007146 NM_025841, BC007146 17

Golgi membrane

KDEL sequence binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

cis-Golgi network

cis-Golgi network

protein retention in ER lumen

endoplasmic reticulum to Golgi vesicle-mediated transport

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

protein transport

membrane

integral component of membrane

vesicle-mediated transport

COPI-coated vesicle membrane

cytoplasmic vesicle

ER retention sequence binding

 
TC0200005271.mm.2 Aurka aurora kinase A 2 -172356189 NM_011497, BC005425, BC014711 NM_011497, BC005425, BC014711 NM_011497, BC005425, BC014711 115

nucleotide binding

meiotic spindle organization

microtubule cytoskeleton organization

mitotic cell cycle

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

centrosome

centrosome

microtubule organizing center

spindle

cytosol

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

cilium

protein phosphorylation

protein phosphorylation

cell cycle

spindle organization

mitotic spindle organization

mitotic spindle organization

spindle assembly involved in female meiosis I

centrosome cycle

mitotic centrosome separation

mitotic centrosome separation

response to wounding

anterior/posterior axis specification

negative regulation of gene expression

microtubule cytoskeleton

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

protein kinase binding

cell projection organization

spindle pole centrosome

spindle pole centrosome

ubiquitin protein ligase binding

regulation of protein stability

negative regulation of protein binding

chromosome passenger complex

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cytokinesis

histone serine kinase activity

histone serine kinase activity

germinal vesicle

cell projection

negative regulation of apoptotic process

axon hillock

pronucleus

protein heterodimerization activity

perinuclear region of cytoplasm

spindle midzone

cell division

meiotic cell cycle

centrosome localization

protein localization to centrosome

mitotic spindle

meiotic spindle

negative regulation of spindle checkpoint

liver regeneration

mitotic spindle pole

positive regulation of oocyte maturation

neuron projection extension

04114

TC0X00000471.mm.2 Hprt hypoxanthine guanine phosphoribosyl transferase X 52988077 NM_013556, BC004686, BC083145 NM_013556, BC004686, BC083145 NM_013556, BC004686, BC083145 521

nucleotide binding

magnesium ion binding

magnesium ion binding

T cell mediated cytotoxicity

response to amphetamine

hypoxanthine phosphoribosyltransferase activity

hypoxanthine phosphoribosyltransferase activity

hypoxanthine phosphoribosyltransferase activity

hypoxanthine phosphoribosyltransferase activity

cytoplasm

cytoplasm

cytosol

purine nucleotide biosynthetic process

purine ribonucleoside salvage

purine ribonucleoside salvage

purine ribonucleoside salvage

adenine salvage

adenine salvage

guanine salvage

guanine salvage

guanine salvage

grooming behavior

locomotory behavior

nucleoside metabolic process

transferase activity

transferase activity, transferring glycosyl groups

striatum development

cerebral cortex neuron differentiation

central nervous system neuron development

GMP salvage

IMP salvage

dopamine metabolic process

identical protein binding

identical protein binding

hypoxanthine salvage

positive regulation of dopamine metabolic process

GMP catabolic process

IMP metabolic process

adenine metabolic process

adenine metabolic process

hypoxanthine metabolic process

hypoxanthine metabolic process

hypoxanthine metabolic process

hypoxanthine metabolic process

lymphocyte proliferation

metal ion binding

dendrite morphogenesis

protein homotetramerization

guanine phosphoribosyltransferase activity

00230

00983

01100

TC1200002246.mm.2 Atxn3 ataxin 3 12 -101918900, -101932923 NM_001167914, NM_029705, BC087880 NM_001167914, NM_029705, BC087880 NM_001167914, NM_029705, BC087880 80

microtubule cytoskeleton organization

RNA polymerase II transcription regulatory region sequence-specific DNA binding

histone deacetylase activity

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

mitochondrial matrix

endoplasmic reticulum membrane

cytosol

plasma membrane

ubiquitin-dependent protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins

peptidase activity

cysteine-type peptidase activity

regulation of cell-substrate adhesion

regulation of cell-substrate adhesion

protein deubiquitination

protein deubiquitination

hydrolase activity

actin cytoskeleton organization

ubiquitin protein ligase binding

ubiquitin protein ligase binding

mitochondrial membrane

cellular response to heat

monoubiquitinated protein deubiquitination

exploration behavior

nuclear inclusion body

identical protein binding

proteasome-mediated ubiquitin-dependent protein catabolic process

intermediate filament cytoskeleton organization

ATPase binding

Lys63-specific deubiquitinase activity

protein K63-linked deubiquitination

protein K48-linked deubiquitination

cellular response to misfolded protein

positive regulation of ERAD pathway

protein localization to cytosolic proteasome complex involved in ERAD pathway

Lys48-specific deubiquitinase activity

04141

TC1600001308.mm.2 Ranbp1 RAN binding protein 1 16 -18239978 NM_011239, BC061140 NM_011239, BC061140 59

GDP-dissociation inhibitor activity

GTPase activator activity

nucleus

nuclear pore

cytoplasm

cytoplasm

cytoplasm

centrosome

centrosome

cytosol

spindle organization

positive regulation of neuron projection development

plasma membrane bounded cell projection cytoplasm

positive regulation of mitotic centrosome separation

positive regulation of mitotic centrosome separation

intracellular transport

cellular response to leptomycin B

axon cytoplasm

 
TC0300001488.mm.2 Mcoln3 mucolipin 3 3 146121790 NM_134160, BC106856, BC106857 NM_134160, BC106856, BC106857 NM_134160, BC106856, BC106857 53

cation channel activity

cytoplasm

lysosomal membrane

endosome

plasma membrane

plasma membrane

ion transport

sensory perception of sound

locomotory behavior

lipid binding

membrane

integral component of membrane

cytoplasmic vesicle

inner ear auditory receptor cell differentiation

cell projection

NAADP-sensitive calcium-release channel activity

 
TC0700004321.mm.2 Sephs2 selenophosphate synthetase 2 7 -127271878 NM_009266, BC016508, BC028966, BC043334 NM_009266, BC016508, BC028966, BC043334 NM_009266, BC016508, BC028966, BC043334 NM_009266, BC016508, BC028966, BC043334 20

nucleotide binding

selenium compound metabolic process

selenium compound metabolic process

selenide, water dikinase activity

selenide, water dikinase activity

ATP binding

cytoplasm

selenocysteine biosynthetic process

selenocysteine biosynthetic process

kinase activity

phosphorylation

transferase activity

metal ion binding

00450

01100

TC0700002924.mm.2         XR_105097      
TC0900001302.mm.2 Topbp1 topoisomerase (DNA) II binding protein 1 9 103305326 NM_176979, BC049797 NM_176979, BC049797 50

condensed nuclear chromosome

male germ cell nucleus

DNA binding

nucleus

nucleoplasm

chromosome

chromosome

cytoplasm

cytoskeleton

plasma membrane

DNA replication initiation

DNA repair

cellular response to DNA damage stimulus

mitotic G2 DNA damage checkpoint

reciprocal meiotic recombination

response to ionizing radiation

actin cytoskeleton

nuclear body

PML body

mitotic DNA replication checkpoint

identical protein binding

intracellular membrane-bounded organelle

 
TC0700002426.mm.2 Sae1 SUMO1 activating enzyme subunit 1 7 -16320235, -16327050 NM_001285891, NM_001285892, NM_019748, BC068164 NM_001285891, NM_001285892, NM_019748, BC068164 NM_001285891, NM_001285892, NM_019748, BC068164 NM_001285891, NM_001285892, NM_019748, BC068164 27

nucleus

nucleoplasm

cytoplasm

cellular protein modification process

protein C-terminus binding

ubiquitin-like modifier activating enzyme activity

ligase activity

protein sumoylation

protein sumoylation

SUMO activating enzyme activity

SUMO activating enzyme activity

SUMO activating enzyme complex

SUMO activating enzyme complex

protein modification by small protein conjugation

positive regulation of protein sumoylation

ATP-dependent protein binding

small protein activating enzyme binding

protein heterodimerization activity

04120

TC0800000648.mm.2 Hpf1 histone PARylation factor 1 8 60890427 NM_028299, BC042740 NM_028299, BC042740 16

nucleus

nucleus

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

zinc ion binding

regulation of protein ADP-ribosylation

regulation of protein ADP-ribosylation

peptidyl-serine ADP-ribosylation

peptidyl-serine ADP-ribosylation

histone binding

histone binding

poly-ADP-D-ribose binding

 
TC0300001046.mm.2 Dennd2c DENN/MADD domain containing 2C 3 103140325, 103127555, 103102658 NM_177857, BC060666 NM_177857, BC060666 21

guanyl-nucleotide exchange factor activity

nucleoplasm

 
TC0100000351.mm.2 Wdr75 WD repeat domain 75 1 45795165 NM_028599, BC117880, BC117881 NM_028599, BC117880, BC117881 NM_028599, BC117880, BC117881 23

nucleus

nucleolus

rRNA processing

ribosome biogenesis

positive regulation of transcription by RNA polymerase I

positive regulation of rRNA processing

03008

TC0700001348.mm.2 Alg8 asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase) 7 97371616 NM_199035, BC061244 NM_199035, BC061244 20

alpha-1,3-mannosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

protein N-linked glycosylation

protein N-linked glycosylation

oligosaccharide-lipid intermediate biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring hexosyl groups

protein N-linked glycosylation via asparagine

dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

00510

01100

TC0600002548.mm.2 Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) 6 -82646711, -82618354 NM_025882, BC023189 NM_025882, BC023189 31

DNA binding

nucleus

Ada2/Gcn5/Ada3 transcription activator complex

epsilon DNA polymerase complex

epsilon DNA polymerase complex

protein heterodimerization activity

00230

00240

01100

03030

03410

03420

TC0600002658.mm.2 Aplf aprataxin and PNKP like factor 6 -87628428, -87628424 NM_001170489, NM_024251, BC002179 NM_001170489, NM_024251, BC002179 NM_001170489, NM_024251, BC002179 19

single strand break repair

nucleotide binding

DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

endodeoxyribonuclease activity

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

DNA repair

double-strand break repair

double-strand break repair

double-strand break repair

cellular response to DNA damage stimulus

3'-5' exonuclease activity

hydrolase activity

site of double-strand break

site of double-strand break

regulation of isotype switching

metal ion binding

positive regulation of DNA ligation

 
TC1000002517.mm.2 Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated 10 -80852824, -80852824 NM_025349, BC027511, BC081444 NM_025349, BC027511, BC081444 NM_025349, BC027511, BC081444 15

mRNA splicing, via spliceosome

nuclear-transcribed mRNA catabolic process

RNA binding

protein binding

nucleus

spliceosomal complex

U6 snRNP

U12-type spliceosomal complex

cytoplasm

mRNA processing

mRNA catabolic process

RNA splicing

U4/U6 x U5 tri-snRNP complex

protein heterodimerization activity

U2-type prespliceosome

U2-type precatalytic spliceosome

catalytic step 2 spliceosome

spliceosomal tri-snRNP complex

Lsm2-8 complex

Lsm1-7-Pat1 complex

ribonucleoprotein complex

 
TC0900001056.mm.2 Cd109 CD109 antigen 9 78615545 NM_153098, BC052443, CD109 NM_153098, BC052443, CD109 NM_153098, BC052443, CD109 36

negative regulation of protein phosphorylation

hair follicle development

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

extracellular region

extracellular space

cytosol

plasma membrane

negative regulation of peptidase activity

negative regulation of keratinocyte proliferation

membrane

peptidase inhibitor activity

negative regulation of transforming growth factor beta receptor signaling pathway

anchored component of membrane

regulation of keratinocyte differentiation

transforming growth factor beta binding

negative regulation of wound healing

osteoclast fusion

 
TC1400002649.mm.2 Obi1 ORC ubiquitin ligase 1 14 -104477533 NM_026047, BC029231 NM_026047, BC029231 21

chromatin

chromatin binding

ubiquitin-protein transferase activity

chromosome

regulation of DNA replication

protein monoubiquitination

transferase activity

metal ion binding

positive regulation of mRNA splicing, via spliceosome

protein autoubiquitination

 
TC0500003271.mm.2 Scarb1 scavenger receptor class B, member 1 5 -125277086, -125283319 NM_001205082, NM_001205083, NM_016741, BC004656 NM_001205082, NM_001205083, NM_016741, BC004656 NM_001205082, NM_001205083, NM_016741, BC004656 NM_001205082, NM_001205083, NM_016741, BC004656 368

lipopolysaccharide binding

amyloid-beta binding

phosphatidylserine binding

lipopolysaccharide immune receptor activity

endothelial cell proliferation

scavenger receptor activity

cytoplasm

cytoplasm

cytoplasm

lysosome

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

caveola

caveola

androgen biosynthetic process

cholesterol catabolic process

cholesterol catabolic process

lipid transport

phagocytosis, recognition

high-density lipoprotein particle binding

lipid binding

cell surface

cell surface

positive regulation of triglyceride biosynthetic process

positive regulation of cholesterol storage

positive regulation of cholesterol storage

regulation of phosphatidylcholine catabolic process

phospholipid transport

lipopolysaccharide transport

membrane

integral component of membrane

low-density lipoprotein particle binding

low-density lipoprotein particle binding

low-density lipoprotein particle binding

cholesterol transport

cholesterol transport

microvillus membrane

detection of lipopolysaccharide

cholesterol efflux

cholesterol efflux

cholesterol efflux

cholesterol efflux

apolipoprotein binding

apolipoprotein binding

apolipoprotein A-I binding

high-density lipoprotein particle remodeling

plasma lipoprotein particle clearance

low-density lipoprotein particle clearance

high-density lipoprotein particle clearance

high-density lipoprotein particle clearance

vitamin transmembrane transport

cholesterol homeostasis

identical protein binding

intracellular membrane-bounded organelle

blood vessel endothelial cell migration

recognition of apoptotic cell

recognition of apoptotic cell

recognition of apoptotic cell

reverse cholesterol transport

adhesion of symbiont to host

regulation of phagocytosis

intestinal absorption

positive regulation of nitric-oxide synthase activity

triglyceride homeostasis

high-density lipoprotein particle receptor activity

high-density lipoprotein particle receptor activity

cholesterol import

cholesterol import

cholesterol import

cholesterol import

04145

04975

04976

04977

05160

TC0600000985.mm.2 Fam136a family with sequence similarity 136, member A 6 86365645, 86365470 NM_025591, BC024049, BC103775 NM_025591, BC024049, BC103775 NM_025591, BC024049, BC103775 17

molecular_function

cytoplasm

cytoplasm

mitochondrion

biological_process

 
TC0500002231.mm.2 Mxd4 Max dimerization protein 4 5 -34176579 NM_010753, BC011303 NM_010753, BC011303 31

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

protein binding

nucleus

regulation of transcription by RNA polymerase II

negative regulation of transcription, DNA-templated

protein dimerization activity

RNA polymerase II transcription regulator complex

 
TC1300000383.mm.2 Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 13 33967152, 33964658 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 NM_001163239, NM_001163241, NM_001163242, NM_020282, BC027629 32

dihydronicotinamide riboside quinone reductase activity

NAD(P)H dehydrogenase (quinone) activity

nucleoplasm

cytoplasm

cytosol

cytosol

zinc ion binding

electron transfer activity

oxidoreductase activity

oxidoreductase activity, acting on other nitrogenous compounds as donors

chloride ion binding

protein homodimerization activity

positive regulation of neuron apoptotic process

metal ion binding

positive regulation of ERK1 and ERK2 cascade

FAD binding

melatonin binding

positive regulation of vascular associated smooth muscle cell proliferation

resveratrol binding

positive regulation of reactive oxygen species metabolic process

 
TC0700002057.mm.2 Ap2a2 adaptor-related protein complex 2, alpha 2 subunit 7 141562179 NM_007459, BC058099 NM_007459, BC058099 78

protein binding

plasma membrane

clathrin-coated pit

intracellular protein transport

endocytosis

receptor-mediated endocytosis

synaptic vesicle

lipid binding

protein transport

membrane

vesicle-mediated transport

kinase binding

protein kinase binding

protein domain specific binding

membrane coat

AP-2 adaptor complex

AP-2 adaptor complex

AP-2 adaptor complex

clathrin adaptor complex

secretory granule

cytoplasmic vesicle

phosphatidylinositol binding

clathrin adaptor activity

protein-containing complex binding

clathrin-dependent endocytosis

clathrin-dependent endocytosis

clathrin-dependent endocytosis

disordered domain specific binding

cargo adaptor activity

regulation of hematopoietic stem cell differentiation

04144

05016

TC0800000912.mm.2 Rnf150 ring finger protein 150 8 82863355 NM_177378, BC160221 NM_177378, BC160221 10

cytoplasm

ubiquitin-dependent protein catabolic process

membrane

integral component of membrane

metal ion binding

ubiquitin protein ligase activity

 
TC0500001648.mm.2 Nxpe5 neurexophilin and PC-esterase domain family, member 5 5 138225903 NM_001013773, BC055004, BC106195 NM_001013773, BC055004, BC106195 NM_001013773, BC055004, BC106195 10

molecular_function

cellular_component

biological_process

 
TC1100002029.mm.2 Mrpl12 mitochondrial ribosomal protein L12 11 120484636 NM_027204, BC005712, BC019565 NM_027204, BC005712, BC019565 NM_027204, BC005712, BC019565 26

structural constituent of ribosome

intracellular anatomical structure

mitochondrion

mitochondrion

mitochondrial ribosome

mitochondrial large ribosomal subunit

mitochondrial large ribosomal subunit

ribosome

mitochondrial transcription

mitochondrial transcription

translation

positive regulation of transcription, DNA-templated

 
TC1800001230.mm.2 Gnpda1 glucosamine-6-phosphate deaminase 1 18 -38327536 NM_011937, BC014800 NM_011937, BC014800 25

glucosamine-6-phosphate deaminase activity

glucosamine-6-phosphate deaminase activity

glucosamine-6-phosphate deaminase activity

cytoplasm

cytoplasm

carbohydrate metabolic process

fructose 6-phosphate metabolic process

glucosamine metabolic process

glucosamine catabolic process

glucosamine catabolic process

N-acetylglucosamine metabolic process

N-acetylglucosamine catabolic process

UDP-N-acetylglucosamine biosynthetic process

generation of precursor metabolites and energy

acrosome reaction

hydrolase activity

N-acetylneuraminate catabolic process

identical protein binding

fructose biosynthetic process

00520

01100

TC1700001357.mm.2 Tfb1m transcription factor B1, mitochondrial 17 -3519250 NM_146074, BC032930 NM_146074, BC032930 26

rRNA modification

rRNA (adenine-N6,N6-)-dimethyltransferase activity

rRNA (adenine-N6,N6-)-dimethyltransferase activity

DNA binding

RNA binding

mitochondrion

mitochondrial matrix

rRNA processing

transcription initiation from mitochondrial promoter

methyltransferase activity

rRNA methyltransferase activity

transferase activity

rRNA methylation

methylation

mitochondrial transcription factor activity

mitochondrial nucleoid

 
TC0200004808.mm.2 Thbd thrombomodulin 2 -148404470 NM_009378, BC019154 NM_009378, BC019154 120

transmembrane signaling receptor activity

calcium ion binding

extracellular space

vacuolar membrane

plasma membrane

plasma membrane

integral component of plasma membrane

female pregnancy

blood coagulation

hemostasis

embryo development

external side of plasma membrane

cell surface

membrane

integral component of membrane

apicolateral plasma membrane

negative regulation of blood coagulation

negative regulation of coagulation

04610

TC0200001056.mm.2 Cdca7 cell division cycle associated 7 2 72476218 NM_025866, BC066169 NM_025866, BC066169 36

molecular_function

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

regulation of transcription, DNA-templated

apoptotic process

regulation of cell population proliferation

 
TC1200001030.mm.2 Ifi27 interferon, alpha-inducible protein 27 12 103434188 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 NM_026790, NM_194066, NM_194067, NM_194068, NM_194069, BC125301, BC125636, BC128276 21

negative regulation of transcription by RNA polymerase II

RNA polymerase II activating transcription factor binding

lamin binding

nuclear inner membrane

mitochondrion

regulation of protein export from nucleus

apoptotic signaling pathway

 
TC1300001509.mm.2 Yae1d1 Yae1 domain containing 1 13 -17986639 NM_025904, BC048453, BC083111 NM_025904, BC048453, BC083111 NM_025904, BC048453, BC083111 15

molecular_function

cellular_component

protein maturation by [4Fe-4S] cluster transfer

 
TC1000001203.mm.2 Poc1b POC1 centriolar protein B 10 99107081 NM_027740, BC145801 NM_027740, BC145801 15

spindle pole

retina homeostasis

molecular_function

cytoplasm

centrosome

centriole

cytoskeleton

centriole replication

cell population proliferation

cell projection organization

ciliary basal body

cell projection

cilium assembly

 
TC1500001653.mm.2 Tmem71 transmembrane protein 71 15 -66526211 NM_172514, BC117823, BC117824 NM_172514, BC117823, BC117824 NM_172514, BC117823, BC117824 13

molecular_function

mitochondrion

biological_process

membrane

integral component of membrane

 
TC0200004376.mm.2 Dph6 diphthamine biosynthesis 6 2 -114516417 NM_025675, BC022995 NM_025675, BC022995 17

nucleotide binding

ATP binding

nucleoplasm

nucleolus

ligase activity

diphthine-ammonia ligase activity

diphthine-ammonia ligase activity

peptidyl-diphthamide biosynthetic process from peptidyl-histidine

 
TC1200000596.mm.2 Frmd6 FERM domain containing 6 12 70825513 NM_028127, BC053929 NM_028127, BC053929 24

apical constriction

protein binding

cytoplasm

cytoskeleton

plasma membrane

membrane

actomyosin structure organization

regulation of actin filament-based process

cellular protein localization

apical junction complex

 
TC1300001419.mm.2 Gtpbp4 GTP binding protein 4 13 -8972477 NM_027000, BC025431 NM_027000, BC025431 30

regulation of cyclin-dependent protein serine/threonine kinase activity

nucleotide binding

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GTPase activity

GTP binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

negative regulation of DNA replication

negative regulation of cell population proliferation

negative regulation of cell-cell adhesion

negative regulation of cell migration

negative regulation of protein ubiquitination

nuclear membrane

negative regulation of collagen binding

ribosome biogenesis

perinuclear region of cytoplasm

protein stabilization

03008

TC1900001313.mm.2 Pum3 pumilio RNA-binding family member 3 19 -27388697 NM_177474 26

DNA binding

RNA binding

mRNA binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

endoplasmic reticulum

regulation of translation

regulation of protein ADP-ribosylation

 
TC0400004151.mm.2 Atad3a ATPase family, AAA domain containing 3A 4 -155740639 NM_179203, BC023301, BC058373, BC060036 NM_179203, BC023301, BC058373, BC060036 NM_179203, BC023301, BC058373, BC060036 NM_179203, BC023301, BC058373, BC060036 43

nucleotide binding

regulation of cell growth

protein binding

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrion organization

zinc ion binding

membrane

integral component of membrane

mitochondrial nucleoid

identical protein binding

negative regulation of apoptotic process

antiviral innate immune response

 
MG-1-pos-10338515_st                
TC0X00003412.mm.2 Ccdc22 coiled-coil domain containing 22 X -7593808 NM_138603, BC011195 NM_138603, BC011195 17

protein binding

endosome

cellular copper ion homeostasis

Golgi to plasma membrane transport

cytoplasmic sequestering of NF-kappaB

protein transport

endocytic recycling

cholesterol homeostasis

positive regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of I-kappaB kinase/NF-kappaB signaling

regulation of plasma lipoprotein particle levels

cullin family protein binding

cullin family protein binding

retrograde transport, endosome to plasma membrane

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process

 
MG-1-neg-10338216_st                
MG-1-pos-10341793_st                
TC0500001844.mm.2 Alox5ap arachidonate 5-lipoxygenase activating protein 5 149265003 NM_009663, BC026209 NM_009663, BC026209 43

leukotriene production involved in inflammatory response

positive regulation of acute inflammatory response

arachidonate 5-lipoxygenase activity

glutathione transferase activity

leukotriene-C4 synthase activity

glutathione peroxidase activity

protein binding

nucleus

nuclear envelope

nuclear envelope

endoplasmic reticulum

endoplasmic reticulum

cytosol

leukotriene metabolic process

enzyme activator activity

membrane

integral component of membrane

leukotriene biosynthetic process

leukotriene biosynthetic process

leukotriene biosynthetic process

leukotriene biosynthetic process

lipoxygenase pathway

enzyme binding

nuclear membrane

identical protein binding

protein-containing complex binding

protein N-terminus binding

arachidonic acid binding

protein homotrimerization

cellular response to calcium ion

 
TC0400002849.mm.2 Megf9 multiple EGF-like-domains 9 4 -70431926 NM_172694, BC088994, BC138128, BC138129 NM_172694, BC088994, BC138128, BC138129 NM_172694, BC088994, BC138128, BC138129 NM_172694, BC088994, BC138128, BC138129 21

basement membrane

basement membrane

animal organ morphogenesis

tissue development

membrane

integral component of membrane

cell migration

substrate adhesion-dependent cell spreading

 
TC1400002231.mm.2 Msra methionine sulfoxide reductase A 14 -64122620, -64122620, -64122620, -64122620, -64122620 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 NM_001253712, NM_001253714, NM_001253715, NM_001253716, NM_026322, BC014738, BC089311 79

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

cytosol

plasma membrane

aging

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

actin cytoskeleton

membrane

oxidoreductase activity

cellular response to oxidative stress

L-methionine-(S)-S-oxide reductase activity

 
TC1700001689.mm.2 Nme4 NME/NM23 nucleoside diphosphate kinase 4 17 -26091744 NM_019731, BC027277, NME/NM23 NM_019731, BC027277, NME/NM23 NM_019731, BC027277, NME/NM23 24

nucleotide binding

nucleoside diphosphate kinase activity

ATP binding

mitochondrion

mitochondrion

mitochondrial intermembrane space

GTP biosynthetic process

UTP biosynthetic process

CTP biosynthetic process

lipid transport

lipid binding

nucleotide metabolic process

membrane

kinase activity

phosphorylation

transferase activity

protein-containing complex binding

metal ion binding

GTPase binding

cardiolipin binding

00230

00240

01100

TC0900000854.mm.2 Pclaf PCNA clamp associated factor 9 65890322 NM_026515, BC021413, BC096393 NM_026515, BC021413, BC096393 NM_026515, BC021413, BC096393 31

chromatin binding

chromatin binding

nucleus

nucleus

cytoplasm

centrosome

DNA replication

DNA repair

cellular response to DNA damage stimulus

centrosome cycle

response to UV

translesion synthesis

translesion synthesis

perinuclear region of cytoplasm

regulation of cell cycle

 
TC0200000517.mm.2 Gle1 GLE1 RNA export mediator (yeast) 2 29935408 NM_028923, BC026797 NM_028923, BC026797 20

inositol hexakisphosphate binding

phospholipid binding

nucleus

nuclear envelope

nuclear pore

nucleolus

cytoplasm

centrosome

centriole

cytosol

mRNA export from nucleus

regulation of translational initiation

regulation of translational termination

protein transport

poly(A)+ mRNA export from nucleus

translation initiation factor binding

nuclear membrane

ciliary basal body

identical protein binding

nuclear pore cytoplasmic filaments

mRNA transport

 
TC1700001805.mm.2 Glo1 glyoxalase 1 17 -30592861 NM_001113560, NM_025374, BC024663, BC081432 NM_001113560, NM_025374, BC024663, BC081432 NM_001113560, NM_025374, BC024663, BC081432 NM_001113560, NM_025374, BC024663, BC081432 99

lactoylglutathione lyase activity

lactoylglutathione lyase activity

nucleoplasm

cytosol

plasma membrane

carbohydrate metabolic process

regulation of transcription by RNA polymerase II

glutathione metabolic process

zinc ion binding

zinc ion binding

methylglyoxal metabolic process

lyase activity

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

osteoclast differentiation

negative regulation of apoptotic process

metal ion binding

00620

TC0400001515.mm.2 Yars tyrosyl-tRNA synthetase 4 129189902 NM_134151, BC013552, BC022143, BC026615 NM_134151, BC013552, BC022143, BC026615 NM_134151, BC013552, BC022143, BC026615 NM_134151, BC013552, BC022143, BC026615 31

tRNA binding

nucleotide binding

RNA binding

aminoacyl-tRNA ligase activity

tyrosine-tRNA ligase activity

ATP binding

cytoplasm

cytosol

translation

tRNA aminoacylation for protein translation

tyrosyl-tRNA aminoacylation

nuclear body

ligase activity

00970

TC1900000711.mm.2 Cnnm2 cyclin M2 19 46761608 NM_001102471, NM_033569 NM_001102471, NM_033569 26

ATP binding

plasma membrane

plasma membrane

transport

ion transport

magnesium ion homeostasis

magnesium ion homeostasis

magnesium ion transmembrane transporter activity

magnesium ion transmembrane transporter activity

magnesium ion transport

membrane

integral component of membrane

basolateral plasma membrane

basolateral plasma membrane

transmembrane transporter activity

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

 
TC1900001619.mm.2 Pcgf6 polycomb group ring finger 6 19 -47033616 NM_027654, BC016195, BC089460 NM_027654, BC016195, BC089460 NM_027654, BC016195, BC089460 35

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

protein binding

nucleus

nucleus

regulation of transcription by RNA polymerase II

protein domain specific binding

PcG protein complex

PcG protein complex

PRC1 complex

PRC1 complex

histone H2A-K119 monoubiquitination

histone H2A-K119 monoubiquitination

negative regulation of transcription, DNA-templated

metal ion binding

 
TC0700000991.mm.2 Chsy1 chondroitin sulfate synthase 1 7 66109491 NM_001081163 20

chondrocyte development

extracellular region

Golgi apparatus

acetylgalactosaminyltransferase activity

proximal/distal pattern formation

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

chondroitin sulfate biosynthetic process

chondroitin sulfate biosynthetic process

chondroitin sulfate biosynthetic process

negative regulation of ossification

Golgi cisterna membrane

positive regulation of smoothened signaling pathway

metal ion binding

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

cartilage development

sulfation

bone morphogenesis

00532

01100

TC0400001217.mm.2 Pdzk1ip1 PDZK1 interacting protein 1 4 115088707 NM_001164557, NM_001164558, NM_026018, BC013542 NM_001164557, NM_001164558, NM_026018, BC013542 NM_001164557, NM_001164558, NM_026018, BC013542 NM_001164557, NM_001164558, NM_026018, BC013542 24

molecular_function

biological_process

membrane

integral component of membrane

 
TC0900003342.mm.2 Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein 9 -88449363, -88455581 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 NM_001284328, NM_019666, NM_019796, BC041148, BC050079, BC080309, BC108363 66

nucleic acid binding

RNA binding

mRNA binding

nucleus

spliceosomal complex

cytoplasm

endoplasmic reticulum

mRNA processing

poly(A) binding

RNA splicing

negative regulation of translation

intracellular membrane-bounded organelle

mRNA 5'-UTR binding

CRD-mediated mRNA stabilization

CRD-mediated mRNA stabilization

CRD-mediated mRNA stability complex

CRD-mediated mRNA stability complex

catalytic step 2 spliceosome

histone pre-mRNA 3'end processing complex

cellular response to interferon-gamma

GAIT complex

ribonucleoprotein complex

ribonucleoprotein complex

 
TC0300000624.mm.2 4930579G24Rik RIKEN cDNA 4930579G24 gene 3 79629078 NM_029482 8

molecular_function

cellular_component

cytoplasm

biological_process

 
TC1000002944.mm.2 Nup107 nucleoporin 107 10 -117750642 NM_134010, BC057591, BC092261 NM_134010, BC057591, BC092261 NM_134010, BC057591, BC092261 26

chromosome, centromeric region

kinetochore

posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery

nucleus

nuclear pore

chromosome

regulation of transcription, DNA-templated

mRNA export from nucleus

mRNA export from nucleus

protein import into nucleus

female gonad development

protein transport

membrane

structural constituent of nuclear pore

structural constituent of nuclear pore

nuclear pore outer ring

nuclear pore outer ring

nuclear membrane

nuclear periphery

mRNA transport

nuclear pore complex assembly

nephron development

03013

TC1800001505.mm.2 Afg3l2 AFG3-like AAA ATPase 2 18 -67404763 NM_027130, BC036999, BC043056 NM_027130, BC036999, BC043056 NM_027130, BC036999, BC043056 46

nucleotide binding

metalloendopeptidase activity

protein binding

ATP binding

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial inner membrane

m-AAA complex

proteolysis

mitochondrion organization

axonogenesis

axonogenesis

neuromuscular junction development

mitochondrial fusion

mitochondrial fusion

peptidase activity

metallopeptidase activity

zinc ion binding

membrane

integral component of membrane

protein processing

protein autoprocessing

hydrolase activity

nerve development

membrane protein proteolysis

mitochondrial protein processing

mitochondrial protein processing

mitochondrial protein processing

calcium import into the mitochondrion

regulation of multicellular organism growth

cristae formation

cristae formation

myelination

metal ion binding

muscle fiber development

mitochondrial calcium ion homeostasis

righting reflex

protein-containing complex assembly

 
TC0100002288.mm.2 Slc39a10 solute carrier family 39 (zinc transporter), member 10 1 -46807543, -46807543 NM_172653, BC052880, BC062918 NM_172653, BC052880, BC062918 NM_172653, BC052880, BC062918 32

negative regulation of B cell apoptotic process

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

plasma membrane

integral component of plasma membrane

ion transport

zinc ion transport

cellular zinc ion homeostasis

cellular zinc ion homeostasis

membrane

integral component of membrane

metal ion transport

positive regulation of B cell proliferation

metal ion transmembrane transporter activity

positive regulation of B cell receptor signaling pathway

positive regulation of B cell receptor signaling pathway

transmembrane transport

zinc ion import across plasma membrane

zinc ion import across plasma membrane

positive regulation of protein tyrosine phosphatase activity

 
TC1600000464.mm.2 Osbpl11 oxysterol binding protein-like 11 16 33185070 NM_176840, BC035278 NM_176840, BC035278 25

nucleoplasm

endosome

Golgi apparatus

cytosol

lipid transport

lipid binding

positive regulation of sequestering of triglyceride

sterol transporter activity

membrane

sterol binding

intracellular membrane-bounded organelle

fat cell differentiation

 
TC1600001471.mm.2 Xxylt1 xyloside xylosyltransferase 1 16 -30955502 NM_198626, BC031419 NM_198626, BC031419 16

magnesium ion binding

protein binding

endoplasmic reticulum

membrane

integral component of membrane

O-glycan processing

O-glycan processing

transferase activity

transferase activity, transferring glycosyl groups

manganese ion binding

manganese ion binding

integral component of endoplasmic reticulum membrane

UDP-xylosyltransferase activity

UDP-xylosyltransferase activity

metal ion binding

 
TC0100000638.mm.2 Bcs1l BCS1-like (yeast) 1 74588288 NM_025784, BC019781 NM_025784, BC019781 28

nucleotide binding

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrion organization

membrane

integral component of membrane

protein insertion into mitochondrial inner membrane from matrix

mitochondrial respiratory chain complex I assembly

mitochondrial cytochrome c oxidase assembly

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex III assembly

 
TC0300000799.mm.2 Ilf2 interleukin enhancer binding factor 2 3 90476200 NM_026374, BC024718 NM_026374, BC024718 43

DNA binding

double-stranded RNA binding

nucleus

nucleus

nucleoplasm

nucleolus

nucleolus

cytoplasm

positive regulation of transcription, DNA-templated

ribonucleoprotein complex

 
TC1800000199.mm.2 Elp2 elongator acetyltransferase complex subunit 2 18 24603960 NM_021448, BC015284, BC051943 NM_021448, BC015284, BC051943 NM_021448, BC015284, BC051943 31

RNA polymerase II complex binding

tRNA wobble uridine modification

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

transcription elongation factor complex

transcription elongation factor complex

tRNA processing

protein kinase binding

elongator holoenzyme complex

elongator holoenzyme complex

regulation of receptor signaling pathway via JAK-STAT

 
TC1100001467.mm.2 Phb prohibitin 11 95666956 NM_008831, BC083354, BC089034 NM_008831, BC083354, BC089034 NM_008831, BC083354, BC089034 91

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

complement component C3a binding

complement component C3b binding

immunoglobulin production

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial inner membrane

early endosome

plasma membrane

plasma membrane

integral component of plasma membrane

regulation of transcription, DNA-templated

mitochondrion organization

mitochondrion organization

activation of phospholipase C activity

protein C-terminus binding

negative regulation of cell population proliferation

cell surface

cell surface

positive regulation of gene expression

positive regulation of cell death

negative regulation of transcription by competitive promoter binding

postsynaptic density

membrane

histone deacetylation

enzyme binding

CD40 signaling pathway

mitochondrial crista

negative regulation of cell growth

extrinsic component of mitochondrial outer membrane

proteinase activated receptor binding

interleukin-17 production

mitochondrial prohibitin complex

RIG-I signaling pathway

B cell activation

negative regulation of protein catabolic process

histone deacetylase binding

negative regulation of apoptotic process

myelin sheath

modulation by host of viral RNA genome replication

positive regulation of G protein-coupled receptor signaling pathway

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of complement activation

viral entry into host cell

protein heterodimerization activity

positive regulation of smooth muscle cell proliferation

protein stabilization

progesterone receptor signaling pathway

positive regulation of protein kinase B signaling

negative regulation of androgen receptor signaling pathway

negative regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

cellular response to interleukin-6

DNA biosynthetic process

T-helper 17 type immune response

extrinsic component of presynaptic active zone membrane

glutamatergic synapse

GABA-ergic synapse

antiviral innate immune response

positive regulation of NIK/NF-kappaB signaling

activation of protein kinase C activity

negative regulation of glucocorticoid receptor signaling pathway

 
TC0700002744.mm.2 Zfp146 zinc finger protein 146 7 -30160486 NM_011980, BC127038, BC127039 NM_011980, BC127038, BC127039 NM_011980, BC127038, BC127039 22

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

nucleus

nucleolus

cytosol

regulation of transcription by RNA polymerase II

metal ion binding

 
TC0300000283.mm.2 Spata5 spermatogenesis associated 5 3 37419949 NM_001163511, NM_021343, BC145302 NM_001163511, NM_021343, BC145302 NM_001163511, NM_021343, BC145302 21

nucleotide binding

ATP binding

cytoplasm

cytoplasm

mitochondrion

spindle

multicellular organism development

spermatogenesis

brain development

hydrolase activity

ATPase activity

cell differentiation

03008

TC0400001034.mm.2 Ak4 adenylate kinase 4 4 101419288, 101419320, 101419702, 101419311 NM_001177602, NM_001177604, NM_001177605, NM_009647, BC086663 NM_001177602, NM_001177604, NM_001177605, NM_009647, BC086663 NM_001177602, NM_001177604, NM_001177605, NM_009647, BC086663 NM_001177602, NM_001177604, NM_001177605, NM_009647, BC086663 NM_001177602, NM_001177604, NM_001177605, NM_009647, BC086663 31

nucleotide binding

regulation of oxidative phosphorylation

adenylate kinase activity

nucleoside diphosphate kinase activity

nucleoside diphosphate kinase activity

ATP binding

GTP binding

cytoplasm

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial matrix

nucleobase-containing compound metabolic process

nucleoside diphosphate phosphorylation

nucleoside diphosphate phosphorylation

nucleoside triphosphate biosynthetic process

nucleoside triphosphate biosynthetic process

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, phosphate group as acceptor

nucleobase-containing compound kinase activity

AMP metabolic process

AMP metabolic process

ATP metabolic process

GTP metabolic process

nucleoside triphosphate adenylate kinase activity

cellular response to hypoxia

regulation of ATP biosynthetic process

00230

01100

TC0300003221.mm.2 Wdr77 WD repeat domain 77 3 105959497 NM_027432, BC005755 NM_027432, BC005755 39

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

cytosol

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

pole plasm assembly

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

methyl-CpG binding

methyl-CpG binding

nuclear receptor coactivator activity

nuclear receptor coactivator activity

methylosome

methylosome

pole plasm

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

negative regulation of epithelial cell proliferation involved in prostate gland development

negative regulation of epithelial cell proliferation involved in prostate gland development

 
TC0900000509.mm.2 Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 9 44396945, 44398353, 44397098 NM_008063, BC075655 NM_008063, BC075655 35

neutrophil homeostasis

cytokine production

myeloid progenitor cell differentiation

glycogen metabolic process

lactate metabolic process

triglyceride metabolic process

cellular calcium ion homeostasis

steroid metabolic process

response to organic cyclic compound

glucose-6-phosphate transmembrane transporter activity

hexose phosphate transport

glucose-6-phosphate transport

glucose-6-phosphate transport

glucose-6-phosphate transport

glucose-6-phosphate transport

integral component of endoplasmic reticulum membrane

neutrophil chemotaxis

negative regulation of chemokine production

post-embryonic hemopoiesis

phosphate ion transmembrane transport

glucose homeostasis

glucose homeostasis

cholesterol homeostasis

positive regulation of catalytic activity

intracellular membrane-bounded organelle

respiratory burst

glucose 6-phosphate:inorganic phosphate antiporter activity

04973

TC1000002639.mm.2 Parpbp PARP1 binding protein 10 -88091397 NM_029249, BC070476 NM_029249, BC070476 21

chromatin

chromatin

DNA binding

protein binding

nucleus

nucleoplasm

cytoplasm

DNA repair

cellular response to DNA damage stimulus

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

 
TC1300002360.mm.2 Polr3g polymerase (RNA) III (DNA directed) polypeptide G 13 -81673836 NM_001081176, BC030063, BC066818 NM_001081176, BC030063, BC066818 NM_001081176, BC030063, BC066818 24

immune system process

chromatin binding

chromatin binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase III complex

RNA polymerase III complex

cytoplasm

cytosol

transcription by RNA polymerase III

cell population proliferation

cell population proliferation

cell population proliferation

nuclear body

positive regulation of interferon-beta production

innate immune response

positive regulation of innate immune response

defense response to virus

00230

00240

01100

03020

04623

TC0800000704.mm.2 Ints10 integrator complex subunit 10 8 68793928 NM_027590, BC031923 NM_027590, BC031923 22

molecular_function

nucleus

snRNA processing

integrator complex

 
TC0200002731.mm.2 Gm2026 predicted gene 2026 2 -175192004, -175419390, 175640390, 175737941, -176470368, -176619932 NM_001177543 9

cellular_component

 
TC1400002058.mm.2 Haus4 HAUS augmin-like complex, subunit 4 14 -54541784 NM_145462, BC004644, BC011095 NM_145462, BC004644, BC011095 NM_145462, BC004644, BC011095 21

cytoplasm

centrosome

cytoskeleton

microtubule

cell cycle

centrosome cycle

centrosome cycle

microtubule minus-end binding

spindle assembly

spindle assembly

cell division

HAUS complex

HAUS complex

mitotic spindle microtubule

 
TC1400000347.mm.2 Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 14 32513520 NM_001081221, BC167234 NM_001081221, BC167234 84

single strand break repair

DNA damage checkpoint

nucleotide binding

response to superoxide

positive regulation of defense response to virus by host

DNA binding

chromatin binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

nucleolus

DNA repair

DNA repair

DNA repair

transcription-coupled nucleotide-excision repair

transcription-coupled nucleotide-excision repair

transcription-coupled nucleotide-excision repair

base-excision repair

pyrimidine dimer repair

transcription elongation from RNA polymerase I promoter

cellular response to DNA damage stimulus

response to oxidative stress

response to oxidative stress

activation of JNKK activity

activation of JUN kinase activity

nervous system development

protein C-terminus binding

transcription elongation factor complex

DNA-dependent ATPase activity

DNA-dependent ATPase activity

intrinsic apoptotic signaling pathway in response to DNA damage

response to UV

response to UV

response to toxic substance

response to X-ray

response to UV-B

response to gamma radiation

positive regulation of gene expression

nuclear body

hydrolase activity

neurogenesis

neuron differentiation

protein tyrosine kinase activator activity

neuron projection development

regulation of DNA-templated transcription, elongation

positive regulation of DNA-templated transcription, elongation

positive regulation of peptidyl-serine phosphorylation of STAT protein

multicellular organism growth

ATP-dependent chromatin remodeling

sequence-specific DNA binding

protein-containing complex binding

photoreceptor cell maintenance

positive regulation of DNA repair

protein N-terminus binding

positive regulation of transcription initiation from RNA polymerase II promoter

positive regulation of transcription initiation from RNA polymerase II promoter

RNA polymerase binding

site of DNA damage

double-strand break repair via classical nonhomologous end joining

positive regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via nonhomologous end joining

03420

TC0200003717.mm.2 Mettl8 methyltransferase like 8 2 -70964560, -70964561 NM_001110512, NM_145524, BC004636, BC057960 NM_001110512, NM_145524, BC004636, BC057960 NM_001110512, NM_145524, BC004636, BC057960 NM_001110512, NM_145524, BC004636, BC057960 18

histone acetyltransferase activity

nucleus

cytoplasm

skeletal muscle tissue development

methyltransferase activity

mRNA methyltransferase activity

mRNA methyltransferase activity

histone acetylation

transferase activity

methylation

fat cell differentiation

tRNA (cytosine-3-)-methyltransferase activity

mRNA methylation

mRNA methylation

 
TC0X00001634.mm.2 Phka2 phosphorylase kinase alpha 2 X 160502161, 160502161, 160502161 NM_001177878, NM_001177879, NM_172783, BC050040 NM_001177878, NM_001177879, NM_172783, BC050040 NM_001177878, NM_001177879, NM_172783, BC050040 NM_001177878, NM_001177879, NM_172783, BC050040 27

catalytic activity

calmodulin binding

plasma membrane

phosphorylase kinase complex

phosphorylase kinase complex

carbohydrate metabolic process

glycogen metabolic process

protein phosphorylation

membrane

04020

04910

TC1200001832.mm.2 Fkbp3 FK506 binding protein 3 12 -65062431 NM_013902, BC002122, FK506 NM_013902, BC002122, FK506 NM_013902, BC002122, FK506 31

peptidyl-prolyl cis-trans isomerase activity

protein binding

nucleus

isomerase activity

 
TC0500002095.mm.2 Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 5 -24862734, -24862734, -24862734 NM_001170555, NM_001170556, NM_145401, BC015283 NM_001170555, NM_001170556, NM_145401, BC015283 NM_001170555, NM_001170556, NM_145401, BC015283 NM_001170555, NM_001170556, NM_145401, BC015283 37

nucleotide binding

AMP-activated protein kinase activity

AMP-activated protein kinase activity

cAMP-dependent protein kinase inhibitor activity

ATP binding

nucleus

nucleoplasm

cytoplasm

cytosol

glycogen metabolic process

regulation of glycolytic process

protein phosphorylation

negative regulation of protein kinase activity

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

cAMP-dependent protein kinase regulator activity

phosphorylase kinase regulator activity

positive regulation of peptidyl-threonine phosphorylation

AMP binding

AMP binding

regulation of fatty acid metabolic process

protein kinase regulator activity

protein kinase binding

protein kinase binding

protein kinase activator activity

nucleotide-activated protein kinase complex

nucleotide-activated protein kinase complex

adenyl ribonucleotide binding

intracellular signal transduction

cellular response to glucose starvation

ADP binding

positive regulation of protein kinase activity

regulation of catalytic activity

regulation of catalytic activity

regulation of protein serine/threonine kinase activity

04910

04920

05410

TC0800003160.mm.2 Ccsap centriole, cilia and spindle associated protein 8 -123840843, -123839973, -123839973 NM_028536, BC024705, BC036300 NM_028536, BC024705, BC036300 NM_028536, BC024705, BC036300 14

cytoplasm

centrosome

centriole

centriole

spindle

spindle

cytoskeleton

microtubule

cilium

axoneme

axoneme

cell cycle

multicellular organism development

microtubule binding

microtubule binding

axon

axon

ciliary transition zone

ciliary transition zone

ciliary basal body

ciliary basal body

cell projection

cell division

mitotic spindle astral microtubule

mitotic spindle

regulation of mitotic spindle assembly

regulation of mitotic spindle assembly

mitotic spindle microtubule depolymerization

 
TC0600002353.mm.2 Pyurf Pigy upstream reading frame 6 -57684738 NM_025574, BC029232 NM_025574, BC029232 16

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

molecular_function

mitochondrion

endoplasmic reticulum membrane

endoplasmic reticulum membrane

plasma membrane

GPI anchor biosynthetic process

GPI anchor biosynthetic process

GPI anchor biosynthetic process

positive regulation of metabolic process

 
TC1900001472.mm.2 Noc3l NOC3 like DNA replication regulator 19 -38788127 NM_021315, BC031132 NM_021315, BC031132 29

chromatin binding

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

mitochondrion

DNA replication initiation

nuclear speck

fat cell differentiation

 
TC0100003783.mm.2 Cenpf centromere protein F 1 -189640613 NM_001081363 56

mitotic cell cycle

mitotic cell cycle

chromosome, centromeric region

chromosome, centromeric region

spindle pole

spindle pole

condensed chromosome outer kinetochore

kidney development

nucleus

nucleus

nucleus

nucleus

nuclear envelope

nucleoplasm

cytoplasm

centrosome

spindle

axoneme

chromosome segregation

protein C-terminus binding

transcription factor binding

regulation of G2/M transition of mitotic cell cycle

regulation of G2/M transition of mitotic cell cycle

protein transport

regulation of striated muscle tissue development

nuclear matrix

ventricular system development

midbody

ciliary basal body

protein homodimerization activity

pronucleus

negative regulation of transcription, DNA-templated

metaphase plate congression

metaphase plate congression

dynein complex binding

dynein complex binding

ciliary transition fiber

ciliary transition fiber

 
TC0800000424.mm.2 Ppp1r3b protein phosphatase 1, regulatory subunit 3B 8 35375758, 35376661 NM_177741, BC079666, XR_105198 NM_177741, BC079666, XR_105198 NM_177741, BC079666, XR_105198 20

protein phosphatase type 1 complex

protein phosphatase type 1 complex

phosphoprotein phosphatase activity

carbohydrate metabolic process

glycogen metabolic process

regulation of glycogen biosynthetic process

regulation of glycogen biosynthetic process

regulation of glycogen catabolic process

protein phosphatase 1 binding

protein phosphatase regulator activity

enzyme binding

glycogen granule

intracellular membrane-bounded organelle

[phosphorylase] phosphatase activity

glycogen binding

04910

TC0400001006.mm.2 Alg6 asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase) 4 99715629 NM_001081264, BC050854 NM_001081264, BC050854 15

endoplasmic reticulum

endoplasmic reticulum membrane

protein N-linked glycosylation

protein N-linked glycosylation

dolichol-linked oligosaccharide biosynthetic process

oligosaccharide-lipid intermediate biosynthetic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

transferase activity, transferring hexosyl groups

dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

glucosyltransferase activity

00510

01100

TC1600000700.mm.2 Cip2a cell proliferation regulating inhibitor of protein phosphatase 2A 16 48994187 NM_172616, BC137719 NM_172616, BC137719 28

cytoplasm

cytosol

plasma membrane

spermatogenesis

membrane

integral component of membrane

protein homodimerization activity

positive regulation of neural precursor cell proliferation

 
TC0200005350.mm.2         NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

molecular_function

cellular_component

nucleus

regulation of transcription by RNA polymerase II

biological_process

 
TC0X00000454.mm.2 Stk26 serine/threonine kinase 26 X 50841370 NM_133729, BC005708, BC132438, BC138193 NM_133729, BC005708, BC132438, BC138193 NM_133729, BC005708, BC132438, BC138193 NM_133729, BC005708, BC132438, BC138193 20

Golgi membrane

nucleotide binding

magnesium ion binding

protein kinase activity

protein serine/threonine kinase activity

ATP binding

cytoplasm

Golgi apparatus

Golgi-associated vesicle

cytosol

protein phosphorylation

apoptotic process

cellular response to starvation

membrane

kinase activity

phosphorylation

apical plasma membrane

transferase activity

microvillus assembly

negative regulation of cell migration

response to hydrogen peroxide

identical protein binding

protein homodimerization activity

regulation of apoptotic process

protein autophosphorylation

metal ion binding

perinuclear region of cytoplasm

cell periphery

regulation of hydrogen peroxide-induced cell death

 
TC1400000980.mm.2 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 14 69337150, 69555400 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 NM_026174, BC043134, XM_003688928, XM_003688929, XM_003688930, XM_003688931 23

Golgi membrane

autophagosome membrane

guanosine-diphosphatase activity

guanosine-diphosphatase activity

Golgi apparatus

UDP catabolic process

nucleoside diphosphate catabolic process

membrane

nucleoside-diphosphatase activity

nucleoside-diphosphatase activity

nucleoside-triphosphatase activity

integral component of Golgi membrane

cytidine-diphosphatase activity

CTPase activity

uridine-diphosphatase activity

uridine-diphosphatase activity

integral component of autophagosome membrane

00230

00240

04142

MG-1-pos-10341055_st                
TC1000000015.mm.2 Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 10 3973074, 3973074 NM_001170785, NM_001170786, NM_172308, BC030437 NM_001170785, NM_001170786, NM_172308, BC030437 NM_001170785, NM_001170786, NM_172308, BC030437 NM_001170785, NM_001170786, NM_172308, BC030437 33

nucleotide binding

neural tube closure

formate-tetrahydrofolate ligase activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

cytosol

one-carbon metabolic process

folic acid-containing compound metabolic process

10-formyltetrahydrofolate biosynthetic process

formate metabolic process

ligase activity

tetrahydrofolate interconversion

protein homodimerization activity

embryonic neurocranium morphogenesis

embryonic viscerocranium morphogenesis

00670

01100

TC0600003074.mm.2 Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 6 -122727808 NM_011401, BC034122, BC058811 NM_011401, BC034122, BC058811 NM_011401, BC034122, BC058811 133

acrosomal membrane

transporter activity

glucose transmembrane transporter activity

glucose binding

cytoplasm

cytoplasm

plasma membrane

plasma membrane

plasma membrane

integral component of plasma membrane

caveola

carbohydrate transport

monosaccharide transmembrane transporter activity

membrane

integral component of membrane

galactoside binding

kinase binding

transmembrane transporter activity

synaptic vesicle membrane

xylose binding

dehydroascorbic acid transmembrane transporter activity

dehydroascorbic acid transmembrane transporter activity

cell projection

D-glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

transmembrane transport

dehydroascorbic acid transport

glucose import across plasma membrane

glutamatergic synapse

integral component of synaptic membrane

transport across blood-brain barrier

glucose transmembrane transport

glucose transmembrane transport

glucose transmembrane transport

 
TC0600000962.mm.2 Smyd5 SET and MYND domain containing 5 6 85431975 NM_144918, BC016525 NM_144918, BC016525 22

molecular_function

cellular_component

biological_process

methyltransferase activity

transferase activity

methylation

metal ion binding

 
TC1100002593.mm.2 Thg1l tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 11 -45945305, -45945305 NM_001080969, BC092541, BC115560, BC115561 NM_001080969, BC092541, BC115560, BC115561 NM_001080969, BC092541, BC115560, BC115561 NM_001080969, BC092541, BC115560, BC115561 16

nucleotide binding

magnesium ion binding

guanyl-nucleotide exchange factor activity

ATP binding

GTP binding

cytoplasm

mitochondrion

tRNA modification

response to oxidative stress

tRNA processing

tRNA processing

mitochondrial fusion

tRNA guanylyltransferase activity

tRNA guanylyltransferase activity

transferase activity

nucleotidyltransferase activity

identical protein binding

metal ion binding

protein homotetramerization

stress-induced mitochondrial fusion

transferase complex

 
TC1200000869.mm.2 Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) 12 87157602, 87147706, 87147164 NM_001252555, NM_001252556, NM_010363, BC031777 NM_001252555, NM_001252556, NM_010363, BC031777 NM_001252555, NM_001252556, NM_010363, BC031777 NM_001252555, NM_001252556, NM_010363, BC031777 26

catalytic activity

glutathione transferase activity

glutathione transferase activity

glutathione transferase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

L-phenylalanine catabolic process

L-phenylalanine catabolic process

tyrosine catabolic process

glutathione metabolic process

glutathione metabolic process

metabolic process

aromatic amino acid family metabolic process

maleylacetoacetate isomerase activity

maleylacetoacetate isomerase activity

transferase activity

isomerase activity

identical protein binding

protein homodimerization activity

00350

00480

00980

00982

01100

TC0100003477.mm.2                
TC1000001020.mm.2 Tcp11l2 t-complex 11 (mouse) like 2 10 84576946 NM_146008, BC029663 NM_146008, BC029663 14

molecular_function

cellular_component

signal transduction

 
TC1100001849.mm.2 Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 11 111066163 NM_008425, BC137841, BC137842 NM_008425, BC137841, BC137842 NM_008425, BC137841, BC137842 120

inward rectifier potassium channel activity

inward rectifier potassium channel activity

voltage-gated ion channel activity

protein binding

phosphatidylinositol-4,5-bisphosphate binding

smooth endoplasmic reticulum

rough endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

ion transport

potassium ion transport

voltage-gated potassium channel complex

intercalated disc

regulation of skeletal muscle contraction via regulation of action potential

magnesium ion transport

membrane

integral component of membrane

T-tubule

dendrite

intrinsic component of membrane

regulation of ion transmembrane transport

identical protein binding

identical protein binding

neuronal cell body

dendritic spine

protein homotetramerization

relaxation of cardiac muscle

regulation of membrane repolarization

potassium ion transmembrane transport

cardiac muscle cell action potential

cardiac muscle cell action potential involved in contraction

regulation of cardiac muscle cell contraction

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization

membrane repolarization during action potential

membrane repolarization during cardiac muscle cell action potential

regulation of heart rate by cardiac conduction

relaxation of skeletal muscle

positive regulation of potassium ion transmembrane transport

potassium ion import across plasma membrane

potassium ion import across plasma membrane

04971

TC0300001987.mm.2 Exosc8 exosome component 8 3 -54728678 NM_001163570, NM_027148, BC059089 NM_001163570, NM_027148, BC059089 NM_001163570, NM_027148, BC059089 24

nuclear exosome (RNase complex)

cytoplasmic exosome (RNase complex)

exosome (RNase complex)

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

fibrillar center

RNA binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

rRNA processing

RNA processing

RNA catabolic process

rRNA catabolic process

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

U1 snRNA 3'-end processing

U4 snRNA 3'-end processing

U5 snRNA 3'-end processing

mRNA 3'-UTR AU-rich region binding

identical protein binding

intracellular membrane-bounded organelle

exonucleolytic catabolism of deadenylated mRNA

nuclear mRNA surveillance

nuclear polyadenylation-dependent rRNA catabolic process

nuclear polyadenylation-dependent tRNA catabolic process

nuclear polyadenylation-dependent mRNA catabolic process

03018

TC0500003637.mm.2 Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 5 -148327409, -148327409 NM_007513, BC145779, BC145781 NM_007513, BC145779, BC145781 NM_007513, BC145779, BC145781 55

L-ornithine transmembrane transporter activity

L-histidine transmembrane transporter activity

plasma membrane

plasma membrane

amino acid transport

basal plasma membrane

amino acid transmembrane transporter activity

amino acid transmembrane transporter activity

basic amino acid transmembrane transporter activity

arginine transmembrane transporter activity

arginine transmembrane transporter activity

arginine transmembrane transporter activity

L-lysine transmembrane transporter activity

L-amino acid transport

arginine transport

arginine transport

lysine transport

ornithine transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

transmembrane transporter activity

regulation of TOR signaling

protein-containing complex

positive regulation of T cell proliferation

transmembrane transport

L-arginine transmembrane transporter activity

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-arginine import across plasma membrane

L-ornithine transmembrane transport

L-histidine import across plasma membrane

arginine transmembrane transport

basic amino acid transmembrane transport

 
TC0100001787.mm.2 Eprs glutamyl-prolyl-tRNA synthetase 1 185363043 NM_029735, BC141049 NM_029735, BC141049 41

nucleotide binding

RNA binding

catalytic activity

aminoacyl-tRNA ligase activity

glutamate-tRNA ligase activity

proline-tRNA ligase activity

proline-tRNA ligase activity

proline-tRNA ligase activity

protein binding

ATP binding

cytoplasm

cytoplasm

cytosol

plasma membrane

translation

regulation of translation

tRNA aminoacylation for protein translation

glutamyl-tRNA aminoacylation

prolyl-tRNA aminoacylation

prolyl-tRNA aminoacylation

prolyl-tRNA aminoacylation

metabolic process

zinc ion binding

membrane

ligase activity

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

negative regulation of translation

negative regulation of translation

cellular response to insulin stimulus

RNA stem-loop binding

identical protein binding

protein homodimerization activity

tRNA aminoacylation

metal ion binding

GTPase binding

cellular response to interferon-gamma

cellular response to interferon-gamma

GAIT complex

regulation of long-chain fatty acid import into cell

regulation of long-chain fatty acid import into cell

ribonucleoprotein complex

00860

00970

01100

TC1000002686.mm.2 Nedd1 neural precursor cell expressed, developmentally down-regulated gene 1 10 -92684744 NM_008682, BC052430, BC066870 NM_008682, BC052430, BC066870 NM_008682, BC052430, BC066870 34

pericentriolar material

pericentriolar material

spindle pole

spindle pole

gamma-tubulin ring complex, centrosomal

nucleoplasm

cytoplasm

centrosome

centrosome

centriole

centriole

cytoskeleton

plasma membrane

microtubule depolymerization

cell cycle

microtubule polymerization or depolymerization

ciliary basal body

ciliary basal body

apical part of cell

cell division

regulation of establishment of protein localization

protein localization to centrosome

 
TC1300001445.mm.2 Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase 13 -12186539 NM_001081128, BC145683, BC145685 NM_001081128, BC145683, BC145685 NM_001081128, BC145683, BC145685 25

folic acid binding

cytoplasm

cytosol

cytosol

protein methylation

methionine metabolic process

methyltransferase activity

zinc ion binding

cellular amino acid biosynthetic process

methionine synthase activity

methionine synthase activity

methionine synthase activity

methionine biosynthetic process

methionine biosynthetic process

cobalamin metabolic process

amino acid binding

transferase activity

axon regeneration

cobalamin binding

methylation

pteridine-containing compound metabolic process

cellular metabolic process

tetrahydrofolate metabolic process

metal ion binding

response to axon injury

homocysteine metabolic process

cellular response to nitric oxide

00270

00450

00670

01100

MG-1-pos-10338434_st                
TC0X00001651.mm.2 Rbbp7 retinoblastoma binding protein 7, chromatin remodeling factor X 162760371 NM_009031, BC003785 NM_009031, BC003785 63

negative regulation of transcription by RNA polymerase II

RNA binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytosol

DNA replication

chromatin organization

chromatin remodeling

NuRD complex

NuRD complex

negative regulation of cell growth

ESC/E(Z) complex

ESC/E(Z) complex

negative regulation of transcription, DNA-templated

cellular heat acclimation

cellular heat acclimation

 
TC0100003483.mm.2 Mgst3 microsomal glutathione S-transferase 3 1 -167371965 NM_025569, BC029669 NM_025569, BC029669 28

glutathione transferase activity

leukotriene-C4 synthase activity

glutathione peroxidase activity

glutathione peroxidase activity

nuclear envelope

endoplasmic reticulum

lipid metabolic process

membrane

integral component of membrane

oxidoreductase activity

transferase activity

leukotriene biosynthetic process

identical protein binding

intracellular membrane-bounded organelle

00480

00980

00982

TC0200003753.mm.2 Gpr155 G protein-coupled receptor 155 2 -73341505 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 NM_001190297, NM_001276443, NM_001276444, BC115698, NM_001080707 13

molecular_function

cognition

 
TC0500001548.mm.2 Gtf2ird2 GTF2I repeat domain containing 2 5 134184037 NM_053266, BC132157, BC132159 NM_053266, BC132157, BC132159 NM_053266, BC132157, BC132159 18

DNA binding

protein binding

nucleus

nucleus

transition between fast and slow fiber

 
TC0200005339.mm.2         NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416 NM_001101804, NM_001177543, NM_001256480, NM_001099349, NM_001100415, NM_001100416  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

molecular_function

cellular_component

nucleus

regulation of transcription by RNA polymerase II

biological_process

 
TC0100003210.mm.2 Rgs18 regulator of G-protein signaling 18 1 -144752682 NM_022881, BC099387, BC132544, BC132546 NM_022881, BC099387, BC132544, BC132546 NM_022881, BC099387, BC132544, BC132546 NM_022881, BC099387, BC132544, BC132546 21

GTPase activator activity

cytoplasm

G protein-coupled receptor signaling pathway

regulation of G protein-coupled receptor signaling pathway

negative regulation of signal transduction

 
TC0100002899.mm.2 Kdsr 3-ketodihydrosphingosine reductase 1 -106720409, -106731201 NM_027534, BC023820 NM_027534, BC023820 23

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

sphingolipid metabolic process

3-keto-sphinganine metabolic process

3-keto-sphinganine metabolic process

membrane

integral component of membrane

oxidoreductase activity

sphingolipid biosynthetic process

sphingolipid biosynthetic process

3-dehydrosphinganine reductase activity

3-dehydrosphinganine reductase activity

00600

01100

TC0900002018.mm.2 Hyls1 HYLS1, centriolar and ciliogenesis associated 9 -35560820 NM_029762, BC035953 NM_029762, BC035953 12

molecular_function

nucleus

cytoplasm

centrosome

centriole

cytosol

cytoskeleton

plasma membrane

cell projection organization

cell projection

cilium assembly

non-motile cilium

 
TC1900000312.mm.2 Prune2 prune homolog 2 19 16956117 NM_181348, BC095978 NM_181348, BC095978 29

exopolyphosphatase activity

cytoplasm

polyphosphate catabolic process

apoptotic process

pyrophosphatase activity

 
TC1100002486.mm.2 Npm1 nucleophosmin 1 11 -33152497, -33154924 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 NM_001252260, NM_001252261, NM_008722, BC054755, BC085278, BC089546, BC090843, BC092378 155

ribosomal large subunit export from nucleus

ribosomal large subunit export from nucleus

ribosomal small subunit export from nucleus

ribosomal small subunit export from nucleus

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

core promoter sequence-specific DNA binding

regulation of cell growth

granular component

p53 binding

nucleic acid binding

DNA binding

chromatin binding

transcription coactivator activity

RNA binding

RNA binding

RNA binding

protein kinase inhibitor activity

protein binding

ATP binding

phosphatidylinositol-3,4,5-trisphosphate binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

cytoplasm

centrosome

centrosome

centrosome

cytosol

cytoskeleton

DNA repair

nucleosome assembly

chromatin remodeling

rRNA export from nucleus

rRNA export from nucleus

rRNA export from nucleus

cell volume homeostasis

cell volume homeostasis

nucleocytoplasmic transport

nucleocytoplasmic transport

centrosome cycle

cell aging

protein localization

protein localization

transcription factor binding

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

rRNA transcription

posttranscriptional regulation of gene expression

negative regulation of gene expression

negative regulation of cardiac muscle cell apoptotic process

regulation of centrosome duplication

regulation of centrosome duplication

positive regulation of centrosome duplication

negative regulation of centrosome duplication

large ribosomal subunit

small ribosomal subunit

nuclear matrix

nuclear speck

rRNA binding

enzyme binding

protein kinase binding

Tat protein binding

positive regulation of cellular biosynthetic process

positive regulation of cellular biosynthetic process

positive regulation of protein ubiquitination

spindle pole centrosome

regulation of protein stability

protein destabilization

regulation of endodeoxyribonuclease activity

protein-containing complex

protein-DNA complex

activating transcription factor binding

cellular response to UV

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

ribosomal small subunit biogenesis

ribosomal small subunit biogenesis

ribosomal small subunit biogenesis

histone binding

histone binding

identical protein binding

identical protein binding

protein homodimerization activity

ribosomal large subunit binding

ribosomal small subunit binding

negative regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of catalytic activity

protein kinase B binding

regulation of DNA damage response, signal transduction by p53 class mediator

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of protein kinase activity by regulation of protein phosphorylation

positive regulation of translation

positive regulation of DNA replication

positive regulation of protein kinase activity

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of centriole replication

protein N-terminus binding

negative regulation of mRNA splicing, via spliceosome

negative regulation of epithelial cell proliferation

protein stabilization

protein stabilization

positive regulation of DNA metabolic process

NF-kappaB binding

unfolded protein binding

positive regulation of NF-kappaB transcription factor activity

regulation of cell cycle

regulation of endoribonuclease activity

regulation of eIF2 alpha phosphorylation by dsRNA

positive regulation of DNA-directed DNA polymerase activity

regulation of mRNA stability involved in cellular response to UV

positive regulation of cell cycle G2/M phase transition

positive regulation of protein localization to nucleolus

ribonucleoprotein complex

ribonucleoprotein complex

 
TC0200004547.mm.2 Ncaph non-SMC condensin I complex, subunit H 2 -127103809 NM_144818, BC021499, BC025060 NM_144818, BC021499, BC025060 NM_144818, BC021499, BC025060 31

condensin complex

condensin complex

condensin complex

condensin complex

chromatin binding

chromatin binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

female meiotic nuclear division

meiotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

DNA topoisomerase binding

meiotic chromosome segregation

cell division

female meiosis chromosome separation

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity

 
TC1800001654.mm.2 Rbfa ribosome binding factor A 18 -80192263 NM_199197, BC064066 NM_199197, BC064066 17

molecular_function

cellular_component

mitochondrion

rRNA processing

 
TC1300000792.mm.2 Zfp369 zinc finger protein 369 13 65278853 NM_178364, BC167204 NM_178364, BC167204 19

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

neurotrophin p75 receptor binding

protein binding

intracellular anatomical structure

nucleus

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

apoptotic process

sequence-specific DNA binding

metal ion binding

regulation of cell cycle

sequence-specific double-stranded DNA binding

04722

TC1700002656.mm.2 Lrpprc leucine-rich PPR-motif containing 17 -84705246 NM_028233, BC059862 NM_028233, BC059862 44

condensed nuclear chromosome

negative regulation of mitochondrial RNA catabolic process

negative regulation of mitochondrial RNA catabolic process

DNA binding

single-stranded DNA binding

RNA binding

protein binding

nucleus

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

cytoskeleton

microtubule

membrane

ubiquitin protein ligase binding

mitochondrial nucleoid

perinuclear region of cytoplasm

beta-tubulin binding

mRNA transport

regulation of mitochondrial translation

ribonucleoprotein complex

 
MG-1-pos-10344497_st                
TC1400000350.mm.2 Tmem273 transmembrane protein 273 14 32785962 NM_001163616 8

molecular_function

cellular_component

biological_process

 
TC0700003608.mm.2 Cpeb1 cytoplasmic polyadenylation element binding protein 1 7 -81347025, -81347025 NM_001252525, NM_001252526, NM_007755, BC125476 NM_001252525, NM_001252526, NM_007755, BC125476 NM_001252525, NM_001252526, NM_007755, BC125476 NM_001252525, NM_001252526, NM_007755, BC125476 64

translation repressor activity, mRNA regulatory element binding

translation repressor activity, mRNA regulatory element binding

nucleic acid binding

RNA binding

mRNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

centrosome

cytosol

mRNA processing

regulation of translation

synaptonemal complex assembly

translation factor activity, RNA binding

negative regulation of cell population proliferation

positive regulation of neuron projection development

postsynaptic density

membrane

negative regulation of translation

cell junction

positive regulation of cell migration

growth cone

cellular response to insulin stimulus

mRNA 3'-UTR AU-rich region binding

neuron projection

ribosome binding

neuronal cell body

translation regulator activity

synapse

positive regulation of translation

metal ion binding

regulation of neuronal synaptic plasticity

perinuclear region of cytoplasm

mRNA transport

positive regulation of nitric-oxide synthase biosynthetic process

cellular response to amino acid stimulus

cellular response to hypoxia

cellular response to hypoxia

meiotic spindle

positive regulation of mRNA polyadenylation

messenger ribonucleoprotein complex

negative regulation of cytoplasmic translation

negative regulation of cytoplasmic translation

negative regulation of cytoplasmic translation

04114

04320

04914

TC0100000456.mm.2 Nop58 NOP58 ribonucleoprotein 1 59685005 NM_018868, BC076604, BC085135 NM_018868, BC076604, BC085135 NM_018868, BC076604, BC085135 31

TFIID-class transcription factor complex binding

fibrillar center

nucleus

nucleoplasm

nucleolus

sno(s)RNA-containing ribonucleoprotein complex

cytosol

Cajal body

snoRNA binding

snoRNA binding

box C/D RNP complex

small-subunit processome

ribosome biogenesis

snoRNA localization

ATPase binding

pre-snoRNP complex

03008

TC1900000683.mm.2 Nolc1 nucleolar and coiled-body phosphoprotein 1 19 46075846 NM_001039351, NM_001039352, NM_001039353, NM_053086 NM_001039351, NM_001039352, NM_001039353, NM_053086 NM_001039351, NM_001039352, NM_001039353, NM_053086 NM_001039351, NM_001039352, NM_001039353, NM_053086 29

protein binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

cytoplasm

nucleolus organization

Cajal body

small nuclear ribonucleoprotein complex

 
TC0700001122.mm.2 Fanci Fanconi anemia, complementation group I 7 79392337 NM_145946 25

nucleus

nucleoplasm

cytoplasm

cytosol

DNA repair

cellular response to DNA damage stimulus

cell cycle

positive regulation of protein ubiquitination

Fanconi anaemia nuclear complex

DNA polymerase binding

DNA polymerase binding

 
TC1000000636.mm.2 Egr2 early growth response 2 10 67537868, 67537929, 67537565, 67537210, 67535498, 67537869 NM_010118, BC009093 NM_010118, BC009093 484

transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

RNA polymerase II activating transcription factor binding

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

protein export from nucleus

rhythmic behavior

rhythmic behavior

motor neuron axon guidance

gene expression

Schwann cell differentiation

positive regulation of Schwann cell differentiation

transferase activity

protein sumoylation

rhombomere 3 development

facial nerve structural organization

facial nerve structural organization

rhombomere 3 structural organization

rhombomere 3 formation

rhombomere 5 structural organization

rhombomere 5 structural organization

rhombomere 5 formation

regulation of ossification

ubiquitin protein ligase binding

positive regulation of myelination

response to insulin

brain segmentation

skeletal muscle cell differentiation

myelination

intracellular membrane-bounded organelle

sequence-specific DNA binding

sequence-specific DNA binding

fat cell differentiation

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

SUMO ligase activity

cellular response to organic substance

HMG box domain binding

sequence-specific double-stranded DNA binding

 
TC0200000432.mm.2 Bmyc brain expressed myelocytomatosis oncogene 2 25706878 NM_023326, BC056436, BC060207, BC061001 NM_023326, BC056436, BC060207, BC061001 NM_023326, BC056436, BC060207, BC061001 NM_023326, BC056436, BC060207, BC061001 31

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity

protein binding

nucleus

spindle

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

positive regulation of cell population proliferation

 
TC0100003505.mm.2 Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 1 -169949536 NM_010476 38

3-keto sterol reductase activity

3-keto sterol reductase activity

3-keto sterol reductase activity

estradiol 17-beta-dehydrogenase activity

estradiol 17-beta-dehydrogenase activity

prolactin receptor binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

estrogen biosynthetic process

estrogen biosynthetic process

nervous system development

brain development

androgen metabolic process

androgen metabolic process

membrane

integral component of membrane

oxidoreductase activity

cell differentiation

5alpha-androstane-3beta,17beta-diol dehydrogenase activity

5alpha-androstane-3beta,17beta-diol dehydrogenase activity

embryonic organ development

embryonic skeletal system development

00100

00140

01100

TC0300002352.mm.2 Cks1b CDC28 protein kinase 1b 3 -89415471 NM_016904, BC076579 NM_016904, BC076579 38

cyclin-dependent protein kinase holoenzyme complex

regulation of transcription, DNA-templated

cell cycle

regulation of mitotic cell cycle

cell population proliferation

embryo development

cyclin-dependent protein serine/threonine kinase regulator activity

SCF ubiquitin ligase complex

protein kinase binding

histone binding

ubiquitin binding

mitotic cell cycle phase transition

cell division

cyclin-dependent protein serine/threonine kinase activator activity

05200

05222

TC1300001630.mm.2 H2bc9 H2B clustered histone 9 13 -23542922 NM_178197, BC092138, BC132584, BC132586 NM_178197, BC092138, BC132584, BC132586 NM_178197, BC092138, BC132584, BC132586 NM_178197, BC092138, BC132584, BC132586 16

nucleosome

DNA binding

nucleus

nucleoplasm

chromosome

nucleosome assembly

protein heterodimerization activity

05322

TC0700003743.mm.2 Ddias DNA damage-induced apoptosis suppressor 7 -92857525 NM_001080995, BC066148 NM_001080995, BC066148 18

molecular_function

nucleus

nucleus

cytoplasm

cytoplasm

apoptotic process

cellular response to DNA damage stimulus

cell cycle

cell cycle arrest

spermatid development

hemopoiesis

cellular response to UV

cellular response to cytokine stimulus

cellular response to hydroperoxide

cellular response to gamma radiation

mitotic cell cycle arrest

mitotic cell cycle arrest

regulation of DNA stability

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

negative regulation of fibroblast apoptotic process

 
TC0200005378.mm.2 Gm14326 predicted gene 14326 2 -177944590, -177935992 NM_001190302, NM_001282028 NM_001190302, NM_001282028 9

molecular_function

cellular_component

biological_process

 
TC0100000642.mm.2 Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 1 74713534 NM_024264, BC002183, BC055028 NM_024264, BC002183, BC055028 NM_024264, BC002183, BC055028 69

monooxygenase activity

iron ion binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial envelope

mitochondrial inner membrane

mitochondrial inner membrane

lipid metabolic process

steroid biosynthetic process

bile acid biosynthetic process

cholesterol catabolic process

steroid metabolic process

cholesterol metabolic process

cholesterol metabolic process

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

heme binding

vitamin D3 25-hydroxylase activity

vitamin D3 25-hydroxylase activity

Hsp70 protein binding

cholesterol 26-hydroxylase activity

cholesterol 26-hydroxylase activity

calcitriol biosynthetic process from calciol

calcitriol biosynthetic process from calciol

metal ion binding

cholestanetriol 26-monooxygenase activity

00120

01100

03320

TC0500001380.mm.2 Ppp1cc protein phosphatase 1 catalytic subunit gamma 5 122158274 NM_013636, BC010613, BC021646, BC085496 NM_013636, BC010613, BC021646, BC085496 NM_013636, BC010613, BC021646, BC085496 NM_013636, BC010613, BC021646, BC085496 109

protein phosphatase type 1 complex

chromosome, centromeric region

kinetochore

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

protein serine/threonine phosphatase activity

protein serine/threonine phosphatase activity

protein binding

lamin binding

nucleus

chromosome

cytoplasm

cytoplasm

mitochondrion

mitochondrial outer membrane

carbohydrate metabolic process

glycogen metabolic process

protein dephosphorylation

protein dephosphorylation

protein dephosphorylation

cell cycle

protein C-terminus binding

protein phosphatase 1 binding

hydrolase activity

phosphatase activity

protein phosphatase binding

protein domain specific binding

neuron differentiation

circadian regulation of gene expression

regulation of circadian rhythm

regulation of circadian rhythm

entrainment of circadian clock by photoperiod

dendritic spine

protein-containing complex binding

regulation of nucleocytoplasmic transport

metal ion binding

protein N-terminus binding

rhythmic process

cell division

positive regulation of glial cell proliferation

presynapse

postsynapse

glutamatergic synapse

04114

04270

04510

04720

04810

04910

TC0600000324.mm.2 Akr1b8 aldo-keto reductase family 1, member B8 6 34354145 NM_008012, BC005789 NM_008012, BC005789 23

retinoid metabolic process

retinal dehydrogenase activity

alditol:NADP+ 1-oxidoreductase activity

cytoplasm

mitochondrion

cytosol

alcohol dehydrogenase (NADP+) activity

farnesol catabolic process

oxidoreductase activity

daunorubicin metabolic process

doxorubicin metabolic process

geranylgeranyl reductase activity

indanol dehydrogenase activity

NADP-retinol dehydrogenase activity

cellular detoxification of aldehyde

00040

00051

00052

00561

00620

01100

TC0900001673.mm.2 Ccr3 chemokine (C-C motif) receptor 3 9 124021970 NM_009914, BC108967, BC108968 NM_009914, BC108967, BC108968 NM_009914, BC108967, BC108968 76

positive regulation of endothelial cell proliferation

mast cell chemotaxis

G protein-coupled receptor activity

chemokine receptor activity

protein binding

extracellular space

cytoplasm

endosome

plasma membrane

chemotaxis

inflammatory response

immune response

signal transduction

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

membrane

integral component of membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

C-C chemokine binding

C-C chemokine binding

angioblast cell migration

positive regulation of angiogenesis

positive regulation of angiogenesis

eosinophil chemotaxis

cell chemotaxis

ERK1 and ERK2 cascade

04060

04062

TC1200002242.mm.2 Fbln5 fibulin 5 12 -101746564, -101746564 NM_011812, BC006636 NM_011812, BC006636 75

negative regulation of transcription by RNA polymerase II

integrin binding

calcium ion binding

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

cell adhesion

protein C-terminus binding

negative regulation of angiogenesis

extracellular matrix constituent conferring elasticity

extracellular matrix organization

positive regulation of osteoblast proliferation

protein localization to cell surface

protein homodimerization activity

positive regulation of transcription by RNA polymerase II

secretion

elastic fiber assembly

elastic fiber assembly

elastic fiber assembly

collagen-containing extracellular matrix

collagen-containing extracellular matrix

collagen-containing extracellular matrix

elastic fiber

intramembranous bone growth

regulation of removal of superoxide radicals

 
TC1900000763.mm.2 Pdcd4 programmed cell death 4 19 53903350, 53892230 NM_001168491, NM_001168492, NM_011050, BC055739 NM_001168491, NM_001168492, NM_011050, BC055739 NM_001168491, NM_001168492, NM_011050, BC055739 NM_001168491, NM_001168492, NM_011050, BC055739 88

RNA binding

protein binding

nucleus

nucleus

cytoplasm

cytosol

cytosol

apoptotic process

cell aging

BMP signaling pathway

positive regulation of smooth muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of transcription, DNA-templated

positive regulation of inflammatory response

regulation of protein metabolic process

epithelial to mesenchymal transition involved in cardiac fibroblast development

cellular response to lipopolysaccharide

negative regulation of cytokine production involved in inflammatory response

positive regulation of NIK/NF-kappaB signaling

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of myofibroblast differentiation

negative regulation of vascular associated smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of endothelial cell apoptotic process

 
TC1300001955.mm.2 Susd3 sushi domain containing 3 13 -49230688, -49230688 NM_025491, NM_028340, BC045525 NM_025491, NM_028340, BC045525 NM_025491, NM_028340, BC045525 17

molecular_function

plasma membrane

plasma membrane

biological_process

membrane

integral component of membrane

 
TC0200003401.mm.2 Strbp spermatid perinuclear RNA binding protein 2 -37569867, -37569867, -37569867, -37569867 NM_009261, BC014710 NM_009261, BC014710 32

manchette

RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

nucleus

cytoplasm

cytoskeleton

movement of cell or subcellular component

multicellular organism development

spermatogenesis

spermatid development

mechanosensory behavior

microtubule binding

microtubule cytoskeleton

tubulin binding

cell differentiation

 
TC1200000719.mm.2 Rad51b RAD51 paralog B 12 79297281, 79297350 NM_001252562, NM_009014, BC058184 NM_001252562, NM_009014, BC058184 NM_001252562, NM_009014, BC058184 22

nucleotide binding

four-way junction DNA binding

four-way junction DNA binding

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

in utero embryonic development

in utero embryonic development

blastocyst growth

DNA binding

double-stranded DNA binding

double-stranded DNA binding

single-stranded DNA binding

single-stranded DNA binding

ATP binding

nucleus

replication fork

replication fork

DNA repair

DNA recombination

cellular response to DNA damage stimulus

DNA-dependent ATPase activity

DNA-dependent ATPase activity

positive regulation of cell population proliferation

positive regulation of G2/M transition of mitotic cell cycle

Rad51B-Rad51C-Rad51D-XRCC2 complex

Rad51B-Rad51C-Rad51D-XRCC2 complex

somite development

03440

TC0600002903.mm.2 Rad18 RAD18 E3 ubiquitin protein ligase 6 -112619850, -112619870, -112628175 NM_001167730, NM_021385, BC011120 NM_001167730, NM_021385, BC011120 NM_001167730, NM_021385, BC011120 41

Y-form DNA binding

chromatin

XY body

DNA binding

single-stranded DNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

replication fork

cytoplasm

centrosome

cytoskeleton

DNA repair

postreplication repair

protein monoubiquitination

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

spermatogenesis

response to UV

response to UV

nuclear body

transferase activity

polyubiquitin modification-dependent protein binding

ubiquitin protein ligase binding

site of double-strand break

nuclear inclusion body

identical protein binding

protein-containing complex binding

negative regulation of DNA recombination

metal ion binding

protein autoubiquitination

positive regulation of chromosome segregation

negative regulation of cell death

ubiquitin protein ligase activity

Rad6-Rad18 complex

 
TC0600002858.mm.2 Shq1 SHQ1 homolog (S. cerevisiae) 6 -100571810 NM_181590, BC052657 NM_181590, BC052657 18

box H/ACA snoRNP assembly

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytosol

ribonucleoprotein complex assembly

positive regulation of apoptotic process

unfolded protein binding

negative regulation of rRNA processing

 
TC0500003651.mm.2 Gm8615 glucosamine-6-phosphate deaminase 1 pseudogene 5 -149154127 NR_028061 1    
TC1400000578.mm.2         NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843 NM_001161731, NM_007447, NM_021472, NM_201239, BC005569, BC055355, BC061105, BC066843  

angiogenesis

angiogenesis

response to hypoxia

response to yeast

response to yeast

positive regulation of endothelial cell proliferation

nucleic acid binding

DNA binding

RNA binding

actin binding

nuclease activity

endonuclease activity

ribonuclease activity

ribonuclease activity

ribonuclease activity

signaling receptor binding

copper ion binding

extracellular region

extracellular region

extracellular region

basement membrane

extracellular space

extracellular space

extracellular space

nucleus

chromosome

nucleolus

diacylglycerol biosynthetic process

activation of phospholipase C activity

multicellular organism development

central nervous system development

heparin binding

cellular response to starvation

rRNA transcription

response to hormone

actin cytoskeleton

cell migration

hydrolase activity

negative regulation of translation

antibacterial humoral response

antibacterial humoral response

antibacterial humoral response

antifungal humoral response

antifungal humoral response

cell differentiation

growth cone

cytoplasmic vesicle

activation of protein kinase B activity

angiogenin-PRI complex

activation of phospholipase A2 activity

peptide binding

positive regulation of phosphorylation

protein homodimerization activity

neuronal cell body

innate immune response

innate immune response

innate immune response

negative regulation of smooth muscle cell proliferation

positive regulation of protein secretion

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

RNA phosphodiester bond hydrolysis

 
TC0X00003301.mm.2 Reps2 RALBP1 associated Eps domain containing protein 2 X -162411951, -162411951 NM_178256, BC139012, BC145500 NM_178256, BC139012, BC145500 NM_178256, BC139012, BC145500 19

molecular_function

calcium ion binding

cytoplasm

plasma membrane

endocytosis

endosomal transport

metal ion binding

 
TC0900001908.mm.2 Anln anillin, actin binding protein 9 -22331213 NM_028390, BC030489, BC032164 NM_028390, BC030489, BC032164 NM_028390, BC030489, BC032164 47

mitotic cytokinesis

mitotic cytokinesis

actomyosin contractile ring assembly

hematopoietic progenitor cell differentiation

actin binding

nucleus

nucleoplasm

cytoplasm

actomyosin contractile ring

actomyosin contractile ring

cytoskeleton

cell cycle

actin cytoskeleton

midbody

septin ring organization

bleb

cell projection

cell division

glomerular visceral epithelial cell migration

cell cortex region

positive regulation of bleb assembly

 
TC0100002481.mm.2 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 1 -65158615, -65158615 NM_001111320, NM_010497, BC088986 NM_001111320, NM_010497, BC088986 NM_001111320, NM_010497, BC088986 147

magnesium ion binding

isocitrate dehydrogenase activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

isocitrate dehydrogenase (NADP+) activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

peroxisome

peroxisome

cytosol

cytosol

cytosol

glyoxylate cycle

tricarboxylic acid cycle

isocitrate metabolic process

isocitrate metabolic process

2-oxoglutarate metabolic process

NADP metabolic process

glutathione metabolic process

response to oxidative stress

response to organic cyclic compound

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

identical protein binding

protein homodimerization activity

metal ion binding

response to steroid hormone

NADP binding

NAD binding

regulation of phospholipid catabolic process

regulation of phospholipid biosynthetic process

00020

00480

01100

04146

TC0600002741.mm.2 Mrps25 mitochondrial ribosomal protein S25 6 -92169522 NM_025578, BC022953 NM_025578, BC022953 28

structural constituent of ribosome

structural constituent of ribosome

mitochondrion

mitochondrion

mitochondrion

mitochondrial small ribosomal subunit

ribosome

mitochondrial translation

 
TC1100003693.mm.2 Top2a topoisomerase (DNA) II alpha 11 -98992946 NM_011623 101

nucleotide binding

nuclear chromosome

magnesium ion binding

resolution of meiotic recombination intermediates

chromosome, centromeric region

condensed chromosome

condensed chromosome

sister chromatid segregation

hematopoietic progenitor cell differentiation

DNA binding

chromatin binding

DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

protein kinase C binding

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

cytoplasm

centriole

DNA metabolic process

DNA topological change

DNA topological change

DNA ligation

cellular response to DNA damage stimulus

chromosome segregation

chromosome segregation

chromosome segregation

female meiotic nuclear division

protein C-terminus binding

DNA-dependent ATPase activity

DNA binding, bending

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex

isomerase activity

enzyme binding

chromosome condensation

apoptotic chromosome condensation

apoptotic chromosome condensation

protein-containing complex

embryonic cleavage

regulation of circadian rhythm

protein homodimerization activity

histone deacetylase binding

positive regulation of apoptotic process

ubiquitin binding

sequence-specific DNA binding

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

positive regulation of transcription by RNA polymerase II

metal ion binding

protein heterodimerization activity

rhythmic process

female meiosis chromosome separation

negative regulation of DNA duplex unwinding

ribonucleoprotein complex

 
TC0700000989.mm.2 Snrpa1 small nuclear ribonucleoprotein polypeptide A' 7 66060335 NM_021336, BC013777, BC029642 NM_021336, BC013777, BC029642 NM_021336, BC013777, BC029642 24

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

RNA binding

nucleus

nucleoplasm

spliceosomal complex

U2 snRNP

U2 snRNP

mRNA processing

spermatogenesis

RNA splicing

nuclear body

nuclear speck

U2 snRNA binding

U2-type precatalytic spliceosome

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

03040

TC1000000312.mm.2 Hdac2 histone deacetylase 2 10 36974543 NM_008229, BC138517 NM_008229, BC138517 299

histone deacetylase complex

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

chromatin

heterochromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II repressing transcription factor binding

RNA polymerase II transcription corepressor binding

chromatin binding

histone deacetylase activity

histone deacetylase activity

histone deacetylase activity

histone deacetylase activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

transcription regulator complex

cytoplasm

cytoplasm

chromatin organization

protein deacetylation

transcription factor binding

transcription factor binding

positive regulation of cell population proliferation

positive regulation of cell population proliferation

epidermal cell differentiation

positive regulation of epithelial to mesenchymal transition

negative regulation of neuron projection development

negative regulation of neuron projection development

dendrite development

histone deacetylation

histone deacetylation

Sin3 complex

NuRD complex

hydrolase activity

transcription repressor complex

deacetylase activity

deacetylase activity

enzyme binding

enzyme binding

hippocampus development

neuron differentiation

heat shock protein binding

chromatin DNA binding

NAD-dependent histone deacetylase activity (H3-K14 specific)

positive regulation of interleukin-1 production

positive regulation of tumor necrosis factor production

circadian regulation of gene expression

protein-containing complex

protein deacetylase activity

protein deacetylase activity

histone deacetylase activity (H4-K16 specific)

ESC/E(Z) complex

Krueppel-associated box domain binding

cellular response to trichostatin A

odontogenesis of dentin-containing tooth

positive regulation of tyrosine phosphorylation of STAT protein

embryonic digit morphogenesis

histone deacetylase binding

negative regulation of apoptotic process

negative regulation of DNA binding

negative regulation of DNA-binding transcription factor activity

sequence-specific DNA binding

positive regulation of proteolysis

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

rhythmic process

positive regulation of oligodendrocyte differentiation

positive regulation of oligodendrocyte differentiation

NF-kappaB binding

positive regulation of DNA-binding transcription factor activity

regulation of protein kinase B signaling

cardiac muscle cell development

negative regulation of cardiac muscle cell proliferation

regulation of sarcomere organization

hair follicle placode formation

negative regulation of dendritic spine development

eyelid development in camera-type eye

fungiform papilla formation

cellular response to hydrogen peroxide

histone H3-K27 methylation

heterochromatin maintenance

histone H3 deacetylation

histone H3 deacetylation

histone H3 deacetylation

histone H4 deacetylation

histone H4 deacetylation

negative regulation of canonical Wnt signaling pathway

regulation of protein deacetylation

RNA polymerase II transcription repressor complex

positive regulation of male mating behavior

negative regulation of pri-miRNA transcription by RNA polymerase II

negative regulation of pri-miRNA transcription by RNA polymerase II

promoter-specific chromatin binding

positive regulation of signaling receptor activity

negative regulation of peptidyl-lysine acetylation

negative regulation of intrinsic apoptotic signaling pathway

04110

04330

05016

05200

05220

TC1900001116.mm.2 Tmem109 transmembrane protein 109 19 -10870660 NM_134142, BC022997, BC023901, BC025033, BC025815 NM_134142, BC022997, BC023901, BC025033, BC025815 NM_134142, BC022997, BC023901, BC025033, BC025815 NM_134142, BC022997, BC023901, BC025033, BC025815 NM_134142, BC022997, BC023901, BC025033, BC025815 27

voltage-gated ion channel activity

protein binding

nucleus

endoplasmic reticulum

ion transport

membrane

integral component of membrane

sarcoplasmic reticulum

nuclear membrane

regulation of ion transmembrane transport

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of cell death

negative regulation of cell death

cellular response to gamma radiation

cellular response to gamma radiation

 
TC1700001192.mm.2 Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 17 78937134 NM_028611, BC108350 NM_028611, BC108350 19

mitochondrion

mitochondrion

mitochondrion

methyltransferase activity

transferase activity

enzyme binding

peptidyl-arginine methylation, to symmetrical-dimethyl arginine

methylation

mitochondrial respiratory chain complex I assembly

mitochondrial respiratory chain complex I assembly

protein-arginine omega-N symmetric methyltransferase activity

protein-arginine omega-N symmetric methyltransferase activity

 
TC0800003059.mm.2 Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 8 -121881145 NM_011404, BC026131 NM_011404, BC026131 56

amino acid transmembrane transport

lysosome

cytosol

plasma membrane

amino acid transport

basal plasma membrane

negative regulation of gene expression

amino acid transmembrane transporter activity

aromatic amino acid transmembrane transporter activity

neutral amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-leucine transmembrane transporter activity

L-tryptophan transmembrane transporter activity

thyroid hormone transmembrane transporter activity

L-amino acid transport

phenylalanine transport

membrane

integral component of membrane

basolateral plasma membrane

apical plasma membrane

transmembrane transporter activity

microvillus membrane

positive regulation of interferon-gamma production

positive regulation of interleukin-17 production

positive regulation of interleukin-4 production

xenobiotic transport

intracellular membrane-bounded organelle

transmembrane transport

thyroid hormone transport

amino acid import across plasma membrane

external side of apical plasma membrane

leucine import across plasma membrane

L-leucine import across plasma membrane

L-tryptophan transmembrane transport

amino acid transport complex

 
TC0800001639.mm.2 Shcbp1 Shc SH2-domain binding protein 1 8 -4735975 NM_011369, BC070455 NM_011369, BC070455 24

protein binding

cellular_component

cytoplasm

cytoskeleton

fibroblast growth factor receptor signaling pathway

fibroblast growth factor receptor signaling pathway

SH2 domain binding

regulation of neural precursor cell proliferation

 
TC0800002869.mm.2         NM_026513, NM_139229, BC094654 NM_026513, NM_139229, BC094654 NM_026513, NM_139229, BC094654  

molecular_function

mitochondrion

mitochondrion

Golgi apparatus

intra-Golgi vesicle-mediated transport

positive regulation of cell population proliferation

protein transport

membrane

Golgi transport complex

Golgi transport complex

peptidyl-methionine modification

peptidyl-methionine modification

N-terminal protein amino acid modification

N-terminal protein amino acid modification

peptide deformylase activity

peptide deformylase activity

co-translational protein modification

 
TC0300003113.mm.2 Adgrl2 adhesion G protein-coupled receptor L2 3 -148815585 NM_001081298, BC172691 NM_001081298, BC172691 26

transmembrane signaling receptor activity

G protein-coupled receptor activity

integral component of plasma membrane

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

brain development

response to bacterium

membrane

integral component of membrane

PDZ domain binding

carbohydrate binding

neuron projection

neuron projection

synapse organization

synapse organization

positive regulation of synapse assembly

glutamatergic synapse

glutamatergic synapse

integral component of postsynaptic membrane

integral component of postsynaptic membrane

 
TC0100000447.mm.2 Cdk15 cyclin-dependent kinase 15 1 59256905 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 NM_001033373, BC147314, BC147315, BC147758, BC147763, BC172036 15

regulation of transcription involved in G1/S transition of mitotic cell cycle

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

cyclin-dependent protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

cytosol

protein phosphorylation

kinase activity

phosphorylation

transferase activity

cyclin binding

metal ion binding

 
TC0100002965.mm.2 Steap3 STEAP family member 3 1 -120226413, -120226413, -120226413, -120226413 NM_001085409, NM_133186, BC037435 NM_001085409, NM_133186, BC037435 NM_001085409, NM_133186, BC037435 33

ferric-chelate reductase activity

ferric-chelate reductase activity

protein binding

cytoplasm

endosome

endosome

multivesicular body

plasma membrane

plasma membrane

ion transport

iron ion transport

apoptotic process

cell cycle

cupric reductase activity

cupric reductase activity

protein secretion

protein secretion

copper ion import

copper ion import

copper ion import

membrane

integral component of membrane

oxidoreductase activity

iron import into cell

identical protein binding

positive regulation of apoptotic process

metal ion binding

ferric-chelate reductase (NADPH) activity

ferric-chelate reductase (NADPH) activity

ferric-chelate reductase (NADPH) activity

iron ion homeostasis

iron ion import across cell outer membrane

iron ion import across cell outer membrane

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

exosomal secretion

04115

TC1500000785.mm.2 Parvb parvin, beta 15 84232042 NM_133167, BC138747, BC138748, BC158113 NM_133167, BC138747, BC138748, BC158113 NM_133167, BC138747, BC138748, BC158113 NM_133167, BC138747, BC138748, BC158113 39

actin binding

protein binding

cytoplasm

cytoskeleton

plasma membrane

focal adhesion

focal adhesion

cell adhesion

establishment or maintenance of cell polarity

actin cytoskeleton

membrane

lamellipodium

lamellipodium

cell projection assembly

cell projection assembly

lamellipodium assembly

lamellipodium assembly

cell junction

actin cytoskeleton reorganization

actin cytoskeleton reorganization

substrate adhesion-dependent cell spreading

cell projection

establishment or maintenance of cell polarity regulating cell shape

04510

TC0800001541.mm.2 Urb2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 8 124021496 NM_001029876, BC151125 NM_001029876, BC151125 13

molecular_function

nucleolus

nucleolus

aggresome

midbody

ribosome biogenesis

 
TC1500001933.mm.2 Polr3h polymerase (RNA) III (DNA directed) polypeptide H 15 -81915029 NM_030229, BC010793 NM_030229, BC010793 23

immune system process

DNA binding

DNA-directed 5'-3' RNA polymerase activity

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase III complex

RNA polymerase III complex

centrosome

nucleobase-containing compound metabolic process

transcription, DNA-templated

transcription by RNA polymerase III

transcription initiation from RNA polymerase III promoter

intracellular membrane-bounded organelle

innate immune response

defense response to virus

00230

00240

01100

03020

04623

TC0200000391.mm.2 Zmynd19 zinc finger, MYND domain containing 19 2 24949776, 24950157 NM_026021, BC027321 NM_026021, BC027321 26

molecular_function

cytoplasm

plasma membrane

biological_process

membrane

synapse

metal ion binding

 
TC0X00002165.mm.2 Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 X -48474943 NM_012019, BC003292 NM_012019, BC003292 149

DNA binding

DNA binding

electron-transferring-flavoprotein dehydrogenase activity

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

mitochondrial intermembrane space

mitochondrial intermembrane space

cytosol

cytosol

cytosol

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

response to oxidative stress

apoptotic mitochondrial changes

positive regulation of cell death

membrane

NAD(P)H oxidase H2O2-forming activity

NAD(P)H oxidase H2O2-forming activity

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H

neuron differentiation

mitochondrial respiratory chain complex I assembly

mitochondrial respiratory chain complex assembly

mitochondrial respiratory chain complex assembly

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

protein import into mitochondrial intermembrane space

protein import into mitochondrial intermembrane space

protein dimerization activity

flavin adenine dinucleotide binding

neuron apoptotic process

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

FAD binding

FAD binding

regulation of apoptotic DNA fragmentation

04210

TC0100001711.mm.2         NM_007415, NR_105869, BC012041 NM_007415, NR_105869, BC012041 NM_007415, NR_105869, BC012041  

telomere maintenance

DNA binding

chromatin binding

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

protein binding

nucleus

nucleus

nucleus

nuclear envelope

nucleoplasm

nucleoplasm

transcription regulator complex

chromosome

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

mitochondrion

DNA metabolic process

DNA repair

base-excision repair

double-strand break repair

double-strand break repair

double-strand break repair

protein ADP-ribosylation

apoptotic process

cellular response to DNA damage stimulus

mitochondrion organization

mitochondrion organization

transforming growth factor beta receptor signaling pathway

transcription factor binding

zinc ion binding

positive regulation of cardiac muscle hypertrophy

regulation of SMAD protein complex assembly

protein autoprocessing

nuclear body

transferase activity

transferase activity, transferring glycosyl groups

peptidyl-serine ADP-ribosylation

peptidyl-glutamic acid poly-ADP-ribosylation

enzyme binding

protein kinase binding

signal transduction involved in regulation of gene expression

estrogen receptor binding

DNA ADP-ribosylation

mitochondrial DNA metabolic process

negative regulation of interleukin-17 production

cellular response to insulin stimulus

protein-containing complex

protein-containing complex

protein-DNA complex

positive regulation of intracellular estrogen receptor signaling pathway

cellular response to oxidative stress

cellular response to UV

site of double-strand break

protein modification process

regulation of growth rate

DNA damage response, detection of DNA damage

identical protein binding

histone deacetylase binding

mitochondrial DNA repair

regulation of DNA methylation

positive regulation of transcription by RNA polymerase II

SMAD binding

metal ion binding

protein N-terminus binding

behavioral response to cocaine

regulation of catalytic activity

voluntary musculoskeletal movement

NAD binding

positive regulation of mitochondrial depolarization

positive regulation of SMAD protein signal transduction

protein poly-ADP-ribosylation

protein poly-ADP-ribosylation

protein poly-ADP-ribosylation

protein auto-ADP-ribosylation

R-SMAD binding

cellular response to superoxide

cellular response to transforming growth factor beta stimulus

site of DNA damage

NAD DNA ADP-ribosyltransferase activity

positive regulation of protein localization to nucleus

positive regulation of neuron death

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of single strand break repair

positive regulation of single strand break repair

positive regulation of single strand break repair

regulation of cellular protein localization

negative regulation of telomere maintenance via telomere lengthening

cellular response to amyloid-beta

positive regulation of myofibroblast differentiation

positive regulation of double-strand break repair via homologous recombination

protein ADP-ribosylase activity

protein ADP-ribosylase activity

protein ADP-ribosylase activity

ATP generation from poly-ADP-D-ribose

positive regulation of transcription regulatory region DNA binding

negative regulation of ATP biosynthetic process

 
TC0100001855.mm.2 Lpgat1 lysophosphatidylglycerol acyltransferase 1 1 191718023, 191718394 NM_001134829, NM_172266, BC013667 NM_001134829, NM_172266, BC013667 NM_001134829, NM_172266, BC013667 17

2-acylglycerol O-acyltransferase activity

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

phospholipid biosynthetic process

endomembrane system

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

triglyceride biosynthetic process

phosphatidylinositol acyl-chain remodeling

positive regulation of fatty acid biosynthetic process

lysophospholipid acyltransferase activity

00564

TC1900000216.mm.2         XM_986941      
TC1500001742.mm.2 Top1mt DNA topoisomerase 1, mitochondrial 15 -75657032 NM_028404, BC138582, BC138583, BC145336 NM_028404, BC138582, BC138583, BC145336 NM_028404, BC138582, BC138583, BC145336 NM_028404, BC138582, BC138583, BC145336 21

DNA binding

DNA topoisomerase activity

DNA topoisomerase type I (single strand cut, ATP-independent) activity

nucleoplasm

chromosome

mitochondrion

mitochondrion

DNA replication

DNA topological change

isomerase activity

mitochondrial nucleoid

mitochondrial nucleoid

 
TC1400002621.mm.2 Tbc1d4 TBC1 domain family, member 4 14 -101442359 NM_001081278, BC117869, BC117870 NM_001081278, BC117869, BC117870 NM_001081278, BC117869, BC117870 73

GTPase activator activity

protein binding

cytoplasm

cytosol

intracellular protein transport

vesicle-mediated transport

cytoplasmic vesicle membrane

negative regulation of vesicle fusion

vesicle

cellular response to insulin stimulus

activation of GTPase activity

 
TC0700002102.mm.2 Dhcr7 7-dehydrocholesterol reductase 7 143830213, 143823166, 143823398 NM_007856, BC006854 NM_007856, BC006854 56

blood vessel development

nuclear outer membrane

endoplasmic reticulum

lipid metabolic process

steroid biosynthetic process

cholesterol biosynthetic process

cholesterol biosynthetic process

steroid metabolic process

cholesterol metabolic process

post-embryonic development

sterol delta7 reductase activity

membrane

integral component of membrane

sterol biosynthetic process

sterol biosynthetic process

brassinosteroid biosynthetic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

cell differentiation

integral component of endoplasmic reticulum membrane

lung development

multicellular organism growth

regulation of cell population proliferation

intracellular membrane-bounded organelle

regulation of cholesterol biosynthetic process

7-dehydrocholesterol reductase activity

7-dehydrocholesterol reductase activity

7-dehydrocholesterol reductase activity

00100

01100

TC1000002175.mm.2 Man1a mannosidase 1, alpha 10 -53904784 NM_008548, BC015265 NM_008548, BC015265 30

Golgi membrane

Golgi membrane

catalytic activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

Golgi apparatus

cytosol

N-glycan processing

metabolic process

membrane

integral component of membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

ubiquitin-dependent ERAD pathway

cytoplasmic vesicle

protein targeting to ER

metal ion binding

mannose trimming involved in glycoprotein ERAD pathway

00510

01100

04141

TC0500000971.mm.2 Enoph1 enolase-phosphatase 1 5 100039993 NM_001163035, NM_026421, NR_027990, BC021429 NM_001163035, NM_026421, NR_027990, BC021429 NM_001163035, NM_026421, NR_027990, BC021429 NM_001163035, NM_026421, NR_027990, BC021429 26

magnesium ion binding

nucleus

cytoplasm

cellular amino acid biosynthetic process

methionine biosynthetic process

hydrolase activity

L-methionine salvage from methylthioadenosine

L-methionine salvage from methylthioadenosine

acireductone synthase activity

acireductone synthase activity

metal ion binding

00270

TC1500000736.mm.2 Xrcc6 X-ray repair complementing defective repair in Chinese hamster cells 6 15 82016368 NM_010247, BC031422 NM_010247, BC031422 137

nucleotide binding

telomere maintenance

transcription regulatory region sequence-specific DNA binding

activation of innate immune response

immune system process

DNA binding

DNA helicase activity

damaged DNA binding

double-stranded DNA binding

double-stranded DNA binding

double-stranded DNA binding

double-stranded telomeric DNA binding

catalytic activity

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

transcription regulator complex

chromosome

nucleolus

cytoplasm

cytoplasm

DNA repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

DNA recombination

cellular response to DNA damage stimulus

protein C-terminus binding

DNA-dependent ATPase activity

metabolic process

response to ionizing radiation

hydrolase activity

lyase activity

cyclin binding

protein-containing complex

protein-DNA complex

V(D)J recombination

telomeric DNA binding

Ku70:Ku80 complex

Ku70:Ku80 complex

protein-containing complex binding

DNA end binding

innate immune response

positive regulation of lymphocyte differentiation

positive regulation of protein kinase activity

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of smooth muscle cell proliferation

positive regulation of neurogenesis

5'-deoxyribose-5-phosphate lyase activity

nonhomologous end joining complex

cellular hyperosmotic salinity response

cellular response to gamma radiation

cellular response to gamma radiation

cellular response to X-ray

cellular response to X-ray

double-strand break repair via classical nonhomologous end joining

03450

MG-1-pos-10338344_st                
MG-1-pos-10343581_st                
TC0100003416.mm.2 BC055324 cDNA sequence BC055324 1 -163954005, -163945992 NM_201364, BC052855, BC055324 NM_201364, BC052855, BC055324 NM_201364, BC052855, BC055324 15

molecular_function

cellular_component

biological_process

 
TC0900002942.mm.2 Pccb propionyl Coenzyme A carboxylase, beta polypeptide 9 -100982031 NM_025835, BC037082, BC055946 NM_025835, BC037082, BC055946 NM_025835, BC037082, BC055946 20

nucleotide binding

propionyl-CoA carboxylase activity

propionyl-CoA carboxylase activity

ATP binding

mitochondrion

mitochondrial matrix

ligase activity

00280

00630

00640

01100

TC1400002863.mm.2 Ipo4 importin 4 14 -55625399 NM_024267, BC003469, BC085150 NM_024267, BC003469, BC085150 NM_024267, BC003469, BC085150 25

chromatin

protein binding

nucleus

cytoplasm

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

protein import into nucleus

protein import into nucleus

intracellular protein transport

nuclear localization sequence binding

protein transport

small GTPase binding

protein-containing complex

ribosome biogenesis

nuclear import signal receptor activity

 
TC0700001951.mm.2 Dock1 dedicator of cytokinesis 1 7 134670686 NM_001033420 46

hematopoietic progenitor cell differentiation

guanyl-nucleotide exchange factor activity

GTPase activator activity

protein binding

nucleoplasm

cytoplasm

cytosol

phagocytosis

apoptotic process

cytoskeleton organization

small GTPase mediated signal transduction

positive regulation of epithelial cell migration

membrane

cell migration

nuclear speck

SH3 domain binding

guanyl-nucleotide exchange factor complex

positive regulation of substrate adhesion-dependent cell spreading

04510

04810

05100

TC0700000289.mm.2 Snrpd2 small nuclear ribonucleoprotein D2 7 19149837 NM_026943, BC043014, BC051208, BC116858, BC116860 NM_026943, BC043014, BC051208, BC116858, BC116860 NM_026943, BC043014, BC051208, BC116858, BC116860 NM_026943, BC043014, BC051208, BC116858, BC116860 NM_026943, BC043014, BC051208, BC116858, BC116860 30

spliceosomal snRNP assembly

spliceosomal snRNP assembly

mRNA splicing, via spliceosome

nucleus

spliceosomal complex

U5 snRNP

U1 snRNP

U1 snRNP

U2 snRNP

U4 snRNP

U12-type spliceosomal complex

cytoplasm

cytosol

mRNA processing

RNA splicing

small nuclear ribonucleoprotein complex

methylosome

pICln-Sm protein complex

SMN-Sm protein complex

U4/U6 x U5 tri-snRNP complex

U4/U6 x U5 tri-snRNP complex

U2-type precatalytic spliceosome

U2-type catalytic step 2 spliceosome

precatalytic spliceosome

catalytic step 2 spliceosome

catalytic step 2 spliceosome

U1 snRNP binding

03040

TC0100000297.mm.2 Il1rl2 interleukin 1 receptor-like 2 1 40324588 NM_133193, BC117797 NM_133193, BC117797 33

immune system process

cytokine receptor activity

interleukin-1 receptor activity

interleukin-1, type I, activating receptor activity

cellular_component

inflammatory response

signal transduction

membrane

integral component of membrane

hydrolase activity

positive regulation of interleukin-6 production

innate immune response

positive regulation of T cell differentiation

NAD(P)+ nucleosidase activity

regulation of inflammatory response

regulation of inflammatory response

NAD+ nucleotidase, cyclic ADP-ribose generating

 
TC1100000475.mm.2 Havcr2 hepatitis A virus cellular receptor 2 11 46454930 NM_134250, BC106851, BC106852 NM_134250, BC106851, BC106852 NM_134250, BC106851, BC106852 137

immunological synapse

positive regulation of cytokine production

adaptive immune response

macrophage activation involved in immune response

immune system process

natural killer cell tolerance induction

regulation of tolerance induction dependent upon immune response

negative regulation of T-helper 1 type immune response

negative regulation of immune response to tumor cell

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

protein binding

extracellular region

early endosome

plasma membrane

inflammatory response

cell surface

cell surface

negative regulation of gene expression

membrane

integral component of membrane

cell junction

negative regulation of myeloid dendritic cell activation

negative regulation of NF-kappaB transcription factor activity

negative regulation of type I interferon production

negative regulation of interferon-alpha production

negative regulation of interferon-gamma production

negative regulation of interferon-gamma production

negative regulation of interleukin-2 production

negative regulation of interleukin-2 production

negative regulation of interleukin-3 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

positive regulation of chemokine production

positive regulation of interferon-gamma production

positive regulation of interleukin-1 production

positive regulation of interleukin-4 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

negative regulation of natural killer cell activation

toll-like receptor 3 signaling pathway

toll-like receptor 7 signaling pathway

toll-like receptor 9 signaling pathway

positive regulation of T cell proliferation

negative regulation of T cell proliferation

positive regulation of macrophage activation

innate immune response

positive regulation of innate immune response

negative regulation of innate immune response

metal ion binding

defense response to Gram-positive bacterium

maternal process involved in female pregnancy

maternal process involved in female pregnancy

positive regulation of ERK1 and ERK2 cascade

cellular response to lipopolysaccharide

negative regulation of granulocyte colony-stimulating factor production

negative regulation of defense response to bacterium

positive regulation of defense response to bacterium

positive regulation of NIK/NF-kappaB signaling

negative regulation of immunological synapse formation

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

 
TC0600001400.mm.2 Clec4b1 C-type lectin domain family 4, member b1 6 123049961 NM_001190310, NM_027218, BC146521 NM_001190310, NM_027218, BC146521 NM_001190310, NM_027218, BC146521 15

positive regulation of release of sequestered calcium ion into cytosol

 
TC1100002102.mm.2 Slc35e4 solute carrier family 35, member E4 11 -3907021 NM_153142, BC020181 NM_153142, BC020181 13

Golgi apparatus

antiporter activity

membrane

integral component of membrane

 
TC0100000471.mm.2 Abi2 abl interactor 2 1 60409618 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 NM_001198570, NM_001198571, NM_198127, BC056345, BC079545, BC079646 33

cytoplasm

cytosol

cytoskeleton

actin filament

adherens junction

adherens junction

nervous system development

learning or memory

actin polymerization or depolymerization

positive regulation of lamellipodium assembly

dendrite development

cell migration

Rac protein signal transduction

SH3 domain binding

SH3 domain binding

peptidyl-tyrosine phosphorylation

lamellipodium

lamellipodium

cell junction

dendrite

SCAR complex

small GTPase binding

ubiquitin protein ligase binding

filopodium tip

signaling adaptor activity

identical protein binding

cell projection

camera-type eye development

dendritic spine

zonula adherens assembly

synapse

regulation of dendritic spine morphogenesis

proline-rich region binding

lens fiber cell morphogenesis

postsynaptic actin cytoskeleton

postsynaptic actin cytoskeleton

postsynaptic actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

glutamatergic synapse

glutamatergic synapse

positive regulation of Arp2/3 complex-mediated actin nucleation

04810

TC1100000053.mm.2 Nipsnap1 nipsnap homolog 1 11 4873950 NM_008698, BC010837 NM_008698, BC010837 28

protein binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

membrane

sensory perception of pain

sensory perception of pain

neurotransmitter binding

synaptic membrane

 
TC1300000247.mm.2 H3c7 H3 clustered histone 7 13 23544051 NM_013548, BC101954, BC101955, BC101956, BC103549 NM_013548, BC101954, BC101955, BC101956, BC103549 NM_013548, BC101954, BC101955, BC101956, BC103549 NM_013548, BC101954, BC101955, BC101956, BC103549 NM_013548, BC101954, BC101955, BC101956, BC103549 55

nucleosome

nucleus

nucleus

nucleosome assembly

05322

TC1300001645.mm.2 H4c1 H4 clustered histone 1 13 -23760794 NM_178192, BC119241, BC119243 NM_178192, BC119241, BC119243 NM_178192, BC119241, BC119243 25

nuclear chromosome

nucleosome

nucleus

nucleosome assembly

DNA replication-dependent nucleosome assembly

DNA replication-independent nucleosome assembly

protein domain specific binding

protein-containing complex

negative regulation of megakaryocyte differentiation

05322

TC0800001917.mm.2 Ddhd2 DDHD domain containing 2 8 -25725323, -25725323 NM_028102, BC118962 NM_028102, BC118962 22

phospholipase activity

triglyceride lipase activity

triglyceride lipase activity

triglyceride lipase activity

cytoplasm

Golgi apparatus

cytosol

lipid metabolic process

locomotory behavior

visual learning

membrane

membrane

lipid catabolic process

hydrolase activity

triglyceride catabolic process

COPII-coated ER to Golgi transport vesicle

lipid droplet organization

centriolar satellite

metal ion binding

positive regulation of mitochondrial fission

 
TC0X00003371.mm.2 Msl3 MSL complex subunit 3 X -168651266, -168651266 NM_010832, BC010226 NM_010832, BC010226 22

histone acetyltransferase complex

DNA binding

nucleus

chromatin organization

chromatin silencing

regulation of transcription, DNA-templated

histone acetylation

histone deacetylation

methylated histone binding

NuA4 histone acetyltransferase complex

histone H4 acetylation

histone H2A acetylation

histone H4-K16 acetylation

histone H4-K16 acetylation

histone acetyltransferase activity (H4-K16 specific)

MSL complex

MSL complex

 
TC0400002549.mm.2 Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 4 -44034074, -44034074 NM_001190414, NM_015828, BC015277, BC051254 NM_001190414, NM_015828, BC015277, BC051254 NM_001190414, NM_015828, BC015277, BC051254 NM_001190414, NM_015828, BC015277, BC051254 49

nucleotide binding

catalytic activity

hydrolase activity, hydrolyzing O-glycosyl compounds

ATP binding

cytoplasm

cytosol

UDP-N-acetylglucosamine metabolic process

N-acetylneuraminate metabolic process

metabolic process

UDP-N-acetylglucosamine 2-epimerase activity

UDP-N-acetylglucosamine 2-epimerase activity

N-acylmannosamine kinase activity

N-acylmannosamine kinase activity

kinase activity

phosphorylation

transferase activity

hydrolase activity

metal ion binding

00520

01100

TC0300001047.mm.2 Bcas2 breast carcinoma amplified sequence 2 3 103171654 NM_026602, BC023382, BC037062 NM_026602, BC023382, BC037062 NM_026602, BC023382, BC037062 25

mRNA splicing, via spliceosome

Prp19 complex

molecular_function

nucleus

DNA replication factor A complex

spliceosomal complex

centrosome

mRNA processing

RNA splicing

nuclear speck

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

03040

TC1000002727.mm.2 Mrpl42 mitochondrial ribosomal protein L42 10 -95480804 NM_026065, BC024337 NM_026065, BC024337 20

mitochondrion

mitochondrion

mitochondrial large ribosomal subunit

mitochondrial large ribosomal subunit

mitochondrial small ribosomal subunit

ribosome

plasma membrane

biological_process

 
TC1700002541.mm.2 Fam98a family with sequence similarity 98, member A 17 -75537084, -75537085 NM_133747, BC004626 NM_133747, BC004626 26

protein binding

protein methylation

protein methyltransferase activity

positive regulation of cell population proliferation

positive regulation of gene expression

lysosome localization

tRNA-splicing ligase complex

positive regulation of ruffle assembly

 
TC1100000609.mm.2 Kif3a kinesin family member 3A 11 53567368 NM_008443, BC052707 NM_008443, BC052707 175

nucleotide binding

in utero embryonic development

kidney development

heart looping

cilium movement

microtubule motor activity

protein binding

ATP binding

cytoplasm

centrosome

centriole

centriole

cytosol

cytoskeleton

kinesin complex

microtubule

spindle microtubule

cilium

axoneme

microtubule-based movement

smoothened signaling pathway

determination of left/right symmetry

heart development

microtubule binding

microtubule binding

anterograde axonal transport

epidermis development

anterior/posterior pattern specification

dorsal/ventral pattern formation

centriole-centriole cohesion

protein transport

microtubule cytoskeleton

ATPase activity

kinesin II complex

kinesin II complex

kinesin binding

protein phosphatase binding

dentate gyrus development

dorsal/ventral neural tube patterning

dorsal/ventral neural tube patterning

neural tube development

cell projection organization

spectrin binding

forebrain development

small GTPase binding

motile cilium

photoreceptor connecting cilium

microtubule anchoring at centrosome

epidermal stem cell homeostasis

cell projection

neuron projection

neuronal cell body

motile cilium assembly

protein-containing complex binding

positive regulation of receptor-mediated endocytosis

positive regulation of epithelial cell proliferation

inner ear receptor cell stereocilium organization

cilium assembly

cilium assembly

neural precursor cell proliferation

positive regulation of intracellular protein transport

ribbon synapse

intraciliary transport particle B binding

protein localization to cell junction

axon cytoplasm

positive regulation of axo-dendritic protein transport

non-motile cilium assembly

positive regulation of establishment or maintenance of cell polarity regulating cell shape

 
TC1300000330.mm.2 Mboat1 membrane bound O-acyltransferase domain containing 1 13 30136489 NM_153546, BC023845, BC024653 NM_153546, BC023845, BC024653 NM_153546, BC023845, BC024653 18

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

phospholipid biosynthetic process

regulation of neuron projection development

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

lipid modification

phosphatidylserine acyl-chain remodeling

phosphatidylethanolamine acyl-chain remodeling

1-acylglycerophosphocholine O-acyltransferase activity

1-acylglycerophosphoethanolamine O-acyltransferase activity

1-acylglycerophosphoethanolamine O-acyltransferase activity

1-acylglycerophosphoserine O-acyltransferase activity

00561

00564

01100

TC1400002524.mm.2                
TC0100002866.mm.2 Pam peptidylglycine alpha-amidating monooxygenase 1 -97821093, -97821093 NM_013626, BC166013 NM_013626, BC166013 51

peptide amidation

long-chain fatty acid metabolic process

catalytic activity

monooxygenase activity

peptidylglycine monooxygenase activity

peptidylglycine monooxygenase activity

peptidylglycine monooxygenase activity

peptidylamidoglycolate lyase activity

copper ion binding

calcium ion binding

extracellular region

extracellular space

trans-Golgi network

cytosol

plasma membrane

integral component of plasma membrane

regulation of transcription by RNA polymerase II

peptide metabolic process

peptide metabolic process

metabolic process

zinc ion binding

response to pH

toxin metabolic process

cell surface

response to zinc ion

membrane

integral component of membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

lyase activity

protein amidation

protein metabolic process

protein kinase binding

secretory granule

secretory granule membrane

cytoplasmic vesicle

L-ascorbic acid binding

regulation of actin cytoskeleton organization

response to drug

identical protein binding

neuron projection

neuronal cell body

perikaryon

metal ion binding

perinuclear region of cytoplasm

regulation of protein secretion

fatty acid primary amide biosynthetic process

 
TC0200004366.mm.2 Arhgap11a Rho GTPase activating protein 11A 2 -113831491 NM_181416, BC050875 NM_181416, BC050875 18

GTPase activator activity

signal transduction

 
TC0200001886.mm.2 Eid1 EP300 interacting inhibitor of differentiation 1 2 125673099 NM_025613, BC160331, EP300 NM_025613, BC160331, EP300 NM_025613, BC160331, EP300 29

negative regulation of transcription by RNA polymerase II

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cell cycle

cell differentiation

histone acetyltransferase regulator activity

histone acetyltransferase binding

regulation of histone acetylation

cytoplasmic ribonucleoprotein granule

regulation of cell differentiation

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

 
TC0300000714.mm.2 Iqgap3 IQ motif containing GTPase activating protein 3 3 88082050 NM_001033484, BC151102, BC172704 NM_001033484, BC151102, BC172704 NM_001033484, BC151102, BC172704 20

G1/S transition of mitotic cell cycle

activation of MAPK activity

positive regulation of protein phosphorylation

GTPase activator activity

protein binding

calmodulin binding

calmodulin binding

cytoplasm

cytoplasm

cell-cell junction

Ras protein signal transduction

regulation of cell size

positive regulation of gene expression

negative regulation of gene expression

lateral plasma membrane

small GTPase binding

regulation of actin cytoskeleton organization

positive regulation of mammary gland epithelial cell proliferation

actin filament binding

ERK1 and ERK2 cascade

myosin VI light chain binding

cellular response to organic substance

04810

TC1400002025.mm.2 Supt16 SPT16, facilitates chromatin remodeling subunit 14 -52160418 NM_033618 43

nucleus

nucleoplasm

chromosome

DNA replication

DNA repair

transcription elongation from RNA polymerase II promoter

cellular response to DNA damage stimulus

nucleosome binding

positive regulation of transcription elongation from RNA polymerase II promoter

DNA replication-independent nucleosome organization

FACT complex

 
TC0800001436.mm.2 6430548M08Rik RIKEN cDNA 6430548M08 gene 8 120114151, 120114151, 120144928 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 NM_001163760, NM_001163761, NM_001163762, NM_172286, BC027126 15

molecular_function

cellular_component

biological_process

 
TC0X00002053.mm.2 Septin6 septin 6 X -36911271, -36913443 NM_001177323, NM_001177324, NM_001253706, NM_019942, BC010489 NM_001177323, NM_001177324, NM_001253706, NM_019942, BC010489 NM_001177323, NM_001177324, NM_001253706, NM_019942, BC010489 NM_001177323, NM_001177324, NM_001253706, NM_019942, BC010489 NM_001177323, NM_001177324, NM_001253706, NM_019942, BC010489 56

nucleotide binding

chromosome, centromeric region

kinetochore

GTPase activity

protein binding

GTP binding

chromosome

cytoplasm

cytoskeleton

cilium

septin ring

septin ring

cell cycle

spermatogenesis

synaptic vesicle

microtubule cytoskeleton

cell differentiation

septin complex

septin complex

septin complex

motile cilium

cell division site

cleavage furrow

septin collar

cellular protein localization

cell projection

axon terminus

cell division

molecular adaptor activity

cilium assembly

cytoskeleton-dependent cytokinesis

sperm annulus

presynapse

 
TC0900001623.mm.2 Ss18l2 SS18, nBAF chromatin remodeling complex subunit like 2 9 121710388 NM_026794, BC027548 NM_026794, BC027548 17

molecular_function

transcription coactivator activity

nucleus

positive regulation of transcription by RNA polymerase II

positive regulation of dendrite morphogenesis

 
TC0500000286.mm.2 Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta 5 30155252 NM_001289798, NM_001289799, NM_145558, BC005585 NM_001289798, NM_001289799, NM_145558, BC005585 NM_001289798, NM_001289799, NM_145558, BC005585 NM_001289798, NM_001289799, NM_145558, BC005585 40

catalytic activity

acetyl-CoA C-acyltransferase activity

acetyl-CoA C-acyltransferase activity

acetyl-CoA C-acyltransferase activity

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

mitochondrial inner membrane

endoplasmic reticulum

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation

fatty acid beta-oxidation

membrane

mitochondrial fatty acid beta-oxidation multienzyme complex

mitochondrial fatty acid beta-oxidation multienzyme complex

transferase activity

transferase activity, transferring acyl groups

transferase activity, transferring acyl groups other than amino-acyl groups

mitochondrial nucleoid

protein-containing complex binding

acetyl-CoA C-myristoyltransferase activity

00062

00071

00280

01100

TC0900002036.mm.2 Chek1 checkpoint kinase 1 9 -36708481 NM_007691, BC100386 NM_007691, BC100386 117

DNA damage checkpoint

DNA damage checkpoint

DNA damage checkpoint

G2/M transition of mitotic cell cycle

nucleotide binding

chromosome, telomeric region

chromatin

condensed nuclear chromosome

inner cell mass cell proliferation

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

replication fork

chromosome

cytoplasm

cytoplasm

centrosome

cytoskeleton

DNA repair

DNA repair

protein phosphorylation

protein phosphorylation

protein phosphorylation

apoptotic process

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

DNA damage induced protein phosphorylation

nucleus organization

cell cycle

mitotic cell cycle checkpoint

regulation of gene expression

regulation of double-strand break repair via homologous recombination

regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

negative regulation of G2/M transition of mitotic cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-threonine phosphorylation

protein domain specific binding

protein-containing complex

histone kinase activity (H3-T11 specific)

histone kinase activity (H3-T11 specific)

intracellular signal transduction

regulation of cell population proliferation

intracellular membrane-bounded organelle

mitotic G2/M transition checkpoint

positive regulation of cell cycle

negative regulation of mitotic nuclear division

regulation of mitotic centrosome separation

chromatin-mediated maintenance of transcription

signal transduction involved in G2 DNA damage checkpoint

apoptotic process involved in development

negative regulation of DNA biosynthetic process

regulation of histone H3-K9 acetylation

04110

04115

TC1500001192.mm.2 Skp2 S-phase kinase-associated protein 2 15 -9111981, -9111981 NM_001285980, NM_013787, BC092236, NM_145468 NM_001285980, NM_013787, BC092236, NM_145468 NM_001285980, NM_013787, BC092236, NM_145468 NM_001285980, NM_013787, BC092236, NM_145468 133

G1/S transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

protein polyubiquitination

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

cytosol

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

positive regulation of intracellular estrogen receptor signaling pathway

identical protein binding

regulation of apoptotic process

proteasome-mediated ubiquitin-dependent protein catabolic process

innate immune response

positive regulation of smooth muscle cell proliferation

defense response to virus

regulation of cell cycle

regulation of cell cycle

protein K48-linked ubiquitination

positive regulation of protein polyubiquitination

04110

04120

05200

05222

TC1200002002.mm.2 Erh ERH mRNA splicing and mitosis factor 12 -80634020 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 NM_007951, BC083141, BC099476, BC107315, BC107316, BC132421, BC132423 34

osteoblast differentiation

nucleus

methyl-CpG binding

membrane

midbody

methylosome

 
TC0300002916.mm.2 Ap1ar adaptor-related protein complex 1 associated regulatory protein 3 -127807006 NM_145964 20

negative regulation of receptor recycling

endosome

endosome

Golgi apparatus

kinesin binding

kinesin binding

transport vesicle

regulation of Arp2/3 complex-mediated actin nucleation

regulation of Arp2/3 complex-mediated actin nucleation

cellular protein localization

AP-1 adaptor complex binding

AP-1 adaptor complex binding

vesicle targeting, trans-Golgi to endosome

vesicle targeting, trans-Golgi to endosome

Arp2/3 complex binding

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of cell motility

 
TC0400004136.mm.2 Ski ski sarcoma viral oncogene homolog (avian) 4 -155154074 NM_011385, BC068305 NM_011385, BC068305 67

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

neural tube closure

lens morphogenesis in camera-type eye

chromatin binding

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

cytoplasm

centrosome

transcription, DNA-templated

zinc ion binding

negative regulation of cell population proliferation

anterior/posterior axis specification

negative regulation of Schwann cell proliferation

myotube differentiation

myotube differentiation

myotube differentiation

nuclear body

PML body

transcription repressor complex

protein kinase binding

protein domain specific binding

olfactory bulb development

myelination in peripheral nervous system

embryonic limb morphogenesis

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

negative regulation of BMP signaling pathway

negative regulation of BMP signaling pathway

ubiquitin protein ligase binding

negative regulation of activin receptor signaling pathway

protein-containing complex

somatic stem cell population maintenance

identical protein binding

camera-type eye development

positive regulation of DNA binding

nose morphogenesis

negative regulation of osteoblast differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

SMAD binding

SMAD binding

histone deacetylase inhibitor activity

negative regulation of fibroblast proliferation

camera-type eye morphogenesis

skeletal muscle fiber development

roof of mouth development

retina development in camera-type eye

face morphogenesis

bone morphogenesis

SMAD protein signal transduction

repressing transcription factor binding

 
TC1300002198.mm.2 Cdc14b CDC14 cell division cycle 14B 13 -64192544, -64192544 NM_001122989, NM_172587, BC049794, BC057357 NM_001122989, NM_172587, BC049794, BC057357 NM_001122989, NM_172587, BC049794, BC057357 NM_001122989, NM_172587, BC049794, BC057357 26

microtubule cytoskeleton organization

mitotic cell cycle

spindle pole

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleoplasm

nucleolus

nucleolus

cytoplasm

centrosome

DNA repair

protein dephosphorylation

cellular response to DNA damage stimulus

regulation of exit from mitosis

protein tyrosine/serine/threonine phosphatase activity

dephosphorylation

hydrolase activity

phosphatase activity

G2 DNA damage checkpoint

positive regulation of cytokinesis

cilium assembly

mitotic cell cycle arrest

signal transduction involved in G2 DNA damage checkpoint

mitotic spindle

positive regulation of ubiquitin protein ligase activity

04110

TC1000001686.mm.2 Fbxo5 F-box protein 5 10 -5799157 NM_025995, BC053434 NM_025995, BC053434 29

oocyte maturation

oocyte maturation

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

spindle

cytoskeleton

regulation of DNA replication

cell cycle

spindle assembly involved in female meiosis I

regulation of mitotic nuclear division

regulation of mitotic cell cycle

positive regulation of cell population proliferation

positive regulation of G2/M transition of mitotic cell cycle

anaphase-promoting complex binding

vesicle organization

protein kinase binding

negative regulation of DNA endoreduplication

regulation of meiotic nuclear division

positive regulation of osteoblast differentiation

negative regulation of meiotic nuclear division

negative regulation of meiotic nuclear division

negative regulation of mitotic metaphase/anaphase transition

microtubule polymerization

metal ion binding

spindle assembly

cell division

negative regulation of ubiquitin-protein transferase activity

positive regulation of meiosis I

positive regulation of biomineral tissue development

meiotic spindle

negative regulation of ubiquitin protein ligase activity

positive regulation of mesenchymal stem cell migration

ubiquitin ligase inhibitor activity

negative regulation of cellular senescence

negative regulation of response to DNA damage stimulus

04114

TC0100000282.mm.2 Npas2 neuronal PAS domain protein 2 1 39194271 NM_008719, BC109166 NM_008719, BC109166 63

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

cytosol

cytosol

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

cellular response to DNA damage stimulus

circadian rhythm

circadian regulation of gene expression

circadian regulation of gene expression

response to drug

circadian sleep/wake cycle

regulation of circadian rhythm

locomotor rhythm

positive regulation of DNA repair

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

metal ion binding

protein dimerization activity

rhythmic process

response to redox state

response to redox state

Hsp90 protein binding

negative regulation of cell death

CLOCK-BMAL transcription complex

sequence-specific double-stranded DNA binding

positive regulation of behavioral fear response

regulation of response to DNA damage stimulus

04710

TC0700003038.mm.2 Saal1 serum amyloid A-like 1 7 -46686107 NM_030233, BC087944 NM_030233, BC087944 20

molecular_function

nucleus

nucleoplasm

positive regulation of synoviocyte proliferation

 
TC0200001911.mm.2 Stard7 START domain containing 7 2 127270228, 127270228, 127270228 NM_139308, BC017524, BC080747 NM_139308, BC017524, BC080747 NM_139308, BC017524, BC080747 25

myeloid dendritic cell activation

extracellular region

cytoplasm

mitochondrion

inflammatory response

lipid binding

T-helper 2 cell cytokine production

type 2 immune response

establishment of skin barrier

mucociliary clearance

 
TC1300002766.mm.2 Nsun2 NOL1/NOP2/Sun domain family member 2 13 69612015 NM_145354, BC013625 NM_145354, BC013625 49

tRNA binding

RNA methylation

in utero embryonic development

RNA binding

extracellular region

nucleus

nucleolus

cytoplasm

cytoplasm

mitochondrion

cytoskeleton

cell cycle

spermatogenesis

spermatid development

tRNA processing

methyltransferase activity

regulation of mRNA export from nucleus

tRNA (cytosine-5-)-methyltransferase activity

tRNA (cytosine-5-)-methyltransferase activity

tRNA (cytosine-5-)-methyltransferase activity

tRNA (cytosine-5-)-methyltransferase activity

transferase activity

cell differentiation

tRNA methylation

tRNA methylation

tRNA methylation

tRNA methylation

methylation

meiotic cell cycle checkpoint

chromatoid body

tRNA stabilization

hair follicle maturation

cell division

mRNA (cytidine-5-)-methyltransferase activity

mRNA (cytidine-5-)-methyltransferase activity

extracellular exosome

mRNA methylation

mRNA methylation

regulation of stem cell differentiation

 
TC0800001863.mm.2 Ckap2 cytoskeleton associated protein 2 8 -22168151 NM_001004140, BC145666, BC146023 NM_001004140, BC145666, BC146023 NM_001004140, BC145666, BC146023 26

mitotic cytokinesis

molecular_function

cytoplasm

centrosome

cytosol

cytoskeleton

microtubule

apoptotic process

negative regulation of microtubule depolymerization

cell cycle

microtubule cytoskeleton

microtubule cytoskeleton

positive regulation of transcription by RNA polymerase II

 
TC1400001671.mm.2 Stab1 stabilin 1 14 -31139016 NM_138672 42

low-density lipoprotein particle receptor activity

scavenger receptor activity

calcium ion binding

hyaluronic acid binding

cytoplasm

integral component of plasma membrane

inflammatory response

cell adhesion

cell-cell signaling

membrane

integral component of membrane

negative regulation of angiogenesis

low-density lipoprotein particle binding

defense response to bacterium

 
TC1000000047.mm.2 Nup43 nucleoporin 43 10 7667503 NM_145706, BC011060 NM_145706, BC011060 16

chromosome, centromeric region

kinetochore

molecular_function

nucleus

nuclear pore

nucleoplasm

chromosome

cytosol

cell cycle

chromosome segregation

protein transport

nuclear speck

nuclear pore outer ring

nuclear pore outer ring

mRNA transport

cell division

03013

TC0X00000958.mm.2 Kif4 kinesin family member 4 X 100626064 NM_008446, BC050946 NM_008446, BC050946 43

nucleotide binding

mitotic cytokinesis

DNA binding

microtubule motor activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

cytoskeleton

microtubule

microtubule-based movement

mitotic spindle organization

microtubule binding

midbody

metal ion binding

mitotic spindle midzone assembly

iron-sulfur cluster binding

 
TC0700002056.mm.2 Tspan4 tetraspanin 4 7 141476379, 141475235 NM_001252588, NM_053082, BC003482, BC083070 NM_001252588, NM_053082, BC003482, BC083070 NM_001252588, NM_053082, BC003482, BC083070 NM_001252588, NM_053082, BC003482, BC083070 24

antigen binding

integrin binding

protein binding

plasma membrane

integral component of plasma membrane

membrane

integral component of membrane

vesicle

protein-containing complex assembly

 
TC0X00002825.mm.2 Magt1 magnesium transporter 1 X -105968084 NM_001190409, NM_025952, BC003881 NM_001190409, NM_025952, BC003881 NM_001190409, NM_025952, BC003881 22

endoplasmic reticulum

plasma membrane

protein N-linked glycosylation

oligosaccharyltransferase complex

oligosaccharyltransferase complex

magnesium ion transmembrane transporter activity

magnesium ion transport

membrane

integral component of membrane

protein N-linked glycosylation via asparagine

protein N-linked glycosylation via asparagine

cognition

 
TC0400003742.mm.2 Man1c1 mannosidase, alpha, class 1C, member 1 4 -134561689 NM_207237, BC067023 NM_207237, BC067023 15

Golgi membrane

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

calcium ion binding

endoplasmic reticulum

Golgi apparatus

mannose metabolic process

N-glycan processing

proteoglycan biosynthetic process

00510

01100

04141

TC0100000399.mm.2 Mars2 methionine-tRNA synthetase 2 (mitochondrial) 1 55237176 NM_175439, BC099669, BC132343, BC137739 NM_175439, BC099669, BC132343, BC137739 NM_175439, BC099669, BC132343, BC137739 NM_175439, BC099669, BC132343, BC137739 20

nucleotide binding

aminoacyl-tRNA ligase activity

methionine-tRNA ligase activity

methionine-tRNA ligase activity

ATP binding

mitochondrion

mitochondrial matrix

translation

tRNA aminoacylation for protein translation

methionyl-tRNA aminoacylation

methionyl-tRNA aminoacylation

ligase activity

00450

00970

TC1400000858.mm.2 Sacs sacsin 14 61138456, 61138456 NM_172809, BC138482, BC138483, BC171956 NM_172809, BC138482, BC138483, BC171956 NM_172809, BC138482, BC138483, BC171956 NM_172809, BC138482, BC138483, BC171956 26

cytoplasm

Hsp70 protein binding

low-density lipoprotein particle receptor binding

chaperone binding

 
TC0200000319.mm.2 Etl4 enhancer trap locus 4 2 20519512, 20289912, 20510046 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 NM_001081006, NM_001177630, NM_001177631, NM_029895, NM_178059, BC158051 46

protein binding

cytoplasm

cytoplasm

multicellular organism development

enzyme regulator activity

embryonic skeletal system development

 
TC0200005496.mm.2 Fam78a family with sequence similarity 78, member A 2 -32050054, -32050054, -32050054, -32066884 NM_175511, BC137951, BC137952 NM_175511, BC137951, BC137952 NM_175511, BC137951, BC137952 11

molecular_function

cellular_component

biological_process

 
TC0700001192.mm.2 Mex3b mex3 RNA binding family member B 7 82867332 NM_175366 19

P-body

nucleic acid binding

RNA binding

nucleus

nucleoplasm

cytoplasm

cytosol

positive regulation of cell-cell adhesion

GTPase activating protein binding

positive regulation of GTPase activity

metal ion binding

positive regulation of phagocytosis

protein localization to cell cortex

 
TC1100001359.mm.2 Srsf1 serine and arginine-rich splicing factor 1 11 88047372 NM_001078167, NM_173374, BC046773, BC058627 NM_001078167, NM_173374, BC046773, BC058627 NM_001078167, NM_173374, BC046773, BC058627 NM_001078167, NM_173374, BC046773, BC058627 79

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

mRNA 5'-splice site recognition

mRNA splicing, via spliceosome

in utero embryonic development

nucleic acid binding

RNA binding

RNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

mRNA processing

RNA splicing

RNA splicing

nuclear speck

nuclear speck

nuclear speck

positive regulation of RNA splicing

exon-exon junction complex

protein kinase B binding

DNA topoisomerase binding

RS domain binding

mRNA transport

cardiac muscle contraction

catalytic step 2 spliceosome

03040

TC0900001419.mm.2 Prkar2a protein kinase, cAMP dependent regulatory, type II alpha 9 108692142 NM_008924, BC075623, BC080276 NM_008924, BC075623, BC080276 NM_008924, BC075623, BC080276 78

nucleotide binding

regulation of protein phosphorylation

cAMP-dependent protein kinase inhibitor activity

protein binding

cytoplasm

cytoplasm

centrosome

cytosol

plasma membrane

axoneme

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase regulator activity

cAMP-dependent protein kinase regulator activity

regulation of protein kinase A signaling

membrane

protein domain specific binding

T-tubule

cAMP binding

nucleotide-activated protein kinase complex

ubiquitin protein ligase binding

beta-2 adrenergic receptor binding

protein-containing complex

protein kinase A catalytic subunit binding

small molecule binding

identical protein binding

regulation of cAMP-mediated signaling

plasma membrane raft

protein-containing complex binding

synapse

synapse

regulation of protein kinase activity

perinuclear region of cytoplasm

modulation of chemical synaptic transmission

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

negative regulation of cAMP-dependent protein kinase activity

04210

04910

TC0200000495.mm.2 Ddx31 DEAD/H box helicase 31 2 28840405 NM_001033294, BC066017, BC132351 NM_001033294, BC066017, BC132351 NM_001033294, BC066017, BC132351 13

nucleotide binding

nucleic acid binding

RNA binding

helicase activity

ATP binding

nucleus

nucleolus

Golgi apparatus

hydrolase activity

ribosome biogenesis

ribosome biogenesis

intracellular membrane-bounded organelle

 
TC0500001865.mm.2 Brca2 breast cancer 2, early onset 5 150522620 NM_001081001, NM_009765, BC172649 NM_001081001, NM_009765, BC172649 NM_001081001, NM_009765, BC172649 178

telomere maintenance via recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

chromosome, telomeric region

lateral element

oocyte maturation

inner cell mass cell proliferation

protease binding

DNA binding

single-stranded DNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

centrosome

cytosol

cytoskeleton

DNA repair

nucleotide-excision repair

double-strand break repair

double-strand break repair

DNA recombination

regulation of transcription, DNA-templated

cellular response to DNA damage stimulus

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cell cycle

male meiosis I

male meiosis I

spermatogenesis

spermatogenesis

brain development

cell aging

protein C-terminus binding

cell population proliferation

female gonad development

intrinsic apoptotic signaling pathway in response to DNA damage

response to X-ray

response to UV-C

response to gamma radiation

H3 histone acetyltransferase activity

H4 histone acetyltransferase activity

hemopoiesis

secretory granule

mammary gland development

homologous chromosome orientation involved in meiotic metaphase I plate congression

regulation of cytokinesis

protein-containing complex

BRCA2-MAGE-D1 complex

negative regulation of mammary gland epithelial cell proliferation

multicellular organism growth

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

chordate embryonic development

gamma-tubulin binding

histone H3 acetylation

histone H4 acetylation

positive regulation of transcription, DNA-templated

positive regulation of mitotic cell cycle

replication fork protection

chromosome organization

centrosome duplication

establishment of protein localization to telomere

establishment of protein localization to telomere

mitotic recombination-dependent replication fork processing

03440

05200

05212

TC0100002936.mm.2 Tsn translin 1 -118298513, -118298513 NM_011650, BC004615 NM_011650, BC004615 53

DNA binding

single-stranded DNA binding

RNA binding

mRNA binding

nuclease activity

endonuclease activity

endoribonuclease activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

endoplasmic reticulum

RNA metabolic process

hydrolase activity

identical protein binding

sequence-specific DNA binding

protein-containing complex binding

 
TC0200005489.mm.2 Zfp965 zinc finger protein 965 2 175470024 NM_001242944 1

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleoplasm

regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
TC1300001560.mm.2 H1f5 H1.5 linker histone, cluster member 13 -21779831 NM_020034, BC146469 NM_020034, BC146469 34

nucleosome

DNA binding

double-stranded DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

muscle organ development

nucleosome positioning

chromosome condensation

nucleosomal DNA binding

negative regulation of chromatin silencing

negative regulation of DNA recombination

 
TC0700004587.mm.2 Nap1l4 nucleosome assembly protein 1-like 4 7 -143513578, -143513578 NM_001285489, NM_001285490, NM_008672, BC132039, BC138518, BC145306, BC145308 NM_001285489, NM_001285490, NM_008672, BC132039, BC138518, BC145306, BC145308 NM_001285489, NM_001285490, NM_008672, BC132039, BC138518, BC145306, BC145308 NM_001285489, NM_001285490, NM_008672, BC132039, BC138518, BC145306, BC145308 NM_001285489, NM_001285490, NM_008672, BC132039, BC138518, BC145306, BC145308 NM_001285489, NM_001285490, NM_008672, BC132039, BC138518, BC145306, BC145308 NM_001285489, NM_001285490, NM_008672, BC132039, BC138518, BC145306, BC145308 43

chromatin

chromatin binding

nucleus

nucleus

cytoplasm

nucleosome assembly

nucleosome assembly

nucleosome assembly

dendrite

nucleosome binding

histone binding

neuronal cell body

 
TC0800002236.mm.2 Spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 8 -54520432 NM_029701, BC054817 NM_029701, BC054817 18

endoplasmic reticulum

signal peptidase complex

signal peptide processing

proteolysis

peptidase activity

membrane

integral component of membrane

hydrolase activity

viral protein processing

intracellular membrane-bounded organelle

protein targeting to ER

03060

TC1900001454.mm.2 Ide insulin degrading enzyme 19 -37268742 NM_031156, BC041675 NM_031156, BC041675 65

nucleotide binding

amyloid-beta binding

catalytic activity

endopeptidase activity

metalloendopeptidase activity

ATP binding

extracellular region

extracellular space

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

peroxisome

peroxisomal matrix

peroxisomal matrix

cytosol

plasma membrane

proteolysis

response to oxidative stress

metabolic process

peptidase activity

metallopeptidase activity

zinc ion binding

determination of adult lifespan

external side of plasma membrane

cell surface

bradykinin catabolic process

ubiquitin recycling

membrane

basolateral plasma membrane

hydrolase activity

ATPase activity

peptide hormone binding

antigen processing and presentation of endogenous peptide antigen via MHC class I

protein catabolic process

cytosolic proteasome complex

beta-endorphin binding

positive regulation of protein binding

peptide binding

hormone catabolic process

hormone catabolic process

identical protein binding

protein homodimerization activity

peptide catabolic process

peptide catabolic process

insulin binding

cellular protein catabolic process

protein-containing complex binding

negative regulation of proteolysis

metal ion binding

amyloid-beta metabolic process

amyloid-beta metabolic process

proteolysis involved in cellular protein catabolic process

proteolysis involved in cellular protein catabolic process

extracellular exosome

amyloid-beta clearance

amyloid-beta clearance

amyloid-beta clearance

ubiquitin-dependent protein binding

amyloid-beta clearance by cellular catabolic process

insulin metabolic process

insulin catabolic process

insulin catabolic process

regulation of aerobic respiration

05010

TC1800001741.mm.2         NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188 NM_033574, NM_033575, NM_033576, NM_033577, NM_033578, NM_033579, NM_033580, NM_033581, NM_033582, NM_033583, NM_033584, NM_033585, NM_033586, NM_033587, NM_033588, NM_033589, NM_033590, NM_033591, NM_033592, NM_033593, NM_033594, NM_033595, BC035540, BC049814, BC054528, BC054555, BC054556, BC054557, BC054741, BC054787, BC056998, BC057404, BC059175, BC059837, BC060691, BC064675, BC064808, BC066823, BC066851, BC077712, BC079567, BC080852, BC098367, BC098457, BC138677, BC138678, BC138701, BC139099, BC139100, BC139178, BC160199, BC167188  

molecular_function

calcium ion binding

protein binding

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

cell-cell junction

cell-cell junction

cell adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

homophilic cell adhesion via plasma membrane adhesion molecules

biological_process

endosome to lysosome transport

membrane

integral component of membrane

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

growth cone

synapse organization

lipid tube assembly involved in organelle fusion

 
TC0900001792.mm.2 Fat3 FAT atypical cadherin 3 9 -15910189 NM_001080814 25

cell morphogenesis involved in differentiation

neuron migration

calcium ion binding

plasma membrane

cell adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

multicellular organism development

retina layer formation

membrane

integral component of membrane

dendrite

cell-cell adhesion

negative regulation of dendrite development

 
TC0700001343.mm.2 Nars2 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) 7 96951526 NM_153591, BC030041 NM_153591, BC030041 18

nucleotide binding

nucleic acid binding

aminoacyl-tRNA ligase activity

asparagine-tRNA ligase activity

ATP binding

nucleoplasm

mitochondrion

mitochondrion

cytosol

translation

tRNA aminoacylation for protein translation

asparaginyl-tRNA aminoacylation

ligase activity

00970

TC1200000334.mm.2 Agmo alkylglycerol monooxygenase 12 37241638 NM_178767, BC148840 NM_178767, BC148840 14

iron ion binding

endoplasmic reticulum

endoplasmic reticulum

membrane lipid metabolic process

membrane lipid metabolic process

lipid biosynthetic process

membrane

integral component of membrane

oxidoreductase activity

ether lipid metabolic process

glyceryl-ether monooxygenase activity

glyceryl-ether monooxygenase activity

 
TC0500000852.mm.2 Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 5 90931195 NM_026788 17

histidine biosynthetic process

catalytic activity

methenyltetrahydrofolate cyclohydrolase activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

purine nucleotide biosynthetic process

one-carbon metabolic process

metabolic process

cellular amino acid biosynthetic process

methionine biosynthetic process

10-formyltetrahydrofolate metabolic process

membrane

oxidoreductase activity

hydrolase activity

tetrahydrofolate interconversion

tetrahydrofolate interconversion

00670

01100

TC1700002561.mm.2 Cebpz CCAAT/enhancer binding protein zeta 17 -78919002 NM_001024806, BC160197 NM_001024806, BC160197 24

transcription coactivator activity

nucleus

nucleus

ribosome biogenesis

positive regulation of transcription by RNA polymerase II

 
TC1600001527.mm.2 Umps uridine monophosphate synthetase 16 -33954781 NM_009471, BC003887, BC095981 NM_009471, BC003887, BC095981 NM_009471, BC003887, BC095981 30

catalytic activity

orotate phosphoribosyltransferase activity

orotate phosphoribosyltransferase activity

orotidine-5'-phosphate decarboxylase activity

orotidine-5'-phosphate decarboxylase activity

nucleus

cytoplasm

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine nucleotide biosynthetic process

UMP biosynthetic process

UMP biosynthetic process

metabolic process

nucleoside metabolic process

transferase activity

transferase activity, transferring glycosyl groups

lyase activity

carboxy-lyase activity

pyrimidine nucleobase biosynthetic process

identical protein binding

'de novo' UMP biosynthetic process

00240

00983

01100

TC1500001791.mm.2 Arhgap39 Rho GTPase activating protein 39 15 -76723984 NM_001168288, NM_198420, BC060637 NM_001168288, NM_198420, BC060637 NM_001168288, NM_198420, BC060637 31

GTPase activator activity

nucleus

cytoplasm

cytoskeleton

signal transduction

postsynapse

glutamatergic synapse

postsynapse organization

 
TC1700002562.mm.2 Prkd3 protein kinase D3 17 -78949404, -78949404 NM_001171004, NM_001171005, NM_029239, BC037012, BC089164 NM_001171004, NM_001171005, NM_029239, BC037012, BC089164 NM_001171004, NM_001171005, NM_029239, BC037012, BC089164 NM_001171004, NM_001171005, NM_029239, BC037012, BC089164 NM_001171004, NM_001171005, NM_029239, BC037012, BC089164 36

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein kinase C activity

ATP binding

nucleoplasm

cytoplasm

cytosol

protein phosphorylation

membrane

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

metal ion binding

protein kinase D signaling

 
TC0700003045.mm.2 Uevld UEV and lactate/malate dehyrogenase domains 7 -46923215 NM_001040695, BC054796 NM_001040695, BC054796 18

catalytic activity

carbohydrate metabolic process

cellular protein modification process

protein transport

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

carboxylic acid metabolic process

 
TC0200001951.mm.2 Slc20a1 solute carrier family 20, member 1 2 129198772, 129207095, 129198772 NM_001159593, NM_015747, BC015085 NM_001159593, NM_015747, BC015085 NM_001159593, NM_015747, BC015085 63

inorganic phosphate transmembrane transporter activity

high-affinity inorganic phosphate:sodium symporter activity

plasma membrane

integral component of plasma membrane

sodium ion transport

phosphate ion transport

symporter activity

membrane

integral component of membrane

biomineral tissue development

phosphate ion transmembrane transport

 
TC1500002037.mm.2 Hdac10 histone deacetylase 10 15 -89123302 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 NM_199198, NR_028447, NR_028448, NR_028449, BC064018 24

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

histone deacetylase activity

nucleus

nucleoplasm

cytoplasm

DNA repair

DNA recombination

regulation of transcription, DNA-templated

autophagy

cellular response to DNA damage stimulus

macroautophagy

histone deacetylation

hydrolase activity

deacetylase activity

enzyme binding

positive regulation of mismatch repair

peptidyl-lysine deacetylation

homologous recombination

histone deacetylase binding

negative regulation of transcription, DNA-templated

metal ion binding

acetylputrescine deacetylase activity

acetylspermidine deacetylase activity

polyamine deacetylation

spermidine deacetylation

 
TC0500001428.mm.2 Kntc1 kinetochore associated 1 5 123749725 NM_001042421 20

chromosome, centromeric region

kinetochore

spindle pole

molecular_function

nucleus

chromosome

cytoplasm

kinetochore microtubule

cytosol

cytoskeleton

plasma membrane

cell cycle

mitotic spindle assembly checkpoint

actin cytoskeleton

cell division

RZZ complex

 
TC1400002260.mm.2 Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 14 -65819026 NM_028039, BC033303, BC071275 NM_028039, BC033303, BC071275 NM_028039, BC033303, BC071275 35

chromatin

XY body

hematopoietic progenitor cell differentiation

lysine N-acetyltransferase activity, acting on acetyl phosphate as donor

nucleus

nucleoplasm

chromosome

pericentric heterochromatin

Golgi apparatus

regulation of DNA replication

regulation of DNA replication

double-strand break repair

cell cycle

chromosome segregation

sister chromatid cohesion

chromocenter

acetyltransferase activity

transferase activity

transferase activity, transferring acyl groups

cell junction

post-translational protein acetylation

post-translational protein acetylation

site of double-strand break

metal ion binding

protein localization to chromatin

 
TC1000001737.mm.2 Stxbp5 syntaxin binding protein 5 (tomosyn) 10 -9755546 NM_001081344 33

GTPase activator activity

protein binding

cytoplasm

cytosol

plasma membrane

acetylcholine-gated channel complex

exocytosis

axonogenesis

synaptic vesicle

regulation of synaptic vesicle priming

regulation of synaptic vesicle priming

regulation of synaptic vesicle priming

protein transport

membrane

syntaxin-1 binding

syntaxin-1 binding

syntaxin-1 binding

regulation of exocytosis

regulation of exocytosis

syntaxin binding

syntaxin binding

secretory granule

SNARE complex

neuromuscular junction

myosin II binding

positive regulation of exocytosis

regulation of protein secretion

extrinsic component of neuronal dense core vesicle membrane

extrinsic component of neuronal dense core vesicle membrane

Schaffer collateral - CA1 synapse

hippocampal mossy fiber to CA3 synapse

hippocampal mossy fiber to CA3 synapse

presynapse

extrinsic component of presynaptic membrane

synaptic vesicle cycle

presynaptic cytosol

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle exocytosis

 
TC1300001762.mm.2 Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a 13 -32842091 NM_025429, BC011140, BC104333 NM_025429, BC011140, BC104333 NM_025429, BC011140, BC104333 39

serine-type endopeptidase inhibitor activity

protein binding

extracellular region

extracellular region

extracellular space

cytoplasm

inflammatory response

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of endopeptidase activity

cellular homeostasis

peptidase inhibitor activity

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 beta production

cytoplasmic ribonucleoprotein granule

regulation of protein catabolic process

type B pancreatic cell proliferation

type B pancreatic cell proliferation

regulation of innate immune response

collagen-containing extracellular matrix

05146

TC0100001853.mm.2 Ints7 integrator complex subunit 7 1 191575635 NM_178632, BC054120 NM_178632, BC054120 25

DNA damage checkpoint

molecular_function

nucleus

chromosome

cytoplasm

cellular response to DNA damage stimulus

snRNA processing

nuclear body

integrator complex

integrator complex

snRNA 3'-end processing

cellular response to ionizing radiation

 
TC0400001215.mm.2 Stil Scl/Tal1 interrupting locus 4 115000117 NM_009185, BC141175, BC145493 NM_009185, BC141175, BC145493 NM_009185, BC141175, BC145493 29

embryonic axis specification

in utero embryonic development

neural tube closure

heart looping

protein binding

cytoplasm

centrosome

centrosome

centriole

centriole

cytoskeleton

mitotic spindle organization

mitotic spindle organization

smoothened signaling pathway

smoothened signaling pathway

multicellular organism development

determination of left/right symmetry

neural tube development

forebrain development

notochord development

floor plate development

multicellular organism growth

identical protein binding

negative regulation of apoptotic process

positive regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of centriole replication

centrosome duplication

centrosome duplication

centrosome duplication

mitotic spindle checkpoint

protein localization to centrosome

protein localization to centrosome

non-motile cilium assembly

 
TC1300000928.mm.2 Mctp1 multiple C2 domains, transmembrane 1 13 76384138, 76579596 NM_030174 13

calcium ion binding

calcium ion binding

endosome

endoplasmic reticulum

membrane

integral component of membrane

integral component of membrane

cell junction

negative regulation of cell migration

synaptic vesicle membrane

synaptic vesicle membrane

cytoplasmic vesicle

synapse

negative regulation of endocytosis

metal ion binding

regulation of neurotransmitter secretion

recycling endosome

negative regulation of response to oxidative stress

 
MG-1-pos-10342736_st                
TC0300001639.mm.2 Fabp4 fatty acid binding protein 4, adipocyte 3 -10204342 NM_024406, BC002148, BC054426 NM_024406, BC002148, BC054426 NM_024406, BC002148, BC054426 198

cytokine production

long-chain fatty acid transporter activity

fatty acid binding

nucleus

nucleoplasm

cytoplasm

cytosol

negative regulation of protein kinase activity

fatty acid metabolic process

positive regulation of cell population proliferation

lipid binding

response to bacterium

long-chain fatty acid transport

long-chain fatty acid binding

cholesterol homeostasis

negative regulation of transcription, DNA-templated

regulation of inflammatory response

positive regulation of inflammatory response

white fat cell differentiation

brown fat cell differentiation

hormone receptor binding

cellular response to lithium ion

cellular response to tumor necrosis factor

positive regulation of cold-induced thermogenesis

03320

TC0100000381.mm.2 Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase 1 52845037 NM_146108, BC026437 NM_146108, BC026437 21

3-hydroxyisobutyryl-CoA hydrolase activity

3-hydroxyisobutyryl-CoA hydrolase activity

mitochondrion

mitochondrion

mitochondrion

valine catabolic process

branched-chain amino acid catabolic process

hydrolase activity

00280

00410

00640

01100

TC0700001131.mm.2 Ticrr TOPBP1-interacting checkpoint and replication regulator 7 79660195 NM_029835, BC158103 NM_029835, BC158103 18

chromatin binding

chromatin binding

nucleus

nucleus

nucleoplasm

cytosol

DNA replication

DNA repair

cellular response to DNA damage stimulus

cell cycle

mitotic G2 DNA damage checkpoint

response to ionizing radiation

regulation of DNA-dependent DNA replication initiation

regulation of DNA-dependent DNA replication initiation

mitotic DNA replication checkpoint

intracellular membrane-bounded organelle

 
TC0300000623.mm.2 Ppid peptidylprolyl isomerase D (cyclophilin D) 3 79591336 NM_026352, BC011499, BC019778 NM_026352, BC011499, BC019778 NM_026352, BC011499, BC019778 32

negative regulation of transcription by RNA polymerase II

protein peptidyl-prolyl isomerization

protein peptidyl-prolyl isomerization

peptidyl-prolyl cis-trans isomerase activity

peptidyl-prolyl cis-trans isomerase activity

peptidyl-prolyl cis-trans isomerase activity

FK506 binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

mitochondrion

cytosol

protein folding

apoptotic process

transcription factor binding

protein transport

cyclosporin A binding

cyclosporin A binding

isomerase activity

enzyme binding

heat shock protein binding

lipid droplet organization

positive regulation of apoptotic process

positive regulation of viral genome replication

positive regulation of protein secretion

Hsp90 protein binding

chaperone-mediated protein folding

protein-containing complex assembly

cellular response to UV-A

04020

05012

05016

TC1000002594.mm.2 Ckap4 cytoskeleton-associated protein 4 10 -84526304 NM_175451, BC138318, BC138320 NM_175451, BC138318, BC138320 NM_175451, BC138318, BC138320 30

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

rough endoplasmic reticulum

rough endoplasmic reticulum

lipid droplet

cytosol

cytoskeleton

plasma membrane

biological_process

cell surface

membrane

integral component of membrane

nuclear speck

cytoplasmic ribonucleoprotein granule

04141

TC0700001442.mm.2 Anapc15 anaphase promoting complex C subunit 15 7 101881324, 101896330, 101885859 NM_027532, BC006736, BC080730 NM_027532, BC006736, BC080730 NM_027532, BC006736, BC080730 20

molecular_function

anaphase-promoting complex

cell cycle

cell division

regulation of mitotic cell cycle spindle assembly checkpoint

 
TC0200002043.mm.2 Mcm8 minichromosome maintenance 8 homologous recombination repair factor 2 132816140 NM_025676, BC046780, BC052070 NM_025676, BC046780, BC052070 NM_025676, BC046780, BC052070 19

nucleotide binding

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

DNA binding

chromatin binding

DNA replication origin binding

single-stranded DNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

cytosol

DNA replication

DNA replication initiation

DNA repair

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

cell cycle

female gamete generation

hydrolase activity

enzyme binding

MutLbeta complex binding

MutSalpha complex binding

MutSbeta complex binding

recombinational interstrand cross-link repair

MCM complex

male gamete generation

protein stabilization

protein localization to chromatin

MCM8-MCM9 complex

MCM8-MCM9 complex

 
TC0600003474.mm.2 Sinhcaf SIN3-HDAC complex associated factor 6 -148921058, -148921058 NM_019643, BC076599 NM_019643, BC076599 28

protein binding

nucleus

positive regulation of cell population proliferation

Sin3 complex

Sin3 complex

negative regulation of cell migration

negative regulation of cell migration

negative regulation of cell differentiation

 
MG-1-pos-10340206_st                
TC1600002169.mm.2 Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 16 4684069 NM_001135112, NM_023646, BC027240 NM_001135112, NM_023646, BC027240 NM_001135112, NM_023646, BC027240 40

negative regulation of transcription by RNA polymerase II

interferon-gamma receptor binding

protein binding

ATP binding

nucleus

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

cytosol

cytosol

actin filament

plasma membrane

mitochondrial DNA replication

protein folding

negative regulation of protein kinase activity

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation-induced cell death of T cells

mitochondrion organization

mitochondrion organization

small GTPase mediated signal transduction

neuromuscular junction development

neuromuscular junction development

cell aging

transcription factor binding

negative regulation of cell population proliferation

response to heat

embryo development

membrane

extrinsic component of plasma membrane

protein kinase binding

cell junction

Hsp70 protein binding

GTPase regulator activity

receptor tyrosine kinase binding

heat shock protein binding

positive regulation of protein ubiquitination

neuromuscular junction

negative regulation of NF-kappaB transcription factor activity

T cell differentiation in thymus

response to interferon-gamma

positive regulation of T cell proliferation

mitochondrial nucleoid

regulation of apoptotic process

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of programmed cell death

negative regulation of I-kappaB kinase/NF-kappaB signaling

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

intracellular membrane-bounded organelle

protein-containing complex binding

synapse

postsynaptic membrane

metal ion binding

protein stabilization

NF-kappaB binding

unfolded protein binding

negative regulation of interferon-gamma-mediated signaling pathway

skeletal muscle acetylcholine-gated channel clustering

IkappaB kinase complex binding

 
TC0800002960.mm.2 Adat1 adenosine deaminase, tRNA-specific 1 8 -111970864, -111966897 NM_013925, BC019976 NM_013925, BC019976 14

RNA binding

adenosine deaminase activity

cellular_component

RNA processing

tRNA processing

tRNA-specific adenosine deaminase activity

tRNA-specific adenosine deaminase activity

hydrolase activity

metal ion binding

 
TC1800001700.mm.2 Tshz1 teashirt zinc finger family member 1 18 -84011626, -84011626 NM_001081300, BC058264 NM_001081300, BC058264 47

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

protein binding

nucleus

regulation of transcription by RNA polymerase II

multicellular organism development

anterior/posterior pattern specification

regulation of gene expression

middle ear morphogenesis

metal ion binding

soft palate development

 
TC1100003945.mm.2 Nol11 nucleolar protein 11 11 -107166652 NM_001161329, NM_133702, BC024874 NM_001161329, NM_133702, BC024874 NM_001161329, NM_133702, BC024874 19

nucleus

nucleolus

nucleolus

rRNA processing

maturation of SSU-rRNA

maturation of SSU-rRNA

t-UTP complex

ribosome biogenesis

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

 
TC1100003694.mm.2 Tns4 tensin 4 11 -99065677 NM_172564, BC055820 NM_172564, BC055820 15

molecular_function

actin binding

cytoplasm

cytoskeleton

focal adhesion

apoptotic process

protein localization

cell junction

 
TC0400002637.mm.2 Mrpl50 mitochondrial ribosomal protein L50 4 -49512596 NM_178603, BC021318 NM_178603, BC021318 21

molecular_function

mitochondrion

mitochondrion

mitochondrial large ribosomal subunit

mitochondrial large ribosomal subunit

ribosome

biological_process

 
TC0600001709.mm.2 Lrmp lymphoid-restricted membrane protein 6 145115635, 145145474, 145121768 NM_001281980, NM_001281981, NM_008511, BC052909 NM_001281980, NM_001281981, NM_008511, BC052909 NM_001281980, NM_001281981, NM_008511, BC052909 NM_001281980, NM_001281981, NM_008511, BC052909 33

immune system process

protein binding

nucleus

nuclear envelope

chromosome

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

cytoskeleton

nucleus organization

single fertilization

microtubule binding

membrane

integral component of membrane

integral component of endoplasmic reticulum membrane

 
TC0100003814.mm.2 Dtl denticleless E3 ubiquitin protein ligase 1 -191537355 NM_029766 33

protein polyubiquitination

ubiquitin-protein transferase activity

nucleus

nucleoplasm

chromosome

nucleolus

cytoplasm

centrosome

cytosol

cytoskeleton

DNA replication

ubiquitin-dependent protein catabolic process

protein monoubiquitination

cellular response to DNA damage stimulus

response to UV

positive regulation of G2/M transition of mitotic cell cycle

membrane

translesion synthesis

Cul4A-RING E3 ubiquitin ligase complex

Cul4B-RING E3 ubiquitin ligase complex

positive regulation of protein catabolic process

rhythmic process

regulation of cell cycle

signal transduction involved in G2 DNA damage checkpoint

Cul4-RING E3 ubiquitin ligase complex

 
TC1700000402.mm.2 Pgap6 post-glycosylphosphatidylinositol attachment to proteins 6 17 26113315 NM_021793, BC005722 NM_021793, BC005722 20

molecular_function

phospholipase A2 activity

lysosome

plasma membrane

integral component of plasma membrane

biological_process

membrane

integral component of membrane

hydrolase activity

 
TC0700004388.mm.2 Nsmce4a NSE4 homolog A, SMC5-SMC6 complex component 7 -130532525 NM_001162855 15

molecular_function

nucleus

nucleoplasm

DNA repair

nuclear body

Smc5-Smc6 complex

Smc5-Smc6 complex

positive regulation of response to DNA damage stimulus

 
TC0200004207.mm.2 Ldlrad3 low density lipoprotein receptor class A domain containing 3 2 -101950200 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 NM_178886, BC138177, BC138178, BC145174, XR_140510 17

amyloid-beta binding

plasma membrane

receptor-mediated endocytosis

membrane

integral component of membrane

regulation of protein processing

 
TC0500001251.mm.2 Pop5 processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) 5 115235850 NM_026398, BC022670 NM_026398, BC022670 19

ribonuclease MRP activity

ribonuclease MRP complex

ribonuclease MRP complex

ribonuclease MRP complex

tRNA 5'-leader removal

ribonuclease P activity

ribonuclease P activity

ribonuclease P activity

ribonuclease activity

nucleus

nucleolar ribonuclease P complex

nucleolar ribonuclease P complex

nucleolus

rRNA processing

rRNA processing

tRNA processing

tRNA processing

RNA metabolic process

hydrolase activity

multimeric ribonuclease P complex

ribonuclease P RNA binding

03008

03013

TC0400000133.mm.2 Tmem64 transmembrane protein 64 4 15265819 NM_181401, BC030341 NM_181401, BC030341 20

protein binding

endoplasmic reticulum

membrane

integral component of membrane

regulation of ATPase activity

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

positive regulation of osteoclast differentiation

positive regulation of bone resorption

regulation of cytosolic calcium ion concentration

negative regulation of canonical Wnt signaling pathway

 
TC0200001881.mm.2 Dut deoxyuridine triphosphatase 2 125247247, 125247514 NM_001159646, NM_023595, BC019979, BC053693 NM_001159646, NM_023595, BC019979, BC053693 NM_001159646, NM_023595, BC019979, BC053693 NM_001159646, NM_023595, BC019979, BC053693 32

magnesium ion binding

dUTP diphosphatase activity

dUTP diphosphatase activity

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

dUMP biosynthetic process

dUMP biosynthetic process

receptor inhibitor activity

pyrimidine deoxyribonucleotide binding

identical protein binding

peroxisome proliferator activated receptor binding

regulation of protein-containing complex assembly

dUTP catabolic process

dUTP catabolic process

00240

01100

TC0900002047.mm.2 Ccdc15 coiled-coil domain containing 15 9 -37267463 NM_001081429 12

molecular_function

centrosome

centrosome

biological_process

 
TC0800000371.mm.2 Fut10 fucosyltransferase 10 8 31187330, 31187330 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 NM_001012517, NM_001286422, NM_001286424, NM_001286425, NM_134161, BC030474, BC062113 17

Golgi membrane

nucleoplasm

endoplasmic reticulum

Golgi apparatus

protein glycosylation

fucosyltransferase activity

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

cerebral cortex radially oriented cell migration

fucosylation

alpha-(1->3)-fucosyltransferase activity

alpha-(1->3)-fucosyltransferase activity

neuronal stem cell population maintenance

 
TC0X00000429.mm.2 Utp14a UTP14A small subunit processome component X 48256933 NM_028276, BC082590 NM_028276, BC082590 22

nucleus

nucleolus

nucleolus

cytosol

rRNA processing

small-subunit processome

ribosome biogenesis

03008

TC1900000814.mm.2 Trub1 TruB pseudouridine (psi) synthase family member 1 19 57452905, 57452905 NM_028115, NM_029839, BC089592 NM_028115, NM_029839, BC089592 NM_028115, NM_029839, BC089592 18

pseudouridine synthesis

RNA binding

nucleus

cytoplasm

mitochondrion

cytosol

RNA processing

tRNA modification

RNA modification

pseudouridine synthase activity

pseudouridine synthase activity

isomerase activity

mRNA pseudouridine synthesis

mRNA pseudouridine synthesis

 
TC1400001152.mm.2 Bora bora, aurora kinase A activator 14 99046376 NM_175265, BC052183 NM_175265, BC052183 19

nucleus

cytoplasm

cell cycle

regulation of mitotic nuclear division

regulation of mitotic nuclear division

protein kinase binding

protein kinase binding

activation of protein kinase activity

regulation of protein localization

cell division

regulation of mitotic spindle organization

regulation of mitotic spindle organization

meiotic spindle

 
TC0500003418.mm.2 Cux1 cut-like homeobox 1 5 -136248134, -136266409, -136266409, -136248134 NM_009986, NM_198602, BC090847 NM_009986, NM_198602, BC090847 NM_009986, NM_198602, BC090847 445

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

kidney development

DNA binding

chromatin binding

nucleus

nucleus

cytoplasm

Golgi apparatus

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

intra-Golgi vesicle-mediated transport

multicellular organism development

membrane

integral component of membrane

integral component of Golgi membrane

lung development

inner ear auditory receptor cell differentiation

neuron projection

sequence-specific DNA binding

positive regulation of dendrite morphogenesis

 
TC0X00001766.mm.2 Clcn5 chloride channel, voltage-sensitive 5 X -7158411, -7158411 NM_001243762, NM_016691, BC036347 NM_001243762, NM_016691, BC036347 NM_001243762, NM_016691, BC036347 71

nucleotide binding

voltage-gated chloride channel activity

voltage-gated chloride channel activity

chloride channel activity

ATP binding

endosome

endosome

early endosome

Golgi apparatus

Golgi apparatus

cytosol

plasma membrane

integral component of plasma membrane

ion transport

chloride transport

endocytosis

synaptic vesicle

antiporter activity

solute:proton antiporter activity

membrane

integral component of membrane

identical protein binding

apical part of cell

apical part of cell

transmembrane transport

 
TC0100001656.mm.2 Exo1 exonuclease 1 1 175880777 NM_012012, BC006671 NM_012012, BC006671 51

immune system process

humoral immune response mediated by circulating immunoglobulin

DNA binding

chromatin binding

catalytic activity

nuclease activity

endonuclease activity

exonuclease activity

nucleus

nucleus

nucleoplasm

plasma membrane

nucleobase-containing compound metabolic process

DNA repair

mismatch repair

mismatch repair

DNA recombination

DNA recombination

cellular response to DNA damage stimulus

5'-3' exonuclease activity

somatic hypermutation of immunoglobulin genes

nuclear body

hydrolase activity

hydrolase activity, acting on ester bonds

5'-flap endonuclease activity

5'-3' exodeoxyribonuclease activity

5'-3' exodeoxyribonuclease activity

single-stranded DNA 5'-3' exodeoxyribonuclease activity

isotype switching

metal ion binding

flap endonuclease activity

meiotic cell cycle

double-stranded DNA 5'-3' exodeoxyribonuclease activity

03430

TC0800002596.mm.2 Rnaseh2a ribonuclease H2, large subunit 8 -84957666, -84956609 NM_027187, BC029252, BC038158 NM_027187, BC029252, BC038158 NM_027187, BC029252, BC038158 24

nucleic acid binding

RNA binding

nuclease activity

endonuclease activity

RNA-DNA hybrid ribonuclease activity

RNA-DNA hybrid ribonuclease activity

nucleus

nucleoplasm

cytosol

mismatch repair

mismatch repair

mismatch repair

RNA catabolic process

RNA metabolic process

hydrolase activity

ribonuclease H2 complex

ribonuclease H2 complex

ribonuclease H2 complex

DNA replication, removal of RNA primer

metal ion binding

03030

TC1300002617.mm.2 Ipo11 importin 11 13 -106794438 NM_029665, BC029746, BC031900, XM_003084943 NM_029665, BC029746, BC031900, XM_003084943 NM_029665, BC029746, BC031900, XM_003084943 NM_029665, BC029746, BC031900, XM_003084943 23

protein binding

nucleus

nuclear envelope

nucleoplasm

cytoplasm

cytosol

cytosol

protein import into nucleus

ribosomal protein import into nucleus

intracellular protein transport

protein transport

small GTPase binding

nuclear import signal receptor activity

 
TC1300000671.mm.2 Ddx46 DEAD box helicase 46 13 55634998 NM_001282055, BC026492, BC092240, NM_145975 NM_001282055, BC026492, BC092240, NM_145975 NM_001282055, BC026492, BC092240, NM_145975 NM_001282055, BC026492, BC092240, NM_145975 26

nucleotide binding

mRNA splicing, via spliceosome

fibrillar center

nucleic acid binding

RNA binding

helicase activity

ATP binding

nucleus

nucleus

mRNA processing

RNA splicing

membrane

nuclear speck

hydrolase activity

03040

TC0200005331.mm.2         XR_140551      
TC0200002579.mm.2 Ddx27 DEAD box helicase 27 2 167015312 NM_153065, BC011321 NM_153065, BC011321 30

nucleotide binding

nucleic acid binding

helicase activity

ATP binding

nucleus

chromosome

nucleolus

nucleolus

rRNA processing

hydrolase activity

ribosome biogenesis

 
TC0900003168.mm.2 Crtap cartilage associated protein 9 -114375130 NM_019922, BC049890 NM_019922, BC049890 28

collagen binding

extracellular region

extracellular space

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

spermatogenesis

peptidyl-proline hydroxylation to 3-hydroxy-L-proline

peptidyl-proline hydroxylation to 3-hydroxy-L-proline

collagen fibril organization

protein stabilization

negative regulation of post-translational protein modification

 
TC1000000191.mm.2 Slc18b1 solute carrier family 18, subfamily B, member 1 10 23796985 NM_183116 17

membrane

integral component of membrane

transmembrane transporter activity

 
TC0800001390.mm.2 Cenpn centromere protein N 8 116921739 NM_028131, BC058243 NM_028131, BC058243 14

chromosome, centromeric region

kinetochore

molecular_function

nucleus

nucleoplasm

chromosome

chromosome segregation

kinetochore assembly

 
TC0400000085.mm.2 Ccne2 cyclin E2 4 11191708, 11191350 NM_001037134, NM_001282943, NM_009830, BC053727 NM_001037134, NM_001282943, NM_009830, BC053727 NM_001037134, NM_001282943, NM_009830, BC053727 NM_001037134, NM_001282943, NM_009830, BC053727 79

regulation of cyclin-dependent protein serine/threonine kinase activity

G1/S transition of mitotic cell cycle

cyclin-dependent protein kinase holoenzyme complex

telomere maintenance

nucleus

cytoplasm

centrosome

DNA replication initiation

cell cycle

homologous chromosome pairing at meiosis

cyclin-dependent protein serine/threonine kinase regulator activity

cyclin-dependent protein serine/threonine kinase regulator activity

protein kinase binding

mitotic cell cycle phase transition

cell division

regulation of cell cycle

chromosome organization involved in meiotic cell cycle

cyclin E1-CDK2 complex

cyclin E2-CDK2 complex

cyclin E2-CDK2 complex

cyclin E2-CDK2 complex

regulation of cellular protein localization

04110

04114

04115

05200

05215

05222

TC1600001254.mm.2 Mcm4 minichromosome maintenance complex component 4 16 -15623896 NM_008565, BC013094 NM_008565, BC013094 66

nucleotide binding

double-strand break repair via break-induced replication

DNA binding

DNA helicase activity

DNA helicase activity

DNA replication origin binding

single-stranded DNA binding

single-stranded DNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

DNA replication

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

DNA unwinding involved in DNA replication

DNA unwinding involved in DNA replication

DNA replication initiation

DNA strand elongation involved in DNA replication

cell cycle

hydrolase activity

MCM complex

MCM complex

mitotic DNA replication initiation

03030

04110

TC1900001428.mm.2 Pank1 pantothenate kinase 1 19 -34806935, -34806935 NM_001114339, NM_023792, BC023496 NM_001114339, NM_023792, BC023496 NM_001114339, NM_023792, BC023496 33

nucleotide binding

pantothenate kinase activity

pantothenate kinase activity

pantothenate kinase activity

ATP binding

nucleus

nucleus

nucleus

cytosol

cytosol

cytosol

coenzyme A biosynthetic process

coenzyme A biosynthetic process

coenzyme A biosynthetic process

coenzyme A biosynthetic process

kinase activity

phosphorylation

transferase activity

clathrin coat

protein homodimerization activity

recycling endosome

cell periphery

acetyl-CoA binding

00770

01100

TC0200001002.mm.2 Nostrin nitric oxide synthase trafficker 2 69135799 NM_181547, BC069942 NM_181547, BC069942 17

DNA binding

protein binding

nucleus

cytoplasm

cytoskeleton

plasma membrane

endocytosis

signal transduction

membrane

cytoplasmic vesicle

negative regulation of transcription, DNA-templated

 
TC0500002232.mm.2 Zfyve28 zinc finger, FYVE domain containing 28 5 -34194893 NM_001015039, BC139050, BC139051 NM_001015039, BC139050, BC139051 NM_001015039, BC139050, BC139051 20

cytoplasm

endosome

cytosol

negative regulation of epidermal growth factor-activated receptor activity

negative regulation of epidermal growth factor-activated receptor activity

membrane

early endosome membrane

early endosome membrane

phosphatidylinositol-3-phosphate binding

negative regulation of epidermal growth factor receptor signaling pathway

metal ion binding

 
TC0100000267.mm.2 Lipt1 lipoyltransferase 1 1 37872218, 37872349, 37871737 NM_001037918, BC019519 NM_001037918, BC019519 16

cytoplasm

mitochondrion

mitochondrion

cellular protein modification process

protein lipoylation

transferase activity

transferase activity, transferring acyl groups

lipoyltransferase activity

00785

01100

TC0300001587.mm.2 Depdc1a DEP domain containing 1a 3 159495432 NM_001172092, NM_001172093, NM_029523, BC023934 NM_001172092, NM_001172093, NM_029523, BC023934 NM_001172092, NM_001172093, NM_029523, BC023934 NM_001172092, NM_001172093, NM_029523, BC023934 12

GTPase activator activity

nucleus

nucleus

signal transduction

transcription repressor complex

transcription repressor complex

intracellular signal transduction

negative regulation of transcription, DNA-templated

 
MG-1-pos-10343924_st                
TC1200001742.mm.2 Egln3 egl-9 family hypoxia-inducible factor 3 12 -54178980 NM_028133, BC044926, BC058278, BC069893, BC022961 NM_028133, BC044926, BC058278, BC069893, BC022961 NM_028133, BC044926, BC058278, BC069893, BC022961 NM_028133, BC044926, BC058278, BC069893, BC022961 NM_028133, BC044926, BC058278, BC069893, BC022961 104

iron ion binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

apoptotic process

cellular response to DNA damage stimulus

ferrous iron binding

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

2-oxoglutarate-dependent dioxygenase activity

protein hydroxylation

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

L-ascorbic acid binding

peptidyl-proline dioxygenase activity

peptidyl-proline dioxygenase activity

peptidyl-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity

regulation of cell population proliferation

regulation of cell population proliferation

regulation of neuron apoptotic process

metal ion binding

dioxygenase activity

cellular response to hypoxia

cellular response to leukemia inhibitory factor

05200

05211

TC0100001548.mm.2 Tmco1 transmembrane and coiled-coil domains 1 1 167308669 NM_001039483, BC011457, BC019761, BC020098 NM_001039483, BC011457, BC019761, BC020098 NM_001039483, BC011457, BC019761, BC020098 NM_001039483, BC011457, BC019761, BC020098 31

calcium channel activity

calcium channel activity

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

ion transport

calcium ion transport

cellular calcium ion homeostasis

ER overload response

membrane

integral component of membrane

integral component of endoplasmic reticulum membrane

endoplasmic reticulum calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

calcium ion transmembrane transport

calcium ion transmembrane transport

 
TC0600000608.mm.2 Cbx3 chromobox 3 6 51471251, 51470615 NM_007624, BC018354, BC059831, BC108370, BC110376 NM_007624, BC018354, BC059831, BC108370, BC110376 NM_007624, BC018354, BC059831, BC108370, BC110376 NM_007624, BC018354, BC059831, BC108370, BC110376 NM_007624, BC018354, BC059831, BC108370, BC110376 103

chromosome, centromeric region

condensed chromosome, centromeric region

chromatin

chromatin

euchromatin

heterochromatin

heterochromatin

transcription regulatory region sequence-specific DNA binding

protein binding

nucleus

nucleus

nuclear envelope

nucleoplasm

pericentric heterochromatin

spindle

chromatin organization

cellular response to DNA damage stimulus

transcription factor binding

chromocenter

enzyme binding

protein domain specific binding

senescence-associated heterochromatin focus

identical protein binding

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

rhythmic process

RNA polymerase II transcription regulator complex

site of DNA damage

histone methyltransferase binding

 
TC1300001806.mm.2 Lyrm4 LYR motif containing 4 13 -35978796 NM_201358, BC034664, BC080772 NM_201358, BC034664, BC080772 NM_201358, BC034664, BC080772 17

molecular_function

nucleus

mitochondrion

mitochondrion

iron-sulfur cluster assembly

nuclear body

L-cysteine desulfurase complex

 
TC0100000829.mm.2 Dgkd diacylglycerol kinase, delta 1 87853286 NM_177646 35

nucleotide binding

NAD+ kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

diacylglycerol kinase activity

ATP binding

cytoplasm

cytosol

plasma membrane

clathrin-coated pit

phosphatidic acid biosynthetic process

endocytosis

signal transduction

protein kinase C-activating G protein-coupled receptor signaling pathway

response to organic substance

protein transport

membrane

kinase activity

phosphorylation

transferase activity

kinase binding

cytoplasmic vesicle

intracellular signal transduction

identical protein binding

protein homodimerization activity

positive regulation of epidermal growth factor receptor signaling pathway

diacylglycerol metabolic process

diacylglycerol metabolic process

diacylglycerol metabolic process

lipid phosphorylation

lipid phosphorylation

lipid phosphorylation

metal ion binding

protein heterodimerization activity

negative regulation of protein kinase C signaling

positive regulation of clathrin-dependent endocytosis

00561

00564

01100

04070

TC1200001348.mm.2 Efr3b EFR3 homolog B 12 -3962553 NM_001082483, BC147643, BC157968 NM_001082483, BC147643, BC157968 NM_001082483, BC147643, BC157968 14

molecular_function

cytoplasm

cytosol

plasma membrane

plasma membrane

actin cytoskeleton

membrane

phosphatidylinositol phosphorylation

protein localization to plasma membrane

protein localization to plasma membrane

 
TC0100001271.mm.2 Kif14 kinesin family member 14 1 136467847 NM_001287179, BC158132, NM_001081258 NM_001287179, BC158132, NM_001081258 NM_001287179, BC158132, NM_001081258 25

nucleotide binding

regulation of cell growth

microtubule motor activity

ATP binding

nucleus

cytoplasm

cytosol

cytoskeleton

kinesin complex

microtubule

microtubule

plasma membrane

microtubule-based movement

mitotic metaphase plate congression

microtubule binding

microtubule binding

positive regulation of cell population proliferation

ATP-dependent microtubule motor activity, plus-end-directed

regulation of G2/M transition of mitotic cell cycle

tubulin binding

ATPase activity

ATPase activity

protein kinase binding

cerebellar granular layer structural organization

cerebellar Purkinje cell layer structural organization

cerebellar cortex development

hippocampus development

olfactory bulb development

cell proliferation in forebrain

cerebral cortex development

regulation of cell adhesion

PDZ domain binding

regulation of cell migration

midbody

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

regulation of myelination

activation of protein kinase activity

positive regulation of cytokinesis

regulation of Rap protein signal transduction

negative regulation of integrin activation

substrate adhesion-dependent cell spreading

negative regulation of apoptotic process

proteasome-mediated ubiquitin-dependent protein catabolic process

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

establishment of protein localization

spindle midzone

cell division

Flemming body

regulation of cell maturation

regulation of G1/S transition of mitotic cell cycle

 
TC0400000567.mm.2 Smc2 structural maintenance of chromosomes 2 4 52439220 NM_008017, BC094380 NM_008017, BC094380 37

single strand break repair

nucleotide binding

nuclear chromosome

condensed chromosome

condensed chromosome

condensin complex

condensin complex

condensin complex

condensin complex

chromatin binding

single-stranded DNA binding

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

nucleolus

cytoplasm

cell cycle

mitotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

meiotic chromosome segregation

chromosome organization

cell division

kinetochore organization

 
TC1000001204.mm.2 Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 10 99108134 NM_015737, BC057882 NM_015737, BC057882 21

polypeptide N-acetylgalactosaminyltransferase activity

Golgi apparatus

Golgi apparatus

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein O-linked glycosylation via serine

protein O-linked glycosylation via threonine

manganese ion binding

carbohydrate binding

metal ion binding

perinuclear region of cytoplasm

00512

01100

TC1300001641.mm.2 Hfe homeostatic iron regulator 13 -23702033 NM_010424, BC116744, BC116746 NM_010424, BC116744, BC116746 NM_010424, BC116744, BC116746 179

negative regulation of T cell antigen processing and presentation

negative regulation of T cell cytokine production

signaling receptor binding

extracellular space

extracellular space

nucleoplasm

early endosome

plasma membrane

ion transport

cellular iron ion homeostasis

external side of plasma membrane

external side of plasma membrane

response to iron ion

positive regulation of gene expression

positive regulation of pathway-restricted SMAD protein phosphorylation

membrane

integral component of membrane

BMP signaling pathway

beta-2-microglobulin binding

cytoplasmic vesicle

positive regulation of protein binding

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of iron ion transport

regulation of iron ion transport

co-receptor binding

hormone biosynthetic process

apical part of cell

basal part of cell

positive regulation of receptor-mediated endocytosis

perinuclear region of cytoplasm

recycling endosome

iron ion homeostasis

iron ion homeostasis

multicellular organismal iron ion homeostasis

cellular response to iron ion

positive regulation of peptide hormone secretion

iron ion import across plasma membrane

negative regulation of receptor binding

positive regulation of receptor binding

negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I

positive regulation of ferrous iron binding

positive regulation of transferrin receptor binding

terminal web

transferrin receptor binding

transferrin receptor binding

transferrin receptor binding

response to iron ion starvation

HFE-transferrin receptor complex

HFE-transferrin receptor complex

regulation of protein localization to cell surface

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process

negative regulation of signaling receptor activity

positive regulation of signaling receptor activity

negative regulation of CD8-positive, alpha-beta T cell activation

 
TC1100001586.mm.2 Cdc6 cell division cycle 6 11 98907800, 98908150 NM_001025779, NM_011799, BC052434 NM_001025779, NM_011799, BC052434 NM_001025779, NM_011799, BC052434 42

nucleotide binding

mitotic cell cycle

spindle pole

chromatin binding

DNA replication origin binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

spindle

cytosol

DNA replication

DNA replication initiation

cell cycle

kinase binding

regulation of mitotic metaphase/anaphase transition

positive regulation of cytokinesis

mitotic DNA replication checkpoint

intercellular bridge

positive regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of fibroblast proliferation

spindle midzone

cell division

positive regulation of chromosome segregation

mitotic spindle

04110

TC1600000503.mm.2 Ccdc58 coiled-coil domain containing 58 16 36071659, 36081274 NM_001159421, NM_001159422, NM_198645, BC024862 NM_001159421, NM_001159422, NM_198645, BC024862 NM_001159421, NM_001159422, NM_198645, BC024862 NM_001159421, NM_001159422, NM_198645, BC024862 19

molecular_function

mitochondrion

mitochondrion

biological_process

 
TC0100002314.mm.2 Gls glutaminase 1 -52185280, -52163449 NM_001081081, NM_001113383 NM_001081081, NM_001113383 82

suckling behavior

regulation of respiratory gaseous exchange by nervous system process

glutaminase activity

glutaminase activity

glutaminase activity

glutaminase activity

protein binding

cytoplasm

mitochondrion

glutamate biosynthetic process

glutamate biosynthetic process

glutamate biosynthetic process

glutamine metabolic process

glutamine catabolic process

glutamine catabolic process

glutamine catabolic process

glutamine catabolic process

chemical synaptic transmission

hydrolase activity

identical protein binding

protein homotetramerization

protein homotetramerization

glutamate homeostasis

00250

00330

00471

00910

01100

04964

TC1800000344.mm.2 Wdr55 WD repeat domain 55 18 36760221 NM_026464, BC131932, BC131934 NM_026464, BC131932, BC131934 NM_026464, BC131932, BC131934 17

molecular_function

nucleus

nucleoplasm

nucleolus

nucleolus

cytoplasm

rRNA processing

rRNA processing

 
TC1500001927.mm.2 Rangap1 RAN GTPase activating protein 1 15 -81704247 NM_001146174, NM_011241, BC014855, BC052862, BC066213, BC071200 NM_001146174, NM_011241, BC014855, BC052862, BC066213, BC071200 NM_001146174, NM_011241, BC014855, BC052862, BC066213, BC071200 NM_001146174, NM_011241, BC014855, BC052862, BC066213, BC071200 NM_001146174, NM_011241, BC014855, BC052862, BC066213, BC071200 NM_001146174, NM_011241, BC014855, BC052862, BC066213, BC071200 54

chromosome, centromeric region

kinetochore

RNA binding

GTPase activator activity

nucleus

nuclear envelope

nuclear pore

chromosome

cytoplasm

cytoplasm

cytosol

cytoskeleton

signal transduction

aggresome

dendrite

small GTPase binding

ubiquitin protein ligase binding

nuclear membrane

intracellular membrane-bounded organelle

nuclear pore cytoplasmic filaments

negative regulation of protein export from nucleus

perinuclear region of cytoplasm

perinuclear region of cytoplasm

cellular response to peptide hormone stimulus

mitotic spindle

activation of GTPase activity

axon cytoplasm

cytoplasmic periphery of the nuclear pore complex

03013

TC0500001066.mm.2 Cdc7 cell division cycle 7 (S. cerevisiae) 5 106964321, 106964560 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 NM_001271566, NM_001271567, NM_001271568, NM_009863, BC072666, BC080702 32

nucleotide binding

double-strand break repair via break-induced replication

protein kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

protein phosphorylation

cell cycle

positive regulation of cell population proliferation

positive regulation of nuclear cell cycle DNA replication

positive regulation of G2/M transition of mitotic cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

cell cycle phase transition

intercellular bridge

metal ion binding

cell division

mitotic spindle

04110

TSUnmapped00000020.mm.2 Snx29 sorting nexin 29 16 11322903, 11405647 NM_001290148 15

molecular_function

biological_process

phosphatidylinositol binding

 
TC0500001512.mm.2         NM_009838, NR_003681, BC018459, BC069917, BC094352 NM_009838, NR_003681, BC018459, BC069917, BC094352 NM_009838, NR_003681, BC018459, BC069917, BC094352 NM_009838, NR_003681, BC018459, BC069917, BC094352 NM_009838, NR_003681, BC018459, BC069917, BC094352  

nucleotide binding

acrosomal vesicle

zona pellucida receptor complex

molecular_function

protein binding

ATP binding

cellular_component

cytoplasm

cytosol

chaperonin-containing T-complex

chaperonin-containing T-complex

chaperonin-containing T-complex

microtubule

protein folding

protein folding

binding of sperm to zona pellucida

biological_process

positive regulation of telomere maintenance via telomerase

protein folding chaperone

cell body

protein stabilization

unfolded protein binding

WD40-repeat domain binding

toxin transport

positive regulation of establishment of protein localization to telomere

 
TC1700001987.mm.2 Mrps18b mitochondrial ribosomal protein S18B 17 -35910379 NM_025878, BC021752 NM_025878, BC021752 27

structural constituent of ribosome

intracellular anatomical structure

nucleoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial small ribosomal subunit

mitochondrial small ribosomal subunit

ribosome

translation

cell junction

mitochondrial translation

 
TC1600001277.mm.2 2610318N02Rik RIKEN cDNA 2610318N02 gene 16 -17113397 NM_183287, BC039993 NM_183287, BC039993 15

molecular_function

cellular_component

biological_process

 
TC1900000491.mm.2 Lipn lipase, family member N 19 34067357 NM_027340 12

extracellular region

lipid metabolic process

lipid catabolic process

hydrolase activity

hydrolase activity, acting on ester bonds

intracellular membrane-bounded organelle

 
MG-1-neg-10341763_st                
TC0X00002689.mm.2 Ophn1 oligophrenin 1 X -98554279, -98873725 NM_052976, BC004845 NM_052976, BC004845 39

actin binding

GTPase activator activity

GTPase activator activity

protein binding

phospholipid binding

cytoplasm

cytoplasm

endocytosis

signal transduction

nervous system development

actin cytoskeleton

actin cytoskeleton

cerebellar granule cell differentiation

cerebral cortex neuron differentiation

actin cytoskeleton organization

actin cytoskeleton organization

cell junction

regulation of endocytosis

regulation of endocytosis

neuron differentiation

dendrite

neuron projection development

cell junction assembly

regulation of Rho protein signal transduction

ionotropic glutamate receptor binding

cell projection

terminal bouton

terminal bouton

dendritic spine

dendritic spine

establishment of epithelial cell apical/basal polarity

synapse

synaptic vesicle endocytosis

synaptic vesicle endocytosis

synaptic vesicle endocytosis

cell morphogenesis involved in neuron differentiation

regulation of synaptic transmission, glutamatergic

regulation of synaptic transmission, glutamatergic

maintenance of postsynaptic specialization structure

glutamatergic synapse

regulation of postsynaptic neurotransmitter receptor internalization

negative regulation of proteasomal protein catabolic process

negative regulation of proteasomal protein catabolic process

 
TC1700002794.mm.2         NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983 NM_001123368, NM_001123367, BC061136, BC131981, BC131983  

molecular_function

protein binding

cellular_component

cytosol

cytoplasmic dynein complex

microtubule-based movement

biological_process

extrinsic component of membrane

sperm flagellum

 
TC0700002004.mm.2 Mtg1 mitochondrial ribosome-associated GTPase 1 7 140137563 NM_199301, BC027306 NM_199301, BC027306 16

nucleotide binding

GTPase activity

GTPase activity

GTP binding

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

mitochondrial ribosome

regulation of translation

membrane

regulation of respiratory system process

regulation of mitochondrial translation

 
TC0X00001674.mm.2 Fancb Fanconi anemia, complementation group B X 164980591 NM_001146081, NM_175027, BC083151 NM_001146081, NM_175027, BC083151 NM_001146081, NM_175027, BC083151 17

molecular_function

nucleus

DNA repair

cellular response to DNA damage stimulus

cellular response to drug

cellular response to drug

interstrand cross-link repair

Fanconi anaemia nuclear complex

Fanconi anaemia nuclear complex

cellular response to camptothecin

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair via homologous recombination

replication-born double-strand break repair via sister chromatid exchange

replication-born double-strand break repair via sister chromatid exchange

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

 
TC0300000412.mm.2 Alg5 asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase) 3 54735538 NM_025442, BC027160 NM_025442, BC027160 19

dolichyl-phosphate beta-glucosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

protein N-linked glycosylation

determination of left/right symmetry

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

00510

01100

TC1200001597.mm.2 Bcap29 B cell receptor associated protein 29 12 -31595353, -31595353 NM_001164090, NM_007530, BC003303, BC021661 NM_001164090, NM_007530, BC003303, BC021661 NM_001164090, NM_007530, BC003303, BC021661 NM_001164090, NM_007530, BC003303, BC021661 24

endoplasmic reticulum

endoplasmic reticulum membrane

intracellular protein transport

endoplasmic reticulum to Golgi vesicle-mediated transport

endoplasmic reticulum to Golgi vesicle-mediated transport

apoptotic process

protein transport

membrane

integral component of membrane

vesicle-mediated transport

protein localization to endoplasmic reticulum exit site

protein localization to endoplasmic reticulum exit site

 
TC1400000501.mm.2 Cdkn3 cyclin-dependent kinase inhibitor 3 14 46760540 NM_028222, BC049694 NM_028222, BC049694 17

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

protein binding

cytoplasm

cytosol

cellular response to DNA damage stimulus

cell cycle

cell cycle arrest

cell cycle arrest

dephosphorylation

hydrolase activity

phosphatase activity

perinuclear region of cytoplasm

 
TC0800002339.mm.2 Psd3 pleckstrin and Sec7 domain containing 3 8 -67689081, -67689081, -67689081 NM_027626, NM_030263, NM_177698 NM_027626, NM_030263, NM_177698 NM_027626, NM_030263, NM_177698 22

guanyl-nucleotide exchange factor activity

plasma membrane

membrane

cell junction

ARF protein signal transduction

regulation of ARF protein signal transduction

ruffle membrane

ruffle membrane

cell projection

synapse

04144

TC1600002094.mm.2 Rcan1 regulator of calcineurin 1 16 -92391950, -92391950 NM_001081549, NM_019466, BC013551 NM_001081549, NM_019466, BC013551 NM_001081549, NM_019466, BC013551 113

response to ischemia

nucleic acid binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

response to stress

response to stress

response to oxidative stress

short-term memory

calcium-dependent protein serine/threonine phosphatase regulator activity

calcium-mediated signaling

locomotion involved in locomotory behavior

calcineurin-NFAT signaling cascade

calcineurin-NFAT signaling cascade

identical protein binding

regulation of phosphoprotein phosphatase activity

skeletal muscle fiber development

negative regulation of calcineurin-NFAT signaling cascade

 
TC0600003003.mm.2 Ankrd26 ankyrin repeat domain 26 6 -118501299 NM_001081112 22

protein binding

cytoplasm

centrosome

actin cytoskeleton

regulation of lipid metabolic process

regulation of fatty acid metabolic process

negative regulation of multicellular organism growth

glucose homeostasis

negative regulation of fat cell differentiation

negative regulation of organ growth

negative regulation of insulin receptor signaling pathway

regulation of feeding behavior

negative regulation of ERK1 and ERK2 cascade

 
TC1300002654.mm.2 Gapt Grb2-binding adaptor, transmembrane 13 -110352614 NM_177713, BC116629, BC118005 NM_177713, BC116629, BC118005 NM_177713, BC116629, BC118005 14

B cell homeostasis

B cell homeostasis

B cell proliferation involved in immune response

B cell proliferation involved in immune response

immunoglobulin production involved in immunoglobulin-mediated immune response

immunoglobulin production involved in immunoglobulin-mediated immune response

Golgi apparatus

plasma membrane

membrane

integral component of membrane

B cell activation

intracellular membrane-bounded organelle

 
TC0900001459.mm.2 Scap SREBF chaperone 9 110333355, 110333287 NM_001001144, NM_001103162, BC070437, BC072633 NM_001001144, NM_001103162, BC070437, BC072633 NM_001001144, NM_001103162, BC070437, BC072633 NM_001001144, NM_001103162, BC070437, BC072633 64

Golgi membrane

response to hypoxia

protein binding

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

Golgi apparatus

lipid metabolic process

immune response

steroid metabolic process

cholesterol metabolic process

lipid binding

cholesterol binding

membrane

integral component of membrane

regulation of fatty acid metabolic process

cytoplasmic vesicle

response to insulin

SREBP signaling pathway

sterol binding

protein-containing complex

regulation of fatty acid biosynthetic process

intracellular membrane-bounded organelle

cellular lipid metabolic process

protein-containing complex binding

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

 
TC0100002844.mm.2 St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 1 -95587681, -95627242 NM_001159745, NM_009183, BC060112 NM_001159745, NM_009183, BC060112 NM_001159745, NM_009183, BC060112 59

ganglioside biosynthetic process

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Golgi apparatus

protein glycosylation

protein glycosylation

N-glycan processing

N-glycan processing

sialyltransferase activity

oligosaccharide metabolic process

oligosaccharide metabolic process

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

 
TC0100002308.mm.2 Myo1b myosin IB 1 -51749757 NM_001161817, NM_010863, BC046300, BC054786 NM_001161817, NM_010863, BC046300, BC054786 NM_001161817, NM_010863, BC046300, BC054786 NM_001161817, NM_010863, BC046300, BC054786 41

microfilament motor activity

microfilament motor activity

nucleotide binding

motor activity

actin binding

calmodulin binding

ATP binding

phosphatidylinositol-4,5-bisphosphate binding

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

cytoplasm

early endosome

actin filament

plasma membrane

plasma membrane

microvillus

brush border

brush border

brush border

post-Golgi vesicle-mediated transport

actin filament organization

actin filament organization

endosome membrane

actin cytoskeleton

myosin complex

actin filament-based movement

vesicle transport along actin filament

filopodium

actin-dependent ATPase activity

actin-dependent ATPase activity

vesicle

trans-Golgi network membrane

transferrin transport

apical part of cell

perinuclear region of cytoplasm

actin filament binding

actin filament binding

actin filament bundle assembly

cell periphery

 
TC1500001568.mm.2 Atad2 ATPase family, AAA domain containing 2 15 -58094046 NM_027435 24

nucleotide binding

chromatin binding

protein binding

ATP binding

nucleus

nucleoplasm

chromatin organization

regulation of transcription, DNA-templated

hydrolase activity

ATPase activity

ATPase activity

negative regulation of chromatin silencing

histone binding

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

 
MG-1-pos-10341530_st                
TC1100004233.mm.2 Fasn fatty acid synthase 11 -120805957 NM_007988, BC046513 NM_007988, BC046513 153

glandular epithelial cell development

catalytic activity

fatty acid synthase activity

fatty acid synthase activity

fatty acid synthase activity

[acyl-carrier-protein] S-acetyltransferase activity

[acyl-carrier-protein] S-malonyltransferase activity

3-oxoacyl-[acyl-carrier-protein] synthase activity

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity

oleoyl-[acyl-carrier-protein] hydrolase activity

cytoplasm

mitochondrion

Golgi apparatus

cytosol

plasma membrane

acetyl-CoA metabolic process

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

fatty acid biosynthetic process

metabolic process

ether lipid biosynthetic process

biosynthetic process

tissue development

myristoyl-[acyl-carrier-protein] hydrolase activity

palmitoyl-[acyl-carrier-protein] hydrolase activity

acyl-[acyl-carrier-protein] hydrolase activity

oxidoreductase activity

transferase activity

hydrolase activity

hydrolase activity, acting on ester bonds

lyase activity

3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

neutrophil differentiation

monocyte differentiation

mammary gland development

phosphopantetheine binding

glycogen granule

identical protein binding

enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity

3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity

cellular response to interleukin-4

establishment of endothelial intestinal barrier

3-oxo-glutaryl-[acp] methyl ester reductase activity

3-oxo-pimeloyl-[acp] methyl ester reductase activity

00061

01100

04910

TC0700001402.mm.2 Pgm2l1 phosphoglucomutase 2-like 1 7 100227606 NM_027629, BC032150, BC076571 NM_027629, BC032150, BC076571 NM_027629, BC032150, BC076571 17

carbohydrate metabolic process

glucose metabolic process

transferase activity

isomerase activity

intramolecular transferase activity, phosphotransferases

metal ion binding

glucose-1,6-bisphosphate synthase activity

glucose-1,6-bisphosphate synthase activity

organic substance metabolic process

00500

TC0600003342.mm.2 Eps8 epidermal growth factor receptor pathway substrate 8 6 -137477244, -137477244, -137477244 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 NM_001271587, NM_001271588, NM_001271589, NM_001271595, NM_007945, BC016890 73

actin binding

actin binding

protein binding

cytoplasm

plasma membrane

brush border

cell cortex

Rho protein signal transduction

adult locomotory behavior

regulation of cell shape

exit from mitosis

postsynaptic density

postsynaptic density

membrane

Rac protein signal transduction

NMDA selective glutamate receptor complex

cell junction

regulation of actin filament length

small GTPase binding

actin cytoskeleton reorganization

stereocilium

stereocilium bundle

stereocilium tip

ruffle membrane

ruffle membrane

regulation of Rho protein signal transduction

signaling adaptor activity

dendritic cell migration

cell projection

neuron projection

synapse

behavioral response to ethanol

barbed-end actin filament capping

barbed-end actin filament capping

actin filament bundle assembly

actin filament bundle assembly

actin filament bundle assembly

actin crosslink formation

actin crosslink formation

actin polymerization-dependent cell motility

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

regulation of postsynaptic membrane neurotransmitter receptor levels

regulation of postsynaptic membrane neurotransmitter receptor levels

regulation of postsynaptic membrane neurotransmitter receptor levels

positive regulation of ruffle assembly

cellular response to leukemia inhibitory factor

 
TC1000000656.mm.2 Rhobtb1 Rho-related BTB domain containing 1 10 69212656, 69208551, 69213193 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 NM_001081347, NM_001252636, NM_001252637, NM_001252638, BC099973, BC137646, BC137647, BC144800 20

nucleotide binding

GTPase activity

protein binding

GTP binding

intracellular anatomical structure

cytoskeleton

plasma membrane

cell cortex

actin filament organization

establishment or maintenance of cell polarity

small GTPase mediated signal transduction

regulation of cell shape

protein kinase binding

cortical cytoskeleton organization

cytoplasmic vesicle

regulation of actin cytoskeleton organization

cell projection

intracellular membrane-bounded organelle

engulfment of apoptotic cell

04120

TC1900000954.mm.2 Pacs1 phosphofurin acidic cluster sorting protein 1 19 -5133684, -5133684 NM_153129, BC062886 NM_153129, BC062886 27

Golgi apparatus

COPI-coated vesicle

positive regulation of protein binding

protein localization to Golgi apparatus

cellular protein localization

ion channel binding

ion channel binding

perinuclear region of cytoplasm

protein localization to plasma membrane

protein localization to plasma membrane

 
TC0700004188.mm.2 Thumpd1 THUMP domain containing 1 7 -119715093 NM_145585, BC004776 NM_145585, BC004776 21

RNA binding

cellular_component

tRNA modification

 
TC1400000177.mm.2 Vcl vinculin 14 20929397 NM_009502, BC008520 NM_009502, BC008520 214

stress fiber

morphogenesis of an epithelium

podosome

dystroglycan binding

actin binding

structural molecule activity

protein binding

cytoplasm

cytoskeleton

actin filament

plasma membrane

cell-cell junction

cell-cell junction

adherens junction

adherens junction

fascia adherens

focal adhesion

focal adhesion

cell adhesion

intercalated disc

actin cytoskeleton

membrane

Z disc

lamellipodium assembly

cell junction

regulation of cell migration

small GTPase binding

ubiquitin protein ligase binding

protein-containing complex

adherens junction assembly

protein localization to cell surface

sarcolemma

sarcolemma

costamere

costamere

apical junction assembly

cell-cell contact zone

membrane raft

alpha-catenin binding

axon extension

actin filament binding

regulation of focal adhesion assembly

epithelial cell-cell adhesion

regulation of establishment of endothelial barrier

regulation of protein localization to adherens junction

04510

04520

04670

04810

05100

05146

TC1300002609.mm.2 Rnf180 ring finger protein 180 13 -105147493, -105130569 NM_027934, BC046775, BC075700 NM_027934, BC046775, BC075700 NM_027934, BC046775, BC075700 19

protein polyubiquitination

protein binding

nucleus

endoplasmic reticulum

membrane

integral component of membrane

transferase activity

adult behavior

intrinsic component of endoplasmic reticulum membrane

intrinsic component of endoplasmic reticulum membrane

positive regulation of protein ubiquitination

ubiquitin conjugating enzyme binding

ubiquitin conjugating enzyme binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

norepinephrine metabolic process

norepinephrine metabolic process

serotonin metabolic process

serotonin metabolic process

metal ion binding

regulation of catalytic activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

organic cyclic compound metabolic process

 
TC0400003271.mm.2 Cdkn2c cyclin dependent kinase inhibitor 2C 4 -109660875, -109660875 NM_007671, BC027026 NM_007671, BC027026 131

regulation of cyclin-dependent protein serine/threonine kinase activity

G1/S transition of mitotic cell cycle

cyclin-dependent protein serine/threonine kinase inhibitor activity

cyclin-dependent protein serine/threonine kinase inhibitor activity

nucleus

cytoplasm

cell cycle

cell cycle arrest

negative regulation of cell population proliferation

negative regulation of cell population proliferation

protein kinase binding

protein kinase binding

negative regulation of cell growth

negative regulation of phosphorylation

negative regulation of cyclin-dependent protein serine/threonine kinase activity

04110

TC1500001262.mm.2 Hnrnpa1l2-ps2 heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2 15 -22713819 NM_001165971 1  

03040

TC0500002650.mm.2 Noa1 nitric oxide associated 1 5 -77294168 NM_019836, BC017154 NM_019836, BC017154 24

nucleotide binding

GTP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

apoptotic process

regulation of cell death

regulation of cell death

regulation of cell death

membrane

extrinsic component of mitochondrial inner membrane

mitochondrial translation

regulation of cellular respiration

regulation of cellular respiration

 
TC1300001326.mm.2 Emb embigin 13 117220572 NM_010330, BC014858 NM_010330, BC014858 43

plasma membrane

integral component of plasma membrane

cell adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

axon guidance

membrane

integral component of membrane

cell junction

axon

plasma membrane lactate transport

synapse

dendrite self-avoidance

cell-cell adhesion mediator activity

 
TC1600000138.mm.2 Snx29 sorting nexin 29 16 11322903, 11405647 NM_028964 15

molecular_function

biological_process

phosphatidylinositol binding

 
TC0700001150.mm.2 Vps33b vacuolar protein sorting 33B 7 80269654 NM_178070, BC034170 NM_178070, BC034170 30

protein binding

cytoplasm

lysosome

lysosome

endosome

late endosome

Golgi apparatus

intracellular protein transport

intracellular protein transport

vesicle docking involved in exocytosis

endosome organization

synaptic vesicle

protein transport

membrane

vesicle-mediated transport

vesicle-mediated transport

peptidyl-lysine hydroxylation

peptidyl-lysine hydroxylation

clathrin-coated vesicle

collagen fibril organization

platelet alpha granule

cytoplasmic vesicle

early endosome membrane

melanosome localization

lysosome localization

collagen metabolic process

collagen metabolic process

CORVET complex

megakaryocyte development

protein-containing complex binding

perinuclear region of cytoplasm

membrane fusion

platelet alpha granule organization

platelet alpha granule organization

regulation of platelet aggregation

 
TC0X00000519.mm.2 Ints6l integrator complex subunit 6 like X 56454838 NM_172779, BC051161, BC066792 NM_172779, BC051161, BC066792 NM_172779, BC051161, BC066792 15

molecular_function

integrator complex

snRNA 3'-end processing

 
TC0X00002158.mm.2 Zdhhc9 zinc finger, DHHC domain containing 9 X -48171970 NM_172465, BC042618, BC090832 NM_172465, BC042618, BC090832 NM_172465, BC042618, BC090832 18

palmitoyltransferase complex

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cytosol

protein targeting to membrane

membrane

integral component of membrane

palmitoyltransferase activity

transferase activity

transferase activity, transferring acyl groups

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein-cysteine S-palmitoyltransferase activity

intrinsic component of Golgi membrane

Ras palmitoyltransferase activity

 
TC0900001692.mm.2 Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 9 -4294792 NM_026276, BC030043, BC038013, BC049851 NM_026276, BC030043, BC038013, BC049851 NM_026276, BC030043, BC038013, BC049851 NM_026276, BC030043, BC038013, BC049851 17

magnesium ion binding

cytoplasm

cytosol

cytosol

holo-[acyl-carrier-protein] synthase activity

holo-[acyl-carrier-protein] synthase activity

transferase activity

lysine biosynthetic process via aminoadipic acid

metal ion binding

 
TC0300000880.mm.2 Selenbp1 selenium binding protein 1 3 94933082 NM_009150, BC011202 NM_009150, BC011202 31

fibrillar center

nucleus

nucleolus

cytoplasm

selenium binding

protein transport

membrane

oxidoreductase activity

methanethiol oxidase activity

brown fat cell differentiation

 
TC0200004537.mm.2 Atp8b4 ATPase, class I, type 8B, member 4 2 -126320972, -126320972 NM_001080944 12

Golgi apparatus

trans-Golgi network

plasma membrane

plasma membrane

Golgi organization

phospholipid translocation

ATPase-coupled intramembrane lipid transporter activity

 
TC1200001861.mm.2 Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 12 -69201778 NM_011133, BC063772 NM_011133, BC063772 23

DNA binding

DNA-directed DNA polymerase activity

nucleus

nucleoplasm

DNA replication

DNA-dependent DNA replication

epsilon DNA polymerase complex

epsilon DNA polymerase complex

nuclear body

error-prone translesion synthesis

intracellular membrane-bounded organelle

00230

00240

01100

03030

03410

03420

TC1400002867.mm.2 Xpo4 exportin 4 14 -57577520, -57639770 NM_020506, BC156636 NM_020506, BC156636 25

nuclear export signal receptor activity

nucleus

nuclear pore

nucleoplasm

cytoplasm

cytosol

protein export from nucleus

protein transport

positive regulation of protein export from nucleus

 
TC0900001398.mm.2 Nicn1 nicolin 1 9 108290442 NM_025449, BC024050 NM_025449, BC024050 21

molecular_function

nucleus

nucleoplasm

nucleoplasm

cytosol

microtubule

biological_process

protein polyglutamylation

 
TC0600000989.mm.2 C87436 expressed sequence C87436 6 86438673, 86438397, 86438645, 86438375 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 NM_001243741, NM_001243742, NM_146170, BC025632, BC026926, BC031913 18

molecular_function

nucleus

nucleoplasm

biological_process

 
TC1300002201.mm.2 Prxl2c peroxiredoxin like 2C 13 -64289797 NM_025370, BC156631 NM_025370, BC156631 13

cellular_component

antioxidant activity

positive regulation of glycolytic process

positive regulation of ERK1 and ERK2 cascade

 
TC1200000825.mm.2 Ylpm1 YLP motif containing 1 12 84996320 NM_178363 25

negative regulation of transcription by RNA polymerase II

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleus

nucleus

nucleus

nucleoplasm

cytosol

nuclear speck

regulation of telomere maintenance

regulation of telomere maintenance

 
TC0200002803.mm.2 Slc17a9 solute carrier family 17, member 9 2 180725338 NM_183161 36

guanine nucleotide transmembrane transporter activity

transporter activity

ATP transmembrane transporter activity

exocytosis

ADP transmembrane transporter activity

ADP transport

ATP transport

membrane

integral component of membrane

secretory granule

chromaffin granule membrane

chromaffin granule membrane

transmembrane transport

guanine nucleotide transmembrane transport

ATP export

 
TC0500003096.mm.2 Gatc glutamyl-tRNA(Gln) amidotransferase, subunit C 5 -115333241 NM_029645, BC021775 NM_029645, BC021775 14

nucleotide binding

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

translation

regulation of translational fidelity

ligase activity

glutamyl-tRNA(Gln) amidotransferase complex

glutamyl-tRNA(Gln) amidotransferase complex

mitochondrial translation

mitochondrial translation

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

glutaminyl-tRNAGln biosynthesis via transamidation

glutaminyl-tRNAGln biosynthesis via transamidation

 
TC0400001683.mm.2 Hnrnpr heterogeneous nuclear ribonucleoprotein R 4 136310941, 136311597 NM_001277121, NM_001277122, NM_001277123, NM_028871, BC038051 NM_001277121, NM_001277122, NM_001277123, NM_028871, BC038051 NM_001277121, NM_001277122, NM_001277123, NM_028871, BC038051 NM_001277121, NM_001277122, NM_001277123, NM_028871, BC038051 NM_001277121, NM_001277122, NM_001277123, NM_028871, BC038051 38

RNA binding

mRNA binding

mRNA 3'-UTR binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

dendrite

growth cone

negative regulation of catalytic activity

axon terminus

positive regulation of mRNA catabolic process

mRNA destabilization

catalytic step 2 spliceosome

ribonucleoprotein complex

ribonucleoprotein complex

 
TC1100003410.mm.2 Aatf apoptosis antagonizing transcription factor 11 -84422855 NM_019816, BC025080 NM_019816, BC025080 42

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

Golgi apparatus

cytosol

regulation of transcription by RNA polymerase II

cell adhesion

regulation of mitotic cell cycle

protein kinase binding

negative regulation of superoxide anion generation

embryonic cleavage

ribosome biogenesis

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of apoptotic process

leucine zipper domain binding

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

tau protein binding

negative regulation of reactive oxygen species metabolic process

negative regulation of apoptotic signaling pathway

 
TC1300000248.mm.2 H1f3 H1.3 linker histone, cluster member 13 23555031 NM_145713, BC117045, BC119173 NM_145713, BC117045, BC119173 NM_145713, BC117045, BC119173 47

negative regulation of transcription by RNA polymerase II

chromatin

nucleosome

euchromatin

DNA binding

double-stranded DNA binding

protein binding

nucleus

chromosome

nucleosome assembly

regulation of transcription by RNA polymerase II

nucleosome positioning

nucleosome positioning

chromosome condensation

chromatin DNA binding

nucleosomal DNA binding

negative regulation of chromatin silencing

negative regulation of DNA recombination

histone H3-K4 trimethylation

histone H3-K27 trimethylation

 
TC1200000140.mm.2 Nol10 nucleolar protein 10 12 17348492 NM_001008421, BC086676 NM_001008421, BC086676 22

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nucleus

nucleolus

nucleolus

small-subunit processome

 
TC0200001741.mm.2 Bub1b BUB1B, mitotic checkpoint serine/threonine kinase 2 118598210 NM_009773, BC031577 NM_009773, BC031577 96

nucleotide binding

chromosome, centromeric region

kinetochore

kinetochore

kinetochore

condensed chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed nuclear chromosome kinetochore

condensed chromosome outer kinetochore

condensed chromosome outer kinetochore

protein kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

chromosome

cytoplasm

spindle

cytosol

protein phosphorylation

apoptotic process

cell cycle

metaphase/anaphase transition of mitotic cell cycle

mitotic spindle assembly checkpoint

kinase activity

phosphorylation

transferase activity

perinuclear region of cytoplasm

cell division

meiotic sister chromatid cohesion, centromeric

protein localization to chromosome, centromeric region

04110

TC0200001836.mm.2         NM_001256055, NM_144545, BC080788 NM_001256055, NM_144545, BC080788 NM_001256055, NM_144545, BC080788  

cytosol

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex

identical protein binding

 
TC0100002963.mm.2 Tmem37 transmembrane protein 37 1 -120067376 NM_019432, BC024613 NM_019432, BC024613 20

voltage-gated ion channel activity

calcium channel activity

ion transport

calcium ion transport

membrane

integral component of membrane

regulation of ion transmembrane transport

calcium ion transmembrane transport

 
TC0200002844.mm.2 Rpp38 ribonuclease P/MRP 38 subunit 2 -3328948 NM_001013376, BC051448 NM_001013376, BC051448 15

fibrillar center

fibrillar center

tRNA 5'-leader removal

tRNA 5'-leader removal

ribonuclease P activity

ribonuclease P activity

nucleus

nucleolus

rRNA processing

tRNA processing

hydrolase activity

multimeric ribonuclease P complex

multimeric ribonuclease P complex

ribonuclease P RNA binding

ribonuclease P RNA binding

03008

03013

TC0100003021.mm.2 Zranb3 zinc finger, RAN-binding domain containing 3 1 -127954178, -127954178, -127954178 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 NM_001285945, NM_027678, BC066035, BC117921, BC117922 20

nucleotide binding

nucleic acid binding

catalytic activity

helicase activity

nuclease activity

endonuclease activity

endodeoxyribonuclease activity

endodeoxyribonuclease activity

ATP binding

nucleus

nucleoplasm

chromosome

DNA repair

DNA repair

cellular response to DNA damage stimulus

metabolic process

response to UV

hydrolase activity

replication fork processing

replication fork processing

DNA rewinding

annealing helicase activity

nuclear replication fork

nuclear replication fork

negative regulation of DNA recombination

metal ion binding

replication fork protection

replication fork protection

K63-linked polyubiquitin modification-dependent protein binding

 
TC0400002709.mm.2 Tmem245 transmembrane protein 245 4 -56876013, -56876012 NM_175518 16

membrane

integral component of membrane

 
TC0900002302.mm.2 Ddx10 DEAD box helicase 10 9 -53098453 NM_029936, BC080729 NM_029936, BC080729 21

nucleotide binding

nucleic acid binding

RNA binding

helicase activity

ATP binding

nucleus

rRNA processing

hydrolase activity

anterior head development

 
TC1500001585.mm.2 Mtss1 MTSS I-BAR domain containing 1 15 -58941233 NM_001146180, NM_144800, BC024131 NM_001146180, NM_144800, BC024131 NM_001146180, NM_144800, BC024131 51

in utero embryonic development

actin binding

actin monomer binding

signaling receptor binding

protein binding

cytoplasm

cytoskeleton

adherens junction

plasma membrane organization

actin filament organization

nervous system development

muscle organ development

magnesium ion homeostasis

actin cytoskeleton

actin cytoskeleton organization

actin filament polymerization

bone mineralization

positive regulation of actin filament bundle assembly

adherens junction maintenance

identical protein binding

identical protein binding

negative regulation of epithelial cell proliferation

actin filament binding

renal tubule morphogenesis

cellular response to fluid shear stress

glomerulus morphogenesis

nephron tubule epithelial cell differentiation

metanephric tubule development

epithelial cell proliferation involved in renal tubule morphogenesis

 
TC1100001331.mm.2 Trim37 tripartite motif-containing 37 11 87127074, 87127074 NM_197987, BC058678, BC059070 NM_197987, BC058678, BC059070 NM_197987, BC058678, BC059070 31

negative regulation of transcription by RNA polymerase II

chromatin binding

transcription coactivator activity

ubiquitin-protein transferase activity

tumor necrosis factor receptor binding

tumor necrosis factor receptor binding

intracellular anatomical structure

cytoplasm

peroxisome

peroxisome

cytosol

zinc ion binding

aggresome

aggresome

protein ubiquitination

transferase activity

ubiquitin protein ligase binding

ubiquitin protein ligase binding

negative regulation of NF-kappaB transcription factor activity

negative regulation of NF-kappaB transcription factor activity

ESC/E(Z) complex

histone H2A monoubiquitination

histone H2A monoubiquitination

histone H2A-K119 monoubiquitination

histone H2A-K119 monoubiquitination

histone H2A-K119 monoubiquitination

protein homodimerization activity

negative regulation of centriole replication

negative regulation of centriole replication

metal ion binding

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

protein autoubiquitination

protein autoubiquitination

ubiquitin protein ligase activity

ubiquitin protein ligase activity

aggresome assembly

04120

TC0400002613.mm.2 Alg2 asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase) 4 -47469832 NM_019998, BC051951, BC052411 NM_019998, BC051951, BC052411 NM_019998, BC051951, BC052411 22

alpha-1,3-mannosyltransferase activity

alpha-1,3-mannosyltransferase activity

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity

nucleus

cytoplasm

cytosol

protein glycosylation

dolichol-linked oligosaccharide biosynthetic process

oligosaccharide-lipid intermediate biosynthetic process

actin cytoskeleton

membrane

integral component of membrane

transferase activity

transferase activity, transferring glycosyl groups

protein glycosylation in endoplasmic reticulum

protein glycosylation in endoplasmic reticulum

protein heterodimerization activity

protein N-terminus binding

calcium-dependent protein binding

perinuclear region of cytoplasm

response to calcium ion

GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity

00510

01100

TC0900001009.mm.2 Myo5a myosin VA 9 75071205 NM_010864 275

microfilament motor activity

microfilament motor activity

microfilament motor activity

microfilament motor activity

SNARE binding

nucleotide binding

ruffle

photoreceptor outer segment

motor activity

motor activity

actin binding

calcium ion binding

protein binding

calmodulin binding

ATP binding

cytoplasm

cytoplasm

cytoplasm

lysosome

early endosome

late endosome

peroxisome

endoplasmic reticulum

smooth endoplasmic reticulum

smooth endoplasmic reticulum

Golgi apparatus

cytosol

cytosol

intermediate filament

actin filament

melanin metabolic process

exocytosis

post-Golgi vesicle-mediated transport

actin filament organization

chemical synaptic transmission

visual perception

synaptic vesicle

protein transport

actin cytoskeleton

membrane

vesicle-mediated transport

myosin complex

unconventional myosin complex

syntaxin-1 binding

regulation of exocytosis

protein kinase binding

actin filament-based movement

actin filament-based movement

vesicle transport along actin filament

vesicle transport along actin filament

vesicle transport along actin filament

insulin secretion

secretory granule

secretory granule

melanocyte differentiation

axon

dendrite

actin-dependent ATPase activity

small GTPase binding

small GTPase binding

regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

vesicle

vesicle

locomotion involved in locomotory behavior

secretory granule localization

secretory granule localization

melanosome localization

melanosome transport

melanosome transport

filopodium tip

insulin-responsive compartment

cellular response to insulin stimulus

melanin biosynthetic process

melanosome

melanosome

odontogenesis

myelination

anagen

actomyosin

actomyosin, myosin complex part

long-chain fatty acid biosynthetic process

identical protein binding

neuron projection

ATP-dependent protein binding

neuronal cell body

neuronal cell body

pigmentation

pigmentation

protein-containing complex binding

developmental pigmentation

calcium-dependent protein binding

hair follicle maturation

synapse organization

neuromuscular process controlling balance

actin filament binding

endoplasmic reticulum localization

recycling endosome

protein-containing complex assembly

protein localization to plasma membrane

disordered domain specific binding

Schaffer collateral - CA1 synapse

postsynapse

postsynapse

postsynaptic actin cytoskeleton

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

establishment of endoplasmic reticulum localization to postsynapse

establishment of endoplasmic reticulum localization to postsynapse

regulation of postsynaptic cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

axo-dendritic protein transport

positive regulation of cellular response to insulin stimulus

positive regulation of protein localization to plasma membrane

positive regulation of vascular associated smooth muscle cell migration

ribonucleoprotein complex

 
TC0200002720.mm.2         NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775 NM_001177404, NM_001177405, NM_001177406, NM_001177407, XM_003688775  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

cellular_component

regulation of transcription by RNA polymerase II

 
TC0200002738.mm.2         NM_001177405, NM_001177406, NM_001177404, NM_001177407 NM_001177405, NM_001177406, NM_001177404, NM_001177407 NM_001177405, NM_001177406, NM_001177404, NM_001177407 NM_001177405, NM_001177406, NM_001177404, NM_001177407  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

cellular_component

regulation of transcription by RNA polymerase II

 
TC0200005341.mm.2         NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068 NM_001177404, NM_001177407, NM_001177405, NM_001177406, XM_001480068  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

cellular_component

regulation of transcription by RNA polymerase II

 
TC0200000647.mm.2 Mrrf mitochondrial ribosome recycling factor 2 36136397 NM_026422, BC019787 NM_026422, BC019787 19

mitochondrion

mitochondrion

translation

ribosome disassembly

ribosomal large subunit binding

 
TC0100001699.mm.2 Sccpdh saccharopine dehydrogenase (putative) 1 179668230 NM_178653, BC025803 NM_178653, BC025803 18

molecular_function

mitochondrion

mitochondrion

lipid droplet

lipid droplet

plasma membrane

glycolipid biosynthetic process

oxidoreductase activity

midbody

 
TC0600000928.mm.2 Bola3 bolA-like 3 (E. coli) 6 83349475, 83349146, 83349215 NM_175277, BC116947, BC116949 NM_175277, BC116947, BC116949 NM_175277, BC116947, BC116949 17

molecular_function

mitochondrion

cytosol

biological_process

nuclear body

 
TC1700000603.mm.2 Wdr46 WD repeat domain 46 17 33940722 NM_020603, BC046977 NM_020603, BC046977 20

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nucleus

nucleolus

small-subunit processome

 
TC0100000464.mm.2 Fam117b family with sequence similarity 117, member B 1 59913005 NM_001037725 15

molecular_function

biological_process

 
TC0200005342.mm.2         NM_001199308, NM_001033123 NM_001199308, NM_001033123  

molecular_function

cellular_component

biological_process

 
TC1500000826.mm.2 Gtse1 G two S phase expressed protein 1 15 85859706, 85859945 NM_001168672, NM_013882, BC027213 NM_001168672, NM_013882, BC027213 NM_001168672, NM_013882, BC027213 28

cytoplasm

cytoskeleton

microtubule

cytoplasmic microtubule

cytoplasmic microtubule

microtubule binding

microtubule cytoskeleton

04115

TC1300001349.mm.2 Tmem267 transmembrane protein 267 13 119488472, 119488085 NM_001039244, NM_001177666, BC021422, BC103784 NM_001039244, NM_001177666, BC021422, BC103784 NM_001039244, NM_001177666, BC021422, BC103784 NM_001039244, NM_001177666, BC021422, BC103784 12

molecular_function

cellular_component

biological_process

membrane

integral component of membrane

 
TC0200005365.mm.2                
TC0100001943.mm.2 Mybl1 myeloblastosis oncogene-like 1 1 -9667410 NM_008651, BC103533 NM_008651, BC103533 43

mitotic cell cycle

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

nucleoplasm

regulation of transcription, DNA-templated

male meiosis I

spermatogenesis

negative regulation of transposition

cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

piRNA biosynthetic process

 
TC1300000543.mm.2 Rnf144b ring finger protein 144B 13 47194002, 47122719 NM_001170643, NM_146042, BC025007 NM_001170643, NM_146042, BC025007 NM_001170643, NM_146042, BC025007 20

ubiquitin ligase complex

protein polyubiquitination

ubiquitin-protein transferase activity

cytoplasm

cytoplasm

mitochondrion

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

apoptotic process

membrane

integral component of membrane

protein ubiquitination

transferase activity

ubiquitin conjugating enzyme binding

mitochondrial membrane

mitochondrial membrane

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of apoptotic process

metal ion binding

ubiquitin protein ligase activity

 
TC1400002756.mm.2 Ggact gamma-glutamylamine cyclotransferase 14 -122890859 NM_145466, BC006662, BC080839 NM_145466, BC006662, BC080839 NM_145466, BC006662, BC080839 12

cytosol

lyase activity

cellular modified amino acid catabolic process

gamma-glutamylaminecyclotransferase activity

 
TC0300002973.mm.2 Gstcd glutathione S-transferase, C-terminal domain containing 3 -132981749, -132981749 NM_026231, BC047136, BC061240 NM_026231, BC047136, BC061240 NM_026231, BC047136, BC061240 20

protein binding

cytoplasm

cytoplasm

biological_process

 
TC1200001314.mm.2 Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 12 117516525, 117533927 NM_175930, BC046627 NM_175930, BC046627 25

guanyl-nucleotide exchange factor activity

intracellular anatomical structure

nucleus

nucleoplasm

small GTPase mediated signal transduction

nuclear body

GTP-dependent protein binding

intracellular signal transduction

 
TC1100000007.mm.2         NM_001253690, NM_001253691, NM_019574, NR_045108, NR_045109, NR_045708, BC043035 NM_001253690, NM_001253691, NM_019574, NR_045108, NR_045109, NR_045708, BC043035 NM_001253690, NM_001253691, NM_019574, NR_045108, NR_045109, NR_045708, BC043035 NM_001253690, NM_001253691, NM_019574, NR_045108, NR_045109, NR_045708, BC043035 NM_001253690, NM_001253691, NM_019574, NR_045108, NR_045109, NR_045708, BC043035 NM_001253690, NM_001253691, NM_019574, NR_045108, NR_045109, NR_045708, BC043035 NM_001253690, NM_001253691, NM_019574, NR_045108, NR_045109, NR_045708, BC043035  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

regulation of transcription, DNA-templated

regulation of transcription by RNA polymerase II

spermatogenesis

male gonad development

regulation of gene expression

negative regulation of endothelial cell migration

T cell differentiation

ubiquitin protein ligase binding

negative regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

 
TC0300001289.mm.2 Zgrf1 zinc finger, GRF-type containing 1 3 127553488 NM_197997 15

RNA binding

cytoplasm

zinc ion binding

membrane

integral component of membrane

5'-flap endonuclease activity

metal ion binding

replication fork reversal

 
TC0700004326.mm.2 Zfp764 zinc finger protein 764 7 -127403667 NM_001167832, NM_146203, BC026397 NM_001167832, NM_146203, BC026397 NM_001167832, NM_146203, BC026397 16

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
TC0600003000.mm.2 Bms1 BMS1, ribosome biogenesis factor 6 -118383380 NM_194339, BC057054 NM_194339, BC057054 17

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GTPase activity

GTP binding

nucleoplasm

chromosome

nucleolus

90S preribosome

U3 snoRNA binding

03008

TC1100003551.mm.2 Utp18 UTP18 small subunit processome component 11 -93859242 NM_001013375, BC119621, BC119622 NM_001013375, BC119621, BC119622 NM_001013375, BC119621, BC119622 21

nucleus

nucleoplasm

nucleolus

rRNA processing

nuclear membrane

small-subunit processome

Pwp2p-containing subcomplex of 90S preribosome

03008

TC0300001797.mm.2 Zmat3 zinc finger matrin type 3 3 -32334793 NM_009517, BC138740, BC138742 NM_009517, BC138740, BC138742 NM_009517, BC138740, BC138742 33

nucleic acid binding

RNA binding

nucleus

nucleoplasm

nucleolus

plasma membrane

apoptotic process

cellular response to DNA damage stimulus

zinc ion binding

protein transport

negative regulation of cell growth

regulation of growth

positive regulation of apoptotic process

metal ion binding

04115

TC1500000165.mm.2 Retreg1 reticulophagy regulator 1 15 25933551, 25940825, 25843297, 25940701, 25942678 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 NM_001034851, NM_001277315, NM_001277316, NM_001277317, NM_001277318, NM_025459, BC019494, BC054415 28

molecular_function

nucleolus

endoplasmic reticulum

Golgi apparatus

cis-Golgi network

autophagy

membrane

integral component of membrane

nuclear body

sensory perception of pain

integral component of endoplasmic reticulum membrane

integral component of endoplasmic reticulum membrane

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

reticulophagy

reticulophagy

reticulophagy

 
TC0300000711.mm.2 Nes nestin 3 87971092 NM_016701, BC060693, BC062893 NM_016701, BC060693, BC062893 NM_016701, BC060693, BC062893 988

protein binding

cytoplasm

intermediate filament

intermediate filament

intermediate filament

multicellular organism development

nervous system development

intermediate filament binding

positive regulation of intermediate filament depolymerization

CCR5 chemokine receptor binding

CCR5 chemokine receptor binding

negative regulation of neuron apoptotic process

cell projection morphogenesis

 
TC0200005476.mm.2 Nup35 nucleoporin 35 2 80639263, 80638811 NM_001190179, NM_027091, BC048814 NM_001190179, NM_027091, BC048814 NM_001190179, NM_027091, BC048814 22

nucleic acid binding

single-stranded DNA binding

phospholipid binding

nucleus

nuclear pore

nuclear lamina

nucleoplasm

plasma membrane

regulation of transcription, DNA-templated

NLS-bearing protein import into nucleus

nuclear pore organization

protein transport

membrane

structural constituent of nuclear pore

nuclear membrane

identical protein binding

nuclear pore central transport channel

nuclear pore nuclear basket

mRNA transport

cellular response to leukemia inhibitory factor

03013

TC0500000785.mm.2 Stap1 signal transducing adaptor family member 1 5 86071745 NM_019992, BC145550, BC145828, BC145830 NM_019992, BC145550, BC145828, BC145830 NM_019992, BC145550, BC145828, BC145830 NM_019992, BC145550, BC145828, BC145830 26

phosphotyrosine residue binding

transmembrane receptor protein tyrosine kinase adaptor activity

macrophage colony-stimulating factor receptor binding

protein binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

transmembrane receptor protein tyrosine kinase signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway

response to bacterium

positive regulation of gene expression

negative regulation of macrophage chemotaxis

protein kinase binding

protein kinase binding

myeloid cell differentiation

protein-macromolecule adaptor activity

receptor tyrosine kinase binding

protein-containing complex

signaling adaptor activity

signaling adaptor activity

negative regulation of phosphorylation

intracellular membrane-bounded organelle

positive regulation of B cell receptor signaling pathway

positive regulation of B cell receptor signaling pathway

positive regulation of phagocytosis, engulfment

cellular response to lipopolysaccharide

negative regulation of ruffle assembly

negative regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of microglial cell activation

positive regulation of non-membrane spanning protein tyrosine kinase activity

negative regulation of microglial cell migration

positive regulation of microglial cell mediated cytotoxicity

positive regulation of actin cytoskeleton reorganization

 
TC0100000937.mm.2 Farp2 FERM, RhoGEF and pleckstrin domain protein 2 1 93512103 NM_145519, BC009153 NM_145519, BC009153 28

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

cytoplasm

cytosol

cytoskeleton

cell adhesion

cytoskeletal protein binding

neuron remodeling

Rac protein signal transduction

hair cycle process

osteoclast differentiation

actin cytoskeleton reorganization

regulation of integrin activation

regulation of Rho protein signal transduction

semaphorin-plexin signaling pathway

podosome assembly

04520

TC1600000530.mm.2 Polq polymerase (DNA directed), theta 16 37011785 NM_001159369, NM_029977, BC138360, BC157900 NM_001159369, NM_029977, BC138360, BC157900 NM_001159369, NM_029977, BC138360, BC157900 NM_001159369, NM_029977, BC138360, BC157900 34

nucleotide binding

nucleic acid binding

DNA binding

chromatin binding

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

Golgi apparatus

cytosol

DNA replication

DNA-dependent DNA replication

DNA repair

DNA repair

base-excision repair

double-strand break repair

cellular response to DNA damage stimulus

5'-3' exonuclease activity

somatic hypermutation of immunoglobulin genes

transferase activity

nucleotidyltransferase activity

single-stranded DNA helicase activity

identical protein binding

protein homooligomerization

5'-deoxyribose-5-phosphate lyase activity

double-strand break repair via alternative nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

 
TC1200002518.mm.2 Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 12 21111755 NM_001004364, NM_001098168, NM_001135192, BC080847, BC096022 NM_001004364, NM_001098168, NM_001135192, BC080847, BC096022 NM_001004364, NM_001098168, NM_001135192, BC080847, BC096022 NM_001004364, NM_001098168, NM_001135192, BC080847, BC096022 NM_001004364, NM_001098168, NM_001135192, BC080847, BC096022 29

GTPase activator activity

cellular_component

cytoplasm

Golgi apparatus

plasma membrane

membrane

metal ion binding

04144

04666

TC0100002631.mm.2 Farsb phenylalanyl-tRNA synthetase, beta subunit 1 -78424744, -78417957 NM_001278075, NM_011811, NR_102757, NR_102758, BC002313, BC016428 NM_001278075, NM_011811, NR_102757, NR_102758, BC002313, BC016428 NM_001278075, NM_011811, NR_102757, NR_102758, BC002313, BC016428 NM_001278075, NM_011811, NR_102757, NR_102758, BC002313, BC016428 NM_001278075, NM_011811, NR_102757, NR_102758, BC002313, BC016428 NM_001278075, NM_011811, NR_102757, NR_102758, BC002313, BC016428 32

nucleotide binding

magnesium ion binding

RNA binding

aminoacyl-tRNA ligase activity

phenylalanine-tRNA ligase activity

ATP binding

cytoplasm

translation

phenylalanyl-tRNA aminoacylation

phenylalanyl-tRNA aminoacylation

phenylalanine-tRNA ligase complex

phenylalanine-tRNA ligase complex

ligase activity

protein heterotetramerization

00970

TC0500002458.mm.2 Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 5 -62602445 NM_178407 18

GTPase activator activity

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

signal transduction

positive regulation of GTPase activity

metal ion binding

04144

TC1300000273.mm.2 Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylase 13 24327403, 24415121 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 NM_001111110, NM_001284519, NM_001284520, NM_007717, BC055079 51

cytoplasm

endoplasmic reticulum

oxidoreductase activity

CMP-N-acetylneuraminate monooxygenase activity

CMP-N-acetylneuraminate monooxygenase activity

CMP-N-acetylneuraminate metabolic process

metal ion binding

iron-sulfur cluster binding

2 iron, 2 sulfur cluster binding

00520

TC1100000383.mm.2 Pank3 pantothenate kinase 3 11 35769494 NM_145962, BC027089 NM_145962, BC027089 27

nucleotide binding

pantothenate kinase activity

pantothenate kinase activity

pantothenate kinase activity

ATP binding

nucleus

cytoplasm

cytosol

cytosol

coenzyme A biosynthetic process

coenzyme A biosynthetic process

coenzyme A biosynthetic process

kinase activity

phosphorylation

transferase activity

vitamin binding

protein homodimerization activity

acetyl-CoA binding

00770

01100

TC1400002341.mm.2 Polr3d polymerase (RNA) III (DNA directed) polypeptide D 14 -70438747, -70438747 NM_001164082, NM_025945, BC016102 NM_001164082, NM_025945, BC016102 NM_001164082, NM_025945, BC016102 19

immune system process

DNA binding

chromatin binding

chromatin binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase III complex

RNA polymerase III complex

cytosol

transcription by RNA polymerase III

positive regulation of interferon-beta production

innate immune response

positive regulation of innate immune response

defense response to virus

00230

00240

01100

03020

04623

TC1300000626.mm.2 Simc1 SUMO-interacting motifs containing 1 13 54503804 NM_176987, BC167252 NM_176987, BC167252 12

cytoplasm

biological_process

sarcomere

peptidase inhibitor activity

SUMO polymer binding

SUMO polymer binding

 
TC0200002044.mm.2 Crls1 cardiolipin synthase 1 2 132847733, 132846665 NM_001024385, NM_025646, BC048702 NM_001024385, NM_025646, BC048702 NM_001024385, NM_025646, BC048702 24

mitochondrion

mitochondrion

mitochondrial inner membrane

lipid metabolic process

phospholipid biosynthetic process

cardiolipin synthase activity

cardiolipin synthase activity

membrane

integral component of membrane

transferase activity

phosphotransferase activity, for other substituted phosphate groups

mitochondrial membrane

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process

response to thyroxine

response to phosphatidylethanolamine

00564

01100

TC1100000544.mm.2 Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 11 50377677, 50378290, 50377796, 50378235, 50376989 NM_021510, BC042187, BC056224 NM_021510, BC042187, BC056224 NM_021510, BC042187, BC056224 52

nucleic acid binding

RNA binding

RNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

spliceosomal complex

cytosol

mRNA processing

RNA splicing

identical protein binding

regulation of RNA splicing

regulation of RNA splicing

catalytic step 2 spliceosome

cellular response to interleukin-7

ribonucleoprotein complex

 
TC0200000459.mm.2 Surf2 surfeit gene 2 2 26916407 NM_013678, BC096401 NM_013678, BC096401 21

molecular_function

nucleoplasm

nucleolus

plasma membrane

biological_process

nuclear speck

 
TC0200003182.mm.2 Qsox2 quiescin Q6 sulfhydryl oxidase 2 2 -26209123 NM_153559, BC030934 NM_153559, BC030934 17

protein disulfide isomerase activity

extracellular space

nucleoplasm

Golgi apparatus

protein folding

membrane

integral component of membrane

oxidoreductase activity

flavin-linked sulfhydryl oxidase activity

thiol oxidase activity

integral component of Golgi membrane

cell redox homeostasis

 
TC0200000055.mm.2 Nudt5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 2 5845033 NM_016918, BC004571, BC049595 NM_016918, BC004571, BC049595 NM_016918, BC004571, BC049595 28

magnesium ion binding

RNA binding

nucleus

nucleus

nucleobase-containing compound metabolic process

chromatin remodeling

nucleoside phosphate metabolic process

ribonucleoside diphosphate catabolic process

transferase activity

nucleotidyltransferase activity

hydrolase activity

nucleoside-diphosphatase activity

ADP-sugar diphosphatase activity

D-ribose catabolic process

ribose phosphate metabolic process

snoRNA binding

identical protein binding

protein homodimerization activity

8-oxo-dGDP phosphatase activity

metal ion binding

ADP-ribose diphosphatase activity

ADP-ribose diphosphatase activity

ATP generation from poly-ADP-D-ribose

00230

TC0900000285.mm.2 Arhgap32 Rho GTPase activating protein 32 9 32115987, 32224274, 32032302, 32016624 NM_001195632, NM_177379, BC132390, BC138042 NM_001195632, NM_177379, BC132390, BC138042 NM_001195632, NM_177379, BC132390, BC138042 NM_001195632, NM_177379, BC132390, BC138042 41

fibrillar center

fibrillar center

GTPase activator activity

GTPase activator activity

protein binding

nucleoplasm

nucleoplasm

cytoplasm

endosome

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cell cortex

cell cortex

signal transduction

small GTPase mediated signal transduction

Rho protein signal transduction

postsynaptic density

actin cytoskeleton

actin cytoskeleton

membrane

cell junction

phosphatidylinositol binding

cell projection

synapse

 
TC0600003148.mm.2 Cd9 CD9 antigen 6 -125460265 NM_007657, BC070474, CD9 NM_007657, BC070474, CD9 NM_007657, BC070474, CD9 130

integrin binding

integrin binding

protein binding

extracellular region

plasma membrane

plasma membrane

integral component of plasma membrane

cell adhesion

single fertilization

fusion of sperm to egg plasma membrane involved in single fertilization

fusion of sperm to egg plasma membrane involved in single fertilization

negative regulation of cell population proliferation

glial cell migration

external side of plasma membrane

cell surface

myoblast fusion involved in skeletal muscle regeneration

membrane

integral component of membrane

apical plasma membrane

paranodal junction assembly

receptor internalization

protein-containing complex

sperm-egg recognition

negative regulation of cellular component movement

extracellular exosome

extracellular exosome

cellular response to low-density lipoprotein particle stimulus

negative regulation of platelet aggregation

regulation of macrophage migration

04640

TC0200005335.mm.2         NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480, XR_140545 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480, XR_140545 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480, XR_140545 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480, XR_140545 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480, XR_140545 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480, XR_140545 NM_001099349, NM_001100415, NM_001100416, NM_001101804, NM_001177543, NM_001256480, XR_140545  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

molecular_function

cellular_component

nucleus

regulation of transcription by RNA polymerase II

biological_process

 
TC1100003345.mm.2 Myo1d myosin ID 11 -80482126 NM_177390, BC150765 NM_177390, BC150765 34

microfilament motor activity

microfilament motor activity

nucleotide binding

motor activity

actin binding

protein binding

calmodulin binding

ATP binding

cytoplasm

endosome

smooth endoplasmic reticulum

plasma membrane

microvillus

brush border

brush border

actin filament organization

negative regulation of phosphatase activity

protein transport

actin cytoskeleton

membrane

basolateral plasma membrane

myosin complex

protein domain specific binding

vesicle transport along actin filament

axon

axolemma

actin-dependent ATPase activity

actin-dependent ATPase activity

cytoplasmic vesicle

vesicle

cell projection

neuron projection

neuronal cell body

neuronal cell body

myelin sheath

myelin sheath

myelin sheath

plasma membrane raft

calcium-dependent protein binding

actin filament binding

actin filament binding

cellular localization

apical dendrite

 
TC1100004000.mm.2 Abca9 ATP-binding cassette, sub-family A (ABC1), member 9 11 -110100821 NM_147220 15

nucleotide binding

lipid transporter activity

ATP binding

mitochondrion

lipid transport

membrane

integral component of membrane

ATPase activity

ATPase-coupled transmembrane transporter activity

intracellular membrane-bounded organelle

02010

TC0900000050.mm.2 Mmp8 matrix metallopeptidase 8 9 7558428 NM_008611, BC042742 NM_008611, BC042742 93

endopeptidase activity

metalloendopeptidase activity

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular space

extracellular space

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

positive regulation of gene expression

negative regulation of gene expression

hydrolase activity

extracellular matrix organization

collagen catabolic process

extracellular matrix

negative regulation of interleukin-10 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of DNA binding

positive regulation of MAPK cascade

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide biosynthetic process

positive regulation of JNK cascade

metal ion binding

positive regulation of neuroinflammatory response

positive regulation of neuroinflammatory response

positive regulation of NIK/NF-kappaB signaling

positive regulation of reactive oxygen species biosynthetic process

positive regulation of microglial cell activation

 
TC1800001255.mm.2 Lars leucyl-tRNA synthetase 18 -42202297 NM_134137, BC052715 NM_134137, BC052715 30

nucleotide binding

aminoacyl-tRNA editing activity

aminoacyl-tRNA ligase activity

glutamine-tRNA ligase activity

leucine-tRNA ligase activity

leucine-tRNA ligase activity

GTPase activator activity

ATP binding

cytoplasm

lysosome

endoplasmic reticulum

cytosol

translation

tRNA aminoacylation for protein translation

glutaminyl-tRNA aminoacylation

leucyl-tRNA aminoacylation

leucyl-tRNA aminoacylation

regulation of cell size

endomembrane system

nuclear body

ligase activity

aminoacyl-tRNA synthetase multienzyme complex

aminoacyl-tRNA synthetase multienzyme complex

positive regulation of TOR signaling

cellular response to amino acid starvation

positive regulation of GTPase activity

cellular response to amino acid stimulus

cellular response to leucine

positive regulation of TORC1 signaling

cellular response to leucine starvation

00290

00970

TC0900000639.mm.2 Poglut3 protein O-glucosyltransferase 3 9 53384022 NM_212445 16

endoplasmic reticulum

endomembrane system

transferase activity

transferase activity, transferring glycosyl groups

protein O-linked glycosylation via serine

UDP-glucosyltransferase activity

UDP-xylosyltransferase activity

glucosyltransferase activity

 
TC1900000758.mm.2 Smc3 structural maintenance of chromosomes 3 19 53600395 NM_007790, BC057345, BC062935 NM_007790, BC057345, BC062935 NM_007790, BC057345, BC062935 75

nucleotide binding

chromosome, centromeric region

chromatin

lateral element

chromatin binding

protein binding

ATP binding

basement membrane

nucleus

nucleoplasm

nucleoplasm

chromosome

regulation of DNA replication

DNA repair

cellular response to DNA damage stimulus

cell cycle

sister chromatid cohesion

cohesin complex

cohesin complex

nuclear matrix

stem cell population maintenance

meiotic cohesin complex

meiotic cohesin complex

nuclear meiotic cohesin complex

mediator complex binding

protein heterodimerization activity

beta-tubulin binding

chromosome organization

cell division

meiotic cell cycle

meiotic cell cycle

dynein complex binding

mitotic spindle assembly

mitotic spindle pole

04110

04114

TC0200000013.mm.2 Fam107b family with sequence similarity 107, member B 2 3713457 NM_025626, BC021353 NM_025626, BC021353 18

molecular_function

cellular_component

sensory perception of sound

 
TC0300002580.mm.2 Wdr3 WD repeat domain 3 3 -100138179 NM_175552, BC063100 NM_175552, BC063100 20

nucleus

nucleoplasm

nucleolus

maturation of SSU-rRNA

snoRNA binding

nuclear membrane

small-subunit processome

Pwp2p-containing subcomplex of 90S preribosome

03008

TC1200001625.mm.2 Hdac9 histone deacetylase 9 12 -34047581, -34371496 NM_001271386, NM_024124, BC098187, XM_003688889 NM_001271386, NM_024124, BC098187, XM_003688889 NM_001271386, NM_024124, BC098187, XM_003688889 NM_001271386, NM_024124, BC098187, XM_003688889 83

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of cytokine production

transcription corepressor activity

transcription corepressor activity

histone deacetylase activity

protein kinase C binding

protein binding

nucleus

nucleus

transcription regulator complex

cytoplasm

cytoplasm

DNA repair

chromatin organization

inflammatory response

nervous system development

heart development

transcription factor binding

transcription factor binding

determination of adult lifespan

histone deacetylation

hydrolase activity

B cell differentiation

NAD-dependent histone deacetylase activity (H3-K14 specific)

cellular response to insulin stimulus

protein deacetylase activity

histone deacetylase activity (H4-K16 specific)

peptidyl-lysine deacetylation

histone methyltransferase complex

B cell activation

cholesterol homeostasis

histone deacetylase binding

negative regulation of striated muscle tissue development

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

negative regulation of transcription, DNA-templated

regulation of skeletal muscle fiber development

negative regulation of lipoprotein lipase activity

regulation of striated muscle cell differentiation

repressing transcription factor binding

repressing transcription factor binding

repressing transcription factor binding

histone H3 deacetylation

histone H4 deacetylation

positive regulation of cell migration involved in sprouting angiogenesis

histone H4-K16 deacetylation

 
TC1100004267.mm.2 Trim16 tripartite motif-containing 16 11 62820252 NM_053169, BC052821 NM_053169, BC052821 20

DNA binding

cytoplasm

cytoplasm

cytosol

plasma membrane

zinc ion binding

PML body

transferase activity

interleukin-1 binding

NACHT domain binding

positive regulation of interleukin-1 beta production

histone H3 acetylation

histone H4 acetylation

positive regulation of keratinocyte differentiation

positive regulation of transcription, DNA-templated

metal ion binding

positive regulation of retinoic acid receptor signaling pathway

response to growth hormone

 
TC0300000916.mm.2 Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 3 95929256 NM_001253757, NM_001253758, NM_023210, BC005690, BC080684 NM_001253757, NM_001253758, NM_023210, BC005690, BC080684 NM_001253757, NM_001253758, NM_023210, BC005690, BC080684 NM_001253757, NM_001253758, NM_023210, BC005690, BC080684 NM_001253757, NM_001253758, NM_023210, BC005690, BC080684 33

nucleus

nucleus

cytoplasm

chromatin organization

phosphatase inhibitor activity

phosphatase inhibitor activity

cytoplasmic vesicle

histone binding

regulation of apoptotic process

histone exchange

 
TC0200001947.mm.2 Polr1b polymerase (RNA) I polypeptide B 2 129100995 NM_009086, BC060656 NM_009086, BC060656 35

DNA binding

DNA-directed 5'-3' RNA polymerase activity

DNA-directed 5'-3' RNA polymerase activity

protein binding

nucleus

nucleoplasm

chromosome

nucleolus

nucleolus

RNA polymerase I complex

RNA polymerase I complex

RNA polymerase I complex

cytosol

transcription, DNA-templated

embryo implantation

rRNA transcription

rRNA transcription

embryo development

transferase activity

nucleotidyltransferase activity

nucleologenesis

ribonucleoside binding

metal ion binding

00230

00240

01100

03020

TC1200001248.mm.2 Zfyve21 zinc finger, FYVE domain containing 21 12 111814169, 111814229 NM_026752, BC019521, BC132248, BC132250 NM_026752, BC019521, BC132248, BC132250 NM_026752, BC019521, BC132248, BC132250 NM_026752, BC019521, BC132248, BC132250 21

molecular_function

cellular_component

endosome

biological_process

cell junction

cytoplasmic vesicle

metal ion binding

 
TC1600000291.mm.2 Polr2h polymerase (RNA) II (DNA directed) polypeptide H 16 20718176, 20717825 NM_145632, BC002306, BC092087, BC125612, BC125638 NM_145632, BC002306, BC092087, BC125612, BC125638 NM_145632, BC002306, BC092087, BC125612, BC125638 NM_145632, BC002306, BC092087, BC125612, BC125638 NM_145632, BC002306, BC092087, BC125612, BC125638 24

DNA binding

single-stranded DNA binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase II, core complex

RNA polymerase II, core complex

RNA polymerase III complex

RNA polymerase I complex

transcription, DNA-templated

transcription by RNA polymerase II

transcription by RNA polymerase II

protein-DNA complex

00230

00240

01100

03020

05016

TC1800000019.mm.2 Svil supervillin 18 5046588, 5046588 NM_153153 32

actin binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

nucleus

cytoplasm

cytoplasm

cytosol

cytoskeleton

plasma membrane

cytoskeleton organization

skeletal muscle tissue development

actin polymerization or depolymerization

actin cytoskeleton

actin cytoskeleton

membrane

cell junction

cell projection

costamere

actin filament severing

actin filament binding

actin filament binding

barbed-end actin filament capping

 
TC0200001757.mm.2 Knl1 kinetochore scaffold 1 2 119047118, 119047118 NM_029617, BC080815 NM_029617, BC080815 19

chromosome, centromeric region

kinetochore

condensed chromosome kinetochore

condensed chromosome kinetochore

acrosomal vesicle

molecular_function

nucleus

nucleus

nucleoplasm

chromosome

cell cycle

chromosome segregation

attachment of spindle microtubules to kinetochore

attachment of spindle microtubules to kinetochore

negative regulation of phosphatase activity

nuclear body

protein localization to kinetochore

protein localization to kinetochore

cell division

 
TC1300001205.mm.2 Depdc1b DEP domain containing 1B 13 108316336 NM_178683, BC152330, BC152331 NM_178683, BC152330, BC152331 NM_178683, BC152330, BC152331 16

molecular_function

GTPase activator activity

signal transduction

cell migration

positive regulation of Wnt signaling pathway

positive regulation of Wnt signaling pathway

intracellular signal transduction

 
TC0700001989.mm.2 Lrrc27 leucine rich repeat containing 27 7 139212987, 139213274 NM_001143755, NM_027164, BC050816 NM_001143755, NM_027164, BC050816 NM_001143755, NM_027164, BC050816 11

molecular_function

 
TC1200000675.mm.2 Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase 12 76255231 NM_138745, BC008523 NM_138745, BC008523 53

histidine biosynthetic process

nucleotide binding

neutrophil homeostasis

neural tube closure

catalytic activity

formate-tetrahydrofolate ligase activity

formate-tetrahydrofolate ligase activity

methenyltetrahydrofolate cyclohydrolase activity

methenyltetrahydrofolate cyclohydrolase activity

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

ATP binding

cytoplasm

mitochondrion

cytosol

cytosol

purine nucleotide biosynthetic process

methionine metabolic process

one-carbon metabolic process

heart development

metabolic process

cellular amino acid biosynthetic process

serine family amino acid metabolic process

serine family amino acid biosynthetic process

methionine biosynthetic process

10-formyltetrahydrofolate biosynthetic process

10-formyltetrahydrofolate biosynthetic process

oxidoreductase activity

hydrolase activity

ligase activity

transsulfuration

tetrahydrofolate interconversion

tetrahydrofolate interconversion

tetrahydrofolate interconversion

somite development

00670

01100

TC1700001084.mm.2 Ddx11 DEAD/H box helicase 11 17 66123519 NM_001003919, BC079656 NM_001003919, BC079656 19

nucleotide binding

chromatin

spindle pole

fibrillar center

nucleic acid binding

DNA binding

DNA helicase activity

DNA helicase activity

chromatin binding

DNA replication origin binding

double-stranded DNA binding

single-stranded DNA binding

RNA binding

single-stranded RNA binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

centrosome

cytoskeleton

nucleobase-containing compound metabolic process

DNA replication

DNA repair

cellular response to DNA damage stimulus

sister chromatid cohesion

multicellular organism development

DNA-dependent ATPase activity

RNA-dependent ATPase activity

hydrolase activity

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

midbody

replication fork processing

Ctf18 RFC-like complex

positive regulation of endodeoxyribonuclease activity

negative regulation of protein binding

DNA duplex unwinding

DNA duplex unwinding

establishment of sister chromatid cohesion

positive regulation of chromatin binding

G-quadruplex DNA unwinding

triplex DNA binding

positive regulation of sister chromatid cohesion

metal ion binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

G-quadruplex DNA binding

cellular response to hydroxyurea

cellular response to cisplatin

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

cellular response to bleomycin

nucleolar chromatin organization

positive regulation of double-strand break repair

 
TC0200000572.mm.2 Pomt1 protein-O-mannosyltransferase 1 2 32236639 NM_145145, BC027325 NM_145145, BC027325 25

mannosyltransferase activity

acrosomal vesicle

dolichyl-phosphate-mannose-protein mannosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

protein O-linked glycosylation

membrane

integral component of membrane

sarcoplasmic reticulum

transferase activity

transferase activity, transferring glycosyl groups

extracellular matrix organization

protein O-linked mannosylation

protein O-linked mannosylation

positive regulation of protein O-linked glycosylation

00514

TC0500000307.mm.2         NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788 NM_001289522, NM_001289523, NM_023525, BC137856, BC144972, NR_105788  

nucleotide binding

UTP binding

catalytic activity

aspartate carbamoyltransferase activity

aspartate carbamoyltransferase activity

carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

dihydroorotase activity

dihydroorotase activity

protein kinase activity

ATP binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

'de novo' pyrimidine nucleobase biosynthetic process

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine nucleotide biosynthetic process

UTP biosynthetic process

UTP biosynthetic process

cellular amino acid metabolic process

glutamine metabolic process

glutamine metabolic process

nitrogen compound metabolic process

metabolic process

zinc ion binding

nuclear matrix

amino acid binding

transferase activity

carboxyl- or carbamoyltransferase activity

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

ligase activity

drug metabolic process

peptidyl-threonine phosphorylation

citrulline biosynthetic process

citrulline biosynthetic process

enzyme binding

response to insulin

protein-containing complex

response to starvation

identical protein binding

cell projection

neuronal cell body

terminal bouton

protein autophosphorylation

metal ion binding

 
TC0200002749.mm.2 Gm14403 predicted gene 14403 2 177498225 NR_036450, BC098094 NR_036450, BC098094 5

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

regulation of transcription by RNA polymerase II

 
TC0700004592.mm.2 Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 7 -143634807 NM_023680 16

protein binding

extracellular region

plasma membrane

external side of plasma membrane

cell surface

membrane

integral component of membrane

TRAIL-activated apoptotic signaling pathway

positive regulation of apoptotic process

TRAIL binding

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

 
TC0900003128.mm.2 Mlh1 mutL homolog 1 9 -111228227 NM_026810, BC021815 NM_026810, BC021815 174

nucleotide binding

leptotene

nuclear-transcribed mRNA poly(A) tail shortening

resolution of meiotic recombination intermediates

condensed chromosome

condensed chromosome

condensed nuclear chromosome

synaptonemal complex

synaptonemal complex

male germ cell nucleus

somatic recombination of immunoglobulin genes involved in immune response

chromatin binding

chromatin binding

single-stranded DNA binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

chromosome

chiasma

late recombination nodule

DNA repair

mismatch repair

mismatch repair

mismatch repair

mismatch repair

double-strand break repair via nonhomologous end joining

cellular response to DNA damage stimulus

cellular response to DNA damage stimulus

cell cycle

male meiosis chromosome segregation

homologous chromosome pairing at meiosis

reciprocal meiotic recombination

male meiotic nuclear division

spermatogenesis

intrinsic apoptotic signaling pathway in response to DNA damage

response to bacterium

female meiosis chromosome segregation

somatic hypermutation of immunoglobulin genes

somatic hypermutation of immunoglobulin genes

somatic recombination of immunoglobulin gene segments

ATPase activity

enzyme binding

mismatched DNA binding

guanine/thymine mispair binding

guanine/thymine mispair binding

mismatch repair complex

MutLalpha complex

MutLalpha complex

MutSalpha complex binding

meiotic metaphase I plate congression

meiotic chromosome segregation

meiotic telomere clustering

homologous chromosome segregation

isotype switching

negative regulation of mitotic recombination

positive regulation of isotype switching to IgA isotypes

positive regulation of isotype switching to IgG isotypes

oogenesis

meiotic spindle midzone assembly

meiotic cell cycle

meiotic cell cycle

03430

05200

05210

05213

TC0100003531.mm.2 Pcp4l1 Purkinje cell protein 4-like 1 1 -171173263 NM_025557 17

molecular_function

cellular_component

biological_process

 
TC0700001906.mm.2 Tacc2 transforming, acidic coiled-coil containing protein 2 7 130577437, 130692617 NM_001004468, NM_021314, NM_206856 NM_001004468, NM_021314, NM_206856 NM_001004468, NM_021314, NM_206856 33

microtubule cytoskeleton organization

microtubule cytoskeleton organization

nucleus

nucleoplasm

cytoplasm

cytosol

cytoskeleton

plasma membrane

mitotic spindle organization

cell population proliferation

cell population proliferation

protein domain specific binding

cerebral cortex development

cerebral cortex development

neurogenesis

interkinetic nuclear migration

astral microtubule organization

regulation of microtubule-based process

nuclear hormone receptor binding

 
TC1000002313.mm.2 Ado 2-aminoethanethiol (cysteamine) dioxygenase 10 -67544510 NM_001005419, BC057106, BC058407 NM_001005419, BC057106, BC058407 NM_001005419, BC057106, BC058407 18

protein binding

mitochondrion

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

metal ion binding

cysteamine dioxygenase activity

dioxygenase activity

00430

01100

TC1300000070.mm.2 Heatr1 HEAT repeat containing 1 13 12395374 NM_144835 20

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

fibrillar center

nucleolus

mitochondrion

snoRNA binding

90S preribosome

small-subunit processome

t-UTP complex

positive regulation of transcription by RNA polymerase I

positive regulation of transcription by RNA polymerase I

positive regulation of rRNA processing

03008

TC1000000940.mm.2 Nopchap1 NOP protein chaperone 1 10 83360220 NM_026579, BC050904, BC094241 NM_026579, BC050904, BC094241 NM_026579, BC050904, BC094241 21

molecular_function

cellular_component

biological_process

 
TC0100002838.mm.2 Dtymk deoxythymidylate kinase 1 -93792575, -93800494 NM_001105667, NM_023136, BC030178, BC069902 NM_001105667, NM_023136, BC030178, BC069902 NM_001105667, NM_023136, BC030178, BC069902 NM_001105667, NM_023136, BC030178, BC069902 24

nucleotide binding

nucleoside diphosphate kinase activity

thymidylate kinase activity

thymidylate kinase activity

thymidylate kinase activity

ATP binding

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrial intermembrane space

mitochondrial matrix

cytosol

dUDP biosynthetic process

dTDP biosynthetic process

dTDP biosynthetic process

dTDP biosynthetic process

dTTP biosynthetic process

dTTP biosynthetic process

uridylate kinase activity

nucleotide biosynthetic process

kinase activity

phosphorylation

transferase activity

cellular response to growth factor stimulus

00240

01100

TC0300000935.mm.2 H2bc18 H2B clustered histone 18 3 96269699 NM_175666, BC019122 NM_175666, BC019122 28

DNA binding

nucleoplasm

nucleoplasm

cytosol

nucleosome assembly

05322

TC0500002025.mm.2 Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 5 -21757276 NM_009584, BC052027 NM_009584, BC052027 33

DNA binding

chromatin binding

protein binding

nucleus

nucleolus

cytoplasm

cytosol

DNA replication

chromatin organization

negative regulation of cell growth

Hsp70 protein binding

nuclear membrane

histone binding

positive regulation of transcription, DNA-templated

ubiquitin modification-dependent histone binding

negative regulation of DNA biosynthetic process

 
TC0600000127.mm.2 Cav2 caveolin 2 6 17281184, 17281184 NM_001277756, NM_016900, BC023095 NM_001277756, NM_016900, BC023095 NM_001277756, NM_016900, BC023095 68

SNARE binding

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

acrosomal membrane

caveolar macromolecular signaling complex

protein binding

nucleus

nuclear envelope

nuclear inner membrane

cytoplasm

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

lipid droplet

cytosol

plasma membrane

plasma membrane

integral component of plasma membrane

integral component of plasma membrane

caveola

caveola

caveola

focal adhesion

focal adhesion

focal adhesion

endocytosis

vesicle fusion

vesicle fusion

mitochondrion organization

endoplasmic reticulum organization

chemical synaptic transmission

negative regulation of cell population proliferation

insulin receptor signaling pathway

insulin receptor signaling pathway

cell surface

membrane

membrane

vesicle organization

receptor-mediated endocytosis of virus by host cell

protein kinase binding

protein kinase binding

protein kinase binding

syntaxin binding

transport vesicle

cell differentiation

negative regulation of transforming growth factor beta receptor signaling pathway

protein-macromolecule adaptor activity

extrinsic component of cytoplasmic side of plasma membrane

extrinsic component of cytoplasmic side of plasma membrane

cytoplasmic vesicle

cytoplasmic vesicle

mitogen-activated protein kinase kinase kinase binding

D1 dopamine receptor binding

D1 dopamine receptor binding

protein-containing complex

protein-containing complex

sarcolemma

protein homodimerization activity

positive regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of GTPase activity

positive regulation by host of viral release from host cell

positive regulation by host of viral process

membrane raft

protein heterodimerization activity

vesicle docking

vesicle docking

perinuclear region of cytoplasm

perinuclear region of cytoplasm

perinuclear region of cytoplasm

skeletal muscle fiber development

positive regulation of peptidyl-tyrosine phosphorylation

phosphoprotein binding

regulation of cytosolic calcium ion concentration

molecular adaptor activity

molecular adaptor activity

positive regulation of dopamine receptor signaling pathway

positive regulation of dopamine receptor signaling pathway

caveola assembly

caveola assembly

caveola assembly

basement membrane organization

scaffold protein binding

positive regulation of protein localization to nucleus

04144

04510

05100

TC1100000021.mm.2 Morc2a microrchidia 2A 11 3649436, 3658671 NM_001159288, NM_198162, BC059243 NM_001159288, NM_198162, BC059243 NM_001159288, NM_198162, BC059243 25

nucleotide binding

magnesium ion binding

heterochromatin

chromatin binding

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

chromatin remodeling

cellular response to DNA damage stimulus

zinc ion binding

nuclear matrix

hydrolase activity

ATPase activity

histone binding

protein homodimerization activity

negative regulation of gene expression, epigenetic

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

metal ion binding

positive regulation of DNA methylation-dependent heterochromatin assembly

positive regulation of DNA methylation-dependent heterochromatin assembly

 
TC0X00001555.mm.2 Rragb Ras-related GTP binding B X 153139957 NM_001004154, BC069180, BC070407 NM_001004154, BC069180, BC070407 NM_001004154, BC069180, BC070407 11

nucleotide binding

GTPase activity

GTPase activity

GTP binding

nucleus

cytoplasm

lysosome

lysosome

cellular response to starvation

regulation of autophagy

hydrolase activity

regulation of TOR signaling

positive regulation of TOR signaling

positive regulation of TOR signaling

guanyl ribonucleotide binding

cellular response to amino acid starvation

EGO complex

cellular protein localization

GTPase binding

cellular response to amino acid stimulus

cellular response to amino acid stimulus

positive regulation of TORC1 signaling

Gtr1-Gtr2 GTPase complex

cellular response to leucine starvation

 
TC1100000164.mm.2 Fbxo48 F-box protein 48 11 16951409, 16951374 NM_176982, BC125589, BC125591 NM_176982, BC125589, BC125591 NM_176982, BC125589, BC125591 10

molecular_function

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

 
MG-1-neg-10340143_st                
TC1100001899.mm.2 Nup85 nucleoporin 85 11 115564443 NM_001002929, BC079856 NM_001002929, BC079856 21

chromosome, centromeric region

kinetochore

nucleus

nuclear pore

nucleoplasm

chromosome

cytoplasm

cytosol

cytoskeleton

plasma membrane

mRNA export from nucleus

protein import into nucleus

chemotaxis

protein transport

membrane

structural constituent of nuclear pore

cytokine-mediated signaling pathway

lamellipodium assembly

nuclear pore outer ring

nuclear pore outer ring

CCR2 chemokine receptor binding

positive regulation of transcription, DNA-templated

macrophage chemotaxis

mRNA transport

nephron development

03013

TC0600003136.mm.2 Ncapd2 non-SMC condensin I complex, subunit D2 6 -125168006 NM_146171, BC026982, BC029133 NM_146171, BC026982, BC029133 NM_146171, BC026982, BC029133 32

nuclear chromosome

mitotic cell cycle

condensed chromosome, centromeric region

condensed chromosome

condensed chromosome

condensin complex

condensin complex

condensin complex

chromatin binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

cell cycle

mitotic chromosome condensation

mitotic chromosome condensation

meiotic chromosome condensation

chromosome condensation

histone binding

histone binding

pronucleus

cell division

 
TC1800000908.mm.2         NM_175542, NR_105777 NM_175542, NR_105777  

molecular_function

cytoplasm

centrosome

centriole

cytoskeleton

cilium

centriole replication

multicellular organism development

determination of left/right symmetry

centriole-centriole cohesion

integral component of membrane

ciliary basal body organization

ciliary basal body

ciliary basal body

cell projection

cilium organization

 
TC0200002721.mm.2         NM_001242943, NM_001242944, XR_140546 NM_001242943, NM_001242944, XR_140546 NM_001242943, NM_001242944, XR_140546  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

cellular_component

nucleoplasm

regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
TC0400000622.mm.2 Abitram actin binding transcription modulator 4 56802328 NM_001081420, BC026590, BC048548 NM_001081420, BC026590, BC048548 NM_001081420, BC026590, BC048548 18

actin binding

actin monomer binding

actin monomer binding

nucleus

nucleus

nuclear speck

lamellipodium

lamellipodium

dendrite

dendrite

growth cone

regulation of actin filament polymerization

regulation of actin filament polymerization

filopodium tip

filopodium tip

cell projection

dendrite morphogenesis

dendrite morphogenesis

actin filament binding

actin filament binding

regulation of filopodium assembly

regulation of filopodium assembly

 
TC0X00000652.mm.2 Hmgb3 high mobility group box 3 X 71555916 NM_008253, BC011276, BC083352, BC158037 NM_008253, BC011276, BC083352, BC158037 NM_008253, BC011276, BC083352, BC158037 NM_008253, BC011276, BC083352, BC158037 39

immune system process

DNA binding

RNA binding

nucleus

chromosome

cytoplasm

regulation of transcription by RNA polymerase II

DNA binding, bending

innate immune response

negative regulation of B cell differentiation

negative regulation of myeloid cell differentiation

 
TC1000001301.mm.2 Phlda1 pleckstrin homology like domain, family A, member 1 10 111506285 NM_009344, BC010295 NM_009344, BC010295 37

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

apoptotic process

cytoplasmic vesicle

positive regulation of apoptotic process

positive regulation of apoptotic process

FasL biosynthetic process

 
TC0400003633.mm.2 Nkain1 Na+/K+ transporting ATPase interacting 1 4 -130530130 NM_025998, BC116391 NM_025998, BC116391 18

regulation of sodium ion transport

plasma membrane

membrane

integral component of membrane

ATPase binding

 
TC1500000392.mm.2 Deptor DEP domain containing MTOR-interacting protein 15 55112316, 55133435 NM_001037937, NM_145470, BC156690 NM_001037937, NM_145470, BC156690 NM_001037937, NM_145470, BC156690 42

negative regulation of protein kinase activity

negative regulation of TOR signaling

intracellular signal transduction

negative regulation of cell size

regulation of extrinsic apoptotic signaling pathway

 
TC1700000070.mm.2 Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 17 7170114 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 NM_011299, BC043064, BC051079, BC055331, BC056946 56

nucleotide binding

magnesium ion binding

oocyte maturation

brain renin-angiotensin system

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ribosomal protein S6 kinase activity

ribosomal protein S6 kinase activity

protein serine/threonine/tyrosine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

spindle

protein phosphorylation

heart development

negative regulation of cell population proliferation

positive regulation of gene expression

cardiac muscle cell apoptotic process

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

intracellular signal transduction

positive regulation of apoptotic process

negative regulation of cell cycle

negative regulation of meiotic nuclear division

heart contraction

regulation of protein processing

regulation of protein processing

cellular response to carbohydrate stimulus

meiotic spindle

04010

04114

04150

04720

04722

04914

TC0900000111.mm.2 Mre11a MRE11A homolog A, double strand break repair nuclease 9 14784653 NM_018736, BC065144 NM_018736, BC065144 75

single-stranded DNA endodeoxyribonuclease activity

single-stranded DNA endodeoxyribonuclease activity

telomere maintenance

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

chromosome, telomeric region

chromosome, telomeric region

chromatin

condensed nuclear chromosome

DNA binding

DNA helicase activity

nuclease activity

endonuclease activity

endodeoxyribonuclease activity

exonuclease activity

protein binding

nucleus

nucleus

nucleoplasm

replication fork

chromosome

cytoplasm

DNA repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

cellular response to DNA damage stimulus

sister chromatid cohesion

mitotic G2 DNA damage checkpoint

mitotic G2 DNA damage checkpoint

homologous chromosome pairing at meiosis

protein C-terminus binding

cell population proliferation

3'-5' exonuclease activity

5'-3' exonuclease activity

PML body

PML body

hydrolase activity

manganese ion binding

Mre11 complex

Mre11 complex

intra-S DNA damage checkpoint

intra-S DNA damage checkpoint

telomeric 3' overhang formation

positive regulation of protein autophosphorylation

positive regulation of telomere maintenance

DNA duplex unwinding

positive regulation of kinase activity

site of double-strand break

site of double-strand break

meiotic DNA double-strand break formation

identical protein binding

negative regulation of apoptotic process

negative regulation of viral entry into host cell

perinuclear region of cytoplasm

chromosome organization

meiotic cell cycle

mitochondrial double-strand break repair via homologous recombination

DNA strand resection involved in replication fork processing

03440

03450

MG-1-pos-10340853_st                
TC0200001756.mm.2 Rpusd2 RNA pseudouridylate synthase domain containing 2 2 119034789 NM_173450, BC117827, BC117828 NM_173450, BC117827, BC117828 NM_173450, BC117827, BC117828 13

enzyme-directed rRNA pseudouridine synthesis

pseudouridine synthesis

RNA binding

RNA modification

pseudouridine synthase activity

 
TC0600000344.mm.2 Nup205 nucleoporin 205 6 35177615 NM_027513, BC141333 NM_027513, BC141333 22

nuclear pore

nuclear pore organization

structural constituent of nuclear pore

structural constituent of nuclear pore

nuclear membrane

nuclear periphery

nuclear pore inner ring

nuclear pore complex assembly

03013

TC1000000158.mm.2 Mtfr2 mitochondrial fission regulator 2 10 20347818 NM_027930, BC019132 NM_027930, BC019132 16

mitochondrial fission

mitochondrial fission

molecular_function

mitochondrion

mitochondrion

mitochondrion organization

aerobic respiration

aerobic respiration

 
TC0300001478.mm.2 Znhit6 zinc finger, HIT type 6 3 145576215, 145576207 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 NM_001081094, BC147498, BC150966, BC150967, BC151198 13

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

box C/D snoRNP assembly

box C/D snoRNP assembly

TFIID-class transcription factor complex binding

nucleus

enzyme binding

ribosome biogenesis

identical protein binding

metal ion binding

snoRNA localization

snoRNA localization

ATPase binding

protein complex oligomerization

pre-snoRNP complex

pre-snoRNP complex

 
TC0200005383.mm.2 Zfp931 zinc finger protein 931 2 -178066877 NM_001162922 11

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
TC0200002719.mm.2         NM_001033123, NM_001199308 NM_001033123, NM_001199308  

molecular_function

cellular_component

biological_process

 
TC0200002737.mm.2         NM_001033123, NM_001199307 NM_001033123, NM_001199307  

molecular_function

cellular_component

biological_process

 
MG-1-neg-10342821_st                
TC0900001442.mm.2 Cdc25a cell division cycle 25A 9 109875578 NM_007658, BC046296 NM_007658, BC046296 68

G1/S transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

intracellular anatomical structure

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

protein dephosphorylation

cell cycle

response to radiation

positive regulation of G2/M transition of mitotic cell cycle

hydrolase activity

protein kinase binding

cellular response to UV

chaperone binding

cell division

positive regulation of G2/MI transition of meiotic cell cycle

positive regulation of cell cycle G2/M phase transition

positive regulation of cholangiocyte proliferation

04110

04914

TC1000002493.mm.2 Gamt guanidinoacetate methyltransferase 10 -80258150 NM_010255, BC049233 NM_010255, BC049233 39

nucleus

cytoplasm

cytosol

creatine biosynthetic process

creatine biosynthetic process

creatine biosynthetic process

spermatogenesis

methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

animal organ morphogenesis

transferase activity

guanidinoacetate N-methyltransferase activity

guanidinoacetate N-methyltransferase activity

methylation

regulation of multicellular organism growth

identical protein binding

cell projection

S-adenosylhomocysteine metabolic process

S-adenosylmethionine metabolic process

00260

00330

01100

MG-1-neg-10339227_st                
TC0X00000897.mm.2         NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209 NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209 NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209 NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209 NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209 NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209 NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209 NM_001199337, NM_001199338, NM_001199339, NM_026673, NR_004438, BC016557, BC107208, BC107209  

Golgi membrane

extracellular region

mitochondrion

mitochondrion

mitochondrial inner membrane

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

cytosol

membrane

integral component of membrane

integral component of mitochondrial inner membrane

cristae formation

cristae formation

MICOS complex

MICOS complex

 
TC1200001306.mm.2 Ncapg2 non-SMC condensin II complex, subunit G2 12 116405435 NM_133762, BC076631 NM_133762, BC076631 27

mitotic sister chromatid segregation

condensin complex

condensin complex

condensin complex

inner cell mass cell proliferation

protein binding

nucleus

nucleus

nucleoplasm

transcription by RNA polymerase II

transcription by RNA polymerase II

cell cycle

nuclear speck

erythrocyte differentiation

erythrocyte differentiation

chromosome condensation

methylated histone binding

bHLH transcription factor binding

cell division

transcription regulator inhibitor activity

 
TC1600000176.mm.2 Nde1 nudE neurodevelopment protein 1 16 14163274 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 NM_001114085, NM_001285503, NM_001285504, NM_023317, BC023267 49

establishment of mitotic spindle orientation

establishment of mitotic spindle orientation

chromosome, centromeric region

kinetochore

kinetochore

neuron migration

protein binding

chromosome

cytoplasm

centrosome

centrosome

centrosome

microtubule organizing center

spindle

cytoskeleton

kinesin complex

microtubule

microtubule nucleation

microtubule nucleation

cell cycle

chromosome segregation

mitotic centrosome separation

multicellular organism development

nervous system development

neuroblast proliferation

microtubule binding

microtubule binding

cell migration

protein domain specific binding

cerebral cortex development

cerebral cortex development

cell differentiation

forebrain development

microtubule organizing center organization

spindle pole centrosome

identical protein binding

identical protein binding

synapse

vesicle transport along microtubule

vesicle transport along microtubule

centrosome duplication

cell division

establishment of chromosome localization

establishment of chromosome localization

centrosome localization

regulation of microtubule motor activity

 
TC1400001533.mm.2 Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 14 -20384637 NM_134081, BC014686, BC023787, BC027012 NM_134081, BC014686, BC023787, BC027012 NM_134081, BC014686, BC023787, BC027012 NM_134081, BC014686, BC023787, BC027012 26

extracellular space

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

plasma membrane

membrane

heat shock protein binding

heat shock protein binding

positive regulation of ATPase activity

 
TC1800000063.mm.2 Colec12 collectin sub-family member 12 18 9707647 NM_130449, BC057936 NM_130449, BC057936 19

scavenger receptor activity

collagen trimer

phagocytosis, recognition

phagocytosis, recognition

immune response

membrane

integral component of membrane

low-density lipoprotein particle binding

low-density lipoprotein particle binding

carbohydrate binding

toll-like receptor 3 signaling pathway

signaling receptor activity

pattern recognition receptor activity

pattern recognition receptor activity

defense response to bacterium

metal ion binding

positive regulation of cell adhesion molecule production

collagen-containing extracellular matrix

04145

TC1100001139.mm.2 Dhrs13 dehydrogenase/reductase (SDR family) member 13 11 78032312 NM_183286, BC115881 NM_183286, BC115881 15

extracellular region

mitochondrial inner membrane

oxidoreductase activity

retinal metabolic process

NADP-retinol dehydrogenase activity

 
TC1500001031.mm.2 Larp4 La ribonucleoprotein domain family, member 4 15 99972779, 99970064 NM_001024526, NM_001080948, NM_001284521, NM_001284522, NM_001284523 NM_001024526, NM_001080948, NM_001284521, NM_001284522, NM_001284523 NM_001024526, NM_001080948, NM_001284521, NM_001284522, NM_001284523 NM_001024526, NM_001080948, NM_001284521, NM_001284522, NM_001284523 NM_001024526, NM_001080948, NM_001284521, NM_001284522, NM_001284523 26

nucleic acid binding

RNA binding

mRNA 3'-UTR binding

cytoplasm

cytosol

polysome

translation

cytoskeleton organization

poly(A) binding

cytoplasmic stress granule

posttranscriptional regulation of gene expression

regulation of cell morphogenesis

cytosolic small ribosomal subunit

positive regulation of translation

 
TC0900000888.mm.2 Vps13c vacuolar protein sorting 13C 9 67840350 NM_177184 29

molecular_function

mitochondrion

mitochondrial outer membrane

cytosol

protein targeting to vacuole

mitochondrion organization

mitochondrion organization

membrane

extrinsic component of membrane

dense core granule membrane

response to insulin

protein retention in Golgi apparatus

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

 
TC1600001050.mm.2 Chaf1b chromatin assembly factor 1, subunit B (p60) 16 93883900 NM_028083, BC013532 NM_028083, BC013532 29

chromatin

protein binding

nucleus

nucleoplasm

cytoplasm

DNA replication

DNA repair

nucleosome assembly

DNA replication-dependent nucleosome assembly

cellular response to DNA damage stimulus

cell cycle

chromatin assembly

protein-containing complex

CAF-1 complex

CAF-1 complex

 
TC0900001083.mm.2 Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 9 82829805 NM_001168240, NM_022986, BC061099 NM_001168240, NM_022986, BC061099 NM_001168240, NM_022986, BC061099 20

protein binding

nucleus

cytoplasm

immune response

I-kappaB kinase/NF-kappaB signaling

I-kappaB kinase/NF-kappaB signaling

 
TC1200001698.mm.2 Gm1818 predicted gene 1818 12   XR_001538 1    
TC1500001202.mm.2 Brix1 BRX1, biogenesis of ribosomes 15 -10474778 NM_026396, BC014832 NM_026396, BC014832 23

ribosomal large subunit assembly

RNA binding

nucleus

chromosome

nucleolus

nucleolus

ribosome biogenesis

 
TC0500002754.mm.2 Sdad1 SDA1 domain containing 1 5 -92284009 NM_172713, BC042708 NM_172713, BC042708 20

ribosomal large subunit export from nucleus

molecular_function

nucleus

nucleoplasm

nucleolus

nucleolus

protein transport

actin cytoskeleton organization

ribosome biogenesis

ribosomal large subunit biogenesis

cellular response to leukemia inhibitory factor

 
TC0200002315.mm.2 Asxl1 ASXL transcriptional regulator 1 2 153345829 NM_001039939, BC172725 NM_001039939, BC172725 55

cell morphogenesis

heart morphogenesis

DNA binding

chromatin binding

transcription coactivator activity

protein binding

nucleus

chromatin organization

transcription, DNA-templated

regulation of transcription, DNA-templated

animal organ morphogenesis

animal organ morphogenesis

negative regulation of lipid storage

hemopoiesis

response to retinoic acid

negative regulation of peroxisome proliferator activated receptor signaling pathway

PR-DUB complex

PR-DUB complex

monoubiquitinated histone H2A deubiquitination

regulation of kidney size

retinoic acid receptor binding

peroxisome proliferator activated receptor binding

peroxisome proliferator activated receptor binding

negative regulation of fat cell differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

positive regulation of retinoic acid receptor signaling pathway

hematopoietic or lymphoid organ development

thymus development

bone marrow development

homeostasis of number of cells

bone development

lung saccule development

glomerular visceral epithelial cell development

 
TC0200002753.mm.2 Gm14327 predicted gene 14327 2 177897162 NR_038101 9

molecular_function

cellular_component

biological_process

 
TC1100003505.mm.2 Akap1 A kinase (PRKA) anchor protein 1 11 -88830791, -88830791, -88830791 NM_001042541, NM_009648, NR_104310 NM_001042541, NM_009648, NR_104310 NM_001042541, NM_009648, NR_104310 58

nucleic acid binding

RNA binding

protein binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

lipid droplet

apoptotic process

microtubule binding

negative regulation of cardiac muscle hypertrophy

regulation of protein kinase A signaling

membrane

integral component of membrane

protein kinase binding

protein phosphatase binding

mitochondrial crista

protein phosphatase 2B binding

neuromuscular junction

protein kinase A regulatory subunit binding

negative regulation of protein dephosphorylation

negative regulation of protein import into nucleus

postsynaptic membrane

beta-tubulin binding

molecular adaptor activity

antiviral innate immune response

 
TC0200005344.mm.2         NM_001177404, NM_001177405, NM_001177406, NM_001177407 NM_001177404, NM_001177405, NM_001177406, NM_001177407 NM_001177404, NM_001177405, NM_001177406, NM_001177407 NM_001177404, NM_001177405, NM_001177406, NM_001177407  

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

cellular_component

regulation of transcription by RNA polymerase II

 
TC0600001744.mm.2 Klhl42 kelch-like 42 6 147091074 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 NM_001081237, BC147633, BC147636, BC151064, BC151065, BC151068, BC151076 16

protein polyubiquitination

protein polyubiquitination

ubiquitin-protein transferase activity

cytoplasm

cytoskeleton

cell cycle

Cul3-RING ubiquitin ligase complex

regulation of microtubule-based process

regulation of microtubule-based process

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

cell division

 
TC0800000691.mm.2 Naf1 nuclear assembly factor 1 ribonucleoprotein 8 66860216 NM_001163564 15

snoRNA guided rRNA pseudouridine synthesis

box H/ACA snoRNP assembly

box H/ACA snoRNP assembly

pseudouridine synthesis

RNA binding

RNA binding

nucleus

nucleoplasm

sno(s)RNA-containing ribonucleoprotein complex

sno(s)RNA-containing ribonucleoprotein complex

cytoplasm

rRNA processing

ribosome biogenesis

ribosome biogenesis

identical protein binding

RNA stabilization

positive regulation of telomerase activity

telomerase RNA binding

telomerase RNA stabilization

positive regulation of telomere maintenance via telomere lengthening

telomerase holoenzyme complex assembly

 
TC1800000081.mm.2 Snrpd1 small nuclear ribonucleoprotein D1 18 10617795 NM_009226, BC024875 NM_009226, BC024875 33

commitment complex

spliceosomal snRNP assembly

spliceosomal snRNP assembly

mRNA splicing, via spliceosome

RNA binding

nucleus

nucleus

spliceosomal complex

U5 snRNP

U1 snRNP

U1 snRNP

U2 snRNP

U4 snRNP

U4 snRNP

U12-type spliceosomal complex

U12-type spliceosomal complex

cytoplasm

cytosol

RNA processing

mRNA processing

RNA splicing

methylosome

pICln-Sm protein complex

pICln-Sm protein complex

SMN-Sm protein complex

SMN-Sm protein complex

U4/U6 x U5 tri-snRNP complex

U2-type precatalytic spliceosome

U2-type catalytic step 2 spliceosome

precatalytic spliceosome

catalytic step 2 spliceosome

catalytic step 2 spliceosome

spliceosomal tri-snRNP complex

U1 snRNP binding

03040

05322

TC1700002286.mm.2 Sgo1 shugoshin 1 17 -53674786 NM_028232, BC089014 NM_028232, BC089014 41

mitotic sister chromatid segregation

chromosome, centromeric region

chromosome, centromeric region

kinetochore

kinetochore

kinetochore

condensed chromosome, centromeric region

condensed chromosome, centromeric region

spindle pole

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

cytosol

cytoskeleton

cell cycle

chromosome segregation

attachment of spindle microtubules to kinetochore

centriole-centriole cohesion

centriole-centriole cohesion

kinase binding

meiotic chromosome segregation

homologous chromosome segregation

meiotic sister chromatid cohesion

cell division

mitotic sister chromatid cohesion, centromeric

04114

TC0400002236.mm.2 Otud6b OTU domain containing 6B 4 -14809504 NM_152812, BC031474, BC087552 NM_152812, BC031474, BC087552 NM_152812, BC031474, BC087552 22

thiol-dependent ubiquitin-specific protease activity

thiol-dependent ubiquitin-specific protease activity

proteolysis

peptidase activity

cysteine-type peptidase activity

cell population proliferation

eukaryotic translation initiation factor 4F complex

protein deubiquitination

protein deubiquitination

hydrolase activity

negative regulation of translation

proteasome assembly

positive regulation of translation

 
TC1900001630.mm.2 Sh3pxd2a SH3 and PX domains 2A 19 -47260173 NM_001164717, NM_008018, BC118022 NM_001164717, NM_008018, BC118022 NM_001164717, NM_008018, BC118022 38

in utero embryonic development

protease binding

podosome

podosome

protein binding

phosphatidylinositol-4,5-bisphosphate binding

cytoplasm

cytoplasm

superoxide metabolic process

superoxide metabolic process

phosphatidylinositol-5-phosphate binding

superoxide-generating NADPH oxidase activator activity

cell junction

phosphatidylinositol-3-phosphate binding

phosphatidylinositol binding

cell projection

phosphatidylinositol-3,4-bisphosphate binding

molecular adaptor activity

phosphatidylinositol-4-phosphate binding

reactive oxygen species metabolic process

osteoclast fusion

 
TC0X00002826.mm.2 Taf9b TATA-box binding protein associated factor 9B X -106206873, -106206873 NM_001001176, NM_001167988, BC066223 NM_001001176, NM_001167988, BC066223 NM_001001176, NM_001167988, BC066223 20

negative regulation of transcription by RNA polymerase II

nucleus

transcription factor TFIID complex

transcription factor TFIID complex

DNA-templated transcription, initiation

transcription by RNA polymerase II

RNA polymerase II general transcription initiation factor activity

positive regulation of cell growth

transcription factor TFTC complex

negative regulation of apoptotic process

protein heterodimerization activity

protein stabilization

03022

TC0600000854.mm.2 Retsat retinol saturase (all trans retinol 13,14 reductase) 6 72598601 NM_026159, BC117751 NM_026159, BC117751 29

nuclear outer membrane

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

membrane

oxidoreductase activity

nuclear membrane

retinol metabolic process

retinol metabolic process

all-trans-retinol 13,14-reductase activity

all-trans-retinol 13,14-reductase activity

all-trans-retinol 13,14-reductase activity

00830

TC0200005468.mm.2 Nup188 nucleoporin 188 2 30286415 NM_198304, BC096591 NM_198304, BC096591 25

nucleus

nuclear pore

RNA export from nucleus

protein import into nucleus

protein import into nucleus

protein transport

structural constituent of nuclear pore

nuclear pore inner ring

mRNA transport

03013

TC0100002413.mm.2 Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 1 -60483184 NM_001045513 23

protein binding

cytosol

cytosol

plasma membrane

plasma membrane

nuclear body

cell leading edge

axon extension

 
TC0100001303.mm.2 Aspm abnormal spindle microtubule assembly 1 139454772 NM_009791 49

spindle pole

neuron migration

neuron migration

positive regulation of neuroblast proliferation

positive regulation of neuroblast proliferation

calmodulin binding

nucleus

cytoplasm

centrosome

cytoskeleton

microtubule

cell cycle

spindle organization

spermatogenesis

brain development

male gonad development

apical plasma membrane

forebrain neuroblast division

cerebral cortex development

midbody

midbody

microtubule minus-end

negative regulation of neuron differentiation

negative regulation of asymmetric cell division

oogenesis

developmental growth

cell division

regulation of meiotic cell cycle

spindle localization

maintenance of centrosome location

meiotic spindle

positive regulation of canonical Wnt signaling pathway

spindle assembly involved in meiosis

neuronal stem cell population maintenance

mitotic spindle pole

mitotic spindle pole

 
TC1100002592.mm.2 Lsm11 U7 snRNP-specific Sm-like protein LSM11 11 -45928268 NM_028185, BC094286, U7-specific-like NM_028185, BC094286, U7-specific-like NM_028185, BC094286, U7-specific-like 19

RNA binding

protein binding

nucleus

nucleoplasm

U7 snRNP

U7 snRNP

U7 snRNP

telomerase holoenzyme complex

mRNA processing

mRNA 3'-end processing by stem-loop binding and cleavage

mRNA 3'-end processing by stem-loop binding and cleavage

nuclear body

histone pre-mRNA 3'end processing complex

U7 snRNA binding

U7 snRNA binding

positive regulation of G1/S transition of mitotic cell cycle

 
TC0800001977.mm.2 Mak16 MAK16 homolog 8 -31159467 NM_026453, BC013079 NM_026453, BC013079 23

maturation of 5.8S rRNA

maturation of LSU-rRNA

nucleus

nucleolus

nucleolus

preribosome, large subunit precursor

intracellular membrane-bounded organelle

 
TC0500001152.mm.2 Chek2 checkpoint kinase 2 5 110839982, 110839982 NM_016681, BC056617 NM_016681, BC056617 109

DNA damage checkpoint

mitotic G2 phase

G2/M transition of mitotic cell cycle

nucleotide binding

chromosome, telomeric region

positive regulation of protein phosphorylation

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

DNA repair

double-strand break repair

regulation of transcription, DNA-templated

protein phosphorylation

apoptotic process

cellular response to DNA damage stimulus

DNA damage induced protein phosphorylation

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cell cycle

intrinsic apoptotic signaling pathway in response to DNA damage

response to gamma radiation

kinase activity

phosphorylation

PML body

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

protein kinase binding

ubiquitin protein ligase binding

regulation of protein catabolic process

signal transduction in response to DNA damage

signal transduction in response to DNA damage

signal transduction in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

protein homodimerization activity

cellular protein catabolic process

mitotic DNA damage checkpoint

positive regulation of transcription, DNA-templated

protein autophosphorylation

metal ion binding

protein stabilization

cell division

negative regulation of cell cycle arrest

cellular response to gamma radiation

signal transduction involved in intra-S DNA damage checkpoint

mitotic spindle assembly

negative regulation of DNA damage checkpoint

positive regulation of anoikis

04110

04115

TC0900001568.mm.2 Ctdspl CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 9 118926535 NM_133710, BC094289 NM_133710, BC094289 17

negative regulation of protein phosphorylation

phosphoprotein phosphatase activity

nucleus

regulation of transcription by RNA polymerase II

RNA polymerase II CTD heptapeptide repeat phosphatase activity

hydrolase activity

phosphatase activity

metal ion binding

negative regulation of G1/S transition of mitotic cell cycle

 
TC0200005346.mm.2         XR_140554      
TC0200005491.mm.2         XM_003688779      
MG-1-neg-10343148_st                
TC0200002755.mm.2 Zfp971 zinc finger protein 971 2 178023283, 178023283 NM_001177399, NM_001177400 NM_001177399, NM_001177400 10

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

regulation of transcription by RNA polymerase II

 
TC0800000172.mm.2 Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) 8 18846278 NM_026792, BC031987 NM_026792, BC031987 28

hematopoietic progenitor cell differentiation

1-acylglycerol-3-phosphate O-acyltransferase activity

1-acylglycerol-3-phosphate O-acyltransferase activity

nucleus

nuclear envelope

mitochondrion

mitochondrion

mitochondrion

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

acylglycerol metabolic process

phospholipid biosynthetic process

endomembrane system

membrane

integral component of membrane

transferase activity

transferase activity, transferring acyl groups

 
TC0700000732.mm.2         XR_030795      
TC1700001197.mm.2 Rmdn2 regulator of microtubule dynamics 2 17 79626674, 79615216, 79615216, 79614899 NM_201361, BC024059 NM_201361, BC024059 16

cytoplasm

cytoplasm

mitochondrion

mitochondrion

Golgi apparatus

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

microtubule binding

microtubule binding

biological_process

membrane

integral component of membrane

mitotic spindle

mitotic spindle pole

mitotic spindle pole

 
TC0X00001658.mm.2 Ap1s2 adaptor-related protein complex 1, sigma 2 subunit X 163909016, 163909016 NM_026887, BC046964 NM_026887, BC046964 28

protein binding

Golgi apparatus

clathrin-coated pit

intracellular protein transport

visual learning

protein transport

membrane

synaptic vesicle budding from endosome

synaptic vesicle budding from endosome

vesicle-mediated transport

vesicle-mediated transport

membrane coat

cytoplasmic vesicle

synaptic vesicle recycling

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

fat cell differentiation

neuromuscular process controlling balance

adipose tissue development

04142

TC0200001352.mm.2 Nup160 nucleoporin 160 2 90677214 NM_021512, BC052450, BC054523 NM_021512, BC052450, BC054523 NM_021512, BC052450, BC054523 28

kinetochore

nucleus

nuclear pore

nuclear pore

nuclear pore

mRNA export from nucleus

mRNA export from nucleus

protein transport

structural constituent of nuclear pore

structural constituent of nuclear pore

structural constituent of nuclear pore

nuclear pore outer ring

mRNA transport

nephron development

03013

TC1300000571.mm.2 Nol8 nucleolar protein 8 13 49653077 NM_001271397, NR_073167, NR_073168, BC125575, BC125579, NM_001081350 NM_001271397, NR_073167, NR_073168, BC125575, BC125579, NM_001081350 NM_001271397, NR_073167, NR_073168, BC125575, BC125579, NM_001081350 NM_001271397, NR_073167, NR_073168, BC125575, BC125579, NM_001081350 NM_001271397, NR_073167, NR_073168, BC125575, BC125579, NM_001081350 NM_001271397, NR_073167, NR_073168, BC125575, BC125579, NM_001081350 22

nucleic acid binding

RNA binding

nucleus

chromosome

nucleolus

nucleolus

rRNA processing

protein localization to nucleolus

protein localization to nucleolus

cellular response to leukemia inhibitory factor

 
TC0X00002631.mm.2 Pola1 polymerase (DNA directed), alpha 1 X -93304765 NM_008892, BC138047 NM_008892, BC138047 36

nucleotide binding

DNA synthesis involved in DNA repair

chromatin

nucleoside binding

nucleic acid binding

DNA binding

chromatin binding

chromatin binding

DNA replication origin binding

double-stranded DNA binding

single-stranded DNA binding

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

protein binding

nucleus

nucleus

nuclear envelope

nucleoplasm

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

alpha DNA polymerase:primase complex

nucleolus

cytoplasm

cytosol

DNA replication

DNA replication

DNA replication

DNA replication, synthesis of RNA primer

DNA replication, synthesis of RNA primer

DNA replication initiation

DNA strand elongation involved in DNA replication

leading strand elongation

leading strand elongation

lagging strand elongation

lagging strand elongation

double-strand break repair via nonhomologous end joining

nuclear matrix

transferase activity

nucleotidyltransferase activity

purine nucleotide binding

purine nucleotide binding

pyrimidine nucleotide binding

pyrimidine nucleotide binding

protein kinase binding

regulation of type I interferon production

metal ion binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

DNA biosynthetic process

mitotic DNA replication initiation

00230

00240

01100

03030

TC0200004250.mm.2 Qser1 glutamine and serine rich 1 2 -104754792 NM_001123327 19

molecular_function

cellular_component

biological_process

 
TC1400002290.mm.2 Cdca2 cell division cycle associated 2 14 -67676353, -67676353 NM_001110162, NM_175384, BC116298, BC116299 NM_001110162, NM_175384, BC116298, BC116299 NM_001110162, NM_175384, BC116298, BC116299 NM_001110162, NM_175384, BC116298, BC116299 22

molecular_function

nucleus

nucleoplasm

chromosome

cytosol

cell cycle

chromosome segregation

positive regulation of protein dephosphorylation

cell division

 
TC0100001494.mm.2 Mettl18 methyltransferase like 18 1 163994888 NM_027279, BC050143, BC052693 NM_027279, BC050143, BC052693 NM_027279, BC050143, BC052693 15

methyltransferase activity

transferase activity

protein-histidine N-methyltransferase activity

heat shock protein binding

methylation

protein-containing complex

peptidyl-histidine methylation, to form tele-methylhistidine

 

1074 Genes